ES2187051T3 - Benzamidas gastrocineticas biciclicas de derivados de 4-(aminometil)-piperidina sustituidos en posicion 3 o 4. - Google Patents

Benzamidas gastrocineticas biciclicas de derivados de 4-(aminometil)-piperidina sustituidos en posicion 3 o 4.

Info

Publication number: ES2187051T3
Authority: ES; Spain
Prior art keywords: sup; sub; hydrogen; alkyl; alk
Prior art date: 1997-07-11
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

ES98940158T

Other languages

English (en)

Spanish (es)

Inventor

Jean-Paul Rene Marie A Bosmans

Michel Anna Jozef De Cleyn

Michel Surkyn

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Janssen Pharmaceutica NV

Original Assignee

Janssen Pharmaceutica NV

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-07-11

Filing date

1998-07-07

Publication date

2003-05-16

1998-07-07 Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV

2003-05-16 Application granted granted Critical

2003-05-16 Publication of ES2187051T3 publication Critical patent/ES2187051T3/es

2018-07-07 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

229940054066 benzamide antipsychotics Drugs 0.000 title 1
150000003936 benzamides Chemical class 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 9
239000001257 hydrogen Substances 0.000 abstract 9
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 4
150000002431 hydrogen Chemical class 0.000 abstract 4
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
125000000623 heterocyclic group Chemical group 0.000 abstract 2
MHCVCKDNQYMGEX-UHFFFAOYSA-N 1,1'-biphenyl;phenoxybenzene Chemical group C1=CC=CC=C1C1=CC=CC=C1.C=1C=CC=CC=1OC1=CC=CC=C1 MHCVCKDNQYMGEX-UHFFFAOYSA-N 0.000 abstract 1
125000000815 N-oxide group Chemical group 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000004656 alkyl sulfonylamino group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
230000030136 gastric emptying Effects 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
125000004193 piperazinyl group Chemical group 0.000 abstract 1
125000003386 piperidinyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/12—Halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/16—Radicals substituted by halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nutrition Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)

ES98940158T 1997-07-11 1998-07-07 Benzamidas gastrocineticas biciclicas de derivados de 4-(aminometil)-piperidina sustituidos en posicion 3 o 4. Expired - Lifetime ES2187051T3 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP97202180		1997-07-11
EP98200624		1998-02-27

Publications (1)

Publication Number	Publication Date
ES2187051T3 true ES2187051T3 (es)	2003-05-16

Family

ID=26146699

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
ES98940158T Expired - Lifetime ES2187051T3 (es)	1997-07-11	1998-07-07	Benzamidas gastrocineticas biciclicas de derivados de 4-(aminometil)-piperidina sustituidos en posicion 3 o 4.
ES98939620T Expired - Lifetime ES2212330T3 (es)	1997-07-11	1998-07-07	Benzamidas gastrocineticas biciclicas de derivados de 4-(aminometil)-piperididina sustituidos en posicion 3 o 4.

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
ES98939620T Expired - Lifetime ES2212330T3 (es)	1997-07-11	1998-07-07	Benzamidas gastrocineticas biciclicas de derivados de 4-(aminometil)-piperididina sustituidos en posicion 3 o 4.

Country Status (33)

