PL2552902T3 - Nienukleozydowe inhibitory odwrotnej transkryptazy - Google Patents

Nienukleozydowe inhibitory odwrotnej transkryptazy

Info

Publication number
PL2552902T3
PL2552902T3 PL11761856T PL11761856T PL2552902T3 PL 2552902 T3 PL2552902 T3 PL 2552902T3 PL 11761856 T PL11761856 T PL 11761856T PL 11761856 T PL11761856 T PL 11761856T PL 2552902 T3 PL2552902 T3 PL 2552902T3
Authority
PL
Poland
Prior art keywords
reverse transcriptase
transcriptase inhibitors
nucleoside reverse
nucleoside
inhibitors
Prior art date
Application number
PL11761856T
Other languages
English (en)
Inventor
Jason Burch
Bernard Cote
Natalie Nguyen
Chun Sing Li
Miguel St-Onge
Danny Gauvreau
Original Assignee
Merck Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44710363&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2552902(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Canada Inc filed Critical Merck Canada Inc
Publication of PL2552902T3 publication Critical patent/PL2552902T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL11761856T 2010-03-30 2011-03-28 Nienukleozydowe inhibitory odwrotnej transkryptazy PL2552902T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US31882410P 2010-03-30 2010-03-30
US32157310P 2010-04-07 2010-04-07
EP11761856.1A EP2552902B1 (en) 2010-03-30 2011-03-28 Non-nucleoside reverse transcriptase inhibitors
PCT/CA2011/000320 WO2011120133A1 (en) 2010-03-30 2011-03-28 Non-nucleoside reverse transcriptase inhibitors

Publications (1)

Publication Number Publication Date
PL2552902T3 true PL2552902T3 (pl) 2015-10-30

Family

ID=44710363

Family Applications (2)

Application Number Title Priority Date Filing Date
PL15157348T PL2924034T3 (pl) 2010-03-30 2011-03-28 Kompozycja farmaceutyczna zawierająca nienukleozydowy inhibitor odwrotnej transkryptazy
PL11761856T PL2552902T3 (pl) 2010-03-30 2011-03-28 Nienukleozydowe inhibitory odwrotnej transkryptazy

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL15157348T PL2924034T3 (pl) 2010-03-30 2011-03-28 Kompozycja farmaceutyczna zawierająca nienukleozydowy inhibitor odwrotnej transkryptazy

Country Status (44)

