ES2186810T3 - Compuestos oligopeptidicos que contienen aminoacido d-2-alquiltriptofano y que son capaces de liberar hormona del crecimiento. - Google Patents

Compuestos oligopeptidicos que contienen aminoacido d-2-alquiltriptofano y que son capaces de liberar hormona del crecimiento.

Info

Publication number
ES2186810T3
ES2186810T3 ES96942326T ES96942326T ES2186810T3 ES 2186810 T3 ES2186810 T3 ES 2186810T3 ES 96942326 T ES96942326 T ES 96942326T ES 96942326 T ES96942326 T ES 96942326T ES 2186810 T3 ES2186810 T3 ES 2186810T3
Authority
ES
Spain
Prior art keywords
mrp
growth
triptophan
alkyl
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96942326T
Other languages
English (en)
Inventor
Romano Dr Deghenghi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ardana Bioscience Ltd
Original Assignee
Ardana Bioscience Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ardana Bioscience Ltd filed Critical Ardana Bioscience Ltd
Application granted granted Critical
Publication of ES2186810T3 publication Critical patent/ES2186810T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

UN PEPTIDO DE FORMULA: A - D - X - D - MRP - B DONDE A ES HIDROGENO, 2 - AMINOISOBUTIRILO, 4 - AMINOISOBUTIRILO, D SE REFIERE AL ISOMERO DEXTRO, X ES MRP, DONDE MRP REPRESENTA 2 ALQUILTRIPTOFANO O X ES UN RESIDUO DE SERINA PROTEGIDA, SER(Y), DONDE Y PUEDE SER BENCILO, P - CLOROBENCILO, 4 - METOXIBENCILO, 2,4,6 - TRIMETOXIBENCIL TERT - BUTILO; B ES NR 2 R 3 , DONDE R 2 Y R 3 , QUE PUEDEN SER IGUALES O DIFERENTES, SON HIDROGENO O UN GRUPO ALQUILO C 1 -C 3 ; UN GRUPO OR 4 , DONDE R 4 ES HIDROGENO O UN GRUPO ALQUILO C SUB,1 -C 3 C - LYS - NH 2 , DONDE C ES PHE O MRP, Y LAS SALES DE ADICION CON ACIDOS ORGANICOS E INORGANICOS FARMACEUTICAMENTE ACEPTABLES DE CUALQUIERA DE DICHOS POLIPEPTIDOS; ESTOS COMPUESTOS SON CAPACES DE PROMOVER LA LIBERACION DE HORMONA DEL CRECIMIENTO Y SON ACTIVOS POR VIA ORAL.
ES96942326T 1995-12-20 1996-12-04 Compuestos oligopeptidicos que contienen aminoacido d-2-alquiltriptofano y que son capaces de liberar hormona del crecimiento. Expired - Lifetime ES2186810T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT95MI002681A IT1277113B1 (it) 1995-12-20 1995-12-20 Composti oligopeptidici contenenti d-2-alchiltriptofano in grado di promuovere la liberazione dell'ormone della crescita

Publications (1)

Publication Number Publication Date
ES2186810T3 true ES2186810T3 (es) 2003-05-16

Family

ID=11372755

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96942326T Expired - Lifetime ES2186810T3 (es) 1995-12-20 1996-12-04 Compuestos oligopeptidicos que contienen aminoacido d-2-alquiltriptofano y que son capaces de liberar hormona del crecimiento.

Country Status (18)

