ES2177522T3 - Preparacion liofilizada y su procedimiento de realizacion. - Google Patents

Preparacion liofilizada y su procedimiento de realizacion.

Info

Publication number
ES2177522T3
ES2177522T3 ES91918946T ES91918946T ES2177522T3 ES 2177522 T3 ES2177522 T3 ES 2177522T3 ES 91918946 T ES91918946 T ES 91918946T ES 91918946 T ES91918946 T ES 91918946T ES 2177522 T3 ES2177522 T3 ES 2177522T3
Authority
ES
Spain
Prior art keywords
preparation
liofilized
performance procedure
emulsion
prior
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91918946T
Other languages
English (en)
Inventor
Junzo Seki
Hirofumi Yamamoto
Shuji Yamane
Yutaka Takahashi
Kouichi Ushimaru
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Shinyaku Co Ltd
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Application granted granted Critical
Publication of ES2177522T3 publication Critical patent/ES2177522T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Colloid Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UNA PREPARACION LIOFILIZADA QUE LIBERA UNA EMULSION GRASA, DONDE LA PARTICULA DE EMULSION POSEE UN DIAMETRO MEDIO DE 10 A 100 NM, CUANDO SE REDISUELVE ANTES DE SU USO. ESTA PREPARACION SE PRODUCE AÑADIENDO MALTOSA EN UN PASO ARBITRARIO DE LA PRODUCCION DE DICHA EMULSION ANTES DE LA LIOFILIZACION.
ES91918946T 1990-11-06 1991-11-05 Preparacion liofilizada y su procedimiento de realizacion. Expired - Lifetime ES2177522T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP30164090 1990-11-06
JP30163990 1990-11-06
JP31205690 1990-11-16

Publications (1)

Publication Number Publication Date
ES2177522T3 true ES2177522T3 (es) 2002-12-16

Family

ID=27338476

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91918946T Expired - Lifetime ES2177522T3 (es) 1990-11-06 1991-11-05 Preparacion liofilizada y su procedimiento de realizacion.

Country Status (10)

Country Link
US (1) US5635491A (es)
EP (1) EP0556394B1 (es)
KR (1) KR0154343B1 (es)
AT (1) ATE219356T1 (es)
AU (1) AU665931B2 (es)
CA (1) CA2095627C (es)
DE (1) DE69133042T2 (es)
ES (1) ES2177522T3 (es)
HU (1) HU217808B (es)
WO (1) WO1992007552A1 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5250236A (en) † 1991-08-05 1993-10-05 Gasco Maria R Method for producing solid lipid microspheres having a narrow size distribution
DE4244122C1 (de) * 1992-12-24 1994-06-01 Sanol Arznei Schwarz Gmbh Lyophilisierte, wirkstoffhaltige Emulsion zur intravenösen Applikation
CA2231682A1 (en) * 1995-09-13 1997-03-20 Junzo Seki Pge1-containing freeze-dried preparation and the production thereof
US6537561B1 (en) 1997-02-27 2003-03-25 Nippon Shinyaku Co., Ltd. Fat emulsion for oral administration
KR20010041623A (ko) * 1998-03-05 2001-05-25 니뽄 신야쿠 가부시키가이샤 흡입 투여용 지방 유제
RU2214398C2 (ru) 1998-03-09 2003-10-20 Такеда Кемикал Индастриз, Лтд. Производное циклоалкена, способ его получения (варианты), фармацевтическая композиция, способ ингибирования, способ профилактики или лечения
US7732404B2 (en) * 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
GB0008785D0 (en) * 2000-04-10 2000-05-31 Novartis Ag Organic compounds
CA2456029C (en) * 2001-08-03 2010-12-07 Takeda Chemical Industries, Ltd. Stable emulsion composition
US20050208083A1 (en) * 2003-06-04 2005-09-22 Nanobio Corporation Compositions for inactivating pathogenic microorganisms, methods of making the compositons, and methods of use thereof
US8557861B2 (en) * 2004-09-28 2013-10-15 Mast Therapeutics, Inc. Low oil emulsion compositions for delivering taxoids and other insoluble drugs
RU2304431C2 (ru) * 2005-08-12 2007-08-20 Александр Иванович Арчаков Способ получения капсулированной лекарственной формы фосфолипидного препарата "фосфоглив" для лечения и профилактики острых и хронических заболеваний печени
RU2304430C2 (ru) 2005-08-12 2007-08-20 Александр Иванович Арчаков Способ получения инъекционной лекарственной формы фосфолипидного препарата "фосфоглив" для лечения и профилактики острых и хронических заболеваний печени
TWI376239B (en) * 2006-02-01 2012-11-11 Andrew Xian Chen Vitamin e succinate stabilized pharmaceutical compositions, methods for the preparation and the use thereof
HUE031951T2 (en) * 2006-10-10 2017-08-28 Jina Pharmaceuticals Inc Aqueous systems for lipid-based drug compounds; preparations, processes and their use
RU2411942C2 (ru) 2009-05-05 2011-02-20 Общество с ограниченной ответственностью "ЭкоБиоФарм" Фармацевтическая композиция, включающая арбидол в составе фосфолипидных наночастиц
PL2445472T3 (pl) 2009-06-24 2018-07-31 Lipoid Gmbh Kompozycja do zastosowań kosmetycznych, farmaceutycznych lub dietetycznych
CN102391342B (zh) * 2011-09-20 2012-11-21 海南灵康制药有限公司 一种地塞米松棕榈酸酯化合物及其制法
GR20120100181A (el) * 2012-03-28 2013-10-15 Μαριαννα Αχιλλεα Παπαμιχαηλ Νεες λυοφιλοποιημενες φαρμακοτεχνικες και καλυντικοτεχνικες μορφες λυοφιλοποιημενων γαλακτωματων
US9492548B2 (en) * 2012-12-14 2016-11-15 Intervet Inc. Emulsion containing a non-live medicinal substance
IL310015B2 (en) * 2013-12-31 2026-02-01 Access To Advanced Health Inst Single vial formulation
EP3585397A4 (en) * 2017-02-21 2020-11-25 iCo Therapeutics Inc. ORAL AMPHOTERICIN B SOLID FORMULATIONS
CN109394704B (zh) * 2018-11-27 2021-09-17 西安力邦肇新生物科技有限公司 一种前列腺素e1甲酯注射用冻干制剂及制备和应用
US11992483B2 (en) * 2021-03-31 2024-05-28 Cali Biosciences Us, Llc Emulsions for local anesthetics

