ES2536295T3 - Inhibidores no nucleosídicos de la transcriptasa inversa - Google Patents

Inhibidores no nucleosídicos de la transcriptasa inversa

Info

Publication number: ES2536295T3
Authority: ES; Spain
Prior art keywords: alkyl; independently; haloalkyl; substituents; cycq
Prior art date: 2010-03-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

ES11761856.1T

Other languages

English (en)

Spanish (es)

Inventor

Jason Burch

Bernard Cote

Natalie Nguyen

Chun Sing Li

Miguel St-Onge

Danny Gauvreau

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck Canada Inc

Original Assignee

Merck Canada Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-03-30

Filing date

2011-03-28

Publication date

2015-05-22

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44710363&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2536295(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2011-03-28 Application filed by Merck Canada Inc filed Critical Merck Canada Inc

2015-05-22 Application granted granted Critical

2015-05-22 Publication of ES2536295T3 publication Critical patent/ES2536295T3/es

Status Active legal-status Critical Current

2031-03-28 Anticipated expiration legal-status Critical

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Communicable Diseases (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Virology (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
AIDS & HIV (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Steroid Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)

ES11761856.1T 2010-03-30 2011-03-28 Inhibidores no nucleosídicos de la transcriptasa inversa Active ES2536295T3 (es)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US31882410P	2010-03-30	2010-03-30
US318824P		2010-03-30
US32157310P	2010-04-07	2010-04-07
US321573P		2010-04-07
PCT/CA2011/000320 WO2011120133A1 (en)	2010-03-30	2011-03-28	Non-nucleoside reverse transcriptase inhibitors

Publications (1)

Publication Number	Publication Date
ES2536295T3 true ES2536295T3 (es)	2015-05-22

Family

ID=44710363

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
ES11761856.1T Active ES2536295T3 (es)	2010-03-30	2011-03-28	Inhibidores no nucleosídicos de la transcriptasa inversa
ES15157348.2T Active ES2609636T3 (es)	2010-03-30	2011-03-28	Composición farmacéutica que comprende un inhibidor no nucleosídico de la transcriptasa inversa

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
ES15157348.2T Active ES2609636T3 (es)	2010-03-30	2011-03-28	Composición farmacéutica que comprende un inhibidor no nucleosídico de la transcriptasa inversa

Country Status (44)

