ES2543383T3 - Tratamiento de tumores de mama con un derivado de rapamicina en combinación con exemestano - Google Patents

Tratamiento de tumores de mama con un derivado de rapamicina en combinación con exemestano Download PDF

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Publication number
ES2543383T3
ES2543383T3 ES10174983.6T ES10174983T ES2543383T3 ES 2543383 T3 ES2543383 T3 ES 2543383T3 ES 10174983 T ES10174983 T ES 10174983T ES 2543383 T3 ES2543383 T3 ES 2543383T3
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Prior art keywords
combination
administration
treatment
exemestane
rapamycin
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ES10174983.6T
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English (en)
Inventor
Heidi Lane
Terence O'reilly
Jeanette Marjorie Wood
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Novartis AG
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Novartis AG
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Priority claimed from GB0104072A external-priority patent/GB0104072D0/en
Priority claimed from GB0124957A external-priority patent/GB0124957D0/en
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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Abstract

40-O-(2-hidroxietil)-rapamicina en combinación con exemestano para su uso en el tratamiento de tumores positivos a receptores hormonales, en donde el tumor positivo a receptores hormonales es un tumor mamario.

Description

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E10174983
22-07-2015
Con las expresiones "coadministración" o "administración combinada" o similares, como se utilizan en el presente documento se pretende abarcar la administración de los agentes terapéuticos seleccionados a un solo paciente y se pretende incluir regímenes de tratamiento en los que los agentes no necesariamente se administran por la misma vía de administración o al mismo tiempo.
Es un objetivo de esta invención proporcionar una composición farmacéutica que comprenda una cantidad, que sea conjuntamente terapéuticamente eficaz contra una enfermedad proliferativa maligna, que comprenda una combinación de la invención. En esta composición, el primer agente a) y el coagente (b) se pueden administrar juntos, uno o después del otro, o por separado en una forma de dosificación unitaria combinada o en dos formas de dosificación unitaria separadas. La forma de dosificación unitaria también puede ser una combinación fija.
Las composiciones farmacéuticas para la administración separada del primer agente a) y el coagente b) y para la administración en una combinación fija, es decir, una sola composición galénica que comprende al menos dos componentes de combinación a) y b), de acuerdo con la invención, se pueden preparar de una manera conocida por sí misma, y son aquellas adecuadas para administración enteral, tal como oral o rectal, y parenteral a mamíferos (animales de sangre caliente), incluyendo seres humanos, comprendiendo una cantidad terapéuticamente eficaz de al menos un componente de combinación farmacológicamente activo solo, por ejemplo como se ha indicado anteriormente, o en combinación con uno o más vehículos o diluyentes farmacéuticamente aceptables, especialmente adecuados para la aplicación enteral o parenteral.
Las composiciones farmacéuticas adecuadas contienen, por ejemplo, de aproximadamente 0,1 % a aproximadamente 99,9 %, preferentemente de aproximadamente 1 % a aproximadamente 60 % de los ingredientes activos. Las preparaciones farmacéuticas para la terapia de combinación para administración enteral o parenteral son, por ejemplo, aquellas que están en formas de dosificación unitaria, tales como comprimidos recubiertos con azúcar, comprimidos, cápsulas o supositorios, o ampollas. Salvo que se indique lo contrario, estas se preparan de una manera conocida por sí misma, por ejemplo, por medio de procesos convencionales de mezcla, granulación, recubrimiento con azúcar, disolución o Iiofilización. Se apreciará que el contenido unitario de un componente de combinación contenido en una dosis individual de cada forma de dosificación no necesita en sí mismo constituir una cantidad eficaz, debido a que se puede alcanzar la cantidad eficaz necesaria mediante la administración de una pluralidad de unidades de dosificación.
