ES2285985T3 - Composiciones de peliculas polimericas para capsulas. - Google Patents

Composiciones de peliculas polimericas para capsulas. Download PDF

Info

Publication number: ES2285985T3
Authority: ES; Spain
Prior art keywords: cellulose; polymer composition; composition according; acid; mixture
Prior art date: 1996-12-17
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

ES00119624T

Other languages

English (en)

Spanish (es)

Inventor

Dominique Cade

Xiongwei He

Robert Anthony Scott

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Warner Lambert Co LLC

Original Assignee

Warner Lambert Co LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-12-17

Filing date

1997-12-05

Publication date

2007-12-01

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9498812&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2285985(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1997-12-05 Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC

2007-12-01 Application granted granted Critical

2007-12-01 Publication of ES2285985T3 publication Critical patent/ES2285985T3/es

2017-12-05 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

239000000203 mixture Substances 0.000 title claims abstract description 65
239000002775 capsule Substances 0.000 title claims description 37
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239000003352 sequestering agent Substances 0.000 claims abstract description 10
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 9
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 12
239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 12
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 12
-1 konjac mannan Chemical compound 0.000 claims description 12
239000002253 acid Substances 0.000 claims description 10
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 10
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 9
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 8
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OMDQUFIYNPYJFM-XKDAHURESA-N (2r,3r,4s,5r,6s)-2-(hydroxymethyl)-6-[[(2r,3s,4r,5s,6r)-4,5,6-trihydroxy-3-[(2s,3s,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]methoxy]oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@H](O)[C@H](O)O1 OMDQUFIYNPYJFM-XKDAHURESA-N 0.000 claims description 2
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MIDXCONKKJTLDX-UHFFFAOYSA-N 3,5-dimethylcyclopentane-1,2-dione Chemical compound CC1CC(C)C(=O)C1=O MIDXCONKKJTLDX-UHFFFAOYSA-N 0.000 claims description 2
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FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 2
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FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 claims description 2
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RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 2
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239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 2
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229920001479 Hydroxyethyl methyl cellulose Polymers 0.000 claims description 2
229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 2
241000557752 Khaya Species 0.000 claims description 2
235000010643 Leucaena leucocephala Nutrition 0.000 claims description 2
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CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 2
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CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 2
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DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims description 2
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239000011975 tartaric acid Substances 0.000 claims 1
235000002906 tartaric acid Nutrition 0.000 claims 1
GMMAPXRGRVJYJY-UHFFFAOYSA-J tetrasodium 4-acetamido-5-hydroxy-6-[[7-sulfonato-4-[(4-sulfonatophenyl)diazenyl]naphthalen-1-yl]diazenyl]naphthalene-1,7-disulfonate Chemical compound [Na+].[Na+].[Na+].[Na+].OC1=C2C(NC(=O)C)=CC=C(S([O-])(=O)=O)C2=CC(S([O-])(=O)=O)=C1N=NC(C1=CC(=CC=C11)S([O-])(=O)=O)=CC=C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 GMMAPXRGRVJYJY-UHFFFAOYSA-J 0.000 claims 1
AAAQKTZKLRYKHR-UHFFFAOYSA-N triphenylmethane Chemical compound C1=CC=CC=C1C(C=1C=CC=CC=1)C1=CC=CC=C1 AAAQKTZKLRYKHR-UHFFFAOYSA-N 0.000 claims 1
239000007902 hard capsule Substances 0.000 abstract description 2
239000007901 soft capsule Substances 0.000 abstract description 2
RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 6
108010010803 Gelatin Proteins 0.000 description 4
239000008273 gelatin Substances 0.000 description 4
229920000159 gelatin Polymers 0.000 description 4
235000019322 gelatine Nutrition 0.000 description 4
235000011852 gelatine desserts Nutrition 0.000 description 4
235000015110 jellies Nutrition 0.000 description 4
239000008274 jelly Substances 0.000 description 4
239000007903 gelatin capsule Substances 0.000 description 3
239000000463 material Substances 0.000 description 3
229960005489 paracetamol Drugs 0.000 description 3
239000000047 product Substances 0.000 description 3
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 2
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
