ATE198313T1 - Heterocyclische methylfreie radikale als biloverbesserungsmittel - Google Patents

Heterocyclische methylfreie radikale als biloverbesserungsmittel

Info

Publication number
ATE198313T1
ATE198313T1 AT95931302T AT95931302T ATE198313T1 AT E198313 T1 ATE198313 T1 AT E198313T1 AT 95931302 T AT95931302 T AT 95931302T AT 95931302 T AT95931302 T AT 95931302T AT E198313 T1 ATE198313 T1 AT E198313T1
Authority
AT
Austria
Prior art keywords
free radicals
bio
methyl free
improvement agents
heterocyclic methyl
Prior art date
Application number
AT95931302T
Other languages
English (en)
Inventor
Sven Andersson
Anna Rydbeck
Rolf Servin
Lars-Goran Wistrand
Finn Radner
Original Assignee
Nycomed Imaging As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Imaging As filed Critical Nycomed Imaging As
Application granted granted Critical
Publication of ATE198313T1 publication Critical patent/ATE198313T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B61/00Other general methods
    • C07B61/02Generation of organic free radicals; Organic free radicals per se
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/20Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations containing free radicals, e.g. trityl radical for overhauser
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D497/00Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/0803Compounds with Si-C or Si-Si linkages
    • C07F7/081Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C07F7/0814Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Pyridine Compounds (AREA)
  • Cosmetics (AREA)
AT95931302T 1995-06-06 1995-09-08 Heterocyclische methylfreie radikale als biloverbesserungsmittel ATE198313T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/467,273 US5728370A (en) 1993-04-02 1995-06-06 Free Radicals
PCT/GB1995/002151 WO1996039367A1 (en) 1994-03-31 1995-09-08 Heterocyclic methyl free radicals as image enhancing agents

Publications (1)

Publication Number Publication Date
ATE198313T1 true ATE198313T1 (de) 2001-01-15

Family

ID=23855069

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95931302T ATE198313T1 (de) 1995-06-06 1995-09-08 Heterocyclische methylfreie radikale als biloverbesserungsmittel

Country Status (16)

