ES2171414T3 - Inmunoensayos para anticuerpos anti-hcv utilizando antigenos con epitopos conformacionales. - Google Patents

Inmunoensayos para anticuerpos anti-hcv utilizando antigenos con epitopos conformacionales.

Info

Publication number
ES2171414T3
ES2171414T3 ES93916942T ES93916942T ES2171414T3 ES 2171414 T3 ES2171414 T3 ES 2171414T3 ES 93916942 T ES93916942 T ES 93916942T ES 93916942 T ES93916942 T ES 93916942T ES 2171414 T3 ES2171414 T3 ES 2171414T3
Authority
ES
Spain
Prior art keywords
antigens
epithopes
hcv
conformational
hcv antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93916942T
Other languages
English (en)
Other versions
ES2171414T5 (es
Inventor
David Y Chien
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25429280&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2171414(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chiron Corp filed Critical Chiron Corp
Publication of ES2171414T3 publication Critical patent/ES2171414T3/es
Application granted granted Critical
Publication of ES2171414T5 publication Critical patent/ES2171414T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G01N33/5767—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis non-A, non-B hepatitis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Communicable Diseases (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)

Abstract

METODOS DE INMUNOENSAYOS, UTILIZANDO ANTIGENOS DE ENVOLTURA HCV QUE CONTIENEN REACTIVOS DE EPITOPES CONFORMES CON ANTICUERPOS DE SUERO PROCEDENTE DE INDIVIDUOS INFECTADOS, SON UTILES PARA TAMIZAR Y DIAGNOSIS. ESTOS ANTIGENOS DETECTAN ANTICUERPOS QUE NO SE DETECTAN MEDIANTE ANTIGENOS DE ENVOLTURA HCV DESNATURALIZADA. ADEMAS, ESTOS ANTIGENOS DE ENVOLTURA HCV, COMPRENDIENDO EPITOPES CONFORMES, SON MAS REACTIVOS INMUNOLOGICAMENTE QUE UN NUMERO DE OTROS ANTIGENOS DE HCV. ESTA ES LA PRIMERA EVIDENCIA DE QUE EPITOPES CONFORMES PUEDEN ESTAR IMPLICADOS EN LA RESPUESTA INMUNOLOGICA A LOS ANTIGENOS DE HCV.
ES93916942T 1992-07-07 1993-07-02 Inmunoensayos para anticuerpos anti-hcv utilizando antigenos con epitopos conformacionales. Expired - Lifetime ES2171414T5 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91075992A 1992-07-07 1992-07-07
US910759 1992-07-07

Publications (2)

Publication Number Publication Date
ES2171414T3 true ES2171414T3 (es) 2002-09-16
ES2171414T5 ES2171414T5 (es) 2006-09-01

Family

ID=25429280

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93916942T Expired - Lifetime ES2171414T5 (es) 1992-07-07 1993-07-02 Inmunoensayos para anticuerpos anti-hcv utilizando antigenos con epitopos conformacionales.

Country Status (19)

Country Link
US (1) US20020150883A1 (es)
EP (1) EP0649537B2 (es)
JP (2) JP3490085B2 (es)
AT (1) ATE216779T1 (es)
AU (1) AU685059B2 (es)
CA (1) CA2139645C (es)
CZ (1) CZ291951B6 (es)
DE (1) DE69331845T3 (es)
DK (1) DK0649537T4 (es)
ES (1) ES2171414T5 (es)
FI (1) FI110546B (es)
HU (1) HUT70473A (es)
NO (1) NO321185B1 (es)
PL (1) PL174686B1 (es)
PT (1) PT649537E (es)
RU (1) RU2126158C1 (es)
SK (1) SK284556B6 (es)
UA (1) UA39944C2 (es)
WO (1) WO1994001778A1 (es)

