ES2187644T3 - Derivados de la acetamida, procedimiento de fabricacion y composicion medicamentosa a base de estos derivados. - Google Patents

Derivados de la acetamida, procedimiento de fabricacion y composicion medicamentosa a base de estos derivados.

Info

Publication number
ES2187644T3
ES2187644T3 ES96909327T ES96909327T ES2187644T3 ES 2187644 T3 ES2187644 T3 ES 2187644T3 ES 96909327 T ES96909327 T ES 96909327T ES 96909327 T ES96909327 T ES 96909327T ES 2187644 T3 ES2187644 T3 ES 2187644T3
Authority
ES
Spain
Prior art keywords
sub
rent
derivatives
lower rent
acetamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96909327T
Other languages
English (en)
Inventor
Teruya Murata
Katsuhiko Hino
Kiyoshi Furukawa
Makoto Oka
Mari Itoh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharma Co Ltd
Original Assignee
Dainippon Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co Ltd filed Critical Dainippon Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2187644T3 publication Critical patent/ES2187644T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

DERIVADOS DE ACETAMIDA REPRESENTADOS POR LA FORMULA GENERAL (I) Y SALES DE ADICION DE ACIDO FISIOLOGICAMENTE ACEPTABLES DE LOS MISMOS, EN DONDE X REPRESENTA B,1} REPRESENTA H, ALQUILO INFERIOR, ALQUENILO INFERIOR O CICLOALQUILALQUILO(INFERIOR); R SUB,2} REPRESENTA ALQUILO INFERIOR, CICLOALQUILO, FENILO OPCIONALMENTE SUSTITUIDO, ETC.; R SUB,3} REPRESENTA H, ALQUILO INFERIOR O HIDROXIALQUILO(INFERIOR); R SUB,4} REPRESENTA H, ALQUILO INFERIOR, ETC.; R SUB,5} REPRESENTA H, ALQUILO INFERIOR, ALQUENILO INFERIOR, HIDROXIALQUILO(INFERIOR), ETC.; R SUB,6} REPRESENTA H, ALQUILO INFERIOR, CF SUB,3} O FENILO OPCIONALMENTE SUSTITUIDO, O R SUB,5} Y R SUB,6} EN CONJUNTO FORMAN (CH SUB,2}) SUB,N} -; R SUB,7} REPRESENTA H, HALOGENO, ALQUILO INFERIOR, ALCOXILO INFERIOR, CF SUB,3}, OH, NH SUB,2}, ETC.; Y R SUB,8} REPRESENTA H, HALOGENO, ALQUILO INFERIOR O ALCOXILO INFERIOR. LOS COMPUESTOS ACTUAN SELECTIVAMENTE SOBRE EL RECEPTOR BZ SUB, OE}3} Y MUESTRAN EFECTOS FARMACOLOGICOS EXCELENTES, LO CUAL LOS HACE UTILES COMO REMEDIO Y PREVENCION PARA ENFERMEDADES CENTRALES, POR EJEMPLO, ENFERMEDADES ASOCIADAS CON ANSIEDAD DEPRESION Y EPILEPSIA, ETC.
ES96909327T 1995-04-13 1996-04-10 Derivados de la acetamida, procedimiento de fabricacion y composicion medicamentosa a base de estos derivados. Expired - Lifetime ES2187644T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11393795 1995-04-13

Publications (1)

Publication Number Publication Date
ES2187644T3 true ES2187644T3 (es) 2003-06-16

Family

ID=14624947

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96909327T Expired - Lifetime ES2187644T3 (es) 1995-04-13 1996-04-10 Derivados de la acetamida, procedimiento de fabricacion y composicion medicamentosa a base de estos derivados.

Country Status (25)

Country Link
US (1) US5972946A (es)
EP (1) EP0826673B1 (es)
KR (1) KR100433589B1 (es)
CN (1) CN1094929C (es)
AR (1) AR002289A1 (es)
AT (1) ATE228113T1 (es)
AU (1) AU694647B2 (es)
BR (1) BR9604894A (es)
CA (1) CA2218033A1 (es)
CZ (1) CZ289093B6 (es)
DE (1) DE69624916T2 (es)
DK (1) DK0826673T3 (es)
ES (1) ES2187644T3 (es)
HU (1) HUP9801688A3 (es)
IL (1) IL117659A (es)
NO (1) NO310619B1 (es)
NZ (1) NZ304982A (es)
PL (1) PL322819A1 (es)
PT (1) PT826673E (es)
RO (1) RO117532B1 (es)
RU (1) RU2160256C2 (es)
SK (1) SK281840B6 (es)
TW (1) TW450963B (es)
WO (1) WO1996032383A1 (es)
ZA (1) ZA962438B (es)

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FR2263750A1 (en) * 1974-03-12 1975-10-10 Delalande Sa N-phenyl-N-(2-aryl-6-methyl-pyrimidin-4-yl)amino acid derivs. - useful e.g. as analeptics, hypotensives, analgesics, etc.
FR2525595A1 (fr) * 1982-04-27 1983-10-28 Pharmuka Lab Nouveaux derives d'arene et d'heteroarenecarboxamides et leur utilisation comme medicaments
FR2582514B1 (fr) * 1985-05-30 1988-02-19 Rhone Poulenc Sante Medicaments a base d'amides, nouveaux amides et leur preparation
DK273689A (da) * 1988-06-06 1989-12-07 Sanofi Sa 4-amino-3-carboxyquinoliner og -naphthyridiner, fremgangsmaade til deres fremstilling og anvendelse deraf i laegemidler
JPH07165721A (ja) * 1993-12-15 1995-06-27 Sumitomo Chem Co Ltd 放射性イソキノリンカルボキサミド誘導体

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CZ322397A3 (cs) 1998-02-18
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NZ304982A (en) 1999-03-29
NO974685D0 (no) 1997-10-10
CN1186487A (zh) 1998-07-01
CN1094929C (zh) 2002-11-27
DK0826673T3 (da) 2003-03-24
IL117659A0 (en) 1996-07-23
ATE228113T1 (de) 2002-12-15
SK281840B6 (sk) 2001-08-06
EP0826673A1 (en) 1998-03-04
KR19980703815A (ko) 1998-12-05
EP0826673B1 (en) 2002-11-20
KR100433589B1 (ko) 2004-09-13
IL117659A (en) 2000-12-06
ZA962438B (en) 1996-10-01
RO117532B1 (ro) 2002-04-30
DE69624916D1 (de) 2003-01-02
EP0826673A4 (en) 1998-09-02
AU5287496A (en) 1996-10-30
WO1996032383A1 (en) 1996-10-17
DE69624916T2 (de) 2003-04-24
HUP9801688A2 (hu) 1999-03-29
NO310619B1 (no) 2001-07-30
HUP9801688A3 (en) 2001-11-28
TW450963B (en) 2001-08-21
AU694647B2 (en) 1998-07-23
PT826673E (pt) 2003-02-28
NO974685L (no) 1997-12-12
CA2218033A1 (en) 1996-10-17
PL322819A1 (en) 1998-02-16
AR002289A1 (es) 1998-03-11
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BR9604894A (pt) 1998-07-14
SK137497A3 (en) 1998-05-06

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