ATE222899T1 - Verfahren zur herstellung von reinem citalopram - Google Patents

Verfahren zur herstellung von reinem citalopram

Info

Publication number: ATE222899T1
Authority: AT; Austria
Prior art keywords: producing pure; pure citalopram; citalopram; producing; pure
Prior art date: 2000-12-28

Application number

AT01913727T

Other languages

English (en)

Inventor

Andrea Castellin

Giulio Volpe

Federico Sbrogio

Original Assignee

Lundbeck & Co As H

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-12-28

Filing date

2001-03-07

Publication date

2002-09-15

2001-03-07 Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H

2002-09-15 Application granted granted Critical

2002-09-15 Publication of ATE222899T1 publication Critical patent/ATE222899T1/de

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT01913727T 2000-12-28 2001-03-07 Verfahren zur herstellung von reinem citalopram ATE222899T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DKPA200001943		2000-12-28
PCT/DK2001/000148 WO2001047877A2 (en)	2000-12-28	2001-03-07	Process for the preparation of pure citalopram

Publications (1)

Publication Number	Publication Date
ATE222899T1 true ATE222899T1 (de)	2002-09-15

Family

ID=8159933

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT01913727T ATE222899T1 (de)	2000-12-28	2001-03-07	Verfahren zur herstellung von reinem citalopram
AT0020901U AT4368U1 (de)	2000-12-28	2001-03-21	Verfahren zur herstellung von reinem citalopram

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT0020901U AT4368U1 (de)	2000-12-28	2001-03-21	Verfahren zur herstellung von reinem citalopram

Country Status (41)

