ES2326264T3 - Combinacion que comprende un inhibidor de transduccion de señal y un derivado epotilona. - Google Patents

Combinacion que comprende un inhibidor de transduccion de señal y un derivado epotilona. Download PDF

Info

Publication number: ES2326264T3
Authority: ES; Spain
Prior art keywords: hydrogen; lower alkyl; formula; combination; pharmaceutically acceptable
Prior art date: 2001-02-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

ES02744903T

Other languages

English (en)

Spanish (es)

Inventor

Elisabeth Buchdunger

Carl-Henrik Heldin

Arne Ostman

Kristian Pietras

Terence O'reilly

John David Rothermel

Peter Traxler

Markus Wartmann

Ralf Brandt

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Novartis AG

Original Assignee

Novartis AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-02-27

Filing date

2002-02-26

Publication date

2009-10-06

2001-02-27 Priority claimed from GBGB0104840.4A external-priority patent/GB0104840D0/en

2002-02-26 Application filed by Novartis AG filed Critical Novartis AG

2009-10-06 Application granted granted Critical

2009-10-06 Publication of ES2326264T3 publication Critical patent/ES2326264T3/es

2022-02-26 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

239000003112 inhibitor Substances 0.000 title claims description 19
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239000008194 pharmaceutical composition Substances 0.000 claims abstract description 7
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239000001257 hydrogen Substances 0.000 claims description 49
-1 4-pyrazinyl Chemical group 0.000 claims description 34
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A—HUMAN NECESSITIES
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Veterinary Medicine (AREA)
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Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Cosmetics (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

ES02744903T 2001-02-27 2002-02-26 Combinacion que comprende un inhibidor de transduccion de señal y un derivado epotilona. Expired - Lifetime ES2326264T3 (es)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GBGB0104840.4A GB0104840D0 (en)	2001-02-27	2001-02-27	Use of organic compounds
GB0104840		2001-02-27
US33904001P	2001-10-30	2001-10-30
US339040P		2001-10-30

Publications (1)

Publication Number	Publication Date
ES2326264T3 true ES2326264T3 (es)	2009-10-06

Family

ID=26245767

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES02744903T Expired - Lifetime ES2326264T3 (es)	2001-02-27	2002-02-26	Combinacion que comprende un inhibidor de transduccion de señal y un derivado epotilona.

Country Status (22)

Country	Link
US (1)	US7723339B2 (pl)
EP (1)	EP1385522B1 (pl)
JP (1)	JP4499359B2 (pl)
KR (1)	KR100848197B1 (pl)
CN (1)	CN1511036B (pl)
AT (1)	ATE434438T1 (pl)
AU (1)	AU2002308218B2 (pl)
BR (1)	BR0207649A (pl)
CA (1)	CA2439268C (pl)
CY (1)	CY1109347T1 (pl)
DE (1)	DE60232719D1 (pl)
DK (1)	DK1385522T3 (pl)
ES (1)	ES2326264T3 (pl)
IL (2)	IL157466A0 (pl)
MX (1)	MXPA03007729A (pl)
NO (1)	NO325416B1 (pl)
NZ (1)	NZ527764A (pl)
PL (1)	PL207197B1 (pl)
PT (1)	PT1385522E (pl)
RU (1)	RU2313345C2 (pl)
SK (1)	SK287489B6 (pl)
WO (1)	WO2002067941A2 (pl)

