ES2540057T3 - Composiciones líquidas que comprenden fenilefrina y acetaminofeno y su uso en el tratamiento de enfermedades respiratorias - Google Patents

Composiciones líquidas que comprenden fenilefrina y acetaminofeno y su uso en el tratamiento de enfermedades respiratorias Download PDF

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Publication number
ES2540057T3
ES2540057T3 ES07735699.6T ES07735699T ES2540057T3 ES 2540057 T3 ES2540057 T3 ES 2540057T3 ES 07735699 T ES07735699 T ES 07735699T ES 2540057 T3 ES2540057 T3 ES 2540057T3
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Prior art keywords
acetaminophen
phenylephrine
treatment
liquid compositions
respiratory diseases
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ES07735699.6T
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ES2540057T5 (es
Inventor
Kelly Lee Martin
Susan Elaine Criss
Douglas William Gledhill
Aloysius Ike Ononye
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Procter and Gamble Co
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Procter and Gamble Co
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Publication of ES2540057T3 publication Critical patent/ES2540057T3/es
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Una composición líquida que comprende una sustancia farmacéuticamente activa seleccionada de fenilefrina, sus formas libre y de sal de adición, y mezclas de las mismas; y acetaminofeno, estando caracterizada la composición por un pH de 6,75 a 7,5.

Description

imagen1
imagen2
imagen3
imagen4
imagen5
imagen6
E07735699
22-06-2015
Ejemplo 1
Se ilustran a continuación varios ejemplos de composiciones de la presente invención. Todos los ejemplos siguientes tendrán un pH de aproximadamente 7,1.
Descripción del material
% p/p % p/p % p/p % p/p % p/p
Premezcla de glicol
Propilenglicol USP
16 16 12 8 16
Polietilenglicol 400 NF
0 4 8 8 8
Sorbitol
8 4 4 8 0
Acetaminofeno USP
1,78 1,78 1,78 1,78 1,78
Dextrometorfano HBr USP
0,05 0,05 0,05 0,05 0,05
Sabor
0,30 0,30 0,30 0,30 0,31
Premezcla de agua
Agua purificada USP
6,6 4 8 8 6,6
Citrato sódico hidratado USP
1,6 1,6 1,6 1,6 1,6
Fenilefrina
0,033 0,033 0,033 0,033 0,033
Ácido cítrico anhidro USP
0,02 0,02 0,02 0,02 0,02
Sacarina sódica USP
0,08 0,08 0,08 0,08 0,08
Color
0,06 0,06 0,06 0,06 0,06
Glicerina USP
4 8 16 12 4,1
Azúcar líquido n.°1
53,8 49 40 45 53,8
Agua purificada USP
c.s. c.s. c.s. c.s. c.s.
Propilenglicol comercializado por Dow Chemical Corp. Plaqremine, LA, EE. UU. Dextrometorfano HBr comercializado por Hoffman-LaRoche, Branchburg, NJ, EE. UU. Acetaminofeno comercializado por Mallinckrodt, Raleigh, NC, EE. UU.
10 Glicerina comercializada por Procter & Gamble Company, Cincinnati, OH, EE. UU. Citrato sódico comercializado por Hoffman-LaRoche, Branchburg, NJ, EE. UU. Ácido cítrico comercializado por ADM, Cork, Ireland Fenilefrina HCL comercializada por Iwaki, Ku Tokyo, Japan Sacarina sódica comercializada por PMC Specialties grupo, Inc., Cincinnati, OH, EE. UU.
15 Azúcar líquido comercializado por Imperial Sugar, Port Wentworth, CA, EE. UU.
8

Claims (1)

  1. imagen1
ES07735699.6T 2006-04-28 2007-04-27 Composiciones líquidas que comprenden fenilefrina y acetaminofeno y su uso en el tratamiento de enfermedades respiratorias Active ES2540057T5 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/413,766 US20070254027A1 (en) 2006-04-28 2006-04-28 Compositions and methods useful for treatment of respiratory illness
US413766 2006-04-28
PCT/IB2007/051583 WO2007125501A2 (en) 2006-04-28 2007-04-27 Liquid compositions comprising phenylephrine and acetaminophen and their use for the treatment of respiratory illness

Publications (2)

Publication Number Publication Date
ES2540057T3 true ES2540057T3 (es) 2015-07-08
ES2540057T5 ES2540057T5 (es) 2018-07-03

Family

ID=38480519

Family Applications (1)

Application Number Title Priority Date Filing Date
ES07735699.6T Active ES2540057T5 (es) 2006-04-28 2007-04-27 Composiciones líquidas que comprenden fenilefrina y acetaminofeno y su uso en el tratamiento de enfermedades respiratorias

Country Status (11)

Country Link
US (1) US20070254027A1 (es)
EP (1) EP2012765B2 (es)
JP (1) JP2009534372A (es)
CN (1) CN101431991B (es)
AU (1) AU2007245300B2 (es)
BR (1) BRPI0711065A2 (es)
CA (1) CA2649997C (es)
ES (1) ES2540057T5 (es)
MX (1) MX2008013664A (es)
PL (1) PL2012765T5 (es)
WO (1) WO2007125501A2 (es)

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US8518439B2 (en) * 2008-12-03 2013-08-27 Novartis Ag Liquid therapeutic composition
BR112012026314A2 (pt) * 2010-04-12 2016-11-29 Univ Singapore biomarcador para função renal em pacientes com diabetes do tipo 2
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Also Published As

Publication number Publication date
US20070254027A1 (en) 2007-11-01
EP2012765B1 (en) 2015-03-25
PL2012765T3 (pl) 2015-08-31
BRPI0711065A2 (pt) 2011-08-23
AU2007245300B2 (en) 2012-06-07
CN101431991A (zh) 2009-05-13
MX2008013664A (es) 2008-11-04
WO2007125501A2 (en) 2007-11-08
EP2012765A2 (en) 2009-01-14
PL2012765T5 (pl) 2018-09-28
JP2009534372A (ja) 2009-09-24
CN101431991B (zh) 2012-04-04
CA2649997A1 (en) 2007-11-08
WO2007125501A3 (en) 2008-01-10
CA2649997C (en) 2012-11-20
AU2007245300A1 (en) 2007-11-08
EP2012765B2 (en) 2018-04-11
ES2540057T5 (es) 2018-07-03

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