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US6274148B1 (en) * 1990-11-08 2001-08-14 Chiron Corporation Hepatitis C virus asialoglycoproteins
US5882852A (en) * 1993-06-29 1999-03-16 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Hepatitic C virus (HCV) core gene nucleotide sequences and related methods of detecting major and minor genotypes of HCV isolates
US7070790B1 (en) 1993-06-29 2006-07-04 The United States Of America As Represented By The Department Of Health And Human Services Nucleotide and deduced amino acid sequences of the envelope 1 and core genes of isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines
WO1996004385A2 (en) * 1994-07-29 1996-02-15 Innogenetics N.V. Purified hepatitis c virus envelope proteins for diagnostic and therapeutic use
DE4428705A1 (de) * 1994-08-12 1996-02-15 Boehringer Mannheim Gmbh Rekombinantes Antigen aus der NS3-Region des Hepatitis C Virus
US5707385A (en) * 1994-11-16 1998-01-13 Advanced Cardiovascular Systems, Inc. Drug loaded elastic membrane and method for delivery
JPH11507129A (ja) * 1995-06-07 1999-06-22 アボツト・ラボラトリーズ Ｃ型肝炎ウイルス第二エンベロープ糖タンパク質に対する抗体の検出法
US6514731B1 (en) 1996-05-24 2003-02-04 Chiron Corporation Methods for the preparation of hepatitis C virus multiple copy epitope fusion antigens
WO2000026673A1 (en) * 1998-11-03 2000-05-11 Abbott Laboratories Methods of detecting chronic infection caused by hcv
US6815160B1 (en) 1999-07-28 2004-11-09 Chiron Corporation Hepatitis C viral antigen immunoassay detection systems
CA2380777C (en) * 1999-07-28 2011-01-04 Chiron Corporation Hepatitis c viral antigen immunoassay detection systems
EP1829891B1 (en) 2000-06-15 2012-12-26 Novartis Vaccines and Diagnostics, Inc. Immunoassays for Anti-HCV Antibodies
SK287694B6 (sk) 2000-06-15 2011-06-06 Novartis Vaccines & Diagnostics, Inc. Pevný nosič imunoeseje a spôsob jeho prípravy, spôsob detekcie infekcie HIV a súprava na imunodiagnostickú skúšku
RU2194993C2 (ru) * 2000-12-28 2002-12-20 Научно-исследовательский институт вирусологии им.Д.И.Ивановского РАМН Способы ускоренной диагностики гепатита с, основанные на обнаружении гемагглютининов вируса гепатита с и антител к ним в рга и ртга в крови людей
AR045702A1 (es) 2001-10-03 2005-11-09 Chiron Corp Composiciones de adyuvantes.
RU2192011C1 (ru) * 2001-11-26 2002-10-27 Иткес Александр Веньяминович Набор "микровирус" для обнаружения днк вич, интегрированной в хромосомы инфицированных клеток
US7166426B2 (en) 2002-09-09 2007-01-23 Novartis Vaccines And Diagnostics, Inc. HCV assay
CN101124315A (zh) * 2003-01-17 2008-02-13 伊势龙医学股份有限公司 利用凝集素亲和性血液透析去除血液中病毒的方法
WO2004071414A2 (en) * 2003-02-05 2004-08-26 Genzyme Corporation Therapeutic anti-hcv (al9) compounds
US7731967B2 (en) 2003-04-30 2010-06-08 Novartis Vaccines And Diagnostics, Inc. Compositions for inducing immune responses
ATE542140T1 (de) * 2004-08-27 2012-02-15 Novartis Vaccines & Diagnostic Nichtstrukturelle hcv-proteinmutanten und verwendungsmöglichkeiten dafür
WO2008024518A2 (en) 2006-08-25 2008-02-28 Novartis Ag Hcv fusion polypeptides
EP2244695A1 (en) 2007-12-07 2010-11-03 Novartis AG Compositions for inducing immune responses
FR2984328B1 (fr) 2011-12-20 2016-12-30 Bio-Rad Innovations Procede de detection d'une infection par le virus de l'hepatite c
EP2970947A4 (en) 2013-03-14 2016-10-12 Abbott Lab RECOMBINANT HCV NS3 ANTIGENS AND THEIR MUTANTS FOR ENHANCED ANTIBODY DETECTION
JP6505076B2 (ja) 2013-03-14 2019-04-24 アボット・ラボラトリーズＡｂｂｏｔｔ Ｌａｂｏｒａｔｏｒｉｅｓ Ｈｃｖ抗原−抗体組み合わせアッセイおよびこれに使用するための方法および組成物
CN105378099B (zh) 2013-03-14 2021-05-11 雅培制药有限公司 Hcv核心脂质结合结构域单克隆抗体
EP3274478B1 (en) 2015-03-27 2020-09-23 Ortho-Clinical Diagnostics, Inc. Hcv ns4a/modified ns3 polypeptides and uses thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4855224A (en) * 1984-03-09 1989-08-08 Genentech, Inc. Molecularly cloned diagnostic product and method of use
BR8807310A (pt) 1987-11-18 1990-03-13 Chiron Corp Polinucleotidio,polinucleotidio recombinante,vetor recombinante,celula hospedeira,sistema de expressao recombinante,celula transformada,polipeptidio,hcv,preparacao de polipeptidio,polipeptidio de hcv,polipeptidio purificado,polipeptidio recombinante,polipeptidio de fusao,anticorpo monoclonal,preparacao purificada de anticorpos policlonais,particula,sonda de polinucleotidio,kit anticorpo para epetopo de hcv,metodo para producao de polipeptidio,metodo para deteccao de acidos nucleicos de hcv,imunoensaio para detectar antigeno de hcv,imunoensaio para detectar anticorpos dirigidos contra antigeno de hcv,vacina para tratamento de infeccao de hcv,celula,celula infectada com hcv,metodo para producao de anticorpos para hcv e metodo para isolar cdna derivado do genoma de um agente infeccioso nao identificado
HU225068B1 (en) 1989-03-17 2006-05-29 Chiron Corp Process for producing diagnostics and vaccine of nanbh
US5372928A (en) * 1989-09-15 1994-12-13 Chiron Corporation Hepatitis C virus isolates
CA2032381C (en) * 1989-12-18 2006-02-21 Peter E. Highfield Viral agent
ZA912040B (en) * 1990-03-30 1991-12-24 Akzo Nv Peptides immunochemically reactive with antibodies directed against hepatitis non-a,non-b virus
WO1991015771A1 (en) * 1990-04-04 1991-10-17 Chiron Corporation Combinations of hepatitis c virus (hcv) antigens for use in immunoassays for anti-hcv antibodies
ES2152922T3 (es) * 1990-04-06 2001-02-16 Genelabs Tech Inc Epitopos del virus de la hepatitis c.
NZ238681A (en) * 1990-06-25 1992-03-26 Univ Osaka Res Found Non-a, non-b hepatitis virus particles and their production
EP0468657A3 (en) * 1990-07-09 1992-02-05 Tonen Corporation Non-a non b hepatitis-specific antigen and its use in hepatitus diagnosis
CA2203443C (en) * 1990-11-08 2001-08-28 Robert O. Ralston Hepatitis c virus asialoglycoproteins
IT1249684B (it) * 1991-07-19 1995-03-09 Sorin Biomedica Spa Epitopi della proteina env del virus dell'epatite c.
JP3439209B2 (ja) * 1992-01-31 2003-08-25 アボツト・ラボラトリーズ Ｈｃｖ蛋白のための哺乳動物発現システム
US5587285A (en) * 1992-01-31 1996-12-24 University Of Texas System Generation serological assay for monitoring HIV exposure