Country Link
US (2) US8486975B2 (pl)
EP (2) EP2552902B1 (pl)
JP (2) JP5281718B2 (pl)
KR (1) KR101421861B1 (pl)
CN (1) CN102971308B (pl)
AR (1) AR080859A1 (pl)
AU (1) AU2011235568B2 (pl)
BR (1) BR112012024691B1 (pl)
CA (1) CA2794377C (pl)
CL (1) CL2012002744A1 (pl)
CO (1) CO6630126A2 (pl)
CR (1) CR20120503A (pl)
CY (3) CY1118774T1 (pl)
DK (2) DK2924034T3 (pl)
DO (1) DOP2012000256A (pl)
EA (1) EA024804B1 (pl)
EC (1) ECSP12012201A (pl)
ES (2) ES2536295T3 (pl)
FI (1) FIC20190021I1 (pl)
GE (1) GEP20156368B (pl)
HN (1) HN2012002039A (pl)
HR (2) HRP20150427T1 (pl)
HU (4) HUE031785T2 (pl)
IL (2) IL222030A (pl)
LT (3) LT2924034T (pl)
LU (2) LUC00113I9 (pl)
MA (1) MA34170B1 (pl)
ME (2) ME02570B (pl)
MX (1) MX2012011379A (pl)
MY (1) MY163979A (pl)
NI (1) NI201200146A (pl)
NL (1) NL300980I2 (pl)
NO (2) NO2019019I1 (pl)
NZ (1) NZ602670A (pl)
PE (1) PE20130158A1 (pl)
PH (1) PH12012501923A1 (pl)
PL (2) PL2924034T3 (pl)
PT (2) PT2552902E (pl)
RS (2) RS55505B1 (pl)
SG (1) SG184347A1 (pl)
SI (2) SI2924034T1 (pl)
TN (1) TN2012000455A1 (pl)
TW (1) TWI458719B (pl)
WO (1) WO2011120133A1 (pl)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2924034T3 (pl) * 2010-03-30 2017-07-31 Merck Canada Inc. Kompozycja farmaceutyczna zawierająca nienukleozydowy inhibitor odwrotnej transkryptazy
CN103517990A (zh) 2010-10-07 2014-01-15 通用医疗公司 癌症生物标志物
WO2014052171A1 (en) * 2012-09-26 2014-04-03 Merck Sharp & Dohme Corp. Crystalline form of a reverse transcriptase inhibitor
JO3470B1 (ar) * 2012-10-08 2020-07-05 Merck Sharp & Dohme مشتقات 5- فينوكسي-3h-بيريميدين-4-أون واستخدامها كمثبطات ناسخ عكسي ل hiv
CA2892919A1 (en) * 2012-12-05 2014-06-12 Merck Sharp & Dohme Corp. Process for making reverse transcriptase inhibitors
RU2661399C1 (ru) * 2013-11-22 2018-07-16 Мерк Шарп И Доум Корп. Композиция ненуклеозидного ингибитора обратной транскриптазы
EP3077376B1 (en) * 2013-12-04 2019-10-16 Merck Sharp & Dohme Corp. Process for making reverse transcriptase inhibitors
EP3785714A1 (en) * 2014-04-01 2021-03-03 Merck Sharp & Dohme Corp. Prodrugs of hiv reverse transcriptase inhibitors
EP3760208B1 (en) 2014-06-25 2024-05-29 The General Hospital Corporation Targeting human satellite ii (hsatii)
RS62466B1 (sr) 2015-12-02 2021-11-30 Merck Sharp & Dohme Farmaceutske kompozicije koje sadrže doravirin, tenofovir dizoproksil fumarat i lamivudin
US11077050B2 (en) 2017-03-24 2021-08-03 Merck Sharp & Dohme Corp. Formulation for parenteral administration
AU2018255954B2 (en) 2017-04-18 2024-04-04 Cipla Limited Combination therapy for use in treating retroviral infections
US20210213041A1 (en) 2018-02-06 2021-07-15 The General Hospital Corporation Repeat rna as biomarkers of tumor immune response
EP3823632B1 (en) * 2018-07-17 2025-10-29 Merck Sharp & Dohme LLC Efda in combination with doravirine for use in treating f227c mutated hiv infections
EP3898595B1 (en) 2018-12-18 2024-05-01 Merck Sharp & Dohme LLC Pyrimidone derivatives as selective cytotoxic agents against hiv infected cells
CN110801455B (zh) * 2019-11-12 2020-06-02 河北医科大学第二医院 用于治疗mrsa的药物组合物及其应用
CN114163309B (zh) * 2021-12-27 2023-04-25 甘肃皓天医药科技有限责任公司 一种多拉韦林中间体的制备方法
CN114349690B (zh) * 2022-02-15 2023-04-25 甘肃皓天医药科技有限责任公司 一种多拉韦林中间体合成方法
CN116903590A (zh) * 2023-06-06 2023-10-20 延边大学 一种含杂环结构的吡啶酮类化合物及其制备方法和用途
CN120157613A (zh) * 2023-12-15 2025-06-17 山东诚创蓝海医药科技有限公司 多拉韦林中间体及其应用和合成方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9904045D0 (sv) 1999-11-09 1999-11-09 Astra Ab Compounds
TW200423930A (en) * 2003-02-18 2004-11-16 Hoffmann La Roche Non-nucleoside reverse transcriptase inhibitors
TW200505441A (en) * 2003-03-24 2005-02-16 Hoffmann La Roche Non-nucleoside reverse transcriptase inhibitorsⅠ
KR20050119652A (ko) 2003-03-24 2005-12-21 에프. 호프만-라 로슈 아게 역전사 효소 저해제로서의 벤질-피리다진온
CN1946680B (zh) 2004-04-23 2011-04-06 弗·哈夫曼-拉罗切有限公司 非核苷逆转录酶抑制剂
US7166738B2 (en) 2004-04-23 2007-01-23 Roche Palo Alto Llc Non-nucleoside reverse transcriptase inhibitors
EP1831157A2 (en) 2004-12-22 2007-09-12 Pfizer Limited Nonnucleoside inhibitors of hiv-1 reverse transcriptase
AR057455A1 (es) 2005-07-22 2007-12-05 Merck & Co Inc Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica
EP1940781A1 (en) 2005-10-19 2008-07-09 F.Hoffmann-La Roche Ag Phenyl-acetamide nnrt inhibitors
CN101287702A (zh) 2005-10-19 2008-10-15 弗·哈夫曼-拉罗切有限公司 N-苯基苯乙酰胺非核苷逆转录酶抑制剂
TW200831085A (en) 2006-12-13 2008-08-01 Merck & Co Inc Non-nucleoside reverse transcriptase inhibitors
KR20100088142A (ko) * 2007-11-20 2010-08-06 머크 샤프 앤드 돔 코포레이션 비-뉴클레오사이드 역전사효소 억제제
PL2924034T3 (pl) * 2010-03-30 2017-07-31 Merck Canada Inc. Kompozycja farmaceutyczna zawierająca nienukleozydowy inhibitor odwrotnej transkryptazy

Also Published As

Publication number Publication date
BR112012024691B1 (pt) 2020-11-17
SG184347A1 (en) 2012-11-29
PE20130158A1 (es) 2013-02-28
CO6630126A2 (es) 2013-03-01
AU2011235568A1 (en) 2012-11-01
PH12012501923A1 (en) 2013-02-04
NO2019018I1 (no) 2019-04-24
GEP20156368B (en) 2015-09-25
HUS1900022I1 (hu) 2019-05-28
LTPA2019507I1 (lt) 2019-04-25
SI2552902T1 (sl) 2015-10-30
EP2924034A1 (en) 2015-09-30
CR20120503A (es) 2013-01-09
KR20120128703A (ko) 2012-11-27
CY2019026I2 (el) 2020-05-29
CA2794377A1 (en) 2011-10-06
JP5886790B2 (ja) 2016-03-16
DK2924034T3 (en) 2017-02-06
NL300980I1 (nl) 2019-04-24
EP2552902A1 (en) 2013-02-06
US20110245296A1 (en) 2011-10-06
CY2019026I1 (el) 2020-05-29
ME02181B (me) 2015-10-20
SI2924034T1 (sl) 2017-05-31
PT2552902E (pt) 2015-06-02
CY1118774T1 (el) 2017-07-12
LTC2552902I2 (lt) 2019-12-10
TN2012000455A1 (en) 2014-01-30
DK2552902T3 (en) 2015-06-15
MA34170B1 (fr) 2013-04-03
BR112012024691A2 (pt) 2019-07-02
LUC00114I1 (pl) 2019-04-17
CN102971308A (zh) 2013-03-13
LTC2924034I2 (lt) 2020-10-12
RS54017B1 (sr) 2015-10-30
AR080859A1 (es) 2012-05-16
JP2013209405A (ja) 2013-10-10
US20130296382A1 (en) 2013-11-07
DOP2012000256A (es) 2012-12-15
IL233334A0 (en) 2014-09-01
LUC00113I2 (pl) 2024-05-22
MX2012011379A (es) 2012-11-30
CN102971308B (zh) 2015-02-04
EA024804B1 (ru) 2016-10-31
HUE031785T2 (en) 2017-08-28
HUS1900021I1 (hu) 2019-05-28
EP2552902B1 (en) 2015-03-11
HRP20161680T1 (hr) 2017-01-27
EP2552902A4 (en) 2013-09-04
HRP20150427T1 (hr) 2015-07-03
JP5281718B2 (ja) 2013-09-04
LT2924034T (lt) 2016-12-27
NI201200146A (es) 2013-03-18
KR101421861B1 (ko) 2014-07-22
HUE025336T2 (en) 2016-03-29
HK1175471A1 (en) 2013-07-05
NZ602670A (en) 2014-09-26
NL300980I2 (nl) 2021-06-17
MY163979A (en) 2017-11-15
CA2794377C (en) 2015-06-16
FIC20190021I1 (fi) 2019-04-17
AU2011235568B2 (en) 2013-09-12
TWI458719B (zh) 2014-11-01
LUC00114I2 (pl) 2020-07-10
ES2536295T3 (es) 2015-05-22
CY2019025I2 (el) 2019-11-27
PT2924034T (pt) 2017-01-06
IL233334A (en) 2015-09-24
WO2011120133A1 (en) 2011-10-06
EA201290976A1 (ru) 2013-03-29
IL222030A (en) 2014-07-31
CY2019025I1 (el) 2019-11-27
JP2013510800A (ja) 2013-03-28
EP2924034B1 (en) 2016-11-02
ME02570B (me) 2017-06-20
US8486975B2 (en) 2013-07-16
TW201139409A (en) 2011-11-16
ECSP12012201A (es) 2012-10-30
HK1209121A1 (en) 2016-03-24
HN2012002039A (es) 2015-08-24
RS55505B1 (sr) 2017-05-31
LUC00113I9 (pl) 2024-06-07
NO2019019I1 (no) 2019-04-24
CL2012002744A1 (es) 2012-12-14
LTPA2019506I1 (lt) 2019-04-25
PL2924034T3 (pl) 2017-07-31
ES2609636T3 (es) 2017-04-21

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