ES2191202T3 - Derivados de benzoilaminotiazol sustituidos y medicamentos que los contienen. - Google Patents

Derivados de benzoilaminotiazol sustituidos y medicamentos que los contienen.

Info

Publication number
ES2191202T3
ES2191202T3 ES97944173T ES97944173T ES2191202T3 ES 2191202 T3 ES2191202 T3 ES 2191202T3 ES 97944173 T ES97944173 T ES 97944173T ES 97944173 T ES97944173 T ES 97944173T ES 2191202 T3 ES2191202 T3 ES 2191202T3
Authority
ES
Spain
Prior art keywords
group
substituted
lower alkyl
alkyl group
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97944173T
Other languages
English (en)
Inventor
Masaaki-Zeria Pharmac Nagasawa
Kenji-Zeria Pharmaceutica Sato
Tadashi-Zeria Pharmac Kurimoto
Shigeru-Zeria Pharmaceuti Ueki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zeria Pharmaceutical Co Ltd
Original Assignee
Zeria Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeria Pharmaceutical Co Ltd filed Critical Zeria Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2191202T3 publication Critical patent/ES2191202T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN DERIVADO DE BENZOILAMINOTIAZOL SUSTITUIDO REPRESENTADO POR LA SIGUIENTE FORMULA (I): EN DONDE, X REPRESENTA UN GRUPO IMINO QUE PUEDE ESTAR SUSTITUIDO POR UN GRUPO ALQUILO DE CADENA INFERIOR O UN ATOMO DE OXIGENO; R 1 REPRESENTA UN GRUPO CIANO, UN GRUPO ALCOXICAR BONILO DE CADENA INFERIOR, UN GRUPO ALCOXICARBONILAMINO DE CADENA INFERIOR, UN GRUPO ALQUILSULFONILAMINO INFERIOR, UN GRUPO ALCANOILO DE CADENA INFERIOR O UN GRUPO ALQUILSULFONILO DE CADENA INFERIOR QUE PUEDE ESTAR SUSTITUIDO POR UN ATOMO DE HALOGENO, UN GRUPO 1 - UREIDO, UN GRUPO ALQUILO DE CADENA INFERIOR SUSTITUIDO POR HALOGENO O UN GRUPO 2 - PIRROLILIMINO; R 2 Y R 3 SON IDENTICOS O DIFERENTES Y REPRESENTAN INDEPENDIENTEMENTE UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO DE CADENA INFERIOR Y M ES UN ENTERO DE 2 A 4; O A UNA SAL DE DICHO DERIVADO. ADEMAS, LA INVENCION SE REFIERE A UN MEDICAMENTO QUE CONTIENE DICHO DERIVADO COMO INGREDIENTE EFECTIVO. EL COMPUESTO DE LA PRESENTE INVENCION ES UTIL COMO AGENTE PREVENTIVO Y TERAPEUTICO PARA LAS MOLESTIAS EPIGASTRICAS, NAUSEAS, VOMITOS, CARDIALGIA, ANOREXIA, DOLOR DE ESTOMAGO, FLATULENCIA ABDOMINAL, GASTRITIS CRONICA O SIMILARES.
ES97944173T 1996-10-24 1997-10-20 Derivados de benzoilaminotiazol sustituidos y medicamentos que los contienen. Expired - Lifetime ES2191202T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP29926696 1996-10-24

Publications (1)

Publication Number Publication Date
ES2191202T3 true ES2191202T3 (es) 2003-09-01

Family

ID=17870324

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97944173T Expired - Lifetime ES2191202T3 (es) 1996-10-24 1997-10-20 Derivados de benzoilaminotiazol sustituidos y medicamentos que los contienen.

Country Status (12)