En particular, se puede administrar una cantidad terapéuticamente eficaz de cada uno de los componentes de combinación de la combinación de la invención de una manera simultánea o secuencial y en cualquier orden, y los componentes se pueden administrar por separado o como una combinación fija. Por ejemplo, el método de ralentización de la progresión o tratamiento de una enfermedad proliferativa maligna de acuerdo con la invención, puede comprender: (i) la administración del primer agente a) en una forma libre o de sal farmacéuticamente aceptable, y (ii) la administración de un coagente b) en una forma libre o de sal farmacéuticamente aceptable, de una manera simultánea o secuencial en cualquier orden, en cantidades conjuntamente eficaces terapéuticamente, preferentemente en cantidades sinérgicamente eficaces, por ejemplo en dosificaciones diarias o intermitentes correspondientes a las cantidades descritas en el presente documento. Los componentes de combinación individuales de la combinación de la invención se pueden administrar por separado en diferentes tiempos durante el curso de la terapia, o de una manera concurrente en formas de combinación divididas o individuales. Además, el término "administrar" también abarca el uso de un profármaco de un componente de combinación que se convierta ín vivo en el componente de combinación como tal. Por consiguiente, se debe entender que la presente invención abarca todos estos regímenes de tratamiento simultáneo o alternado y que el término "administrar" debe interpretarse de conformidad con lo mismo.
La dosificación efectiva de cada uno de los componentes de combinación empleados en la combinación de la invención puede variar dependiendo del compuesto o composición farmacéutica particular empleada, del modo de administración, de la afección que se esté tratando, de la gravedad de la afección que se esté tratando. Por consiguiente, el régimen de dosificación de la combinación de la invención se selecciona de acuerdo con diversos factores, incluyendo la vía de administración, y la función renal y hepática del paciente. Un médico, clínico, o veterinario de experiencia ordinaria puede determinar y prescribir fácilmente la cantidad eficaz de los ingredientes activos individuales requerida para prevenir, contrarrestar o detener la progresión de la afección. La precisión óptima para alcanzar la concentración de los ingredientes activos dentro del intervalo que produzca eficacia sin toxicidad requiere de un régimen basado en la cinética de la disponibilidad de los ingredientes activos en los sitios objetivo.
Las dosificaciones diarias para el primer agente a) por supuesto, variarán dependiendo de diversos factores, por ejemplo del compuesto seleccionado, de la afección particular que se vaya a tratar y del efecto deseado. Sin embargo, en general se logran resultados satisfactorios con la administración del Compuesto A a índices de dosificación diaria del orden de aproximadamente 0,1 a 25 miligramos como una sola dosis o en dosis divididas. El Compuesto A se puede administrar mediante por cualquier vía convencional, en particular por vía enteral, por ejemplo por vía oral, por ejemplo en forma de comprimidos, cápsulas, soluciones para beber, o por vía parenteral, por ejemplo en forma de soluciones o suspensiones inyectables. Las formas de dosificación unitaria adecuadas para administración oral comprenden de aproximadamente 0,05 a 10 miligramos de ingrediente activo, el Compuesto A, junto con uno o más diluyentes o vehículos farmacéuticamente aceptables para el mismo.
