ES2194480T3 - Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion. - Google Patents
Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion.Info
- Publication number
- ES2194480T3 ES2194480T3 ES99931261T ES99931261T ES2194480T3 ES 2194480 T3 ES2194480 T3 ES 2194480T3 ES 99931261 T ES99931261 T ES 99931261T ES 99931261 T ES99931261 T ES 99931261T ES 2194480 T3 ES2194480 T3 ES 2194480T3
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- coating
- procedure
- oral pharmaceutical
- activity compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Comprende un compuesto de actividad antifúngica como principio activo, un núcleo inerte y un recubrimiento que incluye dicho principio activo, y se caracteriza por el hecho de que dicho núcleo inerte presenta un tamaño de partícula comprendido entre 50-600 µm, y por el hecho de que dicho recubrimiento comprende una única capa que se obtiene por nebulización, sobre dicho núcleo inerte, de una solución que comprende un compuesto de actividad antifúngica, un polímero hidrofílico y un agente tensioactivo no iónico. El procedimiento se lleva a cabo mediante un recubrimiento que comprende una única capa de los núcleos inertes de tamaño entre 50 y 600 µm por nebulización de una solución compuesta por el agente antifúngico, el polímero hidrofílico y el agente tensioactivo no iónico a una velocidad de recubrimiento constante durante todo el proceso; y un solo secado de dicho recubrimiento en el mismo equipo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES009801539A ES2157731B1 (es) | 1998-07-21 | 1998-07-21 | Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2194480T3 true ES2194480T3 (es) | 2003-11-16 |
Family
ID=8304581
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES009801539A Expired - Fee Related ES2157731B1 (es) | 1998-07-21 | 1998-07-21 | Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion. |
| ES99931261T Expired - Lifetime ES2194480T3 (es) | 1998-07-21 | 1999-07-20 | Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES009801539A Expired - Fee Related ES2157731B1 (es) | 1998-07-21 | 1998-07-21 | Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion. |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6737082B1 (es) |
| EP (1) | EP1103252B1 (es) |
| JP (1) | JP4190732B2 (es) |
| KR (1) | KR100572135B1 (es) |
| AT (1) | ATE234077T1 (es) |
| AU (1) | AU750730B2 (es) |
| BG (1) | BG65187B1 (es) |
| BR (1) | BR9912300A (es) |
| CA (1) | CA2337509C (es) |
| CZ (1) | CZ291938B6 (es) |
| DE (1) | DE69905905T2 (es) |
| DK (1) | DK1103252T3 (es) |
| EE (1) | EE04415B1 (es) |
| ES (2) | ES2157731B1 (es) |
| HR (1) | HRP20010128B1 (es) |
| HU (1) | HU228895B1 (es) |
| IL (1) | IL140910A (es) |
| ME (1) | MEP26708A (es) |
| MX (1) | MXPA01000681A (es) |
| NO (1) | NO320054B1 (es) |
| NZ (1) | NZ509886A (es) |
| PL (1) | PL194740B1 (es) |
| PT (1) | PT1103252E (es) |
| RS (1) | RS50063B (es) |
| RU (1) | RU2209628C2 (es) |
| SK (1) | SK283279B6 (es) |
| TR (1) | TR200100177T2 (es) |
| UA (1) | UA64009C2 (es) |
| WO (1) | WO2000004881A1 (es) |
| ZA (1) | ZA200101293B (es) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1122456C (zh) * | 1996-01-31 | 2003-10-01 | 南亚拉巴马医学科学基金会 | 含有天然的还原叶酸盐异构体的食品和维生素制品 |
| US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| DZ3227A1 (fr) | 1999-12-23 | 2001-07-05 | Pfizer Prod Inc | Compositions pharmaceutiques fournissant des concentrations de medicaments ameliorees |
| FR2842736B1 (fr) | 2002-07-26 | 2005-07-22 | Flamel Tech Sa | Formulation pharmaceutique orale sous forme d'une pluralite de microcapsules permettant la liberation prolongee de principe(s) actif(s) peu soluble(s) |
| US20040115287A1 (en) * | 2002-12-17 | 2004-06-17 | Lipocine, Inc. | Hydrophobic active agent compositions and methods |
| DK1438961T4 (da) * | 2003-01-14 | 2014-11-17 | Acino Pharma Ag | Bioækvivalent sammensætning af itraconazol dispergeret i en hydrofil polymer |
| SI1438960T2 (sl) * | 2003-01-14 | 2013-04-30 | Cimex Pharma Ag | Sestavek itrakonazola, dispergiranega v hidrofilnem polimeru, z izboljšano biorazpoložljivostjo |
| FR2852607B1 (fr) * | 2003-03-20 | 2006-07-14 | Procede de fabrication de microspheres de sucre de petite taille, les microspheres susceptibles d'etre obtenues par ce procede et leurs applications | |
