ES2180471T1 - Base cristalina de citalopram y su sal hidrocloruro o hidrobromuro. - Google Patents

Base cristalina de citalopram y su sal hidrocloruro o hidrobromuro.

Info

Publication number
ES2180471T1
ES2180471T1 ES02009350T ES02009350T ES2180471T1 ES 2180471 T1 ES2180471 T1 ES 2180471T1 ES 02009350 T ES02009350 T ES 02009350T ES 02009350 T ES02009350 T ES 02009350T ES 2180471 T1 ES2180471 T1 ES 2180471T1
Authority
ES
Spain
Prior art keywords
citalopram
hydrocloride
hydrobromide salt
crystal base
weight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES02009350T
Other languages
English (en)
Other versions
ES2180471T3 (es
Inventor
Hans Petersen
Klaus Peter Boegesoe
Per Holm
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8159320&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2180471(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Publication of ES2180471T1 publication Critical patent/ES2180471T1/es
Application granted granted Critical
Publication of ES2180471T3 publication Critical patent/ES2180471T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Laminated Bodies (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Una base cristalina de citalopram, o una sal hidrocloruro o hidrobromuro de citalopram, caracterizada porque tiene una pureza de más de 99, 8 % en peso/peso, preferiblemente más de 99, 9% en peso/peso.
ES02009350T 2000-03-13 2001-02-28 Base cristalina de citalopram y su sal hidrocloruro o hidrobromuro. Expired - Lifetime ES2180471T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DKPA200000402 2000-03-13
DK200000402 2000-03-13
WOPCT/DK00/00183 2000-04-13
DKPCT/DK00/00183 2000-04-13

Publications (2)

Publication Number Publication Date
ES2180471T1 true ES2180471T1 (es) 2003-02-16
ES2180471T3 ES2180471T3 (es) 2004-05-01

Family

ID=8159320

Family Applications (3)

Application Number Title Priority Date Filing Date
ES02009350T Expired - Lifetime ES2180471T3 (es) 2000-03-13 2001-02-28 Base cristalina de citalopram y su sal hidrocloruro o hidrobromuro.
ES01909568T Expired - Lifetime ES2173054T3 (es) 2000-03-13 2001-02-28 Base cristalina de citalopram.
ES200100548A Expired - Fee Related ES2159491B1 (es) 2000-03-13 2001-03-09 Base cristalina de citalopram

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES01909568T Expired - Lifetime ES2173054T3 (es) 2000-03-13 2001-02-28 Base cristalina de citalopram.
ES200100548A Expired - Fee Related ES2159491B1 (es) 2000-03-13 2001-03-09 Base cristalina de citalopram

Country Status (41)