Country Link
US (1) US6121301A (es)
EP (1) EP0934938B1 (es)
JP (1) JP4153043B2 (es)
KR (1) KR100457240B1 (es)
CN (1) CN1072652C (es)
AT (1) ATE231137T1 (es)
AU (1) AU717588B2 (es)
CA (1) CA2269531C (es)
DE (1) DE69718498T2 (es)
DK (1) DK0934938T3 (es)
ES (1) ES2191202T3 (es)
WO (1) WO1998017654A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE240305T1 (de) * 1997-06-24 2003-05-15 Zeria Pharm Co Ltd Verfahren zur herstellung von 2- hydroxybenzamidderivaten
ATE343384T1 (de) 2000-09-08 2006-11-15 Zeria Pharm Co Ltd Pharmazeutische zusammensetzungen enthaltend aminothiazole derivate zur behandlung von motorischen störungen des dickdarms
CA2491797A1 (en) * 2002-07-10 2004-01-22 Warner-Lambert Company Llc Gastrointestinal compositions
US6986901B2 (en) * 2002-07-15 2006-01-17 Warner-Lambert Company Llc Gastrointestinal compositions
US20040010035A1 (en) * 2002-07-15 2004-01-15 Ciociola Arthur A. Gastrointestinal compositions
TW200524887A (en) * 2003-10-27 2005-08-01 Lundbeck & Co As H N-thiazol-2-yl-benzamide derivatives
GB0412468D0 (en) * 2004-06-04 2004-07-07 Astrazeneca Ab Chemical compounds
BRPI0516958A (pt) * 2004-09-20 2008-03-25 4Sc Ag inibidores da nf-capab heterocìclicos
AU2005287729A1 (en) 2004-09-22 2006-03-30 H. Lundbeck A/S 2-acylaminothiazole derivatives
US7674912B2 (en) 2005-04-25 2010-03-09 H. Lundbeck A/S Pro-drugs of N-thiazol-2-yl-benzamide derivatives
ES2410261B1 (es) 2009-03-06 2014-04-28 Antonio NÚÑEZ JARAMILLO Procedimiento para reciclaje y valoración de los residuos orgánicos producidos en las cocinas en comunidades de vecinos, mediante plantas de biogás prefabricadas para producir electricidad y abono.
WO2011076732A1 (en) * 2009-12-21 2011-06-30 Euroscreen S.A. Compounds, pharmaceutical composition and methods for use in treating gastrointestinal disorders
CN103709120B (zh) * 2014-01-20 2016-01-20 华润赛科药业有限责任公司 一种盐酸阿考替胺三水合物的制备方法
CN104130207B (zh) * 2014-07-07 2016-08-24 湖北华世通生物医药科技有限公司 阿考替胺氢溴酸盐水合物及其晶型的制备方法
US11388311B2 (en) 2020-06-05 2022-07-12 Esko Software Bvba System and method for obtaining a uniform ink layer

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6431424A (en) * 1987-07-28 1989-02-01 Matsushita Electronics Corp Manufacturing equipment for semiconductor
US4829073A (en) * 1988-05-12 1989-05-09 Bristol-Myers Company Thiadiazole oxides for treating gastrointestinal motility disorders
JPH0730064B2 (ja) * 1989-08-17 1995-04-05 協和醗酵工業株式会社 フラン誘導体
US5424431A (en) * 1990-10-24 1995-06-13 Yamanouchi Pharmaceutical Co., Ltd. Thiazole derivatives
JP3029876B2 (ja) * 1991-03-05 2000-04-10 協和醗酵工業株式会社 フラン誘導体
JP2787407B2 (ja) * 1992-06-19 1998-08-20 株式会社大塚製薬工場 ホスホン酸ジエステル誘導体
JPH1135565A (ja) * 1993-10-25 1999-02-09 Zeria Pharmaceut Co Ltd チアゾール誘導体、それを含有する医薬および該化合物の製造中間体
US5510478A (en) * 1994-11-30 1996-04-23 American Home Products Corporation 2-arylamidothiazole derivatives with CNS activity
WO1996036619A1 (en) * 1995-05-18 1996-11-21 Zeria Pharmaceutical Co., Ltd. Aminothiazole derivatives, drug containing the same and intermediate in the production of the compounds
JPH0987282A (ja) * 1995-09-21 1997-03-31 Kyowa Hakko Kogyo Co Ltd チアゾール誘導体
US5712270A (en) * 1995-11-06 1998-01-27 American Home Products Corporation 2-arylamidothiazole derivatives with CNS activity

Also Published As

Publication number Publication date
AU4574297A (en) 1998-05-15
KR20000048999A (ko) 2000-07-25
DK0934938T3 (da) 2003-02-24
CN1234028A (zh) 1999-11-03
CN1072652C (zh) 2001-10-10
US6121301A (en) 2000-09-19
AU717588B2 (en) 2000-03-30
EP0934938B1 (en) 2003-01-15
WO1998017654A1 (en) 1998-04-30
DE69718498T2 (de) 2003-10-09
ATE231137T1 (de) 2003-02-15
JP4153043B2 (ja) 2008-09-17
CA2269531C (en) 2006-03-14
CA2269531A1 (en) 1998-04-30
KR100457240B1 (ko) 2004-11-12
EP0934938A4 (en) 2001-04-18
DE69718498D1 (de) 2003-02-20
EP0934938A1 (en) 1999-08-11

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