ES2173054T1 - Base cristalina de citalopram. - Google Patents

Base cristalina de citalopram.

Info

Publication number
ES2173054T1
ES2173054T1 ES01909568T ES01909568T ES2173054T1 ES 2173054 T1 ES2173054 T1 ES 2173054T1 ES 01909568 T ES01909568 T ES 01909568T ES 01909568 T ES01909568 T ES 01909568T ES 2173054 T1 ES2173054 T1 ES 2173054T1
Authority
ES
Spain
Prior art keywords
citalopram
crystal base
base
precipitated
transformed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES01909568T
Other languages
English (en)
Other versions
ES2173054T3 (es
Inventor
Hans Petersen
Klaus Peter Boegesoe
Per Holm
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8159320&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2173054(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Publication of ES2173054T1 publication Critical patent/ES2173054T1/es
Application granted granted Critical
Publication of ES2173054T3 publication Critical patent/ES2173054T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Laminated Bodies (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un procedimiento para la preparación de una sal de citalopram, caracterizado porque la base de citalopram se pone en libertad y se precipita en forma cristalina, opcionalmente se recristaliza una o más veces y luego se transforma en una de sus sales.
ES01909568T 2000-03-13 2001-02-28 Base cristalina de citalopram. Expired - Lifetime ES2173054T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200000402 2000-03-13
DKPCT/DK00/00183 2000-04-13

Publications (2)

Publication Number Publication Date
ES2173054T1 true ES2173054T1 (es) 2002-10-16
ES2173054T3 ES2173054T3 (es) 2002-12-16

Family

ID=8159320

Family Applications (3)

Application Number Title Priority Date Filing Date
ES02009350T Expired - Lifetime ES2180471T3 (es) 2000-03-13 2001-02-28 Base cristalina de citalopram y su sal hidrocloruro o hidrobromuro.
ES01909568T Expired - Lifetime ES2173054T3 (es) 2000-03-13 2001-02-28 Base cristalina de citalopram.
ES200100548A Expired - Fee Related ES2159491B1 (es) 2000-03-13 2001-03-09 Base cristalina de citalopram

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES02009350T Expired - Lifetime ES2180471T3 (es) 2000-03-13 2001-02-28 Base cristalina de citalopram y su sal hidrocloruro o hidrobromuro.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES200100548A Expired - Fee Related ES2159491B1 (es) 2000-03-13 2001-03-09 Base cristalina de citalopram

Country Status (41)