Country Link
US (7) US20010031784A1 (es)
EP (2) EP1169314B2 (es)
JP (1) JP2003527383A (es)
KR (1) KR20020080486A (es)
CN (2) CN1258530C (es)
AR (1) AR029811A1 (es)
AT (3) ATE223396T1 (es)
AU (2) AU746664B2 (es)
BE (1) BE1013210A3 (es)
BG (1) BG107065A (es)
BR (1) BR0109373A (es)
CA (2) CA2411732A1 (es)
CH (2) CH691477A5 (es)
CZ (1) CZ292077B6 (es)
DE (7) DE20007303U1 (es)
DK (3) DK173903B1 (es)
EA (1) EA200200972A1 (es)
ES (3) ES2180471T3 (es)
FI (2) FI20010156A0 (es)
FR (1) FR2806086B1 (es)
GB (2) GB2357762B (es)
GR (1) GR1003796B (es)
HR (1) HRP20020756A2 (es)
HU (3) HU0001581D0 (es)
IE (1) IES20010109A2 (es)
IL (2) IL147339A (es)
IS (1) IS5841A (es)
IT (2) IT1319645B1 (es)
MX (1) MXPA02008793A (es)
NL (2) NL1016435C1 (es)
NO (2) NO312031B1 (es)
PL (1) PL360158A1 (es)
PT (2) PT1169314E (es)
SE (2) SE517136C2 (es)
SI (2) SI1227088T1 (es)
SK (1) SK285528B6 (es)
TR (1) TR200202185T2 (es)
UA (1) UA74360C2 (es)
WO (1) WO2001068627A1 (es)
YU (1) YU68802A (es)
ZA (1) ZA200207148B (es)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ514671A (en) 1999-04-14 2003-10-31 H Method for the preparation of citalopram
AR021155A1 (es) * 1999-07-08 2002-06-12 Lundbeck & Co As H Tratamiento de desordenes neuroticos
US7713279B2 (en) 2000-12-20 2010-05-11 Fox Hollow Technologies, Inc. Method and devices for cutting tissue
US7708749B2 (en) 2000-12-20 2010-05-04 Fox Hollow Technologies, Inc. Debulking catheters and methods
US8328829B2 (en) 1999-08-19 2012-12-11 Covidien Lp High capacity debulking catheter with razor edge cutting window
US7887556B2 (en) 2000-12-20 2011-02-15 Fox Hollow Technologies, Inc. Debulking catheters and methods
US6299622B1 (en) 1999-08-19 2001-10-09 Fox Hollow Technologies, Inc. Atherectomy catheter with aligned imager
NL1017417C1 (nl) 2000-03-03 2001-03-16 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
GB2357762B (en) * 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
US6977306B2 (en) * 2000-05-02 2005-12-20 Sumitomo Chemical Company, Limited Citalopram hydrobromide crystal and method for crystallization thereof
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
CA2353693C (en) * 2000-08-10 2003-07-22 H. Lundbeck A/S Pharmaceutical composition containing citalopram
GB2376233B (en) * 2000-08-10 2003-09-10 Lundbeck & Co As H Crystals of a pharmaceutically acceptable salt of citalopram wherein the median size of the crystals is at least 40 microns
DE60144107D1 (de) 2000-12-20 2011-04-07 Fox Hollow Technologies Inc Verkleinerungskatheter
JP3798982B2 (ja) * 2000-12-22 2006-07-19 ハー・ルンドベック・アクチエゼルスカベット 純粋なシタロプラムの製造方法
AU2001100195B4 (en) * 2001-01-05 2001-12-20 H Lundbeck As Pharmaceutical composition containing citalopram.
GB0105627D0 (en) * 2001-03-07 2001-04-25 Cipla Ltd Preparation of phthalanes
EA200301195A1 (ru) * 2001-05-01 2004-04-29 Х. Лундбекк А/С Применение энантиомерно чистого эсциталопрама
HRP20031073A2 (en) 2001-07-31 2004-04-30 Lundbeck & Co As H Crystalline composition containing escitalopram
WO2003057132A2 (en) * 2002-01-07 2003-07-17 Sun Pharmaceutical Industries Limited Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile
GB2387844B (en) * 2002-02-27 2005-05-11 Matrix Lab Ltd Separation of impurities from a crude mixture of citalopram
GB2386118A (en) * 2002-02-27 2003-09-10 Cipla Ltd Citalopram
GB2386119A (en) * 2002-02-27 2003-09-10 Cipla Ltd Purification of citalopram
GB0204607D0 (en) 2002-02-27 2002-04-10 Matrix Lab Ltd Process
GB2385848A (en) * 2002-02-27 2003-09-03 Cipla Ltd Citalopram salts
EP1346989A1 (en) * 2002-03-21 2003-09-24 Jubilant Organosys Limited Improved process for the preparation of citalopram and its hydrobromide