Country	Link
US (10)	US6452013B1 (cs)
EP (3)	EP1206938A1 (cs)
JP (2)	JP2002508000A (cs)
KR (2)	KR100500372B1 (cs)
CN (2)	CN1117568C (cs)
AR (2)	AR016324A1 (cs)
AT (2)	ATE226820T1 (cs)
AU (2)	AU747199B2 (cs)
BG (2)	BG64230B1 (cs)
BR (2)	BRPI9811688B8 (cs)
CA (2)	CA2295088C (cs)
CZ (2)	CZ297298B6 (cs)
DE (2)	DE69820065T2 (cs)
DK (2)	DK1000028T3 (cs)
EA (1)	EA002619B1 (cs)
EE (1)	EE04178B1 (cs)
ES (2)	ES2187051T3 (cs)
HR (2)	HRP20000005B1 (cs)
HU (2)	HU227424B1 (cs)
ID (2)	ID24481A (cs)
IL (2)	IL133917A (cs)
MY (2)	MY117803A (cs)
NO (2)	NO317467B1 (cs)
NZ (2)	NZ502208A (cs)
PL (2)	PL190611B1 (cs)
PT (2)	PT991410E (cs)
RU (1)	RU2213089C2 (cs)
SI (2)	SI1000028T1 (cs)
SK (2)	SK284942B6 (cs)
TR (2)	TR200000022T2 (cs)
TW (2)	TW402591B (cs)
UA (1)	UA67745C2 (cs)
WO (2)	WO1999002156A1 (cs)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW402591B (en)	1997-07-11	2000-08-21	Janssen Pharmaceutica Nv	Monocyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
TW570920B (en) *	1998-12-22	2004-01-11	Janssen Pharmaceutica Nv	4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders
US20040253179A1 (en) *	2003-02-26	2004-12-16	Acm Medical Technologies, Inc.	Measuring gastrointestinal parameters
US20080219928A1 (en) *	2003-02-26	2008-09-11	Becker Jane A	Measuring Gastrointestinal Parameters
EP1615883A1 (en) *	2003-04-14	2006-01-18	Warner-Lambert Company	Process for preparing 5-(4-fluorophenyl)-1-[2-((2r,4r)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1h-pyrrole-3-carboxylic acid phenylamide
JO2478B1 (en) *	2003-06-19	2009-01-20	جانسين فارماسوتيكا ان. في.	(Aminomethyl) -biperidine benzamides as 5 HT4 antagonists
ES2293262T3 (es) *	2003-06-19	2008-03-16	Janssen Pharmaceutica N.V.	4-(aminometil)-piperidin benzamidas 5ht4-antagonistas.
WO2005000837A1 (en) *	2003-06-19	2005-01-06	Janssen Pharmaceutica N.V.	Aminosulfonyl substituted 4-(aminomethyl)-piperidine benzamides as 5ht4-antagonists
ATE449093T1 (de) *	2003-06-19	2009-12-15	Janssen Pharmaceutica Nv	Heterocyclisch substituierte 4-(aminomethyl)- piperidinbenzamide als 5ht4-antagonisten
DE602005005167T2 (de) *	2004-01-29	2009-04-30	Pfizer Inc.	1-isopropyl-2-oxo-1,2-dihydropyridin-3-carbonsäureamidderivate mit agonistischer wirkung am 5-ht4-rezeptor
TW200533348A (en) *	2004-02-18	2005-10-16	Theravance Inc	Indazole-carboxamide compounds as 5-ht4 receptor agonists
WO2005092882A1 (en) *	2004-03-01	2005-10-06	Pfizer Japan, Inc.	4-amino-5-halogeno-benzamide derivatives as 5-ht4 receptor agonists for the treatment of gastrointestinal, cns, neurological and cardiovascular disorders
US7728006B2 (en) *	2004-04-07	2010-06-01	Theravance, Inc.	Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
TWI351282B (en) *	2004-04-07	2011-11-01	Theravance Inc	Quinolinone-carboxamide compounds as 5-ht4 recepto
US8309575B2 (en)	2004-04-07	2012-11-13	Theravance, Inc.	Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