Country Link
US (7) US20010031784A1 (es)
EP (2) EP1169314B2 (es)
JP (1) JP2003527383A (es)
KR (1) KR20020080486A (es)
CN (2) CN1680350A (es)
AR (1) AR029811A1 (es)
AT (3) ATE223396T1 (es)
AU (2) AU746664B2 (es)
BE (1) BE1013210A3 (es)
BG (1) BG107065A (es)
BR (1) BR0109373A (es)
CA (2) CA2411732A1 (es)
CH (2) CH691477A5 (es)
CZ (1) CZ292077B6 (es)
DE (7) DE20007303U1 (es)
DK (3) DK173903B1 (es)
EA (1) EA200200972A1 (es)
ES (3) ES2180471T3 (es)
FI (2) FI20010156A0 (es)
FR (1) FR2806086B1 (es)
GB (2) GB2357762B (es)
GR (1) GR1003796B (es)
HR (1) HRP20020756A2 (es)
HU (3) HU0001581D0 (es)
IE (1) IES20010109A2 (es)
IL (2) IL147339A (es)
IS (1) IS5841A (es)
IT (2) IT1319645B1 (es)
MX (1) MXPA02008793A (es)
NL (2) NL1016435C1 (es)
NO (2) NO312031B1 (es)
PL (1) PL360158A1 (es)
PT (2) PT1227088E (es)
SE (2) SE517136C2 (es)
SI (2) SI1169314T2 (es)
SK (1) SK285528B6 (es)
TR (1) TR200202185T2 (es)
UA (1) UA74360C2 (es)
WO (1) WO2001068627A1 (es)
YU (1) YU68802A (es)
ZA (1) ZA200207148B (es)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL145615A0 (en) * 1999-04-14 2002-06-30 Lundbeck & Co As H Method for the preparation of citalopram
AR021155A1 (es) * 1999-07-08 2002-06-12 Lundbeck & Co As H Tratamiento de desordenes neuroticos
US7887556B2 (en) 2000-12-20 2011-02-15 Fox Hollow Technologies, Inc. Debulking catheters and methods
US7713279B2 (en) 2000-12-20 2010-05-11 Fox Hollow Technologies, Inc. Method and devices for cutting tissue
US7708749B2 (en) 2000-12-20 2010-05-04 Fox Hollow Technologies, Inc. Debulking catheters and methods
US8328829B2 (en) 1999-08-19 2012-12-11 Covidien Lp High capacity debulking catheter with razor edge cutting window
US6299622B1 (en) 1999-08-19 2001-10-09 Fox Hollow Technologies, Inc. Atherectomy catheter with aligned imager
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
GB2357762B (en) * 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
US6977306B2 (en) 2000-05-02 2005-12-20 Sumitomo Chemical Company, Limited Citalopram hydrobromide crystal and method for crystallization thereof
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
CA2353693C (en) * 2000-08-10 2003-07-22 H. Lundbeck A/S Pharmaceutical composition containing citalopram
GB2376233B (en) * 2000-08-10 2003-09-10 Lundbeck & Co As H Crystals of a pharmaceutically acceptable salt of citalopram wherein the median size of the crystals is at least 40 microns
JP4080874B2 (ja) 2000-12-20 2008-04-23 フォックス ハロウ テクノロジーズ，インコーポレイティド 減嵩カテーテル
TR200201166T1 (tr) * 2000-12-22 2002-10-21 H.Lundbecks A/S Saf sitalopram hazırlanması için yöntem
AU2001100195B4 (en) * 2001-01-05 2001-12-20 H Lundbeck As Pharmaceutical composition containing citalopram.
GB0105627D0 (en) * 2001-03-07 2001-04-25 Cipla Ltd Preparation of phthalanes
CA2445843A1 (en) * 2001-05-01 2002-11-07 H. Lundbeck A/S The use of enantiomeric pure escitalopram
ATE352546T1 (de) 2001-07-31 2007-02-15 Lundbeck & Co As H Kristalline zusammensetzung enthaltend escitalopram
WO2003057132A2 (en) * 2002-01-07 2003-07-17 Sun Pharmaceutical Industries Limited Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile
GB2386118A (en) * 2002-02-27 2003-09-10 Cipla Ltd Citalopram
GB2385848A (en) * 2002-02-27 2003-09-03 Cipla Ltd Citalopram salts
GB2387844B (en) * 2002-02-27 2005-05-11 Matrix Lab Ltd Separation of impurities from a crude mixture of citalopram
GB0204607D0 (en) 2002-02-27 2002-04-10 Matrix Lab Ltd Process
GB2386119A (en) * 2002-02-27 2003-09-10 Cipla Ltd Purification of citalopram
EP1346989A1 (en) * 2002-03-21 2003-09-24 Jubilant Organosys Limited Improved process for the preparation of citalopram and its hydrobromide
GB0206708D0 (en) * 2002-03-21 2002-05-01 Cipla Ltd Pharmaceutical salts
US6812355B2 (en) 2002-10-22 2004-11-02 Sekhsaria Chemicals Limited Process for the manufacture of citalopram hydrobromide from 5-bromophthalide
AU2003223105A1 (en) * 2003-03-24 2004-10-18 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
WO2004094399A1 (en) * 2003-04-21 2004-11-04 Natco Pharma Ltd An improved process for the preparation of citalopram hydrobromide
US8246640B2 (en) 2003-04-22 2012-08-21 Tyco Healthcare Group Lp Methods and devices for cutting tissue at a vascular location
EP1486492A3 (en) * 2003-06-10 2005-02-23 Sun Pharmaceuticals Industries Ltd. A process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran.
GB0317475D0 (en) * 2003-07-25 2003-08-27 Meditab Specialities Pvt Ltd Product
JP4025735B2 (ja) * 2003-08-21 2007-12-26 ローム アンド ハース カンパニー 水性系を処理する方法
GB0320312D0 (en) 2003-08-29 2003-10-01 Novartis Ag Purification process
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
ITTO20050301A1 (it) * 2005-05-05 2006-11-06 Errekappa Euroterapici Spa Formulazioni liquide orali contenenti citalopram
US20110196032A1 (en) * 2005-05-20 2011-08-11 Ashish Gogia Pharmaceutical Dosage Form of an Antidepressant
US7834201B2 (en) 2005-06-22 2010-11-16 H. Lundbeck A/S Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
TWI358407B (en) * 2005-06-22 2012-02-21 Lundbeck & Co As H Crystalline base of escitalopram and orodispersibl
US7241805B2 (en) 2005-06-27 2007-07-10 Biovail Laboratories, Inc. Modified release formulations of a bupropion salt
US20070276419A1 (en) 2006-05-26 2007-11-29 Fox Hollow Technologies, Inc. Methods and devices for rotating an active element and an energy emitter on a catheter
US8784440B2 (en) 2008-02-25 2014-07-22 Covidien Lp Methods and devices for cutting tissue
EP3275383A1 (en) 2008-10-13 2018-01-31 Covidien LP Devices and methods for manipulating a catheter shaft
AU2010241801B2 (en) 2009-04-29 2013-04-11 Covidien Lp Methods and devices for cutting and abrading tissue
JP5281195B2 (ja) 2009-05-14 2013-09-04 コヴィディエン リミテッド パートナーシップ 簡単に清掃され得るアテレクトミー用カテーテルおよび使用の方法
BR112012013389A2 (pt) 2009-12-02 2018-03-06 Tyco Healthcare métodos e dispositivos para o corte de um tecido
KR101398384B1 (ko) 2009-12-11 2014-05-23 코비디엔 엘피 물질 포획 효율이 향상된 물질 제거 장치 및 사용 방법
US9119662B2 (en) 2010-06-14 2015-09-01 Covidien Lp Material removal device and method of use
CN103200886B (zh) 2010-10-28 2015-07-29 科维蒂恩有限合伙公司 物质移除装置和使用方法
BR112013011632A2 (pt) 2010-11-11 2016-08-09 Covidien Lp cateteres de citorredução flexíveis com imagiologia e métodos de uso e fabricação
WO2013033426A2 (en) 2011-09-01 2013-03-07 Covidien Lp Catheter with helical drive shaft and methods of manufacture
US9579157B2 (en) 2012-09-13 2017-02-28 Covidien Lp Cleaning device for medical instrument and method of use
US9943329B2 (en) 2012-11-08 2018-04-17 Covidien Lp Tissue-removing catheter with rotatable cutter
WO2015200702A1 (en) 2014-06-27 2015-12-30 Covidien Lp Cleaning device for catheter and catheter including the same
US10314667B2 (en) 2015-03-25 2019-06-11 Covidien Lp Cleaning device for cleaning medical instrument
US10292721B2 (en) 2015-07-20 2019-05-21 Covidien Lp Tissue-removing catheter including movable distal tip
US10314664B2 (en) 2015-10-07 2019-06-11 Covidien Lp Tissue-removing catheter and tissue-removing element with depth stop
EP3999058A4 (en) 2019-07-19 2023-05-03 Bioxcel Therapeutics, Inc. TREATMENT SCHEMES FOR NON-SEDATING DEXMEDETOMIDIN
US11806334B1 (en) 2023-01-12 2023-11-07 Bioxcel Therapeutics, Inc. Non-sedating dexmedetomidine treatment regimens