| FR2857591B1 (fr) * | 2003-07-17 | 2007-11-02 | Ethypharm Sa | Particules comprenant un principe actif sous forme de co-precipite |
| CN1822843B (zh) * | 2003-07-17 | 2010-04-28 | 泰博特克药品有限公司 | 制备含有抗病毒药物颗粒的方法 |
| FR2883179B1 (fr) | 2005-03-18 | 2009-04-17 | Ethypharm Sa | Comprime enrobe |
| US8653083B2 (en) | 2005-08-22 | 2014-02-18 | The Johns Hopkins University | Hedgehog pathway antagonists to treat disease |
| CN101283984B (zh) * | 2007-04-12 | 2010-05-26 | 永胜药品工业股份有限公司 | 高生物使用率的经杀真菌剂和聚合物涂覆的核心微粒状物 |
| US11304960B2 (en) | 2009-01-08 | 2022-04-19 | Chandrashekar Giliyar | Steroidal compositions |
| JP2013521249A (ja) * | 2010-03-05 | 2013-06-10 | ビーエーエスエフ ソシエタス・ヨーロピア | 融解物で被覆された医薬形態 |
| US9358241B2 (en) | 2010-11-30 | 2016-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
| US9034858B2 (en) | 2010-11-30 | 2015-05-19 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
| US20180153904A1 (en) | 2010-11-30 | 2018-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
| US20120148675A1 (en) | 2010-12-10 | 2012-06-14 | Basawaraj Chickmath | Testosterone undecanoate compositions |
| US9498485B2 (en) | 2014-08-28 | 2016-11-22 | Lipocine Inc. | Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters |
| US20170246187A1 (en) | 2014-08-28 | 2017-08-31 | Lipocine Inc. | (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE |
| MA40982A (fr) * | 2014-11-19 | 2017-09-26 | Biogen Ma Inc | Formulation de bille pharmaceutique comprenant du fumarate de diméthyle |
| WO2016189481A1 (en) * | 2015-05-25 | 2016-12-01 | Sun Pharmaceutical Industries Limited | Once daily oral pharmaceutical composition of isotretinoin |
| US20160361322A1 (en) | 2015-06-15 | 2016-12-15 | Lipocine Inc. | Composition and method for oral delivery of androgen prodrugs |
| KR102419769B1 (ko) | 2016-08-11 | 2022-07-13 | 아다미스 파마슈티칼스 코포레이션 | 약물 조성물 |
| US20180147215A1 (en) | 2016-11-28 | 2018-05-31 | Lipocine Inc. | Oral testosterone undecanoate therapy |
| EP3720844A4 (en) | 2017-12-08 | 2021-08-11 | Adamis Pharmaceuticals Corporation | MEDICINAL COMPOSITIONS |
| WO2019208801A1 (ja) * | 2018-04-27 | 2019-10-31 | 凸版印刷株式会社 | 徐放性複合粒子、徐放性複合粒子の製造方法、乾燥粉体及び壁紙 |
| US12150945B2 (en) | 2018-07-20 | 2024-11-26 | Lipocine Inc. | Liver disease |
| EP4452232A1 (en) * | 2021-12-22 | 2024-10-30 | Palau Pharma, S.L.U. | Multiparticulate albaconazole composition |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4267179A (en) * | 1978-06-23 | 1981-05-12 | Janssen Pharmaceutica, N.V. | Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles |
| US4916134A (en) * | 1987-03-25 | 1990-04-10 | Janssen Pharmacuetica N.V. | 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4-yl]me]phenyl]-1-piperazinyl]phenyl]triazolones |
| IE61651B1 (en) * | 1990-07-04 | 1994-11-16 | Zambon Spa | Programmed release oral solid pharmaceutical dosage form |
| PH30929A (en) * | 1992-09-03 | 1997-12-23 | Janssen Pharmaceutica Nv | Beads having a core coated with an antifungal and a polymer. |
| TW349870B (en) * | 1993-09-30 | 1999-01-11 | Janssen Pharmaceutica Nv | An antifungal pharmaceutical composition for oral administration and a process for the preparation thereof |
| US5567441A (en) * | 1995-03-24 | 1996-10-22 | Andrx Pharmaceuticals Inc. | Diltiazem controlled release formulation |
| DK0904060T3 (da) * | 1996-05-20 | 2004-04-13 | Janssen Pharmaceutica Nv | Antifungale præparater med forbedret biotilgængelighed |
| ZA974428B (en) * | 1996-05-24 | 1997-11-24 | Schering Corp | Antifungal composition with enhanced bioavailability. |
| NZ333514A (en) * | 1996-06-28 | 2000-05-26 | Schering Corp | Oral pharmaceutical composition comprising a triazole antifungal compound |
| DE19626924C2 (de) * | 1996-07-04 | 1999-08-19 | Epazon B V | Gerät zur Bereitstellung eines Atemgases |
| WO1998042318A1 (en) | 1997-03-26 | 1998-10-01 | Janssen Pharmaceutica N.V. | Pellets having a core coated with an antifungal and a polymer |
-
1998
- 1998-07-21 ES ES009801539A patent/ES2157731B1/es not_active Expired - Fee Related
-
1999
- 1999-07-20 UA UA2001021260A patent/UA64009C2/uk unknown
- 1999-07-20 TR TR2001/00177T patent/TR200100177T2/xx unknown
- 1999-07-20 BR BR9912300-2A patent/BR9912300A/pt not_active Application Discontinuation
