ES2178393T3 - Utilizacion de analogos del vip en la prevencion y el tratamiento de las lesiones cerebrales en el neonato humano. - Google Patents

Utilizacion de analogos del vip en la prevencion y el tratamiento de las lesiones cerebrales en el neonato humano.

Info

Publication number
ES2178393T3
ES2178393T3 ES99907701T ES99907701T ES2178393T3 ES 2178393 T3 ES2178393 T3 ES 2178393T3 ES 99907701 T ES99907701 T ES 99907701T ES 99907701 T ES99907701 T ES 99907701T ES 2178393 T3 ES2178393 T3 ES 2178393T3
Authority
ES
Spain
Prior art keywords
lys
vip
prevention
treatment
nle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99907701T
Other languages
English (en)
Inventor
Pierre Gressens
Patrick Robberecht
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Assistance Publique Hopitaux de Paris APHP
Original Assignee
Assistance Publique Hopitaux de Paris APHP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Assistance Publique Hopitaux de Paris APHP filed Critical Assistance Publique Hopitaux de Paris APHP
Application granted granted Critical
Publication of ES2178393T3 publication Critical patent/ES2178393T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2278—Vasoactive intestinal peptide [VIP]; Related peptides (e.g. Exendin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Vascular Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

Utilización de un análogo del VIP seleccionado en el grupo constituido por los análogos cíclicos del VIP y los derivados del VIP no cíclicos de 31 aminoácidos que incluyen, en posición N-terminal, un grupo N-acetil, y Glu en posición 8 (Glu8), Lys en posición 12 (Lys12), norleucina en posición 17 (Nle17), Ala en posición 19 (Ala19), X1 en posición 21, X2 en posición 25, Leu en posición 26 (Leu26), Lys en posición 27 y 28 (Lys27 y Lys28), Gly en posición 29 y 30 (Gly29 y Gly30) y Thr en posición 31 (Thr31), donde X1 representa Lys (Lys21) o Nle (Nle21) y X2 representa Asp (Asp23 o Asn (Asn25), para la obtención de un medicamento para la prevención o el tratamiento de las lesiones cerebrales del feto, el neonato prematuro o llegado a término, o el lactante humano.
ES99907701T 1998-03-13 1999-03-12 Utilizacion de analogos del vip en la prevencion y el tratamiento de las lesiones cerebrales en el neonato humano. Expired - Lifetime ES2178393T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9803125A FR2775902B1 (fr) 1998-03-13 1998-03-13 Utilisation d'analogues du vip dans la prevention et le traitement des lesions cerebrales du nouveau-ne humain

Publications (1)

Publication Number Publication Date
ES2178393T3 true ES2178393T3 (es) 2002-12-16

Family

ID=9524030

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99907701T Expired - Lifetime ES2178393T3 (es) 1998-03-13 1999-03-12 Utilizacion de analogos del vip en la prevencion y el tratamiento de las lesiones cerebrales en el neonato humano.

Country Status (7)

Country Link
EP (1) EP1061945B1 (es)
AT (1) ATE218363T1 (es)
CA (1) CA2322018A1 (es)
DE (1) DE69901690T2 (es)
ES (1) ES2178393T3 (es)
FR (1) FR2775902B1 (es)
WO (1) WO1999047159A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6972319B1 (en) 1999-09-28 2005-12-06 Bayer Pharmaceuticals Corporation Pituitary adenylate cyclase activating peptide (PACAP)receptor 3 (R3) agonists and their pharmacological methods of use
DE60039111D1 (de) * 1999-09-28 2008-07-17 Bayer Corp Agonisten des rezeptors 3 (r3) von pituitary adenylate cyclase aktivierendem peptid (pacap) und ihre pharmakologische verwendung
US7507714B2 (en) 2000-09-27 2009-03-24 Bayer Corporation Pituitary adenylate cyclase activating peptide (PACAP) receptor 3 (R3) agonists and their pharmacological methods of use
WO2009043447A2 (en) * 2007-09-11 2009-04-09 Mondobiotech Laboratories Ag Use of a peptide as a therapeutic agent

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL105061A (en) * 1993-03-16 2000-11-21 Yeda Res & Dev Pharmaceutical compositions for the treatment of neurodegenerative diseases comprising VIP analogues and fragments thereof
KR100493795B1 (ko) * 1996-02-09 2005-09-09 에프. 호프만-라 로슈 아게 혈관활성장펩타이드유사체의합성방법

Also Published As

Publication number Publication date
EP1061945A1 (fr) 2000-12-27
EP1061945B1 (fr) 2002-06-05
CA2322018A1 (fr) 1999-09-23
ATE218363T1 (de) 2002-06-15
FR2775902A1 (fr) 1999-09-17
FR2775902B1 (fr) 2001-05-11
DE69901690D1 (de) 2002-07-11
DE69901690T2 (de) 2003-02-13
WO1999047159A1 (fr) 1999-09-23

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