230000015572 biosynthetic process Effects 0.000 description 2
239000011575 calcium Substances 0.000 description 2
FDSDTBUPSURDBL-LOFNIBRQSA-N canthaxanthin Chemical compound CC=1C(=O)CCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)CCC1(C)C FDSDTBUPSURDBL-LOFNIBRQSA-N 0.000 description 2
239000001768 carboxy methyl cellulose Substances 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
238000004090 dissolution Methods 0.000 description 2
238000007922 dissolution test Methods 0.000 description 2
235000013980 iron oxide Nutrition 0.000 description 2
239000007787 solid Substances 0.000 description 2
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
OOUTWVMJGMVRQF-DOYZGLONSA-N Phoenicoxanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)C(=O)C(O)CC1(C)C)C=CC=C(/C)C=CC2=C(C)C(=O)CCC2(C)C OOUTWVMJGMVRQF-DOYZGLONSA-N 0.000 description 1
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
239000013543 active substance Substances 0.000 description 1
229920013820 alkyl cellulose Polymers 0.000 description 1
229910000147 aluminium phosphate Inorganic materials 0.000 description 1
229910001424 calcium ion Inorganic materials 0.000 description 1
239000001659 canthaxanthin Substances 0.000 description 1
229940008033 canthaxanthin Drugs 0.000 description 1
235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
239000008112 carboxymethyl-cellulose Substances 0.000 description 1
DGQLVPJVXFOQEV-JNVSTXMASA-N carminic acid Chemical compound OC1=C2C(=O)C=3C(C)=C(C(O)=O)C(O)=CC=3C(=O)C2=C(O)C(O)=C1[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O DGQLVPJVXFOQEV-JNVSTXMASA-N 0.000 description 1
238000005266 casting Methods 0.000 description 1
150000001768 cations Chemical class 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
230000008602 contraction Effects 0.000 description 1
238000004132 cross linking Methods 0.000 description 1
239000008367 deionised water Substances 0.000 description 1
229910021641 deionized water Inorganic materials 0.000 description 1
229960000878 docusate sodium Drugs 0.000 description 1
230000007613 environmental effect Effects 0.000 description 1
238000001125 extrusion Methods 0.000 description 1
SZVJSHCCFOBDDC-UHFFFAOYSA-N ferrosoferric oxide Chemical compound O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 description 1
239000012467 final product Substances 0.000 description 1
230000004927 fusion Effects 0.000 description 1
229940050521 gelatin agent Drugs 0.000 description 1
235000013773 glyceryl triacetate Nutrition 0.000 description 1
239000008187 granular material Substances 0.000 description 1
235000013402 health food Nutrition 0.000 description 1
229920013821 hydroxy alkyl cellulose Polymers 0.000 description 1
238000007654 immersion Methods 0.000 description 1
238000009863 impact test Methods 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
238000001746 injection moulding Methods 0.000 description 1
235000014413 iron hydroxide Nutrition 0.000 description 1
VBMVTYDPPZVILR-UHFFFAOYSA-N iron(2+);oxygen(2-) Chemical class [O-2].[Fe+2] VBMVTYDPPZVILR-UHFFFAOYSA-N 0.000 description 1
239000008101 lactose Substances 0.000 description 1
230000014759 maintenance of location Effects 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 1
WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
238000000465 moulding Methods 0.000 description 1
210000004798 organs belonging to the digestive system Anatomy 0.000 description 1
235000011007 phosphoric acid Nutrition 0.000 description 1
125000005498 phthalate group Chemical class 0.000 description 1
229910001414 potassium ion Inorganic materials 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
230000005855 radiation Effects 0.000 description 1
238000012552 review Methods 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
APSBXTVYXVQYAB-UHFFFAOYSA-M sodium docusate Chemical compound [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 description 1
230000003068 static effect Effects 0.000 description 1
238000003860 storage Methods 0.000 description 1
238000002834 transmittance Methods 0.000 description 1
URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical class CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
- C08L1/08—Cellulose derivatives
- C08L1/26—Cellulose ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/04—Oxygen-containing compounds
- C08K5/09—Carboxylic acids; Metal salts thereof; Anhydrides thereof
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
- C08L1/08—Cellulose derivatives
- C08L1/26—Cellulose ethers
- C08L1/28—Alkyl ethers
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/04—Alginic acid; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Polymers & Plastics (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Compositions Of Macromolecular Compounds (AREA)
Medicinal Preparation (AREA)
Biological Depolymerization Polymers (AREA)
Manufacturing Of Micro-Capsules (AREA)
General Preparation And Processing Of Foods (AREA)
Jellies, Jams, And Syrups (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Fats And Perfumes (AREA)
Medical Preparation Storing Or Oral Administration Devices (AREA)
Manufacture Of Macromolecular Shaped Articles (AREA)

