ES2505700T3 - Vectores de parvovirus duplicados - Google Patents

Vectores de parvovirus duplicados Download PDF

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Publication number
ES2505700T3
ES2505700T3 ES05076932.2T ES05076932T ES2505700T3 ES 2505700 T3 ES2505700 T3 ES 2505700T3 ES 05076932 T ES05076932 T ES 05076932T ES 2505700 T3 ES2505700 T3 ES 2505700T3
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duplexed
parvovirus
duplicate
methods
vector
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Richard Jude Samulski
Douglas M. Mccarty
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University of North Carolina at Chapel Hill
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C12N15/864—Parvoviral vectors, e.g. parvovirus, densovirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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Abstract

Una partícula de parvovirus duplicado que comprende: una cápsida del parvovirus un genoma del vector que comprende en la dirección 5' a 3' : (i) una secuencia de repetición terminal de parvovirus en 5'; (ii) una primera secuencia de nucleótidos heteróloga; (iii) una secuencia de repetición terminal no resolvible que no puede ser resuelta por proteínas Rep en parvovirus; (iv) una secuencia de nucleótidos heteróloga separada que es esencialmente completamente complementaria a dicha primera secuencia de nucleótidos heteróloga; y (v) una secuencia de repetición terminal de parvovirus en 3'; en donde dicho genoma del vector es capaz bajo condiciones adecuadas del apareamiento de bases intracadena entre las secuencias de nucleótidos heterólogas tras la liberación de la cápsida del parvovirus.

Description

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Claims (1)

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ES05076932.2T 2000-06-01 2001-05-31 Vectores de parvovirus duplicados Expired - Lifetime ES2505700T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20860400P 2000-06-01 2000-06-01
US208604P 2000-06-01

Publications (1)

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ES2505700T3 true ES2505700T3 (es) 2014-10-10

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ES01948252T Expired - Lifetime ES2256265T3 (es) 2000-06-01 2001-05-31 Vectores de parvovirus duplicados.
ES05076932.2T Expired - Lifetime ES2505700T3 (es) 2000-06-01 2001-05-31 Vectores de parvovirus duplicados

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ES01948252T Expired - Lifetime ES2256265T3 (es) 2000-06-01 2001-05-31 Vectores de parvovirus duplicados.

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US (4) US7465583B2 (es)
EP (1) EP1290205B1 (es)
JP (1) JP4860886B2 (es)
AT (1) ATE318923T1 (es)
AU (2) AU2001269723B9 (es)
CA (1) CA2410828C (es)
DE (1) DE60117550T2 (es)
ES (2) ES2256265T3 (es)
NZ (1) NZ522840A (es)
WO (1) WO2001092551A2 (es)

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