Also Published As

Publication number Publication date
DE69331845D1 (de) 2002-06-06
RU2126158C1 (ru) 1999-02-10
JPH07509060A (ja) 1995-10-05
DE69331845T2 (de) 2002-08-14
SK284556B6 (sk) 2005-06-02
NO321185B1 (no) 2006-04-03
AU4662993A (en) 1994-01-31
RU94046284A (ru) 1997-02-27
CZ291951B6 (cs) 2003-06-18
CA2139645A1 (en) 1994-01-20
DE69331845T3 (de) 2006-10-05
DK0649537T3 (da) 2002-06-17
ATE216779T1 (de) 2002-05-15
UA39944C2 (uk) 2001-07-16
EP0649537B1 (en) 2002-04-24
AU685059B2 (en) 1998-01-15
SK495A3 (en) 1995-07-11
HUT70473A (en) 1995-10-30
US20020150883A1 (en) 2002-10-17
PT649537E (pt) 2002-09-30
DK0649537T4 (da) 2006-04-10
NO950006D0 (no) 1995-01-02
ES2171414T5 (es) 2006-09-01
CA2139645C (en) 2003-02-11
NO950006L (no) 1995-02-24
PL307178A1 (en) 1995-05-02
PL174686B1 (pl) 1998-08-31
WO1994001778A1 (en) 1994-01-20
EP0649537A1 (en) 1995-04-26
EP0649537B2 (en) 2006-02-22
JP2003329687A (ja) 2003-11-19
CZ695A3 (en) 1996-03-13
JP3490085B2 (ja) 2004-01-26
FI110546B (fi) 2003-02-14
FI950002A0 (fi) 1995-01-02
HU9500008D0 (en) 1995-03-28
FI950002L (fi) 1995-02-27

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