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Claims (1)

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ES10174983.6T 2001-02-19 2002-02-18 Tratamiento de tumores de mama con un derivado de rapamicina en combinación con exemestano Expired - Lifetime ES2543383T3 (es)

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GB0104072A GB0104072D0 (en) 2001-02-19 2001-02-19 Organic compounds
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ES14164259.5T Expired - Lifetime ES2640787T3 (es) 2001-02-19 2002-02-18 Combinación de un derivado de rapamicina y letrozol para tratar el cáncer de mama
ES18155724T Expired - Lifetime ES2744377T3 (es) 2001-02-19 2002-02-18 Derivado de rapamicina para tratar cáncer de páncreas
ES10174983.6T Expired - Lifetime ES2543383T3 (es) 2001-02-19 2002-02-18 Tratamiento de tumores de mama con un derivado de rapamicina en combinación con exemestano
ES18155722T Expired - Lifetime ES2921798T3 (es) 2001-02-19 2002-02-18 Derivado de rapamicina para el tratamiento de tumores sólidos
ES14164565.5T Expired - Lifetime ES2629317T3 (es) 2001-02-19 2002-02-18 Tratamiento de tumores cerebrales sólidos con un derivado de rapamicina
ES18155644T Expired - Lifetime ES2728739T3 (es) 2001-02-19 2002-02-18 Derivado de rapamicina para el tratamiento de un tumor sólido asociado con angiogénesis desregulada
ES10174985.1T Expired - Lifetime ES2600304T3 (es) 2001-02-19 2002-02-18 Tratamiento de tumores sólidos de riñón con un derivado de rapamicina
ES16186041T Expired - Lifetime ES2705016T3 (es) 2001-02-19 2002-02-18 Derivado de rapamicina para el tratamiento de cáncer de pulmón

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ES18155724T Expired - Lifetime ES2744377T3 (es) 2001-02-19 2002-02-18 Derivado de rapamicina para tratar cáncer de páncreas

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ES18155722T Expired - Lifetime ES2921798T3 (es) 2001-02-19 2002-02-18 Derivado de rapamicina para el tratamiento de tumores sólidos
ES14164565.5T Expired - Lifetime ES2629317T3 (es) 2001-02-19 2002-02-18 Tratamiento de tumores cerebrales sólidos con un derivado de rapamicina
ES18155644T Expired - Lifetime ES2728739T3 (es) 2001-02-19 2002-02-18 Derivado de rapamicina para el tratamiento de un tumor sólido asociado con angiogénesis desregulada
ES10174985.1T Expired - Lifetime ES2600304T3 (es) 2001-02-19 2002-02-18 Tratamiento de tumores sólidos de riñón con un derivado de rapamicina
ES16186041T Expired - Lifetime ES2705016T3 (es) 2001-02-19 2002-02-18 Derivado de rapamicina para el tratamiento de cáncer de pulmón

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Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1158985B1 (en) 1999-01-13 2011-12-28 Bayer HealthCare LLC OMEGA-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
MX368013B (es) * 2001-02-19 2019-09-13 Novartis Ag Tratamiento de cáncer.
PL367267A1 (en) * 2001-06-01 2005-02-21 Wyeth Antineoplastic combinations
SI1478358T1 (sl) 2002-02-11 2013-09-30 Bayer Healthcare Llc Sorafenib tozilat za zdravljenje bolezni, značilnih po abnormalni angiogenezi
US8383605B2 (en) * 2002-07-30 2013-02-26 Aeterna Zentaris Gmbh Use of alkylphosphocholines in combination with antimetabolites for the treatment of benign and malignant oncoses in humans and mammals
JP2005535688A (ja) 2002-07-30 2005-11-24 ツェンタリス ゲゼルシャフト ミット ベシュレンクテル ハフツング 抗腫瘍医薬との組合せにおけるアルキルホスホコリンの使用
US7846141B2 (en) 2002-09-03 2010-12-07 Bluesky Medical Group Incorporated Reduced pressure treatment system
CA2501610C (en) * 2002-10-11 2012-01-03 Dana-Farber Cancer Institute Inc Epothilone derivatives for the treatment of multiple myeloma
US7557129B2 (en) 2003-02-28 2009-07-07 Bayer Healthcare Llc Cyanopyridine derivatives useful in the treatment of cancer and other disorders
UA83484C2 (uk) * 2003-03-05 2008-07-25 Уайт Спосіб лікування раку грудей комбінацією похідного рапаміцину і інгібітора ароматази - летрозолу, фармацевтична композиція
EP1636585B2 (en) 2003-05-20 2012-06-13 Bayer HealthCare LLC Diaryl ureas with kinase inhibiting activity
EP1663978B1 (en) 2003-07-23 2007-11-28 Bayer Pharmaceuticals Corporation Fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions
KR20060085246A (ko) 2003-09-18 2006-07-26 마커사이트, 인코포레이티드 경공막 전달
EP1721007A2 (en) * 2004-02-23 2006-11-15 Novartis AG P53 wild-type as biomarker for the treatment with mtor inhibitors in combination with a cytotoxic agent
GB0406446D0 (en) * 2004-03-23 2004-04-28 Astrazeneca Ab Combination therapy
MXPA06010755A (es) * 2004-03-23 2006-12-15 Astrazeneca Ab Terapia de combinacion.