Country Link
US (1) US5728370A (de)
EP (1) EP0832054B1 (de)
JP (1) JP4054376B2 (de)
KR (1) KR19990022477A (de)
CN (1) CN1193952A (de)
AT (1) ATE198313T1 (de)
AU (1) AU709532B2 (de)
CA (1) CA2222331A1 (de)
CZ (1) CZ390197A3 (de)
DE (1) DE69519752T2 (de)
ES (1) ES2153046T3 (de)
HU (1) HUT78020A (de)
NO (1) NO975758L (de)
NZ (1) NZ292582A (de)
PL (1) PL323919A1 (de)
WO (1) WO1996039367A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6063360A (en) * 1993-04-02 2000-05-16 Nycomed Imaging A/S Free radicals comprising benzodithiole derivatives
GB9704669D0 (en) * 1997-03-06 1997-04-23 Nycomed Imaging As Free radicals
ES2201462T3 (es) * 1997-03-06 2004-03-16 Amersham Health As Radicales libres de triarilmetilo como agentes mejoradores de la imagen.
US7122736B2 (en) * 2001-08-16 2006-10-17 Midwest Research Institute Method and apparatus for fabricating a thin-film solar cell utilizing a hot wire chemical vapor deposition technique
US7351402B2 (en) * 2003-08-21 2008-04-01 Massachusetts Institute Of Technology Polarizing agents for dynamic nuclear polarization
NZ552898A (en) * 2004-07-30 2011-02-25 Ge Healthcare As Method of producing a composition, composition and its use
ES2545377T3 (es) * 2004-07-30 2015-09-10 Ge Healthcare As Radicales y su uso como agentes paramagnéticos en un proceso de polarización nuclear dinámica
JP5475995B2 (ja) 2005-12-01 2014-04-16 ジーイー・ヘルスケア・アクスイェ・セルスカプ 動的核分極(dnp)法
CN101325977A (zh) 2005-12-08 2008-12-17 皇家飞利浦电子股份有限公司 使用Overhauser增强的NMR监测体内药物释放的系统和方法
PL1962912T3 (pl) * 2005-12-16 2013-03-29 Ge Healthcare As Sposób wytwarzania hiperpolaryzowanych karboksylanów amin organicznych
EP2018545A4 (de) 2006-05-12 2011-03-09 Massachusetts Inst Technology Biradikale polarisierungsmittel für dynamische nuklearpolarisierung
KR20140144312A (ko) 2006-08-30 2014-12-18 지이 헬스케어 에이에스 동적 핵 분극화 방법 및 이러한 방법에서 사용되는 화합물 및 조성물
EP2072061A1 (de) 2007-12-19 2009-06-24 GE Healthcare Limited Zusammensetzung und Verfahren zur Erzeugung eines metabolischen Profils bei Verwendung von 13C-MR
US8697034B2 (en) 2008-10-10 2014-04-15 The Board Of Regents Of The University Of Texas System Hyperpolarized 89-yttrium and methods relating thereto
US8968703B2 (en) 2009-09-10 2015-03-03 Ge Healthcare Limited 13C-MR detection using hyperpolarised 13C-fructose
JP5758982B2 (ja) 2010-04-08 2015-08-05 ブラッコ・イメージング・ソシエタ・ペル・アチオニBracco Imaging S.P.A. 過分極基質の製造方法およびmriのための方法
FR2967158A1 (fr) 2010-11-08 2012-05-11 Phosphoenix Sarl Nouveaux radicaux triarylmethyle: leur preparation et application
EP2726458B1 (de) * 2011-06-30 2017-01-04 Godavari Biorefineries Ltd. Synthese von cleistanthin a und derivaten davon
WO2013053839A1 (en) 2011-10-12 2013-04-18 Bracco Imaging Spa Process for the preparation of hyperpolarized derivatives for use in mri analysis
US9693828B2 (en) 2011-12-05 2017-07-04 Bracco Imaging S.P.A. Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation in MRI analysis
US8715621B2 (en) 2012-03-15 2014-05-06 Massachusetts Institute Of Technology Radical polarizing agents for dynamic nuclear polarization
WO2013149935A1 (en) 2012-04-02 2013-10-10 Bracco Imaging Spa Hyperpolarized amino acids
US9381257B2 (en) 2012-07-13 2016-07-05 Bracco Imaging S.P.A. Triarylmethyl radicals
WO2014192894A1 (ja) * 2013-05-29 2014-12-04 国立大学法人九州大学 生体における酸化還元反応を検出する方法
CN103951613A (zh) * 2014-04-21 2014-07-30 南开大学 用于蛋白质顺磁标记的dtpa类似物的设计与合成
CN104610138A (zh) * 2015-01-09 2015-05-13 南开大学 用于蛋白质顺磁标记的乙二胺四乙酸类探针的合成方法
WO2019018655A1 (en) * 2017-07-19 2019-01-24 West Virginia University SYNTHESIS OF BIOCOMPATIBLE TRITYLE RADICALS FOR APPLICATIONS AS HYPERPOLARIZATION AGENTS
DE102017122275B4 (de) * 2017-09-26 2021-03-11 Universität Potsdam Fluoreszenzfarbstoffe basierend auf Benzo[1,2-d:4,5- d']bis([1,3]dithiol)
DE102018126261A1 (de) 2018-10-22 2020-04-23 Universität Bielefeld Tritylverbindungen vom Finland-Typ

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3175940B2 (ja) * 1990-02-12 2001-06-11 ニコムド イノベーション アーベー トリアリールメチルラジカルおよび磁気共鳴造影法における不活性炭素フリーラジカルの用途
CA2102605A1 (en) * 1991-05-23 1992-11-24 Evan C. Unger Liposoluble compounds for magnetic resonance imaging
AU668691B2 (en) * 1991-08-09 1996-05-16 Nycomed Innovation Ab Use of persistent free-radicals in magnetic resonance imaging
GB9117258D0 (en) * 1991-08-09 1991-09-25 Hafslund Nycomed Innovation Use of radicals
GB9307027D0 (en) * 1993-04-02 1993-05-26 Nycomed Innovation Ab Free radicals

Also Published As

Publication number Publication date
PL323919A1 (en) 1998-04-27
CA2222331A1 (en) 1996-12-12
EP0832054B1 (de) 2000-12-27
CZ390197A3 (cs) 1998-06-17
EP0832054A1 (de) 1998-04-01
AU3479095A (en) 1996-12-24
JPH11505510A (ja) 1999-05-21
NZ292582A (en) 1998-12-23
JP4054376B2 (ja) 2008-02-27
HUT78020A (hu) 1999-05-28
CN1193952A (zh) 1998-09-23
DE69519752T2 (de) 2001-08-02
NO975758D0 (no) 1997-12-05
DE69519752D1 (de) 2001-02-01
US5728370A (en) 1998-03-17
ES2153046T3 (es) 2001-02-16
AU709532B2 (en) 1999-09-02
KR19990022477A (ko) 1999-03-25
NO975758L (no) 1997-12-05
WO1996039367A1 (en) 1996-12-12

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