ES2170733B1 - Metodo para preparar citalopram purificado - Google Patents

Metodo para preparar citalopram purificado

Info

Publication number
ES2170733B1
ES2170733B1 ES200101763A ES200101763A ES2170733B1 ES 2170733 B1 ES2170733 B1 ES 2170733B1 ES 200101763 A ES200101763 A ES 200101763A ES 200101763 A ES200101763 A ES 200101763A ES 2170733 B1 ES2170733 B1 ES 2170733B1
Authority
ES
Spain
Prior art keywords
citalopram
preparing purified
base
product
optionally
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES200101763A
Other languages
English (en)
Other versions
ES2170733A1 (es
Inventor
Andrea Castellin
Giulio Volpe
Federico Sbrogio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Publication of ES2170733A1 publication Critical patent/ES2170733A1/es
Application granted granted Critical
Publication of ES2170733B1 publication Critical patent/ES2170733B1/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Método para preparar citalopram purificado, caracterizado porque el producto de citalopram crudo se somete opcionalmente a una purificación adicional; y la base de citalopram cruda se somete subsiguientemente a un proceso de destilación en película para separar impurezas de la reacción de elevado peso molecular; después, el producto de citalopram resultante se purifica opcionalmente de forma adicional y se elabora y aísla en forma de la base o una sal farmacéuticamente aceptable del mismo.
ES200101763A 2000-12-28 2001-07-27 Metodo para preparar citalopram purificado Expired - Lifetime ES2170733B1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200001943 2000-12-28

Publications (2)

Publication Number Publication Date
ES2170733A1 ES2170733A1 (es) 2002-08-01
ES2170733B1 true ES2170733B1 (es) 2003-12-16

Family

ID=8159933

Family Applications (2)

Application Number Title Priority Date Filing Date
ES01913727T Expired - Lifetime ES2181663T3 (es) 2000-12-28 2001-03-07 Procedimiento para la preparacion de citalopram puro.
ES200101763A Expired - Lifetime ES2170733B1 (es) 2000-12-28 2001-07-27 Metodo para preparar citalopram purificado

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES01913727T Expired - Lifetime ES2181663T3 (es) 2000-12-28 2001-03-07 Procedimiento para la preparacion de citalopram puro.

Country Status (41)