DK1848431T3 (en) 2005-02-09 2016-04-18 Santen Pharmaceutical Co Ltd LIQUID FORMULATIONS FOR TREATMENT OF DISEASES OR CONDITIONS
US20090035276A1 (en) 2005-03-07 2009-02-05 Robarts Research Institute Use of a combination of myxoma virus and rapamycin for therapeutic treatment
GB0504994D0 (en) * 2005-03-11 2005-04-20 Biotica Tech Ltd Novel compounds
US20100061994A1 (en) * 2005-03-11 2010-03-11 Rose Mary Sheridan Medical uses of 39-desmethoxyrapamycin and analogues thereof
GB0504995D0 (en) * 2005-03-11 2005-04-20 Biotica Tech Ltd Use of a compound
GB0507918D0 (en) 2005-04-19 2005-05-25 Novartis Ag Organic compounds
JP2009501765A (ja) * 2005-07-20 2009-01-22 ノバルティス アクチエンゲゼルシャフト ピリミジルアミノベンズアミドとｍＴＯＲキナーゼ阻害剤の組み合わせ
WO2007059106A2 (en) 2005-11-14 2007-05-24 Ariad Gene Therapeutics, Inc. Administration of mntor inhibitor to treat patients with cancer
NO20220050A1 (no) * 2005-11-21 2008-08-12 Novartis Ag Neuroendokrin tumorbehandling
KR20080090493A (ko) 2006-02-02 2008-10-08 노파르티스 아게 결절성 경화증의 치료
GB0602123D0 (en) * 2006-02-02 2006-03-15 Novartis Ag Organic compounds
KR20140093764A (ko) 2006-02-09 2014-07-28 산텐 세이야꾸 가부시키가이샤 안정한 제제와 그 제조 및 사용 방법
ES2563288T3 (es) 2006-03-23 2016-03-14 Santen Pharmaceutical Co., Ltd Rapamicina en dosis bajas para el tratamiento de enfermedades relacionadas con la permeabilidad vascular
US20090098137A1 (en) * 2006-04-05 2009-04-16 Novartis Ag Combinations of therapeutic agents for treating cancer
EP2056808A4 (en) * 2006-08-28 2009-12-23 Univ California Small molecule potentiator of hormonal therapy for breast cancer
US9820888B2 (en) 2006-09-26 2017-11-21 Smith & Nephew, Inc. Wound dressing
EP2131821B1 (en) * 2007-03-07 2018-05-09 Abraxis BioScience, LLC Nanoparticle comprising rapamycin and albumin as anticancer agent
US8642067B2 (en) 2007-04-02 2014-02-04 Allergen, Inc. Methods and compositions for intraocular administration to treat ocular conditions
CN101292980B (zh) * 2007-04-28 2010-11-10 上海交通大学医学院附属仁济医院 一种含有雷帕霉素的用于治疗大肠癌的药物组合物
WO2009022190A1 (en) * 2007-08-16 2009-02-19 Biocompatibles Uk Limited Delivery of drug combinations
US20090149511A1 (en) * 2007-10-30 2009-06-11 Syndax Pharmaceuticals, Inc. Administration of an Inhibitor of HDAC and an mTOR Inhibitor
US8298200B2 (en) 2009-06-01 2012-10-30 Tyco Healthcare Group Lp System for providing continual drainage in negative pressure wound therapy
WO2009126965A2 (en) * 2008-04-11 2009-10-15 The Regents Of The University Of Colorado Compositions, methods and uses for modulations of brca1
EP2318529B1 (en) * 2008-08-04 2017-10-18 Five Prime Therapeutics, Inc. Fgfr extracellular domain acidic region muteins