US9641902B2 (en)	2007-06-26	2017-05-02	Broadband Itv, Inc.	Dynamic adjustment of electronic program guide displays based on viewer preferences for minimizing navigation in VOD program selection
ATE441646T1 (de) *	2004-11-05	2009-09-15	Theravance Inc	5-ht4-rezeptoragonistenverbindungen
EP1807423B1 (en) *	2004-11-05	2009-05-20	Theravance, Inc.	Quinolinone-carboxamide compounds
US20070020330A1 (en)	2004-11-24	2007-01-25	Medpointe Healthcare Inc.	Compositions comprising azelastine and methods of use thereof
JP5607291B2 (ja)	2004-11-24	2014-10-15	メダファーマシューティカルズインコーポレイテッド	アゼラスチンを含む組成物およびその使用方法
ATE469897T1 (de) *	2004-12-22	2010-06-15	Theravance Inc	Indazolcarbonsäureamidverbindungen
NZ560828A (en) *	2005-03-02	2011-01-28	Theravance Inc	Quinolinone compounds as 5-HT4 receptor agonists
TWI377206B (en) *	2005-04-06	2012-11-21	Theravance Inc	Crystalline form of a quinolinone-carboxamide compound
GB0603550D0 (en) *	2006-02-22	2006-04-05	Glaxo Group Ltd	Novel compounds
US8642772B2 (en)	2008-10-14	2014-02-04	Sk Biopharmaceuticals Co., Ltd.	Piperidine compounds, pharmaceutical composition comprising the same and its use
US20110313319A1 (en) *	2008-11-07	2011-12-22	SAND COUNTY BIOTECHNOLOGY, Inc.	Measuring method for the concentration of intragastric contents
US8232315B2 (en)	2009-06-26	2012-07-31	Sk Biopharmaceuticals Co., Ltd.	Methods for treating drug addiction and improving addiction-related behavior
MX350745B (es)	2009-11-06	2017-09-14	Sk Biopharmaceuticals Co Ltd *	El uso de un compuesto de carbamoilo para el tratamiento del sindrome de fibromialgia.
US8895609B2 (en)	2009-11-06	2014-11-25	Sk Biopharmaceuticals Co., Ltd.	Methods for treating attention-deficit/hyperactivity disorder
KR101180174B1 (ko)	2010-04-23	2012-09-05	동아제약주식회사	신규한 벤즈아미드 유도체
US8623913B2 (en)	2010-06-30	2014-01-07	Sk Biopharmaceuticals Co., Ltd.	Methods for treating restless legs syndrome
US9610274B2 (en)	2010-06-30	2017-04-04	Sk Biopharmaceuticals Co., Ltd.	Methods for treating bipolar disorder
JP6182989B2 (ja)	2012-06-28	2017-08-23	セントラル硝子株式会社	１，３，３，３−テトラフルオロプロペンの製造方法
WO2014083003A1 (en)	2012-11-27	2014-06-05	Shire International Gmbh	Pro-cognitive compound
ES2897946T3 (es) *	2013-07-25	2022-03-03	Dong A St Co Ltd	Método para preparar un derivado de benzamida, intermedio novedoso utilizado en la preparación de la benzamida y método para preparar un intermedio novedoso
BR112022022184A2 (pt) *	2020-05-04	2023-01-17	Takeda Pharmaceuticals Co	Derivados de n-(piperidin-4-il)benzamida agindo luminalmente
EP4393470A1 (en)	2022-12-30	2024-07-03	SkyLab AG	Plant-mineral composition based on aloe barbadensis extract and trimethylglycine for ph-dependent regulation of type 3 aquaporins and transepidermal water flow in deep epidermal layers
CN117623967A (zh) *	2023-11-16	2024-03-01	迪嘉药业集团股份有限公司	一种替米沙坦中间体3-甲基-4-氨基苯甲酸的制备方法