Country	Link
US (2)	US8486975B2 (2)
EP (2)	EP2552902B1 (2)
JP (2)	JP5281718B2 (2)
KR (1)	KR101421861B1 (2)
CN (1)	CN102971308B (2)
AR (1)	AR080859A1 (2)
AU (1)	AU2011235568B2 (2)
BR (1)	BR112012024691B1 (2)
CA (1)	CA2794377C (2)
CL (1)	CL2012002744A1 (2)
CO (1)	CO6630126A2 (2)
CR (1)	CR20120503A (2)
CY (3)	CY1118774T1 (2)
DK (2)	DK2552902T3 (2)
DO (1)	DOP2012000256A (2)
EA (1)	EA024804B1 (2)
EC (1)	ECSP12012201A (2)
ES (2)	ES2536295T3 (2)
FI (1)	FIC20190021I1 (2)
GE (1)	GEP20156368B (2)
HN (1)	HN2012002039A (2)
HR (2)	HRP20150427T1 (2)
HU (4)	HUE025336T2 (2)
IL (2)	IL222030A (2)
LT (3)	LT2924034T (2)
LU (2)	LUC00114I2 (2)
MA (1)	MA34170B1 (2)
ME (2)	ME02181B (2)
MX (1)	MX2012011379A (2)
MY (1)	MY163979A (2)
NI (1)	NI201200146A (2)
NL (1)	NL300980I2 (2)
NO (2)	NO2019019I1 (2)
NZ (1)	NZ602670A (2)
PE (1)	PE20130158A1 (2)
PH (1)	PH12012501923A1 (2)
PL (2)	PL2924034T3 (2)
PT (2)	PT2924034T (2)
RS (2)	RS54017B1 (2)
SG (1)	SG184347A1 (2)
SI (2)	SI2924034T1 (2)
TN (1)	TN2012000455A1 (2)
TW (1)	TWI458719B (2)
WO (1)	WO2011120133A1 (2)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HUE025336T2 (en) *	2010-03-30	2016-03-29	Merck Canada Inc	Non-nucleoside reverse transcriptase inhibitors
EP2625292B1 (en)	2010-10-07	2018-12-05	The General Hospital Corporation	Biomarkers of cancer
BR112015005997A8 (pt) *	2012-09-26	2023-04-11	Merck Sharp & Dohme	Composto
JO3470B1 (ar) *	2012-10-08	2020-07-05	Merck Sharp & Dohme	مشتقات 5- فينوكسي-3h-بيريميدين-4-أون واستخدامها كمثبطات ناسخ عكسي ل hiv
EP2928472B1 (en) *	2012-12-05	2018-05-02	Merck Sharp & Dohme Corp.	Process for making reverse transcriptase inhibitors
RU2661399C1 (ru) *	2013-11-22	2018-07-16	Мерк Шарп И Доум Корп.	Композиция ненуклеозидного ингибитора обратной транскриптазы
BR112016012658B1 (pt)	2013-12-04	2022-06-21	Merck Sharp & Dohme Corp	Métodos para sintetizar inibidores da transcriptase reversa e composto
PL3125894T3 (pl) *	2014-04-01	2021-02-08	Merck Sharp & Dohme Corp.	Proleki inhibitorów odwrotnej transkryptazy hiv
EP3161159B1 (en)	2014-06-25	2020-08-05	The General Hospital Corporation	Targeting human satellite ii (hsatii)
EP4424373B1 (en)	2015-12-02	2025-11-12	Merck Sharp & Dohme LLC	Pharmaceutical compositions containing doravirine, tenofovir disoproxil fumarate and lamivudine