Country Link
US (2) US6855834B2 (es)
EP (1) EP1181272B1 (es)
JP (1) JP2003519121A (es)
KR (1) KR100430746B1 (es)
CN (1) CN1366526A (es)
AR (1) AR029898A1 (es)
AT (2) ATE222899T1 (es)
AU (3) AU2001100399B4 (es)
BE (2) BE1013417A6 (es)
BG (1) BG106219A (es)
BR (1) BR0106271A (es)
CA (1) CA2359810C (es)
CH (1) CH691536A5 (es)
CZ (1) CZ293140B6 (es)
DE (1) DE60100016T2 (es)
DK (1) DK1181272T3 (es)
EA (1) EA003459B1 (es)
ES (2) ES2181663T3 (es)
FI (2) FI108640B (es)
FR (1) FR2818977B1 (es)
GB (2) GB2356199B (es)
GR (1) GR20010100131A (es)
HK (1) HK1049332A1 (es)
HR (1) HRP20020005A2 (es)
HU (2) HU0101028D0 (es)
IE (2) IES20010253A2 (es)
IL (1) IL147162A0 (es)
IS (1) IS5884A (es)
IT (1) ITMI20010604A1 (es)
MX (1) MXPA01013336A (es)
NL (1) NL1017534C1 (es)
NO (1) NO313047B1 (es)
NZ (1) NZ516299A (es)
PL (1) PL353369A1 (es)
PT (1) PT1181272E (es)
SE (1) SE0103044L (es)
SK (1) SK284418B6 (es)
TR (1) TR200200018T1 (es)
UA (1) UA71635C2 (es)
WO (1) WO2001047877A2 (es)
ZA (1) ZA200110133B (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
AU759716B2 (en) 1999-04-14 2003-04-17 H. Lundbeck A/S Method for the preparation of citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
CH692298A5 (de) 1999-10-25 2002-04-30 Lundbeck & Co As H Verfahren zur Herstellung von Zwischenstufen für die Citalopramsynthese sowie zur Herstellung von Escitalopram.
TR200401456T1 (tr) 1999-10-25 2005-04-21 H. Lundbeck A/S Sitalopram hazırlanması için yöntem.
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
EA004742B1 (ru) 1999-12-28 2004-08-26 Х.Лундбекк А/С Способ получения циталопрама
BR9917604A (pt) 1999-12-30 2002-12-31 Lundbeck & Co As H Método para preparação de citalopram
HUP0300343A2 (hu) 2000-01-14 2003-06-28 H. Lundbeck A/S Eljárás 5-cianoftalid előállítására
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
CN1427835A (zh) * 2000-03-13 2003-07-02 H·隆德贝克有限公司 5－取代的1－(4－氟苯基)－1,3－二氢异苯并呋喃的分步烷基化
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
PL360110A1 (en) 2000-03-13 2004-09-06 H.Lundbeck A/S Method for the preparation of citalopram
TR200202155T2 (tr) 2000-03-14 2002-12-23 H. Lundbeck A/S Sitalopramin preparasyon metodu
CZ20023406A3 (cs) * 2000-03-16 2003-01-15 H. Lundbeck A/S Způsob výroby 5-kyano-1-(4-fluorfenyl)-1,3-dihydroisobenzofuranu
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
CA2354877C (en) 2000-08-18 2006-05-02 H. Lundbeck A/S Method for the preparation of citalopram
NL1017525C1 (nl) 2000-12-22 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van zuiver Citalopram
ATE222899T1 (de) 2000-12-28 2002-09-15 Lundbeck & Co As H Verfahren zur herstellung von reinem citalopram
GB2376945A (en) * 2001-06-27 2002-12-31 Cipla Ltd Citalopram preparation
AU2003222435A1 (en) 2002-01-07 2003-07-24 Sun Pharmaceutical Industries Limited Process for the preparation of 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile
ES2194597B2 (es) * 2002-01-25 2004-08-01 Esteve Quimica, S.A. Procedimiento para la obtencion de citalopram.
GB2386119A (en) * 2002-02-27 2003-09-10 Cipla Ltd Purification of citalopram
GB0204607D0 (en) 2002-02-27 2002-04-10 Matrix Lab Ltd Process
EP1346989A1 (en) * 2002-03-21 2003-09-24 Jubilant Organosys Limited Improved process for the preparation of citalopram and its hydrobromide
US20050154052A1 (en) * 2003-03-24 2005-07-14 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
US7019153B2 (en) 2003-06-10 2006-03-28 Sun Pharmaceutical Industries Limited Process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran acetamido-3-substituted-3-cephem-4-carboxylic acid
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
TWI358407B (en) * 2005-06-22 2012-02-21 Lundbeck & Co As H Crystalline base of escitalopram and orodispersibl
US7834201B2 (en) 2005-06-22 2010-11-16 H. Lundbeck A/S Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL135959C (es) 1964-12-23
GB1143702A (es) 1965-03-18
DE1619713A1 (de) * 1967-03-29 1970-12-17 Leybold Heraeus Gmbh & Co Kg Vorrichtung zur Vakuum- und Kurzwegdestillation
DE2135085C3 (de) 1971-07-14 1981-12-03 Basf Ag, 6700 Ludwigshafen Verfahren zur Wiedergewinnung von Caprolactam aus einem Gemisch, das Caprolactam und dessen Oligomere enthält
DE2442426C2 (de) 1974-09-05 1983-04-07 Bayer Ag, 5090 Leverkusen Diisocyanatodiketene, Verfahren zu deren Herstellung und deren Verwendung
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
IT8020902A0 (it) 1980-03-25 1980-03-25 Snia Viscosa Procedimento ed apparecchiatura per la separazione continua per via termica di miscele liquide dicomposti termolabili.
JPS6082101A (ja) 1983-10-13 1985-05-10 Mitsui Toatsu Chem Inc 高沸点重合性化合物の薄膜蒸留による精製方法
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
FR2656305B1 (fr) 1989-12-22 1992-04-10 Norsolor Sa Procede de purification du (meth)acrylate de glycidyle.
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
US5582692A (en) 1994-10-07 1996-12-10 Artisan Industries, Inc. Method for the purification of vitamin E
US6136991A (en) * 1996-05-21 2000-10-24 Exxon Chemical Patents Inc. Glycidyl ester adducts having increased glass transition temperatures
EP0901481B1 (en) 1996-05-21 2003-10-22 ExxonMobil Chemical Patents Inc. Purification of glycidyl esters by thin film evaporation
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
WO1998019513A2 (en) 1997-07-08 1998-05-14 H. Lundbeck A/S Method for the preparation of citalopram
DE19734673A1 (de) 1997-08-11 1999-02-18 Rwe Dea Ag Verfahren zur Herstellung von metallfreien Guerbetalkoholen
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
EP1042310B1 (en) 1997-11-11 2002-07-31 H. Lundbeck A/S Method for the preparation of citalopram
EP0965593B2 (en) 1998-06-19 2008-12-03 Shin-Etsu Chemical Co., Ltd. Distillation of (meth)acryloxybearing alkoxysilane
CA2291134C (en) * 1998-10-20 2006-05-23 H. Lundbeck A/S Method for the preparation of citalopram
TR200101796T2 (tr) 1998-12-23 2001-11-21 H. Lundbeck A/S 5-Siyanofitalitin preparasyonuna yönelik metot
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
AU759716B2 (en) 1999-04-14 2003-04-17 H. Lundbeck A/S Method for the preparation of citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
CH692298A5 (de) 1999-10-25 2002-04-30 Lundbeck & Co As H Verfahren zur Herstellung von Zwischenstufen für die Citalopramsynthese sowie zur Herstellung von Escitalopram.
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
NL1017525C1 (nl) 2000-12-22 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van zuiver Citalopram
ATE222899T1 (de) 2000-12-28 2002-09-15 Lundbeck & Co As H Verfahren zur herstellung von reinem citalopram
US6781003B1 (en) * 2003-06-09 2004-08-24 Aurobindo Pharma Ltd. Preparation of pure citalopram