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1194505A (en) *	1968-05-21	1970-06-10	Science Union & Cie	Piperidinol Derivatives and Process for Preparing Them
IT1046052B (it) *	1973-10-12	1980-06-30	Sigurta Farmaceutici Spa	Processo per la preparazione di i aralchil 4 aminometil piperidin 4 oli
US4348763A (en) *	1980-08-07	1982-09-07	Hewlett-Packard Company	Multiple stripe leaky mode laser
US4711703A (en)	1982-02-03	1987-12-08	Orbisphere Corporation Wilmington, Succursale De Collonge-Bellerive	Thermal protection method for electroanalytical cell
SU1593569A3 (ru) *	1982-07-30	1990-09-15	Janssen Pharmaceutica Nv	Cпocoб пoлучehия пpoизboдhыx n-(3-гидpokcи-4-пипepидиhил)бehзamидa или иx kиcлotho-aддиtиbhыx coлeй
DE3416224C2 (de) *	1983-05-06	1994-05-05	Mitsubishi Chem Ind	Verfahren zur Herstellung eines Kohleverflüssigungsöls
US4772630A (en)	1984-11-23	1988-09-20	Ciba-Geigy Corp.	Benzamides and their salts
US4722630A (en)	1985-09-20	1988-02-02	The Garrett Corporation	Ceramic-metal braze joint
GB8527052D0 (en)	1985-11-02	1985-12-04	Beecham Group Plc	Compounds
US4910312A (en) *	1985-11-08	1990-03-20	Warner-Lambert Company	Various N-substituted 3-piperidine carboxylic acids or N-substituted 3-pyridinecarboxylic acids and derivatives thereof
US4910193A (en)	1985-12-16	1990-03-20	Sandoz Ltd.	Treatment of gastrointestinal disorders
US4746655A (en) *	1987-06-10	1988-05-24	A. H. Robins Company, Incorporated	Fused aromatic-spiropiperidine oxazepinones(and thiones)
BE1000689A6 (fr)	1987-07-14	1989-03-14	Donnay Donnay S A Ets	Raquette de tennis, de squash ou sport analogue.
NZ225152A (en) *	1987-07-17	1990-04-26	Janssen Pharmaceutica Nv	Heterocyclically substituted piperidinyl benzamides as pharmaceuticals
US4906643A (en)	1987-07-17	1990-03-06	Janssen Pharmaceutica N.V.	Substituted N-(3-hydroxy-4-piperidinyl)benzamides as gastrointestinal agents
US5130312A (en)	1987-07-17	1992-07-14	Janssen Pharmaceutica N.V.	Substituted N-(3-hydroxy-4-piperidinyl)benzamides
JPH0719937B2 (ja) *	1987-09-24	1995-03-06	三井石油化学工業株式会社	高周波用積層板およびその製造方法
US4975439A (en)	1987-09-25	1990-12-04	Janssen Pharmaceutical N.V.	Novel substituted N-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides
CA1317940C (en) *	1987-09-25	1993-05-18	Georges H. P. Van Daele	Substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides
US5041454A (en)	1987-09-25	1991-08-20	Janssen Pharmaceutica N.V.	Novel substituted N-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides
JP2573017B2 (ja)	1988-03-08	1997-01-16	三洋電機株式会社	ディスクプレーヤ
US5053412A (en)	1990-04-10	1991-10-01	Israel Institute For Biological Research	Spiro nitrogen-bridged heterocyclic compounds
US5374637A (en) *	1989-03-22	1994-12-20	Janssen Pharmaceutica N.V.	N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
GB9005014D0 (en)	1990-03-06	1990-05-02	Janssen Pharmaceutica Nv	N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives
US5103141A (en)	1990-03-08	1992-04-07	U.S. Philips Corporation	Switching arrangement for increasing the white life of a high pressure sodium lamp
US5407938A (en)	1990-04-10	1995-04-18	Israel Institute For Biological Research	Certain 1-methyl-piperidine-4-spiro-4'-(1'-3'-oxazolines) and corresponding -(1',3' thiazolines)
US5534520A (en)	1990-04-10	1996-07-09	Fisher; Abraham	Spiro compounds containing five-membered rings
TW243449B (cs) *	1991-02-15	1995-03-21	Hokuriku Pharmaceutical
WO1993003725A1 (en)	1991-08-20	1993-03-04	Smithkline Beecham Plc	5-ht4 receptor antagonists
SG49153A1 (en)	1991-09-12	1998-05-18	Smithkline Beecham Plc	5-HT4 receptor antagonists
IT1252567B (it) *	1991-12-20	1995-06-19	Italfarmaco Spa	Derivati di 5-isochinolinsolfonammidi inibitori delle protein-chinasi
WO1993013101A1 (fr)	1991-12-27	1993-07-08	Yoshitomi Pharmaceutical Industries, Ltd.	Compose de pyridonecarboxylate, son utilisation pharmaceutique et compose spiro
EP0625149A1 (en)	1992-02-06	1994-11-23	Smithkline Beecham Plc	Benzopyran, benzothiopyran and benzofuran derivatives as 5-ht4 antagonists
JPH05236345A (ja)	1992-02-21	1993-09-10	Nec Ic Microcomput Syst Ltd	画像用垂直フィルタ回路
MX9306311A (es)	1992-10-13	1994-04-29	Smithkline Beecham Plc	Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
EP0667867A1 (en)	1992-11-05	1995-08-23	Smithkline Beecham Plc	Piperidine derivatives as 5-ht4 receptor antagonists
US6127379A (en) *	1993-02-01	2000-10-03	Smithkline Beecham P.L.C.	Benzopyran, benzothiopyran and benzofuran derivatives as 5-HT4 antagonists
WO1995026953A1 (en) *	1994-03-30	1995-10-12	Yoshitomi Pharmaceutical Industries, Ltd.	Benzoic acid compound and use thereof as medicine
US5864039A (en) *	1994-03-30	1999-01-26	Yoshitomi Pharmaceutical Industries, Ltd.	Benzoic acid compounds and use thereof as medicaments
TW490465B (en) *	1994-11-24	2002-06-11	Janssen Pharmaceutica Nv	Enterokinetic benzamide, the preparation process and the pharmaceutical compositions thereof
GB9507882D0 (en) *	1995-04-18	1995-05-31	Pharmacia Spa	Substituted dihydrobenzofuran derivatives as 5-ht4 agonists
EP0873990A1 (en) *	1995-09-22	1998-10-28	Yoshitomi Pharmaceutical Industries, Ltd.	Benzoic acid compounds and medicinal use thereof
US6096761A (en) *	1996-02-15	2000-08-01	Janssen Pharmaceutica N.V.	Esters of 3-hydroxy-piperidinemethanol derivatives
ES2208870T3 (es) *	1996-02-15	2004-06-16	Janssen Pharmaceutica N.V.	Uso de antagonistas del receptor 5ht4 para resolver los efectos gastrointestinales de los inhibidores de la reabsorcion de serotonina.
TW402591B (en) *	1997-07-11	2000-08-21	Janssen Pharmaceutica Nv	Monocyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
JP2001511934A (ja)	1997-10-31	2001-08-14	ダエウーエレクトロニクスカンパニー，リミテッド	単一動力源によって駆動される駆動メカニズムを有するコンパクトディスクチェンジャー
KR100413150B1 (ko) *	1998-09-10	2003-12-31	에프. 호프만-라 로슈 아게	5-에이치티4 수용체 길항제로서의 디하이드로벤조디옥신 카복스아미드 및 케톤 유도체