WO2018175271A1 (en) *	2017-03-24	2018-09-27	Merck Sharp & Dohme Corp.	Formulation for parenteral administration
CN110769856A (zh)	2017-04-18	2020-02-07	希普拉有限公司	用于治疗逆转录病毒感染的组合疗法
EP4317972A3 (en)	2018-02-06	2024-03-13	The General Hospital Corporation	Repeat rna as biomarkers of tumor immune response
EP3823632B1 (en) *	2018-07-17	2025-10-29	Merck Sharp & Dohme LLC	Efda in combination with doravirine for use in treating f227c mutated hiv infections
PE20211704A1 (es)	2018-12-18	2021-09-01	Merck Sharp & Dohme	Derivados de pirimidona como agentes citotoxicos selectivos contra celulas infectadas por vih
CN110801455B (zh) *	2019-11-12	2020-06-02	河北医科大学第二医院	用于治疗mrsa的药物组合物及其应用
CN114163309B (zh) *	2021-12-27	2023-04-25	甘肃皓天医药科技有限责任公司	一种多拉韦林中间体的制备方法
CN114349690B (zh) *	2022-02-15	2023-04-25	甘肃皓天医药科技有限责任公司	一种多拉韦林中间体合成方法
CN116903590A (zh) *	2023-06-06	2023-10-20	延边大学	一种含杂环结构的吡啶酮类化合物及其制备方法和用途
CN120157613A (zh) *	2023-12-15	2025-06-17	山东诚创蓝海医药科技有限公司	多拉韦林中间体及其应用和合成方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE9904045D0 (sv)	1999-11-09	1999-11-09	Astra Ab	Compounds
TW200423930A (en) *	2003-02-18	2004-11-16	Hoffmann La Roche	Non-nucleoside reverse transcriptase inhibitors
CN100469769C (zh)	2003-03-24	2009-03-18	弗·哈夫曼-拉罗切有限公司	作为逆转录酶抑制剂的苄基-哒嗪酮
TW200505441A (en) *	2003-03-24	2005-02-16	Hoffmann La Roche	Non-nucleoside reverse transcriptase inhibitorsⅠ
BRPI0510059B8 (pt)	2004-04-23	2021-05-25	Hoffmann La Roche	inibidores da transcriptase reversa não-nucleosídica e seus usos
US7166738B2 (en)	2004-04-23	2007-01-23	Roche Palo Alto Llc	Non-nucleoside reverse transcriptase inhibitors
CA2592092A1 (en)	2004-12-22	2006-06-29	Pfizer Limited	Nonnucleoside inhibitors of hiv-1 reverse transcriptase
AR057455A1 (es)	2005-07-22	2007-12-05	Merck & Co Inc	Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica
CN101291905A (zh)	2005-10-19	2008-10-22	弗·哈夫曼-拉罗切有限公司	苯乙酰胺nnrt抑制剂
CA2625039A1 (en)	2005-10-19	2007-04-26	F. Hoffmann-La Roche Ag	N-phenyl phenylacetamide non-nucleoside reverse transcriptase inihibitors
TW200831085A (en)	2006-12-13	2008-08-01	Merck & Co Inc	Non-nucleoside reverse transcriptase inhibitors
KR20100088142A (ko) *	2007-11-20	2010-08-06	머크 샤프 앤드 돔 코포레이션	비-뉴클레오사이드 역전사효소 억제제
HUE025336T2 (en) *	2010-03-30	2016-03-29	Merck Canada Inc	Non-nucleoside reverse transcriptase inhibitors