GB0206708D0 (en) * 2002-03-21 2002-05-01 Cipla Ltd Pharmaceutical salts
US6812355B2 (en) 2002-10-22 2004-11-02 Sekhsaria Chemicals Limited Process for the manufacture of citalopram hydrobromide from 5-bromophthalide
TR200504022T1 (tr) * 2003-03-24 2006-08-21 Hetero Drugs Limited (S)-sitalopram oksalatın yeni sıvı kristal formları.
WO2004094399A1 (en) * 2003-04-21 2004-11-04 Natco Pharma Ltd An improved process for the preparation of citalopram hydrobromide
US8246640B2 (en) 2003-04-22 2012-08-21 Tyco Healthcare Group Lp Methods and devices for cutting tissue at a vascular location
US7019153B2 (en) 2003-06-10 2006-03-28 Sun Pharmaceutical Industries Limited Process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran acetamido-3-substituted-3-cephem-4-carboxylic acid
GB0317475D0 (en) * 2003-07-25 2003-08-27 Meditab Specialities Pvt Ltd Product
JP4025735B2 (ja) * 2003-08-21 2007-12-26 ローム アンド ハース カンパニー 水性系を処理する方法
GB0320312D0 (en) 2003-08-29 2003-10-01 Novartis Ag Purification process
CN100569765C (zh) * 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
ITTO20050301A1 (it) * 2005-05-05 2006-11-06 Errekappa Euroterapici Spa Formulazioni liquide orali contenenti citalopram
US20110196032A1 (en) * 2005-05-20 2011-08-11 Ashish Gogia Pharmaceutical Dosage Form of an Antidepressant
TWI347942B (en) * 2005-06-22 2011-09-01 Lundbeck & Co As H Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
US7834201B2 (en) 2005-06-22 2010-11-16 H. Lundbeck A/S Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
RU2408368C2 (ru) 2005-06-27 2011-01-10 Биовэйл Лэборэториз Интернэшнл С.Р.Л. Препараты соли бупропиона с модифицированным высвобождением
US20070276419A1 (en) 2006-05-26 2007-11-29 Fox Hollow Technologies, Inc. Methods and devices for rotating an active element and an energy emitter on a catheter
US8784440B2 (en) 2008-02-25 2014-07-22 Covidien Lp Methods and devices for cutting tissue
CN102223847B (zh) 2008-10-13 2013-10-30 泰科保健集团有限合伙公司 用于操纵导管轴的装置和方法
KR101323553B1 (ko) 2009-04-29 2013-10-29 코비디엔 엘피 조직을 절제하고 연마하기 위한 방법 및 장치
KR101581091B1 (ko) 2009-05-14 2015-12-30 코비디엔 엘피 세척이 용이한 죽상반 절제 카테터 및 사용 방법
EP2913013B1 (en) 2009-12-02 2016-11-09 Covidien LP Methods and devices for cutting tissue
IN2012DN04977A (es) 2009-12-11 2015-09-25 Tyco Healthcare
WO2011159697A1 (en) 2010-06-14 2011-12-22 Tyco Healthcare Group Lp Material removal device
WO2012058438A1 (en) 2010-10-28 2012-05-03 Tyco Healthcare Group Lp Material removal device and method of use
RU2553930C2 (ru) 2010-11-11 2015-06-20 Ковидиен Лп Гибкие фрагментирующие катетеры с визуализацией и способы их использования и изготовления
JP5806407B2 (ja) 2011-09-01 2015-11-10 コヴィディエン リミテッド パートナーシップ 螺旋駆動軸を有するカテーテルおよび製造方法
US9579157B2 (en) 2012-09-13 2017-02-28 Covidien Lp Cleaning device for medical instrument and method of use
US9943329B2 (en) 2012-11-08 2018-04-17 Covidien Lp Tissue-removing catheter with rotatable cutter
WO2015200702A1 (en) 2014-06-27 2015-12-30 Covidien Lp Cleaning device for catheter and catheter including the same
US10314667B2 (en) 2015-03-25 2019-06-11 Covidien Lp Cleaning device for cleaning medical instrument
US10292721B2 (en) 2015-07-20 2019-05-21 Covidien Lp Tissue-removing catheter including movable distal tip
US10314664B2 (en) 2015-10-07 2019-06-11 Covidien Lp Tissue-removing catheter and tissue-removing element with depth stop
US20240024288A1 (en) 2019-07-19 2024-01-25 Bioxcel Therapeutics, Inc. Non-sedating dexmedetomidine treatment regimens
US11806334B1 (en) 2023-01-12 2023-11-07 Bioxcel Therapeutics, Inc. Non-sedating dexmedetomidine treatment regimens