1998
- 1998-06-12 TW TW087109332A patent/TW402591B/zh not_active IP Right Cessation
- 1998-06-12 TW TW087109331A patent/TW548103B/zh not_active IP Right Cessation
- 1998-07-07 AU AU88063/98A patent/AU747199B2/en not_active Expired
- 1998-07-07 IL IL13391798A patent/IL133917A/xx not_active IP Right Cessation
- 1998-07-07 PT PT98940158T patent/PT991410E/pt unknown
- 1998-07-07 JP JP50812599A patent/JP2002508000A/ja active Pending
- 1998-07-07 CZ CZ0463899A patent/CZ297298B6/cs not_active IP Right Cessation
- 1998-07-07 KR KR10-1999-7012492A patent/KR100500372B1/ko not_active Expired - Lifetime
- 1998-07-07 CA CA002295088A patent/CA2295088C/en not_active Expired - Lifetime
- 1998-07-07 ES ES98940158T patent/ES2187051T3/es not_active Expired - Lifetime
- 1998-07-07 EE EEP200000015A patent/EE04178B1/xx unknown
- 1998-07-07 NZ NZ502208A patent/NZ502208A/en unknown
- 1998-07-07 ID IDW20000036D patent/ID24481A/id unknown
- 1998-07-07 IL IL13391898A patent/IL133918A/en not_active IP Right Cessation
- 1998-07-07 CN CN98806950A patent/CN1117568C/zh not_active Expired - Lifetime
- 1998-07-07 DK DK98939620T patent/DK1000028T3/da active
- 1998-07-07 BR BRPI9811688-6 patent/BRPI9811688B8/pt not_active IP Right Cessation
- 1998-07-07 TR TR2000/00022T patent/TR200000022T2/xx unknown
- 1998-07-07 ID IDW2000030A patent/ID24161A/id unknown
- 1998-07-07 AT AT98940158T patent/ATE226820T1/de active
- 1998-07-07 EP EP02075710A patent/EP1206938A1/en not_active Ceased
- 1998-07-07 RU RU2000103212/04A patent/RU2213089C2/ru active
- 1998-07-07 PL PL98338008A patent/PL190611B1/pl unknown
- 1998-07-07 TR TR2000/00023T patent/TR200000023T2/xx unknown
- 1998-07-07 DE DE69820065T patent/DE69820065T2/de not_active Expired - Lifetime
- 1998-07-07 EP EP98940158A patent/EP0991410B1/en not_active Expired - Lifetime
- 1998-07-07 WO PCT/EP1998/004190 patent/WO1999002156A1/en not_active Ceased
- 1998-07-07 PT PT98939620T patent/PT1000028E/pt unknown
- 1998-07-07 HU HU0002539A patent/HU227424B1/hu unknown
- 1998-07-07 UA UA2000010195A patent/UA67745C2/uk unknown
- 1998-07-07 CZ CZ19994587A patent/CZ295506B6/cs not_active IP Right Cessation
- 1998-07-07 SK SK1840-99A patent/SK284942B6/sk not_active IP Right Cessation
- 1998-07-07 BR BR9811687-8A patent/BR9811687A/pt active Search and Examination
- 1998-07-07 HR HR20000005A patent/HRP20000005B1/xx not_active IP Right Cessation
- 1998-07-07 SK SK1734-99A patent/SK284632B6/sk not_active IP Right Cessation
- 1998-07-07 SI SI9830579T patent/SI1000028T1/xx unknown
- 1998-07-07 SI SI9830311T patent/SI0991410T1/xx unknown
- 1998-07-07 CN CNB988069571A patent/CN1195736C/zh not_active Expired - Lifetime
- 1998-07-07 DK DK98940158T patent/DK0991410T3/da active
- 1998-07-07 HU HU0004564A patent/HUP0004564A3/hu unknown