- 1999-07-20 ME MEP-267/08A patent/MEP26708A/xx unknown
- 1999-07-20 RU RU2001104894/14A patent/RU2209628C2/ru not_active IP Right Cessation
- 1999-07-20 EE EEP200100041A patent/EE04415B1/xx not_active IP Right Cessation
- 1999-07-20 US US09/744,322 patent/US6737082B1/en not_active Expired - Fee Related
- 1999-07-20 RS YUP-39/01A patent/RS50063B/sr unknown
- 1999-07-20 JP JP2000560874A patent/JP4190732B2/ja not_active Expired - Fee Related
- 1999-07-20 SK SK86-2001A patent/SK283279B6/sk not_active IP Right Cessation
- 1999-07-20 WO PCT/ES1999/000230 patent/WO2000004881A1/es not_active Ceased
- 1999-07-20 HR HR20010128A patent/HRP20010128B1/xx not_active IP Right Cessation
- 1999-07-20 KR KR1020017000783A patent/KR100572135B1/ko not_active Expired - Fee Related
- 1999-07-20 AU AU47821/99A patent/AU750730B2/en not_active Ceased
- 1999-07-20 AT AT99931261T patent/ATE234077T1/de active
- 1999-07-20 CA CA002337509A patent/CA2337509C/en not_active Expired - Fee Related
- 1999-07-20 CZ CZ2001175A patent/CZ291938B6/cs not_active IP Right Cessation
- 1999-07-20 ES ES99931261T patent/ES2194480T3/es not_active Expired - Lifetime
- 1999-07-20 PL PL99345625A patent/PL194740B1/pl not_active IP Right Cessation
- 1999-07-20 NZ NZ509886A patent/NZ509886A/xx not_active IP Right Cessation
- 1999-07-20 DK DK99931261T patent/DK1103252T3/da active
- 1999-07-20 HU HU0103708A patent/HU228895B1/hu not_active IP Right Cessation
- 1999-07-20 DE DE69905905T patent/DE69905905T2/de not_active Expired - Lifetime
- 1999-07-20 MX MXPA01000681A patent/MXPA01000681A/es active IP Right Grant
- 1999-07-20 PT PT99931261T patent/PT1103252E/pt unknown
- 1999-07-20 IL IL14091099A patent/IL140910A/en not_active IP Right Cessation
- 1999-07-20 EP EP99931261A patent/EP1103252B1/en not_active Expired - Lifetime
-
2001
- 2001-01-17 NO NO20010289A patent/NO320054B1/no not_active IP Right Cessation
- 2001-02-15 ZA ZA200101293A patent/ZA200101293B/en unknown
- 2001-02-21 BG BG105282A patent/BG65187B1/bg unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2157731B1 (es) | Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion. | |
| CA2396152A1 (en) | Osmotic device within an osmotic device | |
| DK1183014T3 (da) | Smagsmaskerede orale farmaceutiske sammensætninger med kontrolleret frigivelse | |
| AR027091A1 (es) | Forma de dosificacion de farmacos accionada por un hidrogel | |
| IS4328A (is) | Fjöleininga lyfjablanda sem inniheldur prótónupumpublokkara | |
| JP2003512395A5 (es) | ||
| BR9917089A (pt) | Composições e métodos para distribuição mucosal | |
| CA2322875A1 (en) | A coated chewing gum, a method for preparation thereof and the use of one or more active substance(s) in solid form | |
| ES2115733T3 (es) | Composicion antialergica para uso oftalmico o nasal. | |
| CA2395981A1 (en) | Osmotic device having a preformed passageway that increases in size | |
| IL149573A0 (en) | Multi-layer preparation in film form, consisting of hydrophilic polymers, for the rapid release of active ingredients | |
| ES2052016T3 (es) | Composicion emulsionada. | |
| BRPI0015567B8 (pt) | composto, composição farmacêutica, forma de unidade de dosagem, uso da composição farmacêutica e método para preparar uma composição farmacêutica | |
| WO2002098482A3 (en) | System for osmotic delivery of pharmaceutically active agents | |
| DK1077680T3 (da) | Fremgangsmåde til fremstilling af en med bånd forsynet aktivt-stof-doseringsform til prolongeret release | |
| ES2101082T3 (es) | Composiciones de liberacion controlada. | |
| CO5140128A1 (es) | Peliculas de poliuretano preparadas a partir de disperciones de poliuretano | |
| CO5011082A1 (es) | Formulacion medicamentosa con liberacion controlada de sus- tancia activa | |
| AR019745A1 (es) | Dispersion de fragancias | |
| ES2060293T3 (es) | Nueva sustancia antiulcerosa. | |
| WO2001070184A3 (en) | A composition containing monoterpenes for topical oral administration | |
| EP1206907A4 (en) | HERBICIDAL COMPOSITIONS AND METHODS OF USE | |
| AR033862A1 (es) | Formulacion de medicamento que contiene un agente agonista muscarinico | |
| RU2002133953A (ru) | Способ лечения больных генерализованным пародонтитом | |
| UY26503A1 (es) | " forma de dosificación de fármacos accionada por un hidrogel" |