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* Cited by examiner, † Cited by third party
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US6204388B1 (en)	1996-12-03	2001-03-20	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto and analogues thereof
CA2273083C (en)	1996-12-03	2012-09-18	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto, analogues and uses thereof
HRP20030831B1 (en)	2001-03-14	2012-08-31	Bristol-Myers Squibb Company	Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases
MXPA03010401A (es) *	2001-05-16	2004-03-09	Novartis Ag	Combinacion que comprende n-[5-[4- (4-metil- piperazino-metil) -benzoilamido] -2-metilfenil] -4-(3-piridil)-2 -pirimidin-amina, y un agente quimioterapeutico.
EP1704863A3 (en) *	2001-05-16	2010-11-24	Novartis AG	Combination comprising N-5-4-(4-Methyl-Piperazino-Methyl-)Benzoyla Mido]-2-Methylphenyl -4-(3-Pyridyl)-2Phyrimidine-amine and a chemotherapeutic agent
JP2005507424A (ja) *	2001-10-29	2005-03-17	ノバルティスアクチエンゲゼルシャフト	固形腫瘍の処置における７Ｈ−ピロロ［２，３−ｄ］ピリミジン誘導体の使用
US7649006B2 (en)	2002-08-23	2010-01-19	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto and analogues thereof
US6921769B2 (en)	2002-08-23	2005-07-26	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto and analogues thereof
DE60310916T2 (de)	2002-08-23	2007-11-15	Sloan-Kettering Institute For Cancer Research	Synthese von epothilonen, zwischenprodukte dafür, analoga und deren verwendungen
US20050171167A1 (en) *	2003-11-04	2005-08-04	Haby Thomas A.	Process and formulation containing epothilones and analogs thereof
JO2596B1 (en) *	2004-11-30	2011-02-27	نوفارتيس ايه جي	Compositions include epothelones and tyrosine protein kinase inhibitors and their pharmaceutical uses
US20060121511A1 (en)	2004-11-30	2006-06-08	Hyerim Lee	Biomarkers and methods for determining sensitivity to microtubule-stabilizing agents
AU2006336468B2 (en)	2005-02-11	2012-04-12	University Of Southern California	Method of expressing proteins with disulfide bridges
US8008256B2 (en) *	2006-05-01	2011-08-30	University Of Southern California	Combination therapy for treatment of cancer
US8802394B2 (en)	2008-11-13	2014-08-12	Radu O. Minea	Method of expressing proteins with disulfide bridges with enhanced yields and activity
WO2010108503A1 (en)	2009-03-24	2010-09-30	Life & Brain Gmbh	Promotion of neuronal integration in neural stem cell grafts
MX2012013100A (es)	2010-05-18	2013-01-22	Cerulean Pharma Inc	Composiciones y metodos para el tratamiento de enfermedades autoinmunes y otras enfermedades.

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Publication number	Priority date	Publication date	Assignee	Title
JP3040121B2 (ja) *	1988-01-12	2000-05-08	ジェネンテク，インコーポレイテッド	増殖因子レセプターの機能を阻害することにより腫瘍細胞を処置する方法
DE4138042C2 (de)	1991-11-19	1993-10-14	Biotechnolog Forschung Gmbh	Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel
TW225528B (pl)	1992-04-03	1994-06-21	Ciba Geigy Ag
US5654307A (en) *	1994-01-25	1997-08-05	Warner-Lambert Company	Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family
CN1100778C (zh) *	1995-07-06	2003-02-05	诺瓦蒂斯有限公司	吡咯并嘧啶及其制备方法
DE59712968D1 (de)	1996-11-18	2008-10-30	Biotechnolog Forschung Gmbh	Epothilone E und F
CO4940418A1 (es) *	1997-07-18	2000-07-24	Novartis Ag	Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso
US6302838B1 (en) *	1998-02-25	2001-10-16	Novartis Ag	Cancer treatment with epothilones
WO2000000485A1 (de) *	1998-06-30	2000-01-06	Schering Aktiengesellschaft	Epothilon-derivate, verfahren zu deren herstellung, zwischenprodukte und ihre pharmazeutische verwendung
EE200100422A (et) *	1999-02-11	2002-12-16	Schering Aktiengesellschaft	Epotilooni derivaadid, nende valmistamismeetod jafarmatseutiline kasutamine
DE19908760A1 (de) *	1999-02-18	2000-08-24	Schering Ag	Neue Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung

2002
- 2002-02-26 PL PL363288A patent/PL207197B1/pl not_active IP Right Cessation
- 2002-02-26 KR KR1020037011205A patent/KR100848197B1/ko not_active Expired - Fee Related
- 2002-02-26 BR BR0207649-7A patent/BR0207649A/pt not_active Application Discontinuation
- 2002-02-26 CN CN028056086A patent/CN1511036B/zh not_active Expired - Fee Related
- 2002-02-26 AT AT02744903T patent/ATE434438T1/de active
- 2002-02-26 DE DE60232719T patent/DE60232719D1/de not_active Expired - Lifetime
- 2002-02-26 US US10/469,367 patent/US7723339B2/en not_active Expired - Fee Related
- 2002-02-26 WO PCT/EP2002/002049 patent/WO2002067941A2/en not_active Ceased
- 2002-02-26 NZ NZ527764A patent/NZ527764A/en not_active IP Right Cessation
- 2002-02-26 RU RU2003127392/15A patent/RU2313345C2/ru not_active IP Right Cessation
- 2002-02-26 IL IL15746602A patent/IL157466A0/xx unknown
- 2002-02-26 EP EP02744903A patent/EP1385522B1/en not_active Expired - Lifetime
- 2002-02-26 DK DK02744903T patent/DK1385522T3/da active
- 2002-02-26 AU AU2002308218A patent/AU2002308218B2/en not_active Ceased
- 2002-02-26 ES ES02744903T patent/ES2326264T3/es not_active Expired - Lifetime
- 2002-02-26 MX MXPA03007729A patent/MXPA03007729A/es active IP Right Grant
- 2002-02-26 JP JP2002567308A patent/JP4499359B2/ja not_active Expired - Fee Related
- 2002-02-26 PT PT02744903T patent/PT1385522E/pt unknown
- 2002-02-26 CA CA002439268A patent/CA2439268C/en not_active Expired - Fee Related
- 2002-02-26 SK SK1071-2003A patent/SK287489B6/sk not_active IP Right Cessation
2003
- 2003-08-18 IL IL157466A patent/IL157466A/en not_active IP Right Cessation
- 2003-08-25 NO NO20033769A patent/NO325416B1/no not_active IP Right Cessation
2009
- 2009-08-28 CY CY20091100900T patent/CY1109347T1/el unknown