GB0902368D0 (en) 2009-02-13 2009-04-01 Smith & Nephew Wound packing
GB0922332D0 (en) 2009-12-22 2010-02-03 Isis Innovation Method of treatment and screening method
US8791315B2 (en) 2010-02-26 2014-07-29 Smith & Nephew, Inc. Systems and methods for using negative pressure wound therapy to manage open abdominal wounds
WO2011123691A1 (en) 2010-03-31 2011-10-06 Keryx Biopharmaceuticals, Inc. Perifosine and capecitabine as a combined treatment for cancer
AU2011290672B2 (en) 2010-08-20 2015-07-09 Novartis Ag Antibodies for epidermal growth factor receptor 3 (HER3)
EP3590538A1 (en) * 2011-12-05 2020-01-08 Novartis AG Antibodies for epidermal growth factor receptor 3 (her3)
CN107095739B (zh) 2012-05-23 2020-11-13 史密夫及内修公开有限公司 用于负压伤口治疗的装置和方法
EP4699626A3 (en) 2012-08-01 2026-05-06 Smith & Nephew plc Wound dressing and method of treatment
HUE033329T2 (en) 2012-08-01 2017-11-28 Smith & Nephew Wound dressing
EP2968648B1 (en) 2013-03-15 2020-12-23 Smith & Nephew plc Wound dressing and method of treatment
US10682415B2 (en) 2013-07-22 2020-06-16 Wisconsin Alumni Research Foundation Thermogel formulation for combination drug delivery
WO2016066608A1 (en) 2014-10-28 2016-05-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for treatment of pulmonary cell senescence and peripheral aging
JP6623745B2 (ja) * 2015-06-29 2019-12-25 富士通株式会社 電子回路及び発振器の制御方法
SMT202100712T1 (it) * 2015-08-17 2022-01-10 Kura Oncology Inc Metodi di trattamento di pazienti di cancro con inibitori di farnesil trasferasi
EP3429583A1 (en) * 2016-03-15 2019-01-23 Tyme, Inc. Pharmaceutical compositions for the treatment of cancer
US20200081010A1 (en) 2016-12-02 2020-03-12 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and compositions for diagnosing renal cell carcinoma
ES2914123T3 (es) 2017-01-09 2022-06-07 Shuttle Pharmaceuticals Inc Inhibidores selectivos de la histona desacetilasa para el tratamiento de una enfermedad humana
US11584733B2 (en) 2017-01-09 2023-02-21 Shuttle Pharmaceuticals, Inc. Selective histone deacetylase inhibitors for the treatment of human disease
JP7217241B2 (ja) 2017-06-30 2023-02-02 ティージェイ スミス アンド ネフュー リミテッド 陰圧創傷治療装置
AR112834A1 (es) 2017-09-26 2019-12-18 Novartis Ag Derivados de rapamicina
WO2019089556A1 (en) * 2017-10-31 2019-05-09 Steve Gorlin Combinations of chemotherapeutic agents and antimicrobial particles and uses thereof
CN112004537A (zh) 2018-01-09 2020-11-27 穿梭药业公司 用于治疗人疾病的选择性组蛋白去乙酰化酶抑制剂
MX2020011565A (es) 2018-05-01 2021-01-29 Revolution Medicines Inc Analogos de rapamicina ligados a c40, c28 y c-32 como inhibidores de mtor.