Country	Link
US (2)	US6855834B2 (de)
EP (1)	EP1181272B1 (de)
JP (1)	JP2003519121A (de)
KR (1)	KR100430746B1 (de)
CN (1)	CN1366526A (de)
AR (1)	AR029898A1 (de)
AT (2)	ATE222899T1 (de)
AU (3)	AU2001100399B4 (de)
BE (2)	BE1013417A6 (de)
BG (1)	BG106219A (de)
BR (1)	BR0106271A (de)
CA (1)	CA2359810C (de)
CH (1)	CH691536A5 (de)
CZ (1)	CZ293140B6 (de)
DE (1)	DE60100016T2 (de)
DK (1)	DK1181272T3 (de)
EA (1)	EA003459B1 (de)
ES (2)	ES2181663T3 (de)
FI (2)	FI108640B (de)
FR (1)	FR2818977B1 (de)
GB (2)	GB2356199B (de)
GR (1)	GR20010100131A (de)
HK (1)	HK1049332A1 (de)
HR (1)	HRP20020005A2 (de)
HU (2)	HU0101028D0 (de)
IE (2)	IES20010253A2 (de)
IL (1)	IL147162A0 (de)
IS (1)	IS5884A (de)
IT (1)	ITMI20010604A1 (de)
MX (1)	MXPA01013336A (de)
NL (1)	NL1017534C1 (de)
NO (1)	NO313047B1 (de)
NZ (1)	NZ516299A (de)
PL (1)	PL353369A1 (de)
PT (1)	PT1181272E (de)
SE (1)	SE0103044L (de)
SK (1)	SK284418B6 (de)
TR (1)	TR200200018T1 (de)
UA (1)	UA71635C2 (de)
WO (1)	WO2001047877A2 (de)
ZA (1)	ZA200110133B (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR022329A1 (es)	1999-01-29	2002-09-04	Lundbeck & Co As H	Metodo para la preparacion de 5-cianoftalida
NZ514671A (en)	1999-04-14	2003-10-31	H	Method for the preparation of citalopram
ITMI991581A1 (it) *	1999-06-25	2001-01-15	Lundbeck & Co As H	Metodo per la preparazione di citalopram
ITMI991579A1 (it)	1999-06-25	2001-01-15	Lundbeck & Co As H	Metodo per la preparazione di citalopram
EP1298124B1 (de)	1999-10-25	2007-02-28	H. Lundbeck A/S	Verfahren zur Herstellung von Citalopram
CH692298A5 (de)	1999-10-25	2002-04-30	Lundbeck & Co As H	Verfahren zur Herstellung von Zwischenstufen für die Citalopramsynthese sowie zur Herstellung von Escitalopram.
AR026063A1 (es)	1999-11-01	2002-12-26	Lundbeck & Co As H	Metodo para la preparacion de 5-carboxiftalida.
EA004742B1 (ru)	1999-12-28	2004-08-26	Х.Лундбекк А/С	Способ получения циталопрама
WO2001049672A1 (en)	1999-12-30	2001-07-12	H. Lundbeck A/S	Method for the preparation of citalopram
TR200201783T2 (tr)	2000-01-14	2002-12-23	H. Lundbeck A/S	5-Siyanofatalid hazırlamak için yöntem
NL1017417C1 (nl)	2000-03-03	2001-03-16	Lundbeck & Co As H	Werkwijze voor de bereiding van Citalopram.
CZ20023100A3 (cs) *	2000-03-13	2003-02-12	H. Lundbeck A/S	Způsob výroby citalopramu
KR20020080481A (ko)	2000-03-13	2002-10-23	하. 룬트벡 아크티에 셀스카브	시탈로프람의 제조 방법
NL1017500C1 (nl)	2000-03-13	2001-04-26	Lundbeck & Co As H	Werkwijze voor de bereiding van Citalopram.
SK14512002A3 (sk)	2000-03-14	2003-03-04	H. Lundbeck A/S	Spôsob výroby citalopramu, medziprodukt a citalopram výrobený týmto spôsobom
EP1274699A1 (de) *	2000-03-16	2003-01-15	H. Lundbeck A/S	Verfahren zur herstellung von 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofuranen
AR032455A1 (es)	2000-05-12	2003-11-12	Lundbeck & Co As H	Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
IL144817A0 (en)	2000-08-18	2002-06-30	Lundbeck & Co As H	Method for the preparation of citalopram
JP3798982B2 (ja)	2000-12-22	2006-07-19	ハー・ルンドベック・アクチエゼルスカベット	純粋なシタロプラムの製造方法
CA2359810C (en)	2000-12-28	2002-11-05	H. Lundbeck A/S	Process for the preparation of pure citalopram
GB2376945A (en) *	2001-06-27	2002-12-31	Cipla Ltd	Citalopram preparation
WO2003057132A2 (en)	2002-01-07	2003-07-17	Sun Pharmaceutical Industries Limited	Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile
ES2194597B2 (es) *	2002-01-25	2004-08-01	Esteve Quimica, S.A.	Procedimiento para la obtencion de citalopram.
GB2386119A (en) *	2002-02-27	2003-09-10	Cipla Ltd	Purification of citalopram
GB0204607D0 (en)	2002-02-27	2002-04-10	Matrix Lab Ltd	Process
EP1346989A1 (de) *	2002-03-21	2003-09-24	Jubilant Organosys Limited	Verbessertes Verfahren zur Herstellung von Citalopram und Citalopram Hydrobromid
TR200504022T1 (tr) *	2003-03-24	2006-08-21	Hetero Drugs Limited	(S)-sitalopram oksalatın yeni sıvı kristal formları.
US7019153B2 (en)	2003-06-10	2006-03-28	Sun Pharmaceutical Industries Limited	Process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran acetamido-3-substituted-3-cephem-4-carboxylic acid
CN100569765C (zh)	2003-12-19	2009-12-16	杭州民生药业集团有限公司	西酞普兰中间体晶体碱
US7834201B2 (en)	2005-06-22	2010-11-16	H. Lundbeck A/S	Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
TWI347942B (en) *	2005-06-22	2011-09-01	Lundbeck & Co As H	Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base

Family Cites Families (34)