- 1998-07-07 ES ES98939620T patent/ES2212330T3/es not_active Expired - Lifetime
- 1998-07-07 JP JP2000502022A patent/JP4530530B2/ja not_active Expired - Lifetime
- 1998-07-07 KR KR1019997012486A patent/KR100885658B1/ko not_active Expired - Fee Related
- 1998-07-07 EP EP98939620A patent/EP1000028B1/en not_active Expired - Lifetime
- 1998-07-07 AT AT98939620T patent/ATE255092T1/de not_active IP Right Cessation
- 1998-07-07 PL PL98338005A patent/PL190310B1/pl not_active IP Right Cessation
- 1998-07-07 US US09/462,287 patent/US6452013B1/en not_active Expired - Lifetime
- 1998-07-07 AU AU88574/98A patent/AU734475B2/en not_active Expired
- 1998-07-07 NZ NZ502209A patent/NZ502209A/xx not_active IP Right Cessation
- 1998-07-07 CA CA002295087A patent/CA2295087C/en not_active Expired - Lifetime
- 1998-07-07 EA EA200000110A patent/EA002619B1/ru not_active IP Right Cessation
- 1998-07-07 WO PCT/EP1998/004189 patent/WO1999002494A1/en not_active Ceased
- 1998-07-07 HR HR20000006A patent/HRP20000006B1/xx not_active IP Right Cessation
- 1998-07-07 DE DE69809050T patent/DE69809050T2/de not_active Expired - Lifetime
- 1998-07-08 MY MYPI98003107A patent/MY117803A/en unknown
- 1998-07-08 MY MYPI98003106A patent/MY123199A/en unknown
- 1998-07-10 AR ARP980103373A patent/AR016324A1/es active IP Right Grant
- 1998-07-10 AR ARP980103374A patent/AR013361A1/es active IP Right Grant
1999
- 1999-12-10 BG BG103984A patent/BG64230B1/bg unknown
- 1999-12-10 BG BG103983A patent/BG63709B1/bg unknown
2000
- 2000-01-10 NO NO20000116A patent/NO317467B1/no not_active IP Right Cessation
- 2000-01-10 NO NO20000115A patent/NO314662B1/no not_active IP Right Cessation
2001
- 2001-02-22 US US09/791,227 patent/US6635643B2/en not_active Ceased
2002
- 2002-06-05 US US10/162,802 patent/US6750349B2/en not_active Expired - Lifetime
2003
- 2003-08-19 US US10/643,506 patent/US20040058958A1/en not_active Abandoned
2005
- 2005-10-26 US US11/259,719 patent/USRE40793E1/en not_active Expired - Lifetime
2006
- 2006-02-16 US US11/355,326 patent/US20060142341A1/en not_active Abandoned
- 2006-02-17 US US11/357,884 patent/US20060142342A1/en not_active Abandoned
- 2006-10-20 US US11/584,732 patent/US7790750B2/en not_active Expired - Fee Related
2010
- 2010-05-04 US US12/773,183 patent/US8063070B2/en not_active Expired - Fee Related
2011
- 2011-09-20 US US13/237,330 patent/US8318742B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP2002508000A (ja)	2002-03-12
US7790750B2 (en)	2010-09-07
PL338005A1 (en)	2000-09-25
CA2295088C (en)	2007-10-23
US6750349B2 (en)	2004-06-15
HRP20000005A2 (en)	2000-12-31
MY117803A (en)	2004-08-30
CN1117568C (zh)	2003-08-13
KR20010014341A (ko)	2001-02-26
EP0991410B1 (en)	2002-10-30
EE04178B1 (et)	2003-12-15
HK1025047A1 (en)	2000-11-03
NO20000115L (no)	2000-03-13
DE69809050T2 (de)	2003-07-24