2011
- 2011-03-28 HU HUE11761856A patent/HUE025336T2/en unknown
- 2011-03-28 ME MEP-2015-76A patent/ME02181B/me unknown
- 2011-03-28 SG SG2012072401A patent/SG184347A1/en unknown
- 2011-03-28 AU AU2011235568A patent/AU2011235568B2/en active Active
- 2011-03-28 MX MX2012011379A patent/MX2012011379A/es active IP Right Grant
- 2011-03-28 MA MA35324A patent/MA34170B1/fr unknown
- 2011-03-28 DK DK11761856.1T patent/DK2552902T3/en active
- 2011-03-28 EP EP11761856.1A patent/EP2552902B1/en active Active
- 2011-03-28 RS RS20150340A patent/RS54017B1/sr unknown
- 2011-03-28 JP JP2012538161A patent/JP5281718B2/ja active Active
- 2011-03-28 HU HUE15157348A patent/HUE031785T2/en unknown
- 2011-03-28 ME MEP-2016-282A patent/ME02570B/me unknown
- 2011-03-28 LT LTEP15157348.2T patent/LT2924034T/lt unknown
- 2011-03-28 ES ES11761856.1T patent/ES2536295T3/es active Active
- 2011-03-28 PH PH1/2012/501923A patent/PH12012501923A1/en unknown
- 2011-03-28 US US13/073,631 patent/US8486975B2/en active Active
- 2011-03-28 CA CA2794377A patent/CA2794377C/en active Active
- 2011-03-28 KR KR1020127025733A patent/KR101421861B1/ko active Active
- 2011-03-28 DK DK15157348.2T patent/DK2924034T3/en active
- 2011-03-28 NZ NZ602670A patent/NZ602670A/en unknown
- 2011-03-28 HR HRP20150427TT patent/HRP20150427T1/hr unknown
- 2011-03-28 CN CN201180018074.2A patent/CN102971308B/zh active Active
- 2011-03-28 PE PE2012001823A patent/PE20130158A1/es active IP Right Grant
- 2011-03-28 PL PL15157348T patent/PL2924034T3/pl unknown
- 2011-03-28 ES ES15157348.2T patent/ES2609636T3/es active Active
- 2011-03-28 RS RS20161093A patent/RS55505B1/sr unknown
- 2011-03-28 MY MYPI2012004342A patent/MY163979A/en unknown
- 2011-03-28 GE GEAP201112882A patent/GEP20156368B/en unknown
- 2011-03-28 PT PT151573482T patent/PT2924034T/pt unknown
- 2011-03-28 PL PL11761856T patent/PL2552902T3/pl unknown
- 2011-03-28 EA EA201290976A patent/EA024804B1/ru active Protection Beyond IP Right Term
- 2011-03-28 SI SI201131054A patent/SI2924034T1/sl unknown
- 2011-03-28 PT PT117618561T patent/PT2552902E/pt unknown
- 2011-03-28 WO PCT/CA2011/000320 patent/WO2011120133A1/en not_active Ceased
- 2011-03-28 BR BR112012024691-7A patent/BR112012024691B1/pt active IP Right Grant
- 2011-03-28 SI SI201130491T patent/SI2552902T1/sl unknown
- 2011-03-28 EP EP15157348.2A patent/EP2924034B1/en active Active
- 2011-03-29 AR ARP110101028A patent/AR080859A1/es active IP Right Grant
- 2011-03-29 TW TW100110833A patent/TWI458719B/zh active
2012
- 2012-09-20 TN TNP2012000455A patent/TN2012000455A1/en unknown
- 2012-09-20 IL IL222030A patent/IL222030A/en active Protection Beyond IP Right Term
- 2012-09-27 HN HN2012002039A patent/HN2012002039A/es unknown
- 2012-09-28 DO DO2012000256A patent/DOP2012000256A/es unknown
- 2012-09-28 NI NI201200146A patent/NI201200146A/es unknown
- 2012-09-28 CL CL2012002744A patent/CL2012002744A1/es unknown
- 2012-10-01 EC ECSP12012201 patent/ECSP12012201A/es unknown
- 2012-10-01 CR CR20120503A patent/CR20120503A/es unknown
- 2012-10-01 CO CO12171897A patent/CO6630126A2/es active IP Right Grant
2013
- 2013-05-23 JP JP2013108533A patent/JP5886790B2/ja not_active Expired - Fee Related
- 2013-07-03 US US13/934,633 patent/US20130296382A1/en not_active Abandoned
2014
- 2014-06-23 IL IL233334A patent/IL233334A/en active IP Right Grant
2016
- 2016-12-09 HR HRP20161680TT patent/HRP20161680T1/hr unknown
2017
- 2017-01-25 CY CY20171100114T patent/CY1118774T1/el unknown
2019
- 2019-04-09 HU HUS1900021C patent/HUS1900021I1/hu unknown
- 2019-04-09 HU HUS1900022C patent/HUS1900022I1/hu unknown
- 2019-04-11 LT LTPA2019506 patent/LTC2552902I2/lt unknown
- 2019-04-11 LT LTPA2019507C patent/LTC2924034I2/lt unknown
- 2019-04-16 NL NL300980C patent/NL300980I2/nl unknown
- 2019-04-17 FI FIC20190021C patent/FIC20190021I1/fi unknown
- 2019-04-17 LU LU00114C patent/LUC00114I2/fr unknown
- 2019-04-17 LU LU00113C patent/LUC00113I9/fr unknown
- 2019-04-24 NO NO2019019C patent/NO2019019I1/no unknown
- 2019-04-24 NO NO2019018C patent/NO2019018I1/no unknown
- 2019-05-16 CY CY2019026C patent/CY2019026I2/el unknown
- 2019-05-16 CY CY2019025C patent/CY2019025I1/el unknown