ES00119624T 1996-12-17 1997-12-05 Composiciones de peliculas polimericas para capsulas. Expired - Lifetime ES2285985T3 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9615580A FR2757173A1 (fr)	1996-12-17	1996-12-17	Compositions polymeres d'origine non-animale pour la formation de films
FR9615580		1996-12-17

Publications (1)

Publication Number	Publication Date
ES2285985T3 true ES2285985T3 (es)	2007-12-01

Family

ID=9498812

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
ES00119624T Expired - Lifetime ES2285985T3 (es)	1996-12-17	1997-12-05	Composiciones de peliculas polimericas para capsulas.
ES97950816T Expired - Lifetime ES2155703T3 (es)	1996-12-17	1997-12-05	Composiciones de peliculas de polimeros para capsulas.

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
ES97950816T Expired - Lifetime ES2155703T3 (es)	1996-12-17	1997-12-05	Composiciones de peliculas de polimeros para capsulas.

Country Status (16)

Country	Link
US (1)	US6517865B2 (fr)
EP (2)	EP1057862B1 (fr)
JP (3)	JP2001506692A (fr)
KR (1)	KR100502383B1 (fr)
CN (1)	CN1088075C (fr)
AT (2)	ATE365188T1 (fr)
AU (1)	AU5371498A (fr)
CA (1)	CA2272633C (fr)
DE (2)	DE69737834T2 (fr)
DK (2)	DK0946637T3 (fr)
ES (2)	ES2285985T3 (fr)
FR (1)	FR2757173A1 (fr)
GR (1)	GR3035585T3 (fr)
ID (1)	ID22476A (fr)
PT (2)	PT946637E (fr)
WO (1)	WO1998027151A1 (fr)

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1996
- 1996-12-17 FR FR9615580A patent/FR2757173A1/fr not_active Withdrawn
1997
- 1997-12-05 CN CN97180701A patent/CN1088075C/zh not_active Expired - Lifetime
- 1997-12-05 CA CA002272633A patent/CA2272633C/fr not_active Expired - Lifetime
- 1997-12-05 WO PCT/US1997/022177 patent/WO1998027151A1/fr not_active Ceased
- 1997-12-05 DE DE69737834T patent/DE69737834T2/de not_active Expired - Lifetime
- 1997-12-05 ES ES00119624T patent/ES2285985T3/es not_active Expired - Lifetime
- 1997-12-05 AT AT00119624T patent/ATE365188T1/de active
- 1997-12-05 EP EP00119624A patent/EP1057862B1/fr not_active Expired - Lifetime
- 1997-12-05 DK DK97950816T patent/DK0946637T3/da active
- 1997-12-05 PT PT97950816T patent/PT946637E/pt unknown
- 1997-12-05 AU AU53714/98A patent/AU5371498A/en not_active Abandoned
- 1997-12-05 ID IDW990459A patent/ID22476A/id unknown
- 1997-12-05 ES ES97950816T patent/ES2155703T3/es not_active Expired - Lifetime
- 1997-12-05 DK DK00119624T patent/DK1057862T3/da active
- 1997-12-05 DE DE69703897T patent/DE69703897T2/de not_active Expired - Lifetime
- 1997-12-05 AT AT97950816T patent/ATE198612T1/de active
- 1997-12-05 KR KR10-1999-7005385A patent/KR100502383B1/ko not_active Expired - Fee Related
- 1997-12-05 JP JP52776198A patent/JP2001506692A/ja active Pending
- 1997-12-05 PT PT00119624T patent/PT1057862E/pt unknown
- 1997-12-05 EP EP97950816A patent/EP0946637B1/fr not_active Expired - Lifetime
2001
- 2001-03-15 GR GR20010400429T patent/GR3035585T3/el unknown
- 2001-09-26 JP JP2001293558A patent/JP3822810B2/ja not_active Expired - Fee Related
2002
- 2002-05-28 US US10/157,428 patent/US6517865B2/en not_active Expired - Lifetime
2007
- 2007-06-26 JP JP2007167528A patent/JP4838202B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE69703897T2 (de)	2001-06-21
WO1998027151A1 (fr)	1998-06-25
JP2002138035A (ja)	2002-05-14
PT946637E (pt)	2001-05-31
GR3035585T3 (en)	2001-06-29
EP1057862A3 (fr)	2001-02-07
ATE365188T1 (de)	2007-07-15
CN1240461A (zh)	2000-01-05
KR20000057602A (ko)	2000-09-25
CA2272633A1 (fr)	1998-06-25
PT1057862E (pt)	2007-08-07
FR2757173A1 (fr)	1998-06-19
CA2272633C (fr)	2007-03-13
ES2155703T3 (es)	2001-05-16
JP2001506692A (ja)	2001-05-22
CN1088075C (zh)	2002-07-24
DK1057862T3 (da)	2007-10-01
JP3822810B2 (ja)	2006-09-20
ATE198612T1 (de)	2001-01-15
DE69737834T2 (de)	2008-03-06
ID22476A (id)	1999-10-21
EP0946637A1 (fr)	1999-10-06
US20020187190A1 (en)	2002-12-12
EP1057862B1 (fr)	2007-06-20
US6517865B2 (en)	2003-02-11
EP1057862A2 (fr)	2000-12-06
DE69737834D1 (de)	2007-08-02
AU5371498A (en)	1998-07-15
JP4838202B2 (ja)	2011-12-14
HK1024013A1 (zh)	2000-09-29
DK0946637T3 (da)	2001-03-05
EP0946637B1 (fr)	2001-01-10
KR100502383B1 (ko)	2005-07-19
JP2007308713A (ja)	2007-11-29
DE69703897D1 (de)	2001-02-15

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ES2235380T3 (es)	2005-07-01	Composiciones de gelatina.
ES2603225T3 (es)	2017-02-24	Sistema de cápsulas blandas sin gelatina
EP3082778B1 (fr)	2019-04-03	Capsule dure remplie de liquide stable comprenant de l'acide bêta-hydroxy-bêta-méthylbutyrique
CN110191723B (zh)	2023-03-10	表现出改善的凝胶助剂的沉积的硬胶囊及其制备方法
HK1024013B (en)	2003-02-28	Polymer film compositions for capsules
TH42157A (th)	2000-12-29	องค์ประกอบของฟิล์มแป้งที่ได้รับการดัดแปลง