ES2153046T3 - Radicales libres a base de heterociclil-metilo utilizados como agentes intensificadores de imagen. - Google Patents

Radicales libres a base de heterociclil-metilo utilizados como agentes intensificadores de imagen.

Info

Publication number
ES2153046T3
ES2153046T3 ES95931302T ES95931302T ES2153046T3 ES 2153046 T3 ES2153046 T3 ES 2153046T3 ES 95931302 T ES95931302 T ES 95931302T ES 95931302 T ES95931302 T ES 95931302T ES 2153046 T3 ES2153046 T3 ES 2153046T3
Authority
ES
Spain
Prior art keywords
group
sup
radicals
water solubilizing
atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95931302T
Other languages
English (en)
Inventor
Sven Andersson
Anna Rydbeck
Rolf Servin
Lars-Goran Wistrand
Finn Radner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
Nycomed Imaging AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Imaging AS filed Critical Nycomed Imaging AS
Application granted granted Critical
Publication of ES2153046T3 publication Critical patent/ES2153046T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/20—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations containing free radicals, e.g. trityl radical for overhauser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B61/00—Other general methods
    • C07B61/02—Generation of organic free radicals; Organic free radicals per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C07F7/0814—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Hydrogenated Pyridines (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Pyridine Compounds (AREA)
  • Cosmetics (AREA)

Abstract

LA INVENCION PROPONE NOVEDOSOS RADICALES LIBRES PERSISTENTES UTILES EN RMI OVERHAUSER QUE SON RADICALES TRIARILMETILO CON AL MENOS UN GRUPO ARILO DE FORMULA (1) O (2), DONDE CADA X, QUE PUEDEN SER IGUALES O DIFERENTES, ES UN ATOMO DE OXIGENO O AZUFRE O UN GRUPO CO O S(O) SUB,N} (DONDE N ES DE 1 A 3) CON LA CONDICION DE QUE AL MENOS UN GRUPO X SEA UN ATOMO DE AZUFRE O UN GRUPO S(O) SUB,N}; R SUP,1} ES UN ATOMO DE HIDROGENO O UN GRUPO DE FORMULA SOLUBILIZADOR EN AGUA, Y AR SUP,2} REPRESENTA UN ANILLO AROMATICO DE 5 A 10 MIEMBROS OPCIONALMENTE SUSTITUIDO POR UN GRUPO M SOLUBILIZADOR EN AGUA; Y CADA UNO DE LOS GRUPOS R SUP,7}, QUE PUEDEN SER IGUALES O DIFERENTES, ES UN ATOMO DE HIDROGENO O UN GRUPO HIDROCARBURO O UN GRUPO M SOLUBILIZADOR EN AGUA, O DOS GRUPOS R SUP,7} JUNTO CON EL ATOMO AL QUE ESTAN ENLAZADOS REPRESENTAN UN GRUPO CARBONILO O UN CICLOALQUILIDENO DE 5 A 8 MIEMBROS, MONO QUILIDENO O MONO ICIO, Y CUANDO R SUP,7} NO ES HIDROGENO ESTA OPCIONALMENTE SUSTITUIDO POR UN GRUPO HIDROXILO,UN GRUPO ACILOXI O ALQUILO OPCIONALMENTE ALCOXILADO Y OPCIONALMENTE HIDROXILADO O UN GRUPO M SOLUBILIZADOR EN AGUA. LOS RADICALES NOVEDOSOS PRESENTAN BUENA ESTABILIDAD, TIEMPOS DE RELAJACION LARGOS Y BUENA RELAJABILIDAD.
ES95931302T 1995-06-06 1995-09-08 Radicales libres a base de heterociclil-metilo utilizados como agentes intensificadores de imagen. Expired - Lifetime ES2153046T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/467,273 US5728370A (en) 1993-04-02 1995-06-06 Free Radicals

Publications (1)

Publication Number Publication Date
ES2153046T3 true ES2153046T3 (es) 2001-02-16

Family

ID=23855069

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95931302T Expired - Lifetime ES2153046T3 (es) 1995-06-06 1995-09-08 Radicales libres a base de heterociclil-metilo utilizados como agentes intensificadores de imagen.

Country Status (16)