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Publication number	Priority date	Publication date	Assignee	Title
NL135959C (de)	1964-12-23
GB1143703A (de)	1965-03-18
DE1619713A1 (de) *	1967-03-29	1970-12-17	Leybold Heraeus Gmbh & Co Kg	Vorrichtung zur Vakuum- und Kurzwegdestillation
DE2135085C3 (de)	1971-07-14	1981-12-03	Basf Ag, 6700 Ludwigshafen	Verfahren zur Wiedergewinnung von Caprolactam aus einem Gemisch, das Caprolactam und dessen Oligomere enthält
DE2442426C2 (de)	1974-09-05	1983-04-07	Bayer Ag, 5090 Leverkusen	Diisocyanatodiketene, Verfahren zu deren Herstellung und deren Verwendung
GB1526331A (en) *	1976-01-14	1978-09-27	Kefalas As	Phthalanes
IT8020902A0 (it)	1980-03-25	1980-03-25	Snia Viscosa	Procedimento ed apparecchiatura per la separazione continua per via termica di miscele liquide dicomposti termolabili.
JPS6082101A (ja)	1983-10-13	1985-05-10	Mitsui Toatsu Chem Inc	高沸点重合性化合物の薄膜蒸留による精製方法
GB8419963D0 (en)	1984-08-06	1984-09-12	Lundbeck & Co As H	Intermediate compound and method
GB8814057D0 (en)	1988-06-14	1988-07-20	Lundbeck & Co As H	New enantiomers & their isolation
FR2656305B1 (fr)	1989-12-22	1992-04-10	Norsolor Sa	Procede de purification du (meth)acrylate de glycidyle.
US5296507A (en)	1990-09-06	1994-03-22	H.Lundbeck A/S	Treatment of cerbrovascular disorders
US5582692A (en)	1994-10-07	1996-12-10	Artisan Industries, Inc.	Method for the purification of vitamin E
ATE252568T1 (de)	1996-05-21	2003-11-15	Exxonmobil Chem Patents Inc	Reinigung von glycidylestern durch dünnschichtverdampfung
US6136991A (en) *	1996-05-21	2000-10-24	Exxon Chemical Patents Inc.	Glycidyl ester adducts having increased glass transition temperatures
DE19626659A1 (de)	1996-07-03	1998-01-08	Basf Ag	Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de)	1996-07-10	1998-01-15	Basf Ag	Verfahren zur Herstellung von Phthaliden
TR200000066T2 (tr)	1997-07-08	2000-11-21	H. Lundbeck A/S	Sitalopram hazırlanması için yöntem.
DE19734673A1 (de)	1997-08-11	1999-02-18	Rwe Dea Ag	Verfahren zur Herstellung von metallfreien Guerbetalkoholen
UA62985C2 (en)	1997-11-10	2004-01-15	Lunnbeck As H	A method for the preparation of citalopram
ES2149734T3 (es)	1997-11-11	2003-02-16	Lundbeck & Co As H	Metodo para la preparacion de citalopram.
EP0965593B2 (de)	1998-06-19	2008-12-03	Shin-Etsu Chemical Co., Ltd.	Destillationsverfahren für (Meth)acryloxysilane
PL199423B1 (pl) *	1998-10-20	2008-09-30	Lundbeck & Co As H	Sposób wytwarzania citalopramu
CN1149208C (zh)	1998-12-23	2004-05-12	H.隆德贝克有限公司	制备5-氰基2-苯并[c]呋喃酮的方法
AR022329A1 (es)	1999-01-29	2002-09-04	Lundbeck & Co As H	Metodo para la preparacion de 5-cianoftalida
NZ514671A (en)	1999-04-14	2003-10-31	H	Method for the preparation of citalopram
ITMI991579A1 (it) *	1999-06-25	2001-01-15	Lundbeck & Co As H	Metodo per la preparazione di citalopram
ITMI991581A1 (it) *	1999-06-25	2001-01-15	Lundbeck & Co As H	Metodo per la preparazione di citalopram
CH692298A5 (de)	1999-10-25	2002-04-30	Lundbeck & Co As H	Verfahren zur Herstellung von Zwischenstufen für die Citalopramsynthese sowie zur Herstellung von Escitalopram.
US6310222B1 (en)	1999-11-01	2001-10-30	Sumika Fine Chemicals Co., Ltd.	Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
GB0005477D0 (en)	2000-03-07	2000-04-26	Resolution Chemicals Limited	Process for the preparation of citalopram
JP3798982B2 (ja)	2000-12-22	2006-07-19	ハー・ルンドベック・アクチエゼルスカベット	純粋なシタロプラムの製造方法
CA2359810C (en)	2000-12-28	2002-11-05	H. Lundbeck A/S	Process for the preparation of pure citalopram
US6781003B1 (en) *	2003-06-09	2004-08-24	Aurobindo Pharma Ltd.	Preparation of pure citalopram