IL312291A (en) 2018-05-01 2024-06-01 Revolution Medicines Inc C-26-linked rapamycin analogs as MTOR inhibitors
CN108825638A (zh) * 2018-08-01 2018-11-16 安徽送变电工程有限公司 一种应用于螺纹工件的防盗装置
HRP20250197T1 (hr) 2018-12-18 2025-04-11 Novartis Ag Derivati rapamicina
GB201905780D0 (en) 2019-04-25 2019-06-05 La Thangue Nicholas Cancer therapy
WO2020232227A1 (en) 2019-05-14 2020-11-19 Tyme, Inc. Compositions and methods for treating cancer
US10905698B1 (en) 2020-05-14 2021-02-02 Tyme, Inc. Methods of treating SARS-COV-2 infections
EP4417205A4 (en) 2021-10-14 2025-10-22 Pharos Ibio Co Ltd COMPOSITION FOR COMBINATION THERAPY COMPRISING A 2,3,5-SUBSTITUTED THIOPHENE COMPOUND
IL317056A (en) 2022-05-18 2025-01-01 Hadasit Med Res Service Combining endocannabinoid and MTOR inhibitors in the treatment of neuroendocrine tumors
CA3256390A1 (en) 2022-05-25 2023-11-30 Revolution Medicines, Inc. CANCER TREATMENT METHODS USING AN MTOR INHIBITOR

Family Cites Families (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US876165A (en) 1904-05-11 1908-01-07 George K Woodworth Wireless telegraph transmitting system.
GB104072A (en) 1916-04-14 1917-02-22 William Henry Nosworthy Apparatus for Lighting Fires or Heating or other purposes.
GB124957A (en) 1918-06-04 1919-04-10 Frederick William Miller Improvement in Glass Moulding.
GB1524747A (en) 1976-05-11 1978-09-13 Ici Ltd Polypeptide
US5206018A (en) * 1978-11-03 1993-04-27 Ayerst, Mckenna & Harrison, Inc. Use of rapamycin in treatment of tumors
US5066493A (en) * 1978-11-03 1991-11-19 American Home Products Corporation Rapamycin in treatment of tumors
BE877700A (fr) * 1978-11-03 1980-01-14 Ayerst Mckenna & Harrison Compositions pharmaceutiques a base de rapamycine pour le traitement de tumeurs carcinogenes
US4885171A (en) * 1978-11-03 1989-12-05 American Home Products Corporation Use of rapamycin in treatment of certain tumors
ATE28864T1 (de) 1982-07-23 1987-08-15 Ici Plc Amide-derivate.
GB8327256D0 (en) 1983-10-12 1983-11-16 Ici Plc Steroid derivatives
GB8517360D0 (en) 1985-07-09 1985-08-14 Erba Farmitalia Substituted androsta-1,4-diene-3,17-diones
US5093330A (en) 1987-06-15 1992-03-03 Ciba-Geigy Corporation Staurosporine derivatives substituted at methylamino nitrogen
IL86632A0 (en) 1987-06-15 1988-11-30 Ciba Geigy Ag Derivatives substituted at methyl-amino nitrogen
US5010099A (en) 1989-08-11 1991-04-23 Harbor Branch Oceanographic Institution, Inc. Discodermolide compounds, compositions containing same and method of preparation and use
US5194447A (en) * 1992-02-18 1993-03-16 American Home Products Corporation Sulfonylcarbamates of rapamycin
NZ243082A (en) 1991-06-28 1995-02-24 Ici Plc 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof
GB9300059D0 (en) 1992-01-20 1993-03-03 Zeneca Ltd Quinazoline derivatives
JP3140228B2 (ja) * 1992-02-17 2001-03-05 ファイザー製薬株式会社 新規な大環状ラクトンおよびその生産菌
US5521184A (en) 1992-04-03 1996-05-28 Ciba-Geigy Corporation Pyrimidine derivatives and processes for the preparation thereof
TW225528B (es) 1992-04-03 1994-06-21 Ciba Geigy Ag
US5256790A (en) * 1992-08-13 1993-10-26 American Home Products Corporation 27-hydroxyrapamycin and derivatives thereof
GB9221220D0 (en) 1992-10-09 1992-11-25 Sandoz Ag Organic componds
AU5151093A (en) 1992-10-14 1994-05-09 Unichema Chemie Bv Process for the preparation of alkylglycosides
AU687727B2 (en) 1992-10-28 1998-03-05 Genentech Inc. Vascular endothelial cell growth factor antagonists