Country Link
EP (1) EP0868429B1 (es)
JP (1) JP2000502089A (es)
KR (1) KR100369104B1 (es)
CN (1) CN1126759C (es)
AT (1) ATE226214T1 (es)
AU (1) AU1175997A (es)
BR (1) BR9612146A (es)
CA (1) CA2239702C (es)
DE (1) DE69624371T2 (es)
DK (1) DK0868429T3 (es)
ES (1) ES2186810T3 (es)
IL (1) IL124507A (es)
IT (1) IT1277113B1 (es)
MX (1) MX9804868A (es)
PT (1) PT868429E (es)
RU (1) RU2182156C2 (es)
WO (1) WO1997022620A1 (es)
ZA (1) ZA9610591B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0100777A3 (en) 1998-01-16 2001-12-28 Novo Nordisk As Tripeptides with growth hormone releasing properties, pharmaceutical compositions comprising thereof and their use
US5932548A (en) * 1998-06-03 1999-08-03 Deghenghi; Romano Lysine containing peptides for treatment of heart disease
US6919315B1 (en) 1998-06-30 2005-07-19 Novo Nordisk A/S Compounds with growth hormone releasing properties
JP2002542151A (ja) 1999-02-18 2002-12-10 科研製薬株式会社 成長ホルモン分泌促進物質としての新規なアミド誘導体
US6417397B1 (en) 1999-10-04 2002-07-09 The Regents Of The University Of California, San Diego N-substituted alkylamino acids for use as amino-protecting groups
US6211156B1 (en) * 1999-11-10 2001-04-03 Asta Medica A.G. Peptides for treatment of erectile dysfunction
DE60140285D1 (de) 2000-05-31 2009-12-10 Pfizer Prod Inc Verwendung von Wachstumshormonsekretagoga zur Förderung der Beweglichkeit des Verdauungstrakts
US7476653B2 (en) 2003-06-18 2009-01-13 Tranzyme Pharma, Inc. Macrocyclic modulators of the ghrelin receptor
ES2309756T3 (es) * 2004-04-28 2008-12-16 Mediolanum Farmaceutici S.P.A. Secretagogos pseudopeptidicos de la hormana del crecimiento.
GB0603295D0 (en) 2006-02-18 2006-03-29 Ardana Bioscience Ltd Methods and kits
CU23558A1 (es) 2006-02-28 2010-07-20 Ct Ingenieria Genetica Biotech Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento
CN101657436A (zh) 2007-02-09 2010-02-24 特兰齐姆制药公司 大环生长素释放肽受体调节剂及其使用方法
US9119832B2 (en) 2014-02-05 2015-09-01 The Regents Of The University Of California Methods of treating mild brain injury
WO2017075535A1 (en) 2015-10-28 2017-05-04 Oxeia Biopharmaceuticals, Inc. Methods of treating neurodegenerative conditions

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1175810A (en) * 1979-03-30 1984-10-09 Frank A. Momany Synthetic peptides having pituitary growth hormone releasing activity
SU1316565A3 (ru) * 1979-09-20 1987-06-07 Фармиталия Карло Эрба С.П.А. (Фирма) Способ получени пептидов
SU1341970A1 (ru) * 1985-10-04 1990-03-23 Институт Органического Синтеза Ан Латвсср Аналог энкефалина, обладающий анальгетической активностью
IT1240643B (it) * 1990-05-11 1993-12-17 Mediolanum Farmaceutici Spa Peptidi biologicamente attivi contenenti in catena 2-alchiltriptofano
ATE225806T1 (de) * 1994-09-27 2002-10-15 Bioscience Limited Ardana D-2-alkyltryptophan enthaltende polypeptide mit wachstumhormon freisetzender aktivitaet

Also Published As

Publication number Publication date
JP2000502089A (ja) 2000-02-22
IT1277113B1 (it) 1997-11-04
DE69624371D1 (de) 2002-11-21
HK1016193A1 (en) 1999-10-29
AU1175997A (en) 1997-07-14
IL124507A0 (en) 1998-12-06
BR9612146A (pt) 1999-07-13
CN1204341A (zh) 1999-01-06
DE69624371T2 (de) 2003-06-18
ITMI952681A1 (it) 1997-06-20
MX9804868A (es) 1998-10-31
CA2239702C (en) 2007-08-07
CA2239702A1 (en) 1997-06-26
KR20000064444A (ko) 2000-11-06
DK0868429T3 (da) 2003-02-10
ZA9610591B (en) 1997-06-24
IL124507A (en) 2001-03-19
ITMI952681A0 (es) 1995-12-20
ATE226214T1 (de) 2002-11-15
EP0868429B1 (en) 2002-10-16
RU2182156C2 (ru) 2002-05-10
WO1997022620A1 (en) 1997-06-26
KR100369104B1 (ko) 2003-06-12
EP0868429A1 (en) 1998-10-07
CN1126759C (zh) 2003-11-05
PT868429E (pt) 2003-02-28

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