ES2191717T3 - Composicion de cisplatino en combinacion con 2,2'-ditio-bis(etanosulfonato) (dimesna). - Google Patents

Composicion de cisplatino en combinacion con 2,2'-ditio-bis(etanosulfonato) (dimesna).

Info

Publication number
ES2191717T3
ES2191717T3 ES95939282T ES95939282T ES2191717T3 ES 2191717 T3 ES2191717 T3 ES 2191717T3 ES 95939282 T ES95939282 T ES 95939282T ES 95939282 T ES95939282 T ES 95939282T ES 2191717 T3 ES2191717 T3 ES 2191717T3
Authority
ES
Spain
Prior art keywords
bis
ethanosulphonate
cisplatino
ditio
dimesna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95939282T
Other languages
English (en)
Inventor
Frederick Herman Hausheer
Kochat Haridas
Dhanabalan Murali
Dasharatha Gauravaram Reddy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BioNumerik Pharmaceuticals Inc
Original Assignee
BioNumerik Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BioNumerik Pharmaceuticals Inc filed Critical BioNumerik Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2191717T3 publication Critical patent/ES2191717T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Uso de una forma farmacéuticamente aceptable de 2, 2¿-ditio-bis(etanosulfonato) en la fabricación de un medicamento para la reducción de la nefrotoxicidad del cisplatino, siendo dicho medicamento para la administración conjunta, simultánea o secuencial, con cisplatino a un paciente humano, de modo que el sulfonato y el cisplatino están presentes conjuntamente en la sangre del paciente humano.
ES95939282T 1994-11-14 1995-11-14 Composicion de cisplatino en combinacion con 2,2'-ditio-bis(etanosulfonato) (dimesna). Expired - Lifetime ES2191717T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/338,379 US5789000A (en) 1994-11-14 1994-11-14 Sterile aqueous parenteral formulations of cis-diammine dichloro platinum

Publications (1)

Publication Number Publication Date
ES2191717T3 true ES2191717T3 (es) 2003-09-16

Family

ID=23324592

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95939282T Expired - Lifetime ES2191717T3 (es) 1994-11-14 1995-11-14 Composicion de cisplatino en combinacion con 2,2'-ditio-bis(etanosulfonato) (dimesna).

Country Status (13)

Country Link
US (5) US5789000A (es)
EP (1) EP0792154B1 (es)
JP (3) JP4171526B2 (es)
KR (1) KR100411380B1 (es)
CN (2) CN1165483B (es)
AT (1) ATE237337T1 (es)
AU (1) AU706181B2 (es)
CA (1) CA2202170C (es)
DE (1) DE69530412T2 (es)
DK (1) DK0792154T3 (es)
ES (1) ES2191717T3 (es)
PT (1) PT792154E (es)
WO (1) WO1996014852A1 (es)

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US6037336A (en) * 1996-09-23 2000-03-14 Bionumerik Pharmaceuticals, Inc. Reducing toxic effects of carboplatin using dithioethers
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US20070142267A1 (en) * 1998-11-23 2007-06-21 Novelos Therapeutics, Inc. Methods for production of the oxidized glutathione composite with CIS-diamminedichloroplatinum and pharmaceutical compositions based thereof regulating metabolism, proliferation, differentiation and apoptotic mechanisms for normal and transformed cells
US6197831B1 (en) * 1999-02-09 2001-03-06 Bionumerik Pharmaceuticals, Inc. Method of treating septic shock
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US8710095B2 (en) * 2002-04-30 2014-04-29 Bionumerik Pharmaceuticals, Inc. Drugs for prophylaxis or mitigation of taxane-induced neurotoxicity
US20040014730A1 (en) * 2002-07-10 2004-01-22 Frederick Hausheer Formulations and methods of reducing toxicity of anti-infective agents
JP2006513190A (ja) * 2002-12-21 2006-04-20 バイオニューメリック・ファーマスーティカルズ・インコーポレイテッド 有毒化学試薬に曝露した患者の処置方法
CA2520172C (en) 2003-03-27 2012-10-02 Lankenau Institute For Medical Research Novel methods for the treatment of cancer with an indoleamine 2, 3-dioxygenase inhibitor
US20060020119A1 (en) * 2004-03-29 2006-01-26 Stephen Grimes Monoclonal antibodies to gastrin hormone
CN100450999C (zh) * 2003-12-17 2009-01-14 比奥纽默里克药物公司 合成二硫化物的方法
US20090111735A1 (en) * 2004-05-12 2009-04-30 Bionumerik Pharmaceuticals, Inc. Compounds and methods for reducing undesired toxicity of chemotherapeutic agents
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US20060063742A1 (en) * 2004-09-21 2006-03-23 Hausheer Frederick H Method of treatment for or protection against lymphedema
US7282602B2 (en) * 2004-09-21 2007-10-16 Bionumerik Pharmaceuticals, Inc. Medicinal disulfide salts
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Also Published As

Publication number Publication date
JP4171526B2 (ja) 2008-10-22
US5789000A (en) 1998-08-04
DE69530412D1 (de) 2003-05-22
WO1996014852A1 (en) 1996-05-23
DK0792154T3 (da) 2003-08-04
EP0792154A1 (en) 1997-09-03
US5866617A (en) 1999-02-02
CN1165483A (zh) 1997-11-19
MX9703460A (es) 1997-07-31
AU4116896A (en) 1996-06-06
JP2012211198A (ja) 2012-11-01
CN1165483B (zh) 2012-09-05
PT792154E (pt) 2003-09-30
US5902610A (en) 1999-05-11
CA2202170A1 (en) 1996-05-23
AU706181B2 (en) 1999-06-10
JPH10509143A (ja) 1998-09-08
KR970706830A (ko) 1997-12-01
ATE237337T1 (de) 2003-05-15
CA2202170C (en) 2007-04-10
DE69530412T2 (de) 2003-10-30
JP2008133304A (ja) 2008-06-12
CN101987111A (zh) 2011-03-23
US5866169A (en) 1999-02-02
US5866615A (en) 1999-02-02
KR100411380B1 (ko) 2004-04-30
EP0792154B1 (en) 2003-04-16

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