ES2173248T3 - Anticuerpo monocional contra la subunidad r2 de la ribonucleotido reductasa. - Google Patents

Anticuerpo monocional contra la subunidad r2 de la ribonucleotido reductasa.

Info

Publication number
ES2173248T3
ES2173248T3 ES96300819T ES96300819T ES2173248T3 ES 2173248 T3 ES2173248 T3 ES 2173248T3 ES 96300819 T ES96300819 T ES 96300819T ES 96300819 T ES96300819 T ES 96300819T ES 2173248 T3 ES2173248 T3 ES 2173248T3
Authority
ES
Spain
Prior art keywords
subunity
ribonucleotide
monotional
reduced
antibody against
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96300819T
Other languages
English (en)
Inventor
Toshiaki Saeki
Toshiaki Kamei
Akiko Furuya
Nobuo Hanai
Takeshi Takahashi
Motoo Yamasaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Application granted granted Critical
Publication of ES2173248T3 publication Critical patent/ES2173248T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

SE DESCRIBE UN ANTICUERPO MONOCLONAL. EL ANTICUERPO MONOCLONAL ES ESPECIFICAMENTE REACTIVO CON UNA SUBUNIDAD R2 DE REDUCTASA DE RIBONUCLEOTIDO E INHIBE LA ACTIVIDAD DE LA REDUCTASA DE RIBONUCLEOTIDO. EN UN ASPECTO PREFERIDO, UN ANTICUERPO MONOCLONAL KM1054, KM1056 O KM1060, DE SUBUNIDAD R2 DE REDUCTASA DE ANTIRIBONUCLEOTIDO (RNR), QUE PERTENECE A LA SUBCLASE IGG2A, REACCIONA CON UNA SUBUNIDAD R2 DE RNR, E INHIBE LA ACTIVIDAD DE LA RNR. EL ANTICUERPO ES EFECTIVO PARA LA DETECCION INMUNOLOGICA DE RNR Y PARA DETECTAR INMUNOLOGICAMENTE LA PRESENCIA DE CELULAS CANCERIGENAS HUMANAS.
ES96300819T 1995-02-07 1996-02-07 Anticuerpo monocional contra la subunidad r2 de la ribonucleotido reductasa. Expired - Lifetime ES2173248T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1887995 1995-02-07

Publications (1)

Publication Number Publication Date
ES2173248T3 true ES2173248T3 (es) 2002-10-16

Family

ID=11983846

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96300819T Expired - Lifetime ES2173248T3 (es) 1995-02-07 1996-02-07 Anticuerpo monocional contra la subunidad r2 de la ribonucleotido reductasa.

Country Status (6)

Country Link
US (1) US5885830A (es)
EP (1) EP0726277B1 (es)
AT (1) ATE216709T1 (es)
CA (1) CA2169024A1 (es)
DE (1) DE69620814T2 (es)
ES (1) ES2173248T3 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2259123C (en) 1996-07-01 2003-10-21 Lorus Therapeutics Inc. Oligonucleotides from the untranslated regions of ribonucleotide reductase and their use to modulate cell growth
WO2000017225A2 (en) 1998-09-24 2000-03-30 The Trustees Of Columbia University In The City Of New York A small protein that interacts with a ribonucleotide reductase subunit and uses thereof
US6682917B1 (en) * 1999-06-28 2004-01-27 Takeda Chemical Industries, Ltd Protein having a ribonucleotide Reductase activity and a DNA thereof
CN1301816A (zh) * 1999-12-27 2001-07-04 上海博德基因开发有限公司 一种新的多肽——核苷酸还原酶10和编码这种多肽的多核苷酸
US8029815B2 (en) * 2004-04-28 2011-10-04 Elford Howard L Methods for treating or preventing restenosis and other vascular proliferative disorders
EP2030615A3 (en) * 2007-08-13 2009-12-02 ELFORD, Howard L. Ribonucleotide reductase inhibitors for use in the treatment or prevention of neuroinflammatory or autoimmune diseases
WO2015123654A1 (en) 2014-02-17 2015-08-20 The Cleveland Clinic Foundation Amine passivated nanoparticles for cancer treatment and imaging

Also Published As

Publication number Publication date
CA2169024A1 (en) 1996-08-08
EP0726277A3 (en) 1997-01-15
US5885830A (en) 1999-03-23
EP0726277B1 (en) 2002-04-24
ATE216709T1 (de) 2002-05-15
DE69620814D1 (de) 2002-05-29
DE69620814T2 (de) 2002-12-12
EP0726277A2 (en) 1996-08-14

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