2001
- 2001-03-07 CA CA002359810A patent/CA2359810C/en not_active Expired - Fee Related
- 2001-03-07 DE DE60100016T patent/DE60100016T2/de not_active Expired - Fee Related
- 2001-03-07 SK SK1847-2001A patent/SK284418B6/sk unknown
- 2001-03-07 BR BR0106271-9A patent/BR0106271A/pt not_active IP Right Cessation
- 2001-03-07 EA EA200200016A patent/EA003459B1/ru not_active IP Right Cessation
- 2001-03-07 AT AT01913727T patent/ATE222899T1/de not_active IP Right Cessation
- 2001-03-07 JP JP2001549350A patent/JP2003519121A/ja active Pending
- 2001-03-07 ES ES01913727T patent/ES2181663T3/es not_active Expired - Lifetime
- 2001-03-07 MX MXPA01013336A patent/MXPA01013336A/es active IP Right Grant
- 2001-03-07 IL IL14716201A patent/IL147162A0/xx unknown
- 2001-03-07 AU AU2001100399A patent/AU2001100399B4/en not_active Ceased
- 2001-03-07 DK DK01913727T patent/DK1181272T3/da active
- 2001-03-07 CN CN01801127A patent/CN1366526A/zh active Pending
- 2001-03-07 EP EP01913727A patent/EP1181272B1/de not_active Expired - Lifetime
- 2001-03-07 AU AU39202/01A patent/AU3920201A/en active Pending
- 2001-03-07 HK HK03101406.3A patent/HK1049332A1/zh unknown
- 2001-03-07 PL PL01353369A patent/PL353369A1/xx not_active Application Discontinuation
- 2001-03-07 PT PT01913727T patent/PT1181272E/pt unknown
- 2001-03-07 WO PCT/DK2001/000148 patent/WO2001047877A2/en not_active Ceased
- 2001-03-07 HR HR20020005A patent/HRP20020005A2/hr not_active Application Discontinuation
- 2001-03-07 TR TR2002/00018T patent/TR200200018T1/xx unknown
- 2001-03-07 KR KR10-2001-7016757A patent/KR100430746B1/ko not_active Expired - Fee Related
- 2001-03-08 NL NL1017534A patent/NL1017534C1/nl not_active IP Right Cessation
- 2001-03-09 IS IS5884A patent/IS5884A/is unknown
- 2001-03-09 HU HU0101028A patent/HU0101028D0/hu unknown
- 2001-03-12 CZ CZ2001891A patent/CZ293140B6/cs not_active IP Right Cessation
- 2001-03-12 GB GB0105981A patent/GB2356199B/en not_active Revoked
- 2001-03-13 FI FI20010501A patent/FI108640B/fi active
- 2001-03-13 NO NO20011272A patent/NO313047B1/no unknown
- 2001-03-15 IE IE20010253A patent/IES20010253A2/en not_active IP Right Cessation
- 2001-03-15 AR ARP010101210A patent/AR029898A1/es unknown
- 2001-03-16 GR GR20010100131A patent/GR20010100131A/el unknown
- 2001-03-21 AT AT0020901U patent/AT4368U1/de unknown
- 2001-03-22 BE BE2001/0189A patent/BE1013417A6/fr not_active IP Right Cessation
- 2001-03-22 IT IT2001MI000604A patent/ITMI20010604A1/it unknown
- 2001-03-22 CH CH00546/01A patent/CH691536A5/de not_active IP Right Cessation
- 2001-03-26 FR FR0104025A patent/FR2818977B1/fr not_active Expired - Fee Related
- 2001-07-03 UA UA2002021553A patent/UA71635C2/uk unknown
- 2001-07-05 HU HU0102818A patent/HUP0102818A3/hu unknown
- 2001-07-05 IE IE20010632A patent/IES20010632A2/en not_active IP Right Cessation
- 2001-07-09 BE BE2001/0466A patent/BE1013316A6/fr not_active IP Right Cessation
- 2001-07-13 GB GB0117095A patent/GB2361697A/en not_active Withdrawn
- 2001-07-26 FI FI20011578A patent/FI109023B/fi not_active IP Right Cessation
- 2001-07-27 ES ES200101763A patent/ES2170733B1/es not_active Expired - Lifetime
- 2001-08-27 AU AU65478/01A patent/AU750006B1/en not_active Ceased
- 2001-09-14 SE SE0103044A patent/SE0103044L/xx not_active Application Discontinuation
- 2001-12-10 ZA ZA200110133A patent/ZA200110133B/en unknown
- 2001-12-13 BG BG106219A patent/BG106219A/xx unknown
- 2001-12-20 US US10/035,005 patent/US6855834B2/en not_active Expired - Fee Related
- 2001-12-20 NZ NZ516299A patent/NZ516299A/xx unknown
2003
- 2003-02-10 US US10/361,800 patent/US20030178295A1/en not_active Abandoned