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GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
US5296507A (en) * 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DK213290D0 (da) 1990-09-06 1990-09-06 Lundbeck & Co As H Treatment of cerebrovascular disorders
CA2120874E (en) * 1994-04-08 2002-01-08 Keshava Murthy Form of form 1 ranitidine
TR200000066T2 (tr) * 1997-07-08 2000-11-21 H. Lundbeck A/S Sitalopram hazırlanması için yöntem.
UA62985C2 (en) * 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
ES2149734T3 (es) * 1997-11-11 2003-02-16 Lundbeck & Co As H Metodo para la preparacion de citalopram.
PL199423B1 (pl) * 1998-10-20 2008-09-30 Lundbeck & Co As H Sposób wytwarzania citalopramu
NZ514671A (en) 1999-04-14 2003-10-31 H Method for the preparation of citalopram
ITMI991581A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
US6433196B1 (en) * 2000-02-17 2002-08-13 Sumika Fine Chemicals Co., Ltd. Production method of citalopram, intermediate therefor and production method of the intermediate
GB2357762B (en) * 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
US6977306B2 (en) * 2000-05-02 2005-12-20 Sumitomo Chemical Company, Limited Citalopram hydrobromide crystal and method for crystallization thereof

Also Published As

Publication number Publication date
CH691537A5 (de) 2001-08-15
DE10108042A1 (de) 2001-10-18
NO20020356D0 (no) 2002-01-23
CN1680350A (zh) 2005-10-12
DK1227088T3 (da) 2003-12-22
FI109022B (fi) 2002-05-15
US20010031784A1 (en) 2001-10-18
SI1169314T2 (sl) 2011-08-31
NO315851B1 (no) 2003-11-03
WO2001068627A1 (en) 2001-09-20
ITMI20010406A1 (it) 2002-08-28
HUP0100531A2 (hu) 2002-01-28
DE60100786T2 (de) 2004-07-15
IL147339A (en) 2004-09-27
EP1169314B2 (en) 2011-06-01
YU68802A (sh) 2005-11-28
EA200200972A1 (ru) 2003-02-27
HU0100450D0 (en) 2001-04-28
DE60100022D1 (de) 2002-10-10
SI1169314T1 (en) 2002-12-31
FI20010225L (fi) 2001-09-14
EP1227088A1 (en) 2002-07-31
SE526022C2 (sv) 2005-06-14
EP1169314A1 (en) 2002-01-09
DE60100786D1 (de) 2003-10-23
AT4364U1 (de) 2001-06-25
BE1013210A3 (fr) 2001-10-02
CZ2001808A3 (cs) 2002-01-16
EP1169314B1 (en) 2002-09-04
HU0001581D0 (en) 2000-06-28
CA2360287C (en) 2003-09-09
DE20007303U1 (de) 2000-07-27
GB2357762B (en) 2002-01-30
IS5841A (is) 2001-09-14
PT1227088E (pt) 2003-12-31
DK173903B1 (da) 2002-02-11
FI20010156A0 (fi) 2001-01-25
AU3725201A (en) 2001-09-13
ES2173054T1 (es) 2002-10-16
US20060247451A1 (en) 2006-11-02
AU746664B2 (en) 2002-05-02
BG107065A (bg) 2003-05-30
CA2360287A1 (en) 2001-09-20
PT1169314E (pt) 2002-11-29
ATE250050T1 (de) 2003-10-15
NO312031B1 (no) 2002-03-04
DE20121240U1 (de) 2002-07-04
CN1429220A (zh) 2003-07-09
KR20020080486A (ko) 2002-10-23
US20040167210A1 (en) 2004-08-26
SE0200730L (sv) 2002-08-29
MXPA02008793A (es) 2003-02-12
BR0109373A (pt) 2002-12-24
GB0102797D0 (en) 2001-03-21
JP2003527383A (ja) 2003-09-16
GB0105982D0 (en) 2001-05-02
IT1319645B1 (it) 2003-10-23
TR200202185T2 (tr) 2002-12-23
CZ292077B6 (cs) 2003-07-16
EP1227088B1 (en) 2003-09-17
ITMI20002425A1 (it) 2002-05-09
ES2159491A1 (es) 2001-10-01
SE517136C2 (sv) 2002-04-16
HU0100531D0 (en) 2001-03-28
FI20010225A0 (fi) 2001-02-07
HUP0100531A3 (en) 2004-04-28
HK1054750A1 (en) 2003-12-12
AR029811A1 (es) 2003-07-16
ES2173054T3 (es) 2002-12-16
IL147339A0 (en) 2002-08-14
NL1016435C1 (nl) 2000-11-06
ES2159491B1 (es) 2002-05-01
GR1003796B (el) 2002-02-08
FR2806086A1 (fr) 2001-09-14
CH691477A5 (de) 2001-07-31
US20030078442A1 (en) 2003-04-24
HRP20020756A2 (en) 2004-12-31
PL360158A1 (en) 2004-09-06
SI1227088T1 (en) 2003-12-31
AU2001100197B4 (en) 2001-12-06
CA2411732A1 (en) 2001-09-20
GB2357762A (en) 2001-07-04
NO20010619L (no) 2001-09-14
DE60100022T2 (de) 2003-03-06
NL1017413C1 (nl) 2001-09-13
NO20010619D0 (no) 2001-02-06
DK1169314T3 (da) 2002-10-14
AU2001100197A4 (en) 2001-09-20
ES2180471T3 (es) 2004-05-01
FR2806086B1 (fr) 2003-05-09
IL158072A0 (en) 2004-03-28
SK13132002A3 (sk) 2003-01-09
US20050165244A1 (en) 2005-07-28
US20040132808A1 (en) 2004-07-08
CN1258530C (zh) 2006-06-07
SK285528B6 (sk) 2007-03-01
ATE223396T1 (de) 2002-09-15
SE0200730D0 (sv) 2002-03-12
NO20020356L (no) 2001-09-14
SE0103046D0 (sv) 2001-09-14
DE10164687B4 (de) 2006-04-27
DE60100022T3 (de) 2011-11-17
ZA200207148B (en) 2003-04-23
SE0103046L (sv) 2001-11-14
UA74360C2 (uk) 2005-12-15
US20050165092A1 (en) 2005-07-28
IES20010109A2 (en) 2002-02-20
DE1227088T1 (de) 2003-02-06

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