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4102999A (en) * 1975-02-10 1978-07-25 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Process for producing stable macromomycin powder
JPS5924132B2 (ja) * 1980-12-02 1984-06-07 株式会社 林原生物化学研究所 栄養補給用乳剤の製法
JPS601123A (ja) * 1983-06-17 1985-01-07 Dai Ichi Seiyaku Co Ltd 外用製剤
JPS6045514A (ja) * 1983-08-22 1985-03-12 Shionogi & Co Ltd 安定な抗菌性凍結乾燥製剤
JPH0647533B2 (ja) * 1984-08-10 1994-06-22 裕 水島 ４−ビフエニリル酢酸系化合物含有脂肪乳剤
FR2581543B1 (fr) * 1985-05-09 1989-07-07 Tressens Dominique Pharmacotechnie permettant la realisation d'une preparation insulinique active par voie orale
IL78930A0 (en) * 1985-07-29 1986-09-30 Abbott Lab Lyophilized emulsion compositions for parenteral administration
IL78929A0 (en) * 1985-07-29 1986-09-30 Abbott Lab Microemulsion compositions for parenteral administration
IL88076A (en) * 1987-10-28 1993-01-14 Nippon Shinyaku Co Ltd Fat emulsions as drug carriers
JPH0798740B2 (ja) * 1987-10-28 1995-10-25 日本新薬株式会社 薬物担体
JP2734520B2 (ja) * 1988-03-29 1998-03-30 大正製薬株式会社 微粒子脂肪乳剤

Also Published As

Publication number Publication date
DE69133042D1 (de) 2002-07-25
KR930701972A (ko) 1993-09-08
CA2095627A1 (en) 1992-05-07
EP0556394A1 (en) 1993-08-25
AU8766791A (en) 1992-05-26
CA2095627C (en) 1999-01-05
US5635491A (en) 1997-06-03
EP0556394A4 (en) 1994-03-17
EP0556394B1 (en) 2002-06-19
HUT64864A (en) 1994-03-28
DE69133042T2 (de) 2003-01-30
HU9301323D0 (en) 1993-09-28
KR0154343B1 (ko) 1998-11-16
AU665931B2 (en) 1996-01-25
HU217808B (hu) 2000-04-28
ATE219356T1 (de) 2002-07-15
WO1992007552A1 (fr) 1992-05-14

Similar Documents

Publication Publication Date Title
ES2177522T3 (es) Preparacion liofilizada y su procedimiento de realizacion.
DE3853191D1 (de) Arzneimittelträger.
DE69534992D1 (de) Mutierendes enterotoxin als nichttoxisches orales adjuvans
SE7410757L (es)
ATE97424T1 (de) Modifizierte polydextrose und deren herstellung.
DE69106361D1 (de) Einschlusskomplex von nimesulide mit cyclodextrinen.
IT1076278B (it) Apparecchio depuratore d'aria,sepcialmente cappa aspirante da applicare al disopra di cucine e simili
DE59009112D1 (de) Scheinwerfer, der in seiner Helligkeit stufenlos regelbar ist.
ES2016231A4 (es) Nuevo dextrano producido mediante "leuconostoc dextranicum".
DE69316206D1 (de) Im wesentlichen reines synthetisches melanin, besonders geeignet fuer optische vorrichtungen von geringer truebung
ATE104554T1 (de) Topische praeparate.
DE59107240D1 (de) Emulgatorfreie Emulsionspolymere in pharmazeutischen Zubereitungen mit verzögerter Wirkstofffreigabe und ihre Herstellung
BR9101315A (pt) Composicoes de copolimero e processo para melhorar as propriedades de fluxo de copolimeros alternantes de monoxido de carbono
SU626302A1 (ru) Быстроразъемное соединение
Cere Ecclesiology and enlightenment social theory: the reconstruction of ecclesiology in the tradition of Anglican religious liberalism from John Hales to Thomas Arnold
Tarasov Concerning psychology of art
YU183089A (sh) Amrel sa automatskim otvaranjem
KR910000147A (ko) 항 궤양 치료제
IT8421842A0 (it) Congegno azionato manualmente o a mezzo di molla in modo che l'aria compressa in un condotto provochi la spinta e la fuga di un tappo cavo e di giocattoli e di oggetti vari a cui detto tappo e' ancorabile o fisso.
SV1990000045A (es) Preparacion de cicloalcano [b] dehidroindol e-inosulfonamidas sustituidas, ref. le a 27 157-sv.
SE8703386L (sv) Flaektkaapa
JPS51139303A (en) Tone arm
JPS5325753A (en) Clutch release magnetic bearing
NL190411B (nl) Esters van 1,5-dimethylbicyclo (3.2.1)octanol-8, de bereiding van deze verbindingen en de toepassing daarvan als reukstof.
TH7336S (th) เครื่องปรับอากาศ