Also Published As

Publication number Publication date
NZ516299A (en) 2002-12-20
AU2001100399B4 (en) 2002-03-21
HK1049332A1 (zh) 2003-05-09
GB0117095D0 (en) 2001-09-05
CN1366526A (zh) 2002-08-28
HU0101028D0 (en) 2001-05-28
FI20011578A0 (fi) 2001-07-26
ATE222899T1 (de) 2002-09-15
FR2818977A1 (fr) 2002-07-05
MXPA01013336A (es) 2002-07-09
SK284418B6 (sk) 2005-04-01
ITMI20010604A0 (it) 2001-03-22
SE0103044D0 (sv) 2001-09-14
HUP0102818A2 (hu) 2001-12-28
EP1181272B1 (en) 2002-08-28
FI109023B (fi) 2002-05-15
ZA200110133B (en) 2003-01-13
TR200200018T1 (tr) 2002-06-21
KR100430746B1 (ko) 2004-05-10
JP2003519121A (ja) 2003-06-17
IS5884A (is) 2002-06-28
FI108640B (fi) 2002-02-28
IES20010632A2 (en) 2002-03-06
SK18472001A3 (sk) 2002-05-09
DK1181272T3 (da) 2002-12-30
EA200200016A1 (ru) 2002-04-25
AR029898A1 (es) 2003-07-23
NO20011272L (no) 2002-07-01
BE1013316A6 (fr) 2001-11-06
GB0105981D0 (en) 2001-05-02
AU750006B1 (en) 2002-07-11
PL353369A1 (pl) 2003-11-17
SE0103044L (sv) 2002-06-29
WO2001047877A2 (en) 2001-07-05
ES2170733A1 (es) 2002-08-01
CZ2001891A3 (cs) 2002-08-14
IES20010253A2 (en) 2002-03-06
GR20010100131A (el) 2002-10-09
FR2818977B1 (fr) 2003-12-05
WO2001047877A3 (en) 2001-12-27
CA2359810A1 (en) 2001-07-05
HRP20020005A2 (en) 2003-04-30
CA2359810C (en) 2002-11-05
CH691536A5 (de) 2001-08-15
EA003459B1 (ru) 2003-06-26
NO20011272D0 (no) 2001-03-13
UA71635C2 (uk) 2004-12-15
EP1181272A2 (en) 2002-02-27
BG106219A (bg) 2002-08-30
PT1181272E (pt) 2003-01-31
GB2356199B (en) 2001-10-03
HU0102818D0 (en) 2001-09-28
DE60100016T2 (de) 2003-04-17
KR20020073379A (ko) 2002-09-26
ITMI20010604A1 (it) 2002-09-22
IL147162A0 (en) 2002-08-14
NL1017534C1 (nl) 2001-04-26
BE1013417A6 (fr) 2001-12-04
FI20010501A0 (fi) 2001-03-13
GB2356199A (en) 2001-05-16
ES2181663T3 (es) 2003-03-01
NO313047B1 (no) 2002-08-05
GB2361697A (en) 2001-10-31
US20020087012A1 (en) 2002-07-04
US6855834B2 (en) 2005-02-15
AU3920201A (en) 2001-07-09
AU2001100399A4 (en) 2001-11-01
CZ293140B6 (cs) 2004-02-18
AT4368U1 (de) 2001-06-25
BR0106271A (pt) 2002-05-21
US20030178295A1 (en) 2003-09-25
HUP0102818A3 (en) 2003-07-28
DE60100016D1 (de) 2002-10-02

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