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US5296507A (en) * 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DK213290D0 (da) 1990-09-06 1990-09-06 Lundbeck & Co As H Treatment of cerebrovascular disorders
CA2120874E (en) * 1994-04-08 2002-01-08 Keshava Murthy Form of form 1 ranitidine
JP3526581B2 (ja) * 1997-07-08 2004-05-17 ハー・ルンドベック・アクティーゼルスカブ シタロプラムの製造方法
UA62985C2 (en) * 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
CN1286687A (zh) * 1997-11-11 2001-03-07 H·隆德贝克有限公司 制备西酞普兰的方法
WO2000023431A1 (en) * 1998-10-20 2000-04-27 H. Lundbeck A/S Method for the preparation of citalopram
IL145615A0 (en) 1999-04-14 2002-06-30 Lundbeck & Co As H Method for the preparation of citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
US6433196B1 (en) * 2000-02-17 2002-08-13 Sumika Fine Chemicals Co., Ltd. Production method of citalopram, intermediate therefor and production method of the intermediate
GB2357762B (en) * 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
US6977306B2 (en) * 2000-05-02 2005-12-20 Sumitomo Chemical Company, Limited Citalopram hydrobromide crystal and method for crystallization thereof

Also Published As

Publication number Publication date
EP1227088B1 (en) 2003-09-17
ES2173054T3 (es) 2002-12-16
DK173903B1 (da) 2002-02-11
JP2003527383A (ja) 2003-09-16
AU2001100197A4 (en) 2001-09-20
HU0100531D0 (en) 2001-03-28
GB2357762B (en) 2002-01-30
SK13132002A3 (sk) 2003-01-09
EA200200972A1 (ru) 2003-02-27
GB0102797D0 (en) 2001-03-21
SI1169314T1 (en) 2002-12-31
PT1169314E (pt) 2002-11-29
GB2357762A (en) 2001-07-04
SE526022C2 (sv) 2005-06-14
ES2159491A1 (es) 2001-10-01
US20030078442A1 (en) 2003-04-24
NO20020356D0 (no) 2002-01-23
CN1680350A (zh) 2005-10-12
EP1169314B1 (en) 2002-09-04
CH691537A5 (de) 2001-08-15
AU2001100197B4 (en) 2001-12-06
SE0200730D0 (sv) 2002-03-12
IL158072A0 (en) 2004-03-28
AT4364U1 (de) 2001-06-25
YU68802A (sh) 2005-11-28
EP1169314B2 (en) 2011-06-01
FI20010156A0 (fi) 2001-01-25
FI109022B (fi) 2002-05-15
DK1169314T3 (da) 2002-10-14
DE60100786D1 (de) 2003-10-23
DE60100022T3 (de) 2011-11-17
HUP0100531A2 (hu) 2002-01-28
SI1169314T2 (sl) 2011-08-31
US20060247451A1 (en) 2006-11-02
ITMI20002425A1 (it) 2002-05-09
CN1429220A (zh) 2003-07-09
US20050165244A1 (en) 2005-07-28
ES2159491B1 (es) 2002-05-01
IES20010109A2 (en) 2002-02-20
HRP20020756A2 (en) 2004-12-31
KR20020080486A (ko) 2002-10-23
DE60100022T2 (de) 2003-03-06
FR2806086A1 (fr) 2001-09-14
FR2806086B1 (fr) 2003-05-09
AR029811A1 (es) 2003-07-16
DE10108042A1 (de) 2001-10-18
IT1319645B1 (it) 2003-10-23
US20040167210A1 (en) 2004-08-26
IL147339A0 (en) 2002-08-14
DE60100786T2 (de) 2004-07-15
NO312031B1 (no) 2002-03-04
ZA200207148B (en) 2003-04-23
FI20010225L (fi) 2001-09-14
DE20121240U1 (de) 2002-07-04
ATE223396T1 (de) 2002-09-15
SI1227088T1 (en) 2003-12-31
NL1016435C1 (nl) 2000-11-06
SE0200730L (sv) 2002-08-29
CZ292077B6 (cs) 2003-07-16
AU3725201A (en) 2001-09-13
HU0001581D0 (en) 2000-06-28
SE0103046L (sv) 2001-11-14
IS5841A (is) 2001-09-14
HK1054750A1 (en) 2003-12-12
AU746664B2 (en) 2002-05-02
IL147339A (en) 2004-09-27
ITMI20010406A1 (it) 2002-08-28
FI20010225A0 (fi) 2001-02-07
NO20020356L (no) 2001-09-14
DK1227088T3 (da) 2003-12-22
GR1003796B (el) 2002-02-08
CH691477A5 (de) 2001-07-31
UA74360C2 (uk) 2005-12-15
US20050165092A1 (en) 2005-07-28
CA2360287A1 (en) 2001-09-20
SK285528B6 (sk) 2007-03-01
CN1258530C (zh) 2006-06-07
BR0109373A (pt) 2002-12-24
NL1017413C1 (nl) 2001-09-13
NO20010619D0 (no) 2001-02-06
US20040132808A1 (en) 2004-07-08
PT1227088E (pt) 2003-12-31
CA2411732A1 (en) 2001-09-20
BE1013210A3 (fr) 2001-10-02
CZ2001808A3 (cs) 2002-01-16
DE10164687B4 (de) 2006-04-27
DE1227088T1 (de) 2003-02-06
HUP0100531A3 (en) 2004-04-28
TR200202185T2 (tr) 2002-12-23
PL360158A1 (en) 2004-09-06
SE0103046D0 (sv) 2001-09-14
HU0100450D0 (en) 2001-04-28
US20010031784A1 (en) 2001-10-18
CA2360287C (en) 2003-09-09
DE20007303U1 (de) 2000-07-27
ATE250050T1 (de) 2003-10-15
EP1227088A1 (en) 2002-07-31
DE60100022D1 (de) 2002-10-10
NO315851B1 (no) 2003-11-03
WO2001068627A1 (en) 2001-09-20
BG107065A (bg) 2003-05-30
ES2180471T3 (es) 2004-05-01
EP1169314A1 (en) 2002-01-09
GB0105982D0 (en) 2001-05-02
SE517136C2 (sv) 2002-04-16
MXPA02008793A (es) 2003-02-12
NO20010619L (no) 2001-09-14
ES2180471T1 (es) 2003-02-16

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