Also Published As

Publication number	Publication date
NO20033769L (no)	2003-08-25
DK1385522T3 (da)	2009-10-12
WO2002067941A3 (en)	2003-11-20
NZ527764A (en)	2006-01-27
CA2439268A1 (en)	2002-09-06
WO2002067941A8 (en)	2003-12-18
EP1385522A2 (en)	2004-02-04
CN1511036A (zh)	2004-07-07
MXPA03007729A (es)	2003-12-04
IL157466A (en)	2012-04-30
JP2004527493A (ja)	2004-09-09
AU2002308218B2 (en)	2005-11-10
IL157466A0 (en)	2004-03-28
SK10712003A3 (sk)	2004-02-03
ATE434438T1 (de)	2009-07-15
RU2313345C2 (ru)	2007-12-27
DE60232719D1 (de)	2009-08-06
BR0207649A (pt)	2004-03-09
CN1511036B (zh)	2010-05-05
PT1385522E (pt)	2009-09-04
KR20040025900A (ko)	2004-03-26
US7723339B2 (en)	2010-05-25
NO325416B1 (no)	2008-04-21
WO2002067941A2 (en)	2002-09-06
HK1062266A1 (en)	2004-10-29
US20040132754A1 (en)	2004-07-08
PL363288A1 (pl)	2004-11-15
JP4499359B2 (ja)	2010-07-07
CY1109347T1 (el)	2014-07-02
SK287489B6 (sk)	2010-11-08
KR100848197B1 (ko)	2008-07-24
CA2439268C (en)	2010-01-19
RU2003127392A (ru)	2005-03-27
PL207197B1 (pl)	2010-11-30
NO20033769D0 (no)	2003-08-25
EP1385522B1 (en)	2009-06-24

Publication	Publication Date	Title
ES2326264T3 (es)	2009-10-06	Combinacion que comprende un inhibidor de transduccion de señal y un derivado epotilona.
KR101292508B1 (ko)	2013-08-01	백혈병의 치료를 위한, 피리미딜아미노벤즈아미드 화합물과 조합된 ｃ-ｓｒｃ 억제제의 용도
AU2002308218A1 (en)	2003-03-06	Combination comprising a signal transduction inhibitor and an epothilone derivative
US20110281902A1 (en)	2011-11-17	Combinations comprising a protein kinase inhibitor being a pyrimidylaminobenzamide compound and a hsp90 inhibitor such as 17-aag
US20120053559A1 (en)	2012-03-01	Treatment of Proliferative Diseases with Epothilone Derivatives and Radiation
TR201806682T4 (tr)	2018-06-21	Farmasötik kombinasyonlar.
AU2006255559B2 (en)	2009-12-17	Combination of pyrimidylaminobenzamide compounds and imatinib for treating or preventing proliferative diseases
HK1062266B (en)	2010-02-26	Combination comprising a signal transduction inhibitor and an epothilone derivative
CZ20032277A3 (cs)	2004-01-14	Kombinace inhibitoru přenosu signálu a derivátu epothilonu k léčení proliferativních onemocnění
AU2011202950B2 (en)	2012-03-22	Use of c-Src inhibitors in combination with a pyrimidylaminobenzamide compound for the treatment of leukemia
AU2013201915A1 (en)	2013-04-11	Use of c-Src inhibitors in combination with a pyrimidylaminobenzamide compound for the treatment of leukemia