US5258389A (en) * 1992-11-09 1993-11-02 Merck & Co., Inc. O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives
GB2273704B (en) * 1992-12-16 1997-01-22 Orion Yhtymae Oy Triazolyl diaryl selective aromatase inhibiting compounds
DE4301781C2 (de) 1993-01-23 1995-07-20 Lohmann Therapie Syst Lts Nitroglycerinhaltiges Pflaster, Verfahren zu seiner Herstellung und Verwendung
GB9314893D0 (en) 1993-07-19 1993-09-01 Zeneca Ltd Quinazoline derivatives
US5387680A (en) * 1993-08-10 1995-02-07 American Home Products Corporation C-22 ring stabilized rapamycin derivatives
CA2175215C (en) 1993-11-19 2008-06-03 Yat Sun Or Semisynthetic analogs of rapamycin (macrolides) being immunomodulators
GB9325400D0 (en) 1993-12-11 1994-02-16 Sarll David P G Temperature recorder
SK78196A3 (en) 1993-12-17 1997-02-05 Sandoz Ag Rapamycin demethoxy-derivatives, preparation method thereof and pharmaceutical agent containing them
WO1995028156A1 (en) * 1994-04-14 1995-10-26 Sepracor, Inc. Treating estrogen-dependent diseases with (-)-fadrozole
US5362718A (en) 1994-04-18 1994-11-08 American Home Products Corporation Rapamycin hydroxyesters
GB9417873D0 (en) 1994-09-06 1994-10-26 Sandoz Ltd Organic compounds
IL129547A (en) 1994-10-26 2001-01-11 Novartis Ag Pharmaceutical compositions comprising a macrolide and an acid
DE69536015D1 (de) 1995-03-30 2009-12-10 Pfizer Prod Inc Chinazolinone Derivate
GB9508538D0 (en) 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
US5747498A (en) 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines
US5843901A (en) 1995-06-07 1998-12-01 Advanced Research & Technology Institute LHRH antagonist peptides
US5880141A (en) 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
US5985890A (en) 1995-06-09 1999-11-16 Novartis Ag Rapamycin derivatives
SI9620103A (sl) 1995-07-06 1998-10-31 Novartis Ag Pirolopirimidini in postopki za njihovo pripravo
US5567831A (en) * 1995-08-16 1996-10-22 Duguesne University Of The Holy Ghost Non-steroidal sulfatase inhibitor compounds and their method of use
US6245805B1 (en) * 1995-10-26 2001-06-12 Baker Norton Pharmaceuticals, Inc. Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents
DE19544507B4 (de) 1995-11-29 2007-11-15 Novartis Ag Cyclosporin enthaltende Präparate
GB9601120D0 (en) 1996-01-19 1996-03-20 Sandoz Ltd Organic compounds
US5760041A (en) 1996-02-05 1998-06-02 American Cyanamid Company 4-aminoquinazoline EGFR Inhibitors
GB9603095D0 (en) 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline derivatives
GB9606452D0 (en) * 1996-03-27 1996-06-05 Sandoz Ltd Organic compounds
EA001595B1 (ru) 1996-04-12 2001-06-25 Варнер-Ламберт Компани Необратимые ингибиторы тирозинкиназ
ATE233098T1 (de) 1996-06-11 2003-03-15 Novartis Ag Kombination eines somatostatin analogs und eines rapamycins
CA2258548C (en) 1996-06-24 2005-07-26 Pfizer Inc. Phenylamino-substituted tricyclic derivatives for treatment of hyperproliferative diseases
US6492330B1 (en) * 1996-08-16 2002-12-10 National Institute Of Immunology Antiangiogenic drugs
US5922730A (en) 1996-09-09 1999-07-13 American Home Products Corporation Alkylated rapamycin derivatives
EP0927182A2 (en) 1996-09-09 1999-07-07 American Home Products Corporation Alkylated rapamycin derivatives
DE19638745C2 (de) 1996-09-11 2001-05-10 Schering Ag Monoklonale Antikörper gegen die extrazelluläre Domäne des menschlichen VEGF - