ES2531052T3 - Métodos y composiciones basados en microARN para el diagnóstico de cánceres de mama - Google Patents

Métodos y composiciones basados en microARN para el diagnóstico de cánceres de mama Download PDF

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ES2531052T3
ES2531052T3 ES12154349T ES12154349T ES2531052T3 ES 2531052 T3 ES2531052 T3 ES 2531052T3 ES 12154349 T ES12154349 T ES 12154349T ES 12154349 T ES12154349 T ES 12154349T ES 2531052 T3 ES2531052 T3 ES 2531052T3
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mir
microrna
diagnosis
methods
compositions based
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Carlo Croce
George Calin
Stefano Volinia
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Ohio State University Research Foundation
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    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

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Abstract

Un método para diagnosticar si un sujeto tiene cáncer de mama, que comprende: medir los niveles de un grupo de productos génicos de miR que consisten en miR-125b-2, miR-5 125b-1, miR-10b, miR-181a, miR-140, miR-213, miR-29a prec, miR-199b, miR-29b-1, miR-130a, miR-155, let-7a-2, miR-29c, miR- 224, miR-31, miR-122a, miR-16-2, miR-21, miR-145, miR-205, miR-100, miR-30c, miR-17-5p, miR-210, miR-29b- 2, miR-146 y miR-181b-1 en una muestra de ensayo del sujeto; en el que una alteración en los niveles del grupo de productos génicos de miR en la muestra de ensayo, en relación a los niveles de los correspondientes productos génicos de miR en una muestra de control, es indicativo de que el sujeto tiene cáncer de mama, y en el que la muestra de ensayo es tejido mamario.
ES12154349T 2006-01-05 2007-01-03 Métodos y composiciones basados en microARN para el diagnóstico de cánceres de mama Active ES2531052T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US75658506P 2006-01-05 2006-01-05

Publications (1)

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ES2531052T3 true ES2531052T3 (es) 2015-03-10

Family

ID=38256892

Family Applications (22)

Application Number Title Priority Date Filing Date
ES12154307T Active ES2440787T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN y composiciones para el diagnóstico y el tratamiento de cánceres sólidos
ES12154341T Active ES2530843T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN para el diagnóstico de cáncer de páncreas
ES12154342.5T Active ES2557411T3 (es) 2006-01-05 2007-01-03 Métodos y composiciones basados en microARN para el diagnóstico y el tratamiento de cánceres sólidos
ES12154344T Active ES2465600T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN y composiciones para el diagnóstico y tratamiento de cánceres sólidos del páncreas
ES12154332.6T Active ES2526787T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN para el diagnóstico de cánceres de colon, páncreas y estómago
ES12154334.2T Active ES2545118T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN y composiciones para el diagnóstico y tratamiento de cánceres sólidos
ES12154327.6T Active ES2544713T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN y composiciones para el diagnóstico y tratamiento de cánceres sólidos
ES12154354.0T Active ES2536437T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN para el diagnóstico de cáncer de estómago
ES12154343.3T Active ES2604324T3 (es) 2006-01-05 2007-01-03 Métodos y composiciones basadas en microARN para el diagnóstico y el tratamiento de cánceres sólidos
ES12154348.2T Active ES2536422T3 (es) 2006-01-05 2007-01-03 Métodos y composiciones basados en microARN para el diagnóstico y tratamiento de cáncer pancreático
ES07717903.4T Active ES2508893T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN para el diagnóstico de cánceres de estómago
ES12154345T Active ES2461189T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN y composiciones para el diagnóstico y el tratamiento de cánceres sólidos de mama o pulmón
ES12154322.7T Active ES2547805T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN y composiciones para el diagnóstico y el tratamiento de cánceres sólidos
ES12154339.1T Active ES2545119T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN y composiciones para el diagnóstico y el tratamiento de cánceres sólidos
ES12154315.1T Active ES2527592T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN para el diagnóstico del cáncer de colon
ES12154304.5T Active ES2490995T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN y composiciones para el diagnóstico y el tratamiento de cánceres sólidos
ES12154346.6T Active ES2537880T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN para el diagnóstico de cáncer de próstata o cánceres de estómago
ES12154349T Active ES2531052T3 (es) 2006-01-05 2007-01-03 Métodos y composiciones basados en microARN para el diagnóstico de cánceres de mama
ES12154350.8T Active ES2525584T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN y composiciones para el diagnóstico y el tratamiento de cánceres sólidos
ES12154337.5T Active ES2546425T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN y composiciones para el diagnóstico y el tratamiento de cánceres sólidos
ES12154353.2T Active ES2536423T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN para el diagnóstico de cáncer de próstata
ES12154321.9T Active ES2545360T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN y composiciones para el diagnóstico y tratamiento de cánceres sólidos

Family Applications Before (17)

