ES2181685T3 - Metodos para producir eg iii celulasa, xilanasa o una mezcla de ambos usando polietilenglicol. - Google Patents
Metodos para producir eg iii celulasa, xilanasa o una mezcla de ambos usando polietilenglicol.Info
- Publication number
- ES2181685T3 ES2181685T3 ES93908750T ES93908750T ES2181685T3 ES 2181685 T3 ES2181685 T3 ES 2181685T3 ES 93908750 T ES93908750 T ES 93908750T ES 93908750 T ES93908750 T ES 93908750T ES 2181685 T3 ES2181685 T3 ES 2181685T3
- Authority
- ES
- Spain
- Prior art keywords
- methods
- iii
- produce
- mixture
- xyllase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 title abstract 3
- 108010059892 Cellulase Proteins 0.000 title 1
- 239000002202 Polyethylene glycol Substances 0.000 title 1
- 229940106157 cellulase Drugs 0.000 title 1
- 229920001223 polyethylene glycol Polymers 0.000 title 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract 2
- 229920002678 cellulose Polymers 0.000 abstract 2
- 239000001913 cellulose Substances 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- -1 POLYETHYLENE Polymers 0.000 abstract 1
- 239000004698 Polyethylene Substances 0.000 abstract 1
- 241000223259 Trichoderma Species 0.000 abstract 1
- 238000005194 fractionation Methods 0.000 abstract 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 abstract 1
- 229920000573 polyethylene Polymers 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
- C11D3/38645—Preparations containing enzymes, e.g. protease or amylase containing cellulase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2434—Glucanases acting on beta-1,4-glucosidic bonds
- C12N9/2437—Cellulases (3.2.1.4; 3.2.1.74; 3.2.1.91; 3.2.1.150)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2477—Hemicellulases not provided in a preceding group
- C12N9/248—Xylanases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01004—Cellulase (3.2.1.4), i.e. endo-1,4-beta-glucanase
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M16/00—Biochemical treatment of fibres, threads, yarns, fabrics, or fibrous goods made from such materials, e.g. enzymatic
- D06M16/003—Biochemical treatment of fibres, threads, yarns, fabrics, or fibrous goods made from such materials, e.g. enzymatic with enzymes or microorganisms
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M2200/00—Functionality of the treatment composition and/or properties imparted to the textile material
- D06M2200/50—Modified hand or grip properties; Softening compositions
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/945—Trichoderma
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Textile Engineering (AREA)
- Enzymes And Modification Thereof (AREA)
- Detergent Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE DESCUBREN METODOS PARA PRODUCIR EG III CELULASA SUSTANCIALMENTE PURA A PARTIR DE TRICHODERMA SPP. EN PARTICULAR EL METODO DE LA PRESENTE INVENCION COMPRENDE SEPARACION DEL COMPONENTE EG III CELULASA DE UNA MEZCLA ACUOSA DE ENZIMAS POR LA ADICION DE POLIETILENO GLICOL A LA MEZCLA ACUOSA PARA CREAR UN SISTEMA DE DOS FASES Y SEPARAR LA FASE EG III ENRIQUECIDA. LA PRESENTE INVENCION ESTA TAMBIEN DIRIGIDA EN PARTE A METODOS PARA PREPARAR SUSTANCIALMENTE COMPONENTE EG III CELULASA POR FRACCIONAMIENTO O POR COMBINACION DE LOS DOS METODOS ANTERIORES.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/862,846 US5328841A (en) | 1990-10-05 | 1992-04-03 | Methods for isolating EG III cellulase component and EG III cellulase in polyethylene glycol using inorganic salt and polyethylene glycol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2181685T3 true ES2181685T3 (es) | 2003-03-01 |
Family
ID=25339525
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES93908750T Expired - Lifetime ES2181685T3 (es) | 1992-04-03 | 1993-04-05 | Metodos para producir eg iii celulasa, xilanasa o una mezcla de ambos usando polietilenglicol. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5328841A (es) |
| EP (1) | EP0635057B1 (es) |
| JP (1) | JP3522744B2 (es) |
| AT (1) | ATE222292T1 (es) |
| CA (1) | CA2133436C (es) |
| DE (1) | DE69332200T2 (es) |
| DK (1) | DK0635057T3 (es) |
| ES (1) | ES2181685T3 (es) |
| FI (1) | FI116530B (es) |
| WO (1) | WO1993020208A1 (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI85384C (fi) * | 1989-09-06 | 1992-04-10 | Cultor Oy | Foerfarande foer hydrolysering av hemicellulosa med immobiliserade enzymer och produkt som omfattar ett immobiliserat hemicellulolytiskt enzym. |
| US5290474A (en) * | 1990-10-05 | 1994-03-01 | Genencor International, Inc. | Detergent composition for treating cotton-containing fabrics containing a surfactant and a cellulase composition containing endolucanase III from trichoderma ssp |
| CA2093422C (en) * | 1990-10-05 | 2001-04-03 | Genencor International, Inc. | DETERGENT COMPOSITIONS CONTAINING LOW CBH I CONTENT CELLULASE COMPOSITIONS |
| US5475101A (en) * | 1990-10-05 | 1995-12-12 | Genencor International, Inc. | DNA sequence encoding endoglucanase III cellulase |
| GB9416841D0 (en) | 1994-08-19 | 1994-10-12 | Finnfeeds Int Ltd | An enzyme feed additive and animal feed including it |
| US5703032A (en) * | 1996-03-06 | 1997-12-30 | Lever Brothers Company, Division Of Conopco, Inc. | Heavy duty liquid detergent composition comprising cellulase stabilization system |
| US6268328B1 (en) * | 1998-12-18 | 2001-07-31 | Genencor International, Inc. | Variant EGIII-like cellulase compositions |
| US6437101B1 (en) * | 1999-05-07 | 2002-08-20 | Akzo Nobel N.V. | Methods for protein purification using aqueous two-phase extraction |
| DE10142019A1 (de) * | 2001-08-28 | 2003-03-20 | Philips Corp Intellectual Pty | Schaltungsanordnung zur Demodulation von Signalen |
| DE10304066B4 (de) * | 2003-01-31 | 2007-01-18 | Henkel Kgaa | Verfahren zur Veredelung konzentrierter Enzymlösungen |
| US8346482B2 (en) * | 2003-08-22 | 2013-01-01 | Fernandez Dennis S | Integrated biosensor and simulation system for diagnosis and therapy |
| DE10360841A1 (de) * | 2003-12-20 | 2005-07-14 | Henkel Kgaa | Helle, stabile, staub- und geruchsarme Enzymgranulate |
| JP5043654B2 (ja) * | 2004-06-29 | 2012-10-10 | アレス トレーディング ソシエテ アノニム | Il−18結合タンパク質の精製のための方法 |
| BR112015023537B1 (pt) * | 2013-03-15 | 2022-11-29 | Inpex Corporation | Mutante de um microrganismo produtor de celulase,e, método para produção de uma celulase |
| HRP20211551T1 (hr) * | 2014-10-01 | 2021-12-24 | Impossible Foods Inc. | Postupci ekstrakcije i pročišćavanja denaturiranih bjelančevina |
| US11051532B2 (en) | 2017-09-22 | 2021-07-06 | Impossible Foods Inc. | Methods for purifying protein |
| US12011016B2 (en) | 2020-09-14 | 2024-06-18 | Impossible Foods Inc. | Protein methods and compositions |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL286954A (es) * | 1962-01-03 | |||
| GB1368599A (en) * | 1970-09-29 | 1974-10-02 | Unilever Ltd | Softening compositions |
| DE2512735A1 (de) * | 1975-03-22 | 1976-09-30 | Henkel & Cie Gmbh | Verfahren zur gewinnung von proteinen aus waessrigen protein- loesungen |
| GB1589581A (en) * | 1976-04-14 | 1981-05-13 | Biotechnolog Forschung Gmbh | Process for the separation of enzymes |
| US4275163A (en) * | 1978-11-20 | 1981-06-23 | The United States Of America As Represented By The Secretary Of The Army | Cellulase-producing microorganism |
| DE2943016C2 (de) * | 1979-10-24 | 1984-09-06 | Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim | Verfahren zur Reinigung von Interferon |
| DK187280A (da) * | 1980-04-30 | 1981-10-31 | Novo Industri As | Ruhedsreducerende middel til et fuldvaskemiddel fuldvaskemiddel og fuldvaskemetode |
| GB2095275B (en) * | 1981-03-05 | 1985-08-07 | Kao Corp | Enzyme detergent composition |
| GB2094826B (en) * | 1981-03-05 | 1985-06-12 | Kao Corp | Cellulase enzyme detergent composition |
| JPS5836217A (ja) * | 1981-08-25 | 1983-03-03 | Asahi Chem Ind Co Ltd | 風合の改良されたセルロ−ス系繊維の製造法 |
| JPS5854082A (ja) * | 1981-09-22 | 1983-03-30 | 倉敷紡績株式会社 | セルロ−ス系繊維の改質方法 |
| US4487831A (en) * | 1982-05-19 | 1984-12-11 | Research Corporation | Process for the conversion of cellulose to glucose |
| US4439358A (en) * | 1982-06-17 | 1984-03-27 | Miles Laboratories, Inc. | Method of preparing alpha-1-proteinase inhibitor |
| GB8306645D0 (en) * | 1983-03-10 | 1983-04-13 | Unilever Plc | Detergent compositions |
| US4472504A (en) * | 1983-03-28 | 1984-09-18 | The United States Of America As Represented By The Secretary Of The Army | Hyperproducing cellulase microorganism |
| US4508825A (en) * | 1983-03-30 | 1985-04-02 | Miles Laboratories, Inc. | Method for the separation of extracellular amylase and protease produced during the fermentation of enzyme producing microorganisms |
| FR2545501B1 (fr) * | 1983-05-06 | 1985-08-02 | Elf Bio Rech | Procede de purification de la dextrane-saccharase |
| CA1338400C (en) * | 1983-08-31 | 1996-06-18 | David H. Gelfand | Recombinant fungal cellulases |
| US4797361A (en) * | 1983-10-24 | 1989-01-10 | Lehigh University | Microorganism and process |
| FR2555603B1 (fr) * | 1983-11-29 | 1986-10-03 | Inst Francais Du Petrole | Procede de production d'enzymes cellulolytiques |
| US4470969A (en) * | 1983-12-02 | 1984-09-11 | Miles Laboratories, Inc. | Process for producing a concentrate of coagulation factors VII and VIIa |
| FI841500A0 (fi) * | 1984-04-13 | 1984-04-13 | Valtion Teknillinen | Foerfarande foer uppbygnande av cellulolytiska jaeststammar. |
| GB8421800D0 (en) * | 1984-08-29 | 1984-10-03 | Unilever Plc | Detergent compositions |
| GB8421801D0 (en) * | 1984-08-29 | 1984-10-03 | Unilever Plc | Detergent composition |
| US4683294A (en) * | 1985-04-03 | 1987-07-28 | Smith Kline Rit, S.A. | Process for the extraction and purification of proteins from culture media producing them |
| US4728613A (en) * | 1985-09-04 | 1988-03-01 | Miles Laboratories, Inc. | Method for the recovery of extracellular enzymes from whole fermentation beer |
| US4684723A (en) * | 1985-09-11 | 1987-08-04 | Miles Laboratories, Inc. | Method of separating proteins from aqueous solutions |
| DK163591C (da) * | 1985-10-08 | 1992-08-24 | Novo Nordisk As | Fremgangsmaade til behandling af et tekstilstof med en cellulase |
| US4697003A (en) * | 1985-11-01 | 1987-09-29 | Miles Laboratories, Inc. | Method of preparing alpha-1-proteinase inhibitor |
| US4725544A (en) * | 1986-04-25 | 1988-02-16 | Tan Larry U | Method for purifying xylanase |
| GB8610600D0 (en) * | 1986-04-30 | 1986-06-04 | Novo Industri As | Transformation of trichoderma |
| DE3787866T2 (de) * | 1986-10-28 | 1994-05-19 | Kao Corp | Alkalische Cellulasen und Mikroorganismen zu deren Herstellung. |
| US4822516A (en) * | 1986-12-08 | 1989-04-18 | Kao Corporation | Detergent composition for clothing incorporating a cellulase |
| JPH0240787B2 (ja) * | 1987-08-07 | 1990-09-13 | Kanebo Ltd | Fuainokairyosaretaseruroosukeisenikozobutsunoseizoho |
| US4832864A (en) * | 1987-09-15 | 1989-05-23 | Ecolab Inc. | Compositions and methods that introduce variations in color density into cellulosic fabrics, particularly indigo dyed denim |
| JP2728531B2 (ja) * | 1988-03-24 | 1998-03-18 | ノボ ノルディスク アクティーゼルスカブ | セルラーゼ調製品 |
| JP2652871B2 (ja) * | 1988-04-25 | 1997-09-10 | 花王株式会社 | アルカリセルラーゼおよびその製造法 |
| US4952505A (en) * | 1988-08-08 | 1990-08-28 | Florida State University | Fermentation of trichoderma reesei and apparatus therefor |
| US5006126A (en) * | 1988-09-15 | 1991-04-09 | Ecolab Inc. | Cellulase compositions and methods that introduce variations in color density into cellulosic fabrics, particularly indigo dyed denim |
| US5139943A (en) * | 1989-06-13 | 1992-08-18 | Genencor International, Inc. | Processes for the recovery of microbially produced chymosin |
| US5151358A (en) * | 1989-06-13 | 1992-09-29 | Genencor International, Inc. | Processes for the recovery of naturally produced chymosin |
| EP0477285B1 (en) * | 1989-06-13 | 1996-12-18 | Genencor International, Inc. | Processes for the recovery of microbially produced chymosin |
| EP0496783B1 (en) * | 1989-10-19 | 1995-12-27 | Genencor International, Inc. | Degradation resistant detergent compositions |
| US5120463A (en) * | 1989-10-19 | 1992-06-09 | Genencor International, Inc. | Degradation resistant detergent compositions based on cellulase enzymes |
| WO1992006210A1 (en) * | 1990-10-05 | 1992-04-16 | Genencor International, Inc. | Detergent compositions containing cellulase compositions enriched in acidic endoglucanase type components |
| US5290474A (en) * | 1990-10-05 | 1994-03-01 | Genencor International, Inc. | Detergent composition for treating cotton-containing fabrics containing a surfactant and a cellulase composition containing endolucanase III from trichoderma ssp |
-
1992
- 1992-04-03 US US07/862,846 patent/US5328841A/en not_active Expired - Lifetime
-
1993
- 1993-04-05 DK DK93908750T patent/DK0635057T3/da active
- 1993-04-05 DE DE69332200T patent/DE69332200T2/de not_active Expired - Lifetime
- 1993-04-05 ES ES93908750T patent/ES2181685T3/es not_active Expired - Lifetime
- 1993-04-05 AT AT93908750T patent/ATE222292T1/de active
- 1993-04-05 WO PCT/US1993/003251 patent/WO1993020208A1/en not_active Ceased
- 1993-04-05 EP EP93908750A patent/EP0635057B1/en not_active Expired - Lifetime
- 1993-04-05 CA CA002133436A patent/CA2133436C/en not_active Expired - Lifetime
-
1994
- 1994-09-30 FI FI944559A patent/FI116530B/fi not_active IP Right Cessation
-
2003
- 2003-07-07 JP JP2003271259A patent/JP3522744B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP3522272B2 (ja) | 2004-04-26 |
| FI944559A0 (fi) | 1994-09-30 |
| WO1993020208A1 (en) | 1993-10-14 |
| FI116530B (fi) | 2005-12-15 |
| FI944559L (fi) | 1994-09-30 |
| US5328841A (en) | 1994-07-12 |
| EP0635057A1 (en) | 1995-01-25 |
| DK0635057T3 (da) | 2002-12-09 |
| EP0635057B1 (en) | 2002-08-14 |
| JP2004041205A (ja) | 2004-02-12 |
| JP3522744B2 (ja) | 2004-04-26 |
| CA2133436C (en) | 2007-06-12 |
| CA2133436A1 (en) | 1993-10-14 |
| DE69332200T2 (de) | 2002-12-12 |
| ATE222292T1 (de) | 2002-08-15 |
| JPH07505296A (ja) | 1995-06-15 |
| DE69332200D1 (de) | 2002-09-19 |
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