Also Published As

Publication number	Publication date
KR100430746B1 (ko)	2004-05-10
BE1013316A6 (fr)	2001-11-06
BE1013417A6 (fr)	2001-12-04
KR20020073379A (ko)	2002-09-26
HU0102818D0 (en)	2001-09-28
AU2001100399A4 (en)	2001-11-01
HUP0102818A3 (en)	2003-07-28
ITMI20010604A1 (it)	2002-09-22
ES2170733B1 (es)	2003-12-16
AU3920201A (en)	2001-07-09
WO2001047877A3 (en)	2001-12-27
NZ516299A (en)	2002-12-20
HK1049332A1 (zh)	2003-05-09
SK284418B6 (sk)	2005-04-01
FI108640B (fi)	2002-02-28
GB2356199B (en)	2001-10-03
FI20011578A0 (fi)	2001-07-26
FR2818977B1 (fr)	2003-12-05
ITMI20010604A0 (it)	2001-03-22
CZ2001891A3 (cs)	2002-08-14
DE60100016T2 (de)	2003-04-17
NO20011272L (no)	2002-07-01
AU750006B1 (en)	2002-07-11
CA2359810A1 (en)	2001-07-05
HUP0102818A2 (hu)	2001-12-28
IES20010253A2 (en)	2002-03-06
FR2818977A1 (fr)	2002-07-05
US6855834B2 (en)	2005-02-15
US20030178295A1 (en)	2003-09-25
IS5884A (is)	2002-06-28
EP1181272B1 (de)	2002-08-28
GB2361697A (en)	2001-10-31
SE0103044D0 (sv)	2001-09-14
GB0105981D0 (en)	2001-05-02
NO20011272D0 (no)	2001-03-13
UA71635C2 (uk)	2004-12-15
HRP20020005A2 (en)	2003-04-30
MXPA01013336A (es)	2002-07-09
US20020087012A1 (en)	2002-07-04
ES2181663T3 (es)	2003-03-01
IL147162A0 (en)	2002-08-14
DE60100016D1 (de)	2002-10-02
BG106219A (bg)	2002-08-30
CH691536A5 (de)	2001-08-15
EA200200016A1 (ru)	2002-04-25
JP2003519121A (ja)	2003-06-17
FI109023B (fi)	2002-05-15
ZA200110133B (en)	2003-01-13
DK1181272T3 (da)	2002-12-30
AU2001100399B4 (en)	2002-03-21
AR029898A1 (es)	2003-07-23
AT4368U1 (de)	2001-06-25
EP1181272A2 (de)	2002-02-27
NO313047B1 (no)	2002-08-05
PT1181272E (pt)	2003-01-31
IES20010632A2 (en)	2002-03-06
CZ293140B6 (cs)	2004-02-18
SE0103044L (sv)	2002-06-29
FI20010501A0 (fi)	2001-03-13
GB2356199A (en)	2001-05-16
NL1017534C1 (nl)	2001-04-26
EA003459B1 (ru)	2003-06-26
WO2001047877A2 (en)	2001-07-05
HU0101028D0 (en)	2001-05-28
ES2170733A1 (es)	2002-08-01
CA2359810C (en)	2002-11-05
PL353369A1 (pl)	2003-11-17
SK18472001A3 (sk)	2002-05-09
TR200200018T1 (tr)	2002-06-21
GB0117095D0 (en)	2001-09-05
BR0106271A (pt)	2002-05-21
GR20010100131A (el)	2002-10-09
CN1366526A (zh)	2002-08-28

Legal Events

Date

Code

Title

Description

2003-02-15

UEP

Publication of translation of european patent specification

Ref document number: 1181272

Country of ref document: EP

2008-12-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE60100016D1 (de)	2002-10-02	Verfahren zur herstellung von reinem citalopram
ATE237604T1 (de)	2003-05-15	Verfahren zur herstellung von citalopram
ATE281447T1 (de)	2004-11-15	Verfahren zur herstellung von citalopram
ATE213237T1 (de)	2002-02-15	Verfahren zur herstellung von citalopram
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