Country Link
US (1) US5728370A (es)
EP (1) EP0832054B1 (es)
JP (1) JP4054376B2 (es)
KR (1) KR19990022477A (es)
CN (1) CN1193952A (es)
AT (1) ATE198313T1 (es)
AU (1) AU709532B2 (es)
CA (1) CA2222331A1 (es)
CZ (1) CZ390197A3 (es)
DE (1) DE69519752T2 (es)
ES (1) ES2153046T3 (es)
HU (1) HUT78020A (es)
NO (1) NO975758D0 (es)
NZ (1) NZ292582A (es)
PL (1) PL323919A1 (es)
WO (1) WO1996039367A1 (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9704669D0 (en) * 1997-03-06 1997-04-23 Nycomed Imaging As Free radicals
US6063360A (en) * 1993-04-02 2000-05-16 Nycomed Imaging A/S Free radicals comprising benzodithiole derivatives
ES2201462T3 (es) * 1997-03-06 2004-03-16 Amersham Health As Radicales libres de triarilmetilo como agentes mejoradores de la imagen.
US7122736B2 (en) * 2001-08-16 2006-10-17 Midwest Research Institute Method and apparatus for fabricating a thin-film solar cell utilizing a hot wire chemical vapor deposition technique
US7351402B2 (en) * 2003-08-21 2008-04-01 Massachusetts Institute Of Technology Polarizing agents for dynamic nuclear polarization
JP5535435B2 (ja) * 2004-07-30 2014-07-02 ジーイー・ヘルスケア・アクスイェ・セルスカプ ラジカル及び、ｄｎｐ処理における常磁性試薬としてのその使用
NZ552898A (en) 2004-07-30 2011-02-25 Ge Healthcare As Method of producing a composition, composition and its use
CA2628539C (en) 2005-12-01 2014-04-29 Ge Healthcare As Method of dynamic nuclear polarisation (dnp) using a trityl radical and a paramagnetic metal ion
US20090004114A1 (en) 2005-12-08 2009-01-01 Koninklijke Philips Electronics N. V. System and Method for Monitoring in Vivo Drug Release Using Overhauser-Enhanced Nmr
ES2393750T3 (es) * 2005-12-16 2012-12-27 Ge Healthcare As Procedimiento para producir carbosilatos hiperpolarizados de aminas orgánicas
US7985594B2 (en) 2006-05-12 2011-07-26 Massachusetts Institute Of Technology Biradical polarizing agents for dynamic nuclear polarization
JP5269791B2 (ja) 2006-08-30 2013-08-21 ジーイー・ヘルスケア・アクスイェ・セルスカプ 動的核分極（ｄｎｐ）方法並びに該方法で使用するための化合物及び組成物
EP2072061A1 (en) 2007-12-19 2009-06-24 GE Healthcare Limited Composition and method for generating a metabolic profile using 13C-MR detection
US8697034B2 (en) 2008-10-10 2014-04-15 The Board Of Regents Of The University Of Texas System Hyperpolarized 89-yttrium and methods relating thereto
US8968703B2 (en) 2009-09-10 2015-03-03 Ge Healthcare Limited 13C-MR detection using hyperpolarised 13C-fructose
WO2011124672A1 (en) 2010-04-08 2011-10-13 Bracco Imaging Spa Process for preparing hyperpolarized substrates and method for mri
FR2967158A1 (fr) 2010-11-08 2012-05-11 Phosphoenix Sarl Nouveaux radicaux triarylmethyle: leur preparation et application
EP2726458B1 (en) * 2011-06-30 2017-01-04 Godavari Biorefineries Ltd. Synthesis of cleistanthin a and derivatives thereof
US9511154B2 (en) 2011-10-12 2016-12-06 Bracco Imaging S.P.A. Process for the preparation of hyperpolarized derivatives for use in MRI analysis
US9693828B2 (en) 2011-12-05 2017-07-04 Bracco Imaging S.P.A. Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation in MRI analysis
US8715621B2 (en) 2012-03-15 2014-05-06 Massachusetts Institute Of Technology Radical polarizing agents for dynamic nuclear polarization
US9925280B2 (en) 2012-04-02 2018-03-27 Bracco Imaging S.P.A. Hyperpolarized amino acids
US9381257B2 (en) 2012-07-13 2016-07-05 Bracco Imaging S.P.A. Triarylmethyl radicals
JPWO2014192894A1 (ja) * 2013-05-29 2017-02-23 国立大学法人九州大学 生体における酸化還元反応を検出する方法
CN103951613A (zh) * 2014-04-21 2014-07-30 南开大学 用于蛋白质顺磁标记的dtpa类似物的设计与合成
CN104610138A (zh) * 2015-01-09 2015-05-13 南开大学 用于蛋白质顺磁标记的乙二胺四乙酸类探针的合成方法
WO2019018655A1 (en) * 2017-07-19 2019-01-24 West Virginia University SYNTHESIS OF BIOCOMPATIBLE TRITYLE RADICALS FOR APPLICATIONS AS HYPERPOLARIZATION AGENTS
DE102017122275B4 (de) * 2017-09-26 2021-03-11 Universität Potsdam Fluoreszenzfarbstoffe basierend auf Benzo[1,2-d:4,5- d']bis([1,3]dithiol)
DE102018126261A1 (de) 2018-10-22 2020-04-23 Universität Bielefeld Tritylverbindungen vom Finland-Typ

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0515458T3 (da) * 1990-02-12 1995-09-25 Nycomed Innovation Ab Triarylmethylradikaler og anvendelse af inerte, frie carbon-radikaler ved MRI
AU660033B2 (en) * 1991-05-23 1995-06-08 Imarx Pharmaceutical Corp. Liposoluble compounds for magnetic resonance imaging
GB9117258D0 (en) * 1991-08-09 1991-09-25 Hafslund Nycomed Innovation Use of radicals
ES2114566T3 (es) * 1991-08-09 1998-06-01 Nycomed Innovation Ab Uso de radicales libres persistentes en formacion de imagenes por resonancia magnetica nuclear.
GB9307027D0 (en) * 1993-04-02 1993-05-26 Nycomed Innovation Ab Free radicals

Also Published As

Publication number Publication date
DE69519752T2 (de) 2001-08-02
NO975758L (no) 1997-12-05
NO975758D0 (no) 1997-12-05
CZ390197A3 (cs) 1998-06-17
JPH11505510A (ja) 1999-05-21
HUT78020A (hu) 1999-05-28
CN1193952A (zh) 1998-09-23
KR19990022477A (ko) 1999-03-25
AU3479095A (en) 1996-12-24
EP0832054B1 (en) 2000-12-27
WO1996039367A1 (en) 1996-12-12
JP4054376B2 (ja) 2008-02-27
US5728370A (en) 1998-03-17
NZ292582A (en) 1998-12-23
ATE198313T1 (de) 2001-01-15
DE69519752D1 (de) 2001-02-01
EP0832054A1 (en) 1998-04-01
PL323919A1 (en) 1998-04-27
AU709532B2 (en) 1999-09-02
CA2222331A1 (en) 1996-12-12

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