US20060142341A1 (en)	2006-06-29
USRE40793E1 (en)	2009-06-23
AR016324A1 (es)	2001-07-04
HK1025093A1 (en)	2000-11-03
KR100500372B1 (ko)	2005-07-11
UA67745C2 (uk)	2004-07-15
EA002619B1 (ru)	2002-06-27
BR9811687A (pt)	2000-09-26
MY123199A (en)	2006-05-31
HUP0002539A3 (en)	2002-03-28
HRP20000005B1 (en)	2008-12-31
KR20010014336A (ko)	2001-02-26
PL190611B1 (pl)	2005-12-30
BG103984A (en)	2000-09-29
HUP0002539A2 (hu)	2000-12-28
US6635643B2 (en)	2003-10-21
BRPI9811688A (pt)	2000-09-26
CZ463899A3 (cs)	2000-04-12
CA2295087A1 (en)	1999-01-21
HUP0004564A3 (en)	2001-08-28
HRP20000006B1 (en)	2009-06-30
TR200000022T2 (tr)	2000-06-21
NO314662B1 (no)	2003-04-28
CN1262621A (zh)	2000-08-09
BG103983A (en)	2000-09-29
BG64230B1 (bg)	2004-06-30
EP0991410A1 (en)	2000-04-12
WO1999002156A1 (en)	1999-01-21
KR100885658B1 (ko)	2009-02-25
HU227424B1 (en)	2011-05-30
IL133917A (en)	2005-05-17
DK0991410T3 (da)	2003-02-24
CN1262674A (zh)	2000-08-09
DE69820065D1 (de)	2004-01-08
IL133918A (en)	2004-06-20
BRPI9811688B8 (pt)	2021-07-06
US20030078427A1 (en)	2003-04-24
US20120028987A1 (en)	2012-02-02
AU8806398A (en)	1999-02-08
ID24161A (id)	2000-07-13
ATE226820T1 (de)	2002-11-15
US20100210657A1 (en)	2010-08-19
EE200000015A (et)	2000-10-16
AU734475B2 (en)	2001-06-14
US6452013B1 (en)	2002-09-17
JP2001509503A (ja)	2001-07-24
CZ295506B6 (cs)	2005-08-17
ES2212330T3 (es)	2004-07-16
IL133917A0 (en)	2001-04-30
AR013361A1 (es)	2000-12-27
DE69820065T2 (de)	2004-08-26
HRP20000006A2 (en)	2000-12-31
CN1195736C (zh)	2005-04-06
TW548103B (en)	2003-08-21
NO20000116D0 (no)	2000-01-10
US20040058958A1 (en)	2004-03-25
EP1206938A1 (en)	2002-05-22
SK184099A3 (en)	2000-09-12
SK284942B6 (sk)	2006-02-02
WO1999002494A1 (en)	1999-01-21
EA200000110A1 (ru)	2000-08-28
PL338008A1 (en)	2000-09-25
RU2213089C2 (ru)	2003-09-27
HUP0004564A2 (hu)	2001-07-30
BG63709B1 (bg)	2002-10-31
US8063070B2 (en)	2011-11-22
NZ502209A (en)	2001-01-26
US20020086879A1 (en)	2002-07-04
US20060142342A1 (en)	2006-06-29
CA2295087C (en)	2007-05-15
SK284632B6 (sk)	2005-08-04
PT991410E (pt)	2003-03-31
NZ502208A (en)	2001-04-27
EP1000028A1 (en)	2000-05-17
CZ297298B6 (cs)	2006-11-15
SI1000028T1 (en)	2004-04-30
TW402591B (en)	2000-08-21
ID24481A (id)	2000-07-20
SK173499A3 (en)	2000-06-12
DE69809050D1 (de)	2002-12-05
SI0991410T1 (en)	2003-04-30
AU8857498A (en)	1999-02-08
EP1000028B1 (en)	2003-11-26
DK1000028T3 (da)	2004-04-05
NO317467B1 (no)	2004-11-01
PL190310B1 (pl)	2005-11-30
NO20000116L (no)	2000-03-07
ATE255092T1 (de)	2003-12-15
US20070037850A1 (en)	2007-02-15
JP4530530B2 (ja)	2010-08-25
IL133918A0 (en)	2001-04-30
NO20000115D0 (no)	2000-01-10
AU747199B2 (en)	2002-05-09
US8318742B2 (en)	2012-11-27
TR200000023T2 (tr)	2000-09-21
CA2295088A1 (en)	1999-01-21
CZ458799A3 (cs)	2000-05-17
PT1000028E (pt)	2004-04-30
BRPI9811688B1 (pt)	2011-10-18

Publication	Publication Date	Title
ES2187051T3 (es)	2003-05-16	Benzamidas gastrocineticas biciclicas de derivados de 4-(aminometil)-piperidina sustituidos en posicion 3 o 4.
BR0010746A (pt)	2002-02-13	Derivados heterocìclicos úteis com agentes anticâncer
TW430663B (en)	2001-04-21	Novel substituted piperidines useful for the treatment of allergic diseases
AR038762A1 (es)	2005-01-26	Derivados de indolina, un proceso para su preparacion, composicion farmaceutica, proceso para la preparacion de dicha composicion y el uso de dichos derivados para la fabricacion de un medicamento
AR030553A1 (es)	2003-08-27	Uso de derivados de tiazolilo 2,4-disustituidos para la fabricacion de un medicamento para la prevencion o el tratamiento de enfermedades mediadas a traves de citoquinas, derivados de tiazolilo 2,4-disustituidos, composiciones farmaceuticas que los comprenden, procesos para preparar dichos derivados
FR2662162B1 (fr)	1995-01-20	Nouveaux derives de l'amino piperidine, de l'amino pyrrolidine et de l'amino perhydroazepine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
NO305028B1 (no)	1999-03-22	AnalogifremgangsmÕte for fremstilling av terapeutisk aktive pyridin N-oxydderivater av diarylmethylpiperidiner eller piperaziner
MX9300786A (es)	1994-03-31	Compuestos hipolipidaemicos.
SE9904738D0 (sv)	1999-12-22	Novel compounds
ES2158778B1 (es)	2002-03-16	Compuestos de sales de paroxetina, su preparacion y uso, y composiciones farmaceuticas que los contienen.
BR9916491A (pt)	2001-09-04	4-(aminometil)-piperidina benzamidas para tratamento de distúrbios gastrintestinais
AR029373A1 (es)	2003-06-25	Metodo para el tratamiento de migranas, utilizando compuestos antagonistas selectivos de los receptores iglur5, uso de dichos compuestos antagonistas selectivos en la manufactura de medicamentos para el tratamiento de migranas y dichos compuestos antagonistas
MX9300616A (es)	1993-09-01	Compuestos antagonistas del receptor 5-hidroxitriptamina, proceso para su prepararcion y composicion farmaceutica que los contiene
NO942952L (no)	1995-03-21	11-benzaldoksin-17 ater, fremgangsmåte for deres fremstilling samt legemiddel inneholdende slike
AR008875A1 (es)	2000-02-23	Derivados de 2-cianoiminoimidazol inhibidores de pde iv, procedimiento para su preparacion, composicion que los contienen, procedimiento para preparar dicha composicion y uso de dichos compuestos para la preparacion de medicamentos.
AR006518A1 (es)	1999-09-08	Esteres de derivados de 1,4-piperidina disustituida, un procedimiento para su preparacion, una composicion farmaceutica que los contiene y un procedimiento para su preparacion
MX2024011914A (es)	2024-11-08	Derivados de n-(pirrolidin-3-il o piperidin-4-il)acetamida
AR036131A1 (es)	2004-08-11	Derivados de benzo (g) quinolina, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos derivados para la fabricacion de un medicamento
DK360584D0 (da)	1984-07-23	Triazol-pyrimidinderivater og fremgangsmaade til fremstilling deraf samt disses terapeutiske anvendelse som cardiotoniske midler
NO20045132L (no)	1998-07-24	Benzo(c)kinolizinderivater, deres fremstilling og anvendelse som 5alfa- reduktaseinhibitorer
UY27001A1 (es)	2001-12-28	Derivados de la indolilpiperidina como agentes antihistamínicos y antialérgicos
ES2088567T3 (es)	1996-08-16	Empleo de derivados de la 2-iminotioazolidin-4-ona como nuevos productos activos para medicamentos.
GB1164496A (en)	1969-09-17	0-Oxaphenanthridine Derivatives and Method for the Preparation
ES380930A1 (es)	1972-09-16	Un procedimiento de preparacion de nuevas 2-hidroxi-5-aminobenzamidas.
ATE48840T1 (de)	1990-01-15	Benzimidazole.