Application Number Title Priority Date Filing Date
ES12154307T Active ES2440787T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN y composiciones para el diagnóstico y el tratamiento de cánceres sólidos
ES12154341T Active ES2530843T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN para el diagnóstico de cáncer de páncreas
ES12154342.5T Active ES2557411T3 (es) 2006-01-05 2007-01-03 Métodos y composiciones basados en microARN para el diagnóstico y el tratamiento de cánceres sólidos
ES12154344T Active ES2465600T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN y composiciones para el diagnóstico y tratamiento de cánceres sólidos del páncreas
ES12154332.6T Active ES2526787T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN para el diagnóstico de cánceres de colon, páncreas y estómago
ES12154334.2T Active ES2545118T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN y composiciones para el diagnóstico y tratamiento de cánceres sólidos
ES12154327.6T Active ES2544713T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN y composiciones para el diagnóstico y tratamiento de cánceres sólidos
ES12154354.0T Active ES2536437T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN para el diagnóstico de cáncer de estómago
ES12154343.3T Active ES2604324T3 (es) 2006-01-05 2007-01-03 Métodos y composiciones basadas en microARN para el diagnóstico y el tratamiento de cánceres sólidos
ES12154348.2T Active ES2536422T3 (es) 2006-01-05 2007-01-03 Métodos y composiciones basados en microARN para el diagnóstico y tratamiento de cáncer pancreático
ES07717903.4T Active ES2508893T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN para el diagnóstico de cánceres de estómago
ES12154345T Active ES2461189T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN y composiciones para el diagnóstico y el tratamiento de cánceres sólidos de mama o pulmón
ES12154322.7T Active ES2547805T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN y composiciones para el diagnóstico y el tratamiento de cánceres sólidos
ES12154339.1T Active ES2545119T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN y composiciones para el diagnóstico y el tratamiento de cánceres sólidos
ES12154315.1T Active ES2527592T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN para el diagnóstico del cáncer de colon
ES12154304.5T Active ES2490995T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN y composiciones para el diagnóstico y el tratamiento de cánceres sólidos
ES12154346.6T Active ES2537880T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN para el diagnóstico de cáncer de próstata o cánceres de estómago

Family Applications After (4)

Application Number Title Priority Date Filing Date
ES12154350.8T Active ES2525584T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN y composiciones para el diagnóstico y el tratamiento de cánceres sólidos
ES12154337.5T Active ES2546425T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN y composiciones para el diagnóstico y el tratamiento de cánceres sólidos
ES12154353.2T Active ES2536423T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN para el diagnóstico de cáncer de próstata
ES12154321.9T Active ES2545360T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN y composiciones para el diagnóstico y tratamiento de cánceres sólidos

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US (24) US8148069B2 (es)
EP (31) EP1969147B1 (es)
JP (4) JP5395439B2 (es)
CN (3) CN103642900B (es)
AU (1) AU2007205163B2 (es)
CA (1) CA2633754C (es)
ES (22) ES2440787T3 (es)
WO (1) WO2007081740A2 (es)

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EP2302055B1 (en) 2004-11-12 2014-08-27 Asuragen, Inc. Methods and compositions involving miRNA and miRNA inhibitor molecules
WO2006133022A2 (en) * 2005-06-03 2006-12-14 The Johns Hopkins University Compositions and methods for decreasing microrna expression for the treatment of neoplasia
CN103820562B (zh) * 2005-08-01 2015-05-13 俄亥俄州立大学研究基金会 用于乳腺癌的诊断、预后和治疗的基于MicroRNA的方法和组合物
JP2009507918A (ja) 2005-09-12 2009-02-26 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション Ｂｃｌ２関連癌の診断及び療法のための組成物及び方法
US8445198B2 (en) * 2005-12-01 2013-05-21 Medical Prognosis Institute Methods, kits and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy
EP1969147B1 (en) * 2006-01-05 2014-07-30 The Ohio State University Research Foundation microRNA-based methods for the diagnosis of stomach cancer
ES2553442T3 (es) 2006-01-05 2015-12-09 The Ohio State University Research Foundation Procedimientos basados en los microARN para el diagnóstico, pronóstico y tratamiento del cáncer de pulmón
US7670840B2 (en) 2006-01-05 2010-03-02 The Ohio State University Research Foundation Micro-RNA expression abnormalities of pancreatic, endocrine and acinar tumors
EP2369011A1 (en) 2006-03-20 2011-09-28 The Ohio State University Research Foundation Microrna fingerprints during human megakaryocytopoiesis
EP2041317A4 (en) * 2006-07-13 2009-10-14 Univ Ohio State Res Found METHODS AND COMPOSITIONS BASED ON MICRO-RNA FOR THE DIAGNOSIS AND TREATMENT OF COLON CANCER RELATED DISEASES
EP2061907B1 (en) 2006-09-19 2011-11-23 The Ohio State University Research Foundation Tcl1 expression in chronic lymphocytic leukemia (cll) regulated by mir-29 and mir-181
US8252538B2 (en) 2006-11-01 2012-08-28 The Ohio State University MicroRNA expression signature for predicting survival and metastases in hepatocellular carcinoma
US8975026B2 (en) * 2007-01-16 2015-03-10 Somalogic, Inc. Method for generating aptamers with improved off-rates
WO2008094545A2 (en) 2007-01-31 2008-08-07 The Ohio State University Research Foundation Mic orna-based methods and compositions for the treatment of acute myeloid leukemia
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