Also Published As

Publication number	Publication date
MX2012011379A (es)	2012-11-30
CA2794377A1 (en)	2011-10-06
BR112012024691A2 (pt)	2019-07-02
HUE025336T2 (en)	2016-03-29
LUC00114I1 (2)	2019-04-17
HN2012002039A (es)	2015-08-24
IL233334A0 (en)	2014-09-01
LTPA2019506I1 (lt)	2019-04-25
CY2019025I2 (el)	2019-11-27
EP2924034A1 (en)	2015-09-30
NI201200146A (es)	2013-03-18
DOP2012000256A (es)	2012-12-15
JP2013209405A (ja)	2013-10-10
HUE031785T2 (en)	2017-08-28
RS54017B1 (sr)	2015-10-30
MA34170B1 (fr)	2013-04-03
RS55505B1 (sr)	2017-05-31
CO6630126A2 (es)	2013-03-01
KR20120128703A (ko)	2012-11-27
PT2924034T (pt)	2017-01-06
NL300980I2 (nl)	2021-06-17
DK2552902T3 (en)	2015-06-15
CN102971308A (zh)	2013-03-13
GEP20156368B (en)	2015-09-25
NO2019018I1 (no)	2019-04-24
HK1209121A1 (en)	2016-03-24
DK2924034T3 (en)	2017-02-06
IL222030A (en)	2014-07-31
WO2011120133A1 (en)	2011-10-06
AU2011235568B2 (en)	2013-09-12
CY1118774T1 (el)	2017-07-12
EA024804B1 (ru)	2016-10-31
CY2019026I1 (el)	2020-05-29
HUS1900021I1 (hu)	2019-05-28
BR112012024691B1 (pt)	2020-11-17
EA201290976A1 (ru)	2013-03-29
CA2794377C (en)	2015-06-16
TN2012000455A1 (en)	2014-01-30
TWI458719B (zh)	2014-11-01
ME02570B (me)	2017-06-20
CY2019026I2 (el)	2020-05-29
LUC00113I2 (2)	2024-05-22
JP5281718B2 (ja)	2013-09-04
PE20130158A1 (es)	2013-02-28
LUC00114I2 (2)	2020-07-10
SG184347A1 (en)	2012-11-29
NO2019019I1 (no)	2019-04-24
PL2552902T3 (pl)	2015-10-30
ECSP12012201A (es)	2012-10-30
PH12012501923A1 (en)	2013-02-04
SI2552902T1 (sl)	2015-10-30
CL2012002744A1 (es)	2012-12-14
FIC20190021I1 (fi)	2019-04-17
AR080859A1 (es)	2012-05-16
EP2552902A4 (en)	2013-09-04
CN102971308B (zh)	2015-02-04
CR20120503A (es)	2013-01-09
EP2924034B1 (en)	2016-11-02
LUC00113I9 (2)	2024-06-07
US20130296382A1 (en)	2013-11-07
PT2552902E (pt)	2015-06-02
HRP20150427T1 (hr)	2015-07-03
IL233334A (en)	2015-09-24
ES2609636T3 (es)	2017-04-21
EP2552902B1 (en)	2015-03-11
LTC2552902I2 (lt)	2019-12-10
TW201139409A (en)	2011-11-16
HK1175471A1 (en)	2013-07-05
LTC2924034I2 (lt)	2020-10-12
AU2011235568A1 (en)	2012-11-01
KR101421861B1 (ko)	2014-07-22
JP5886790B2 (ja)	2016-03-16
SI2924034T1 (sl)	2017-05-31
PL2924034T3 (pl)	2017-07-31
LTPA2019507I1 (lt)	2019-04-25
CY2019025I1 (el)	2019-11-27
HRP20161680T1 (hr)	2017-01-27
LT2924034T (lt)	2016-12-27
NL300980I1 (nl)	2019-04-24
JP2013510800A (ja)	2013-03-28
HUS1900022I1 (hu)	2019-05-28
MY163979A (en)	2017-11-15
ME02181B (me)	2015-10-20
NZ602670A (en)	2014-09-26
US8486975B2 (en)	2013-07-16
US20110245296A1 (en)	2011-10-06
EP2552902A1 (en)	2013-02-06

Publication	Publication Date	Title
ES2536295T3 (es)	2015-05-22	Inhibidores no nucleosídicos de la transcriptasa inversa
US20100113421A1 (en)	2010-05-06	Non-nucleoside reverse transcriptase inhibitors
ES2828951T3 (es)	2021-05-28	Profármacos de inhibidores de la transcriptasa inversa del VIH
JP2009504652A (ja)	2009-02-05	非ヌクレオシド逆転写酵素阻害剤
HK1175471B (en)	2015-08-21	Non-nucleoside reverse transcriptase inhibitors
HK1209121B (en)	2017-08-18	Pharmaceutical composition comprising a non-nucleoside reverse transcriptase inhibitor
HK40042531A (en)	2021-09-03	Prodrugs of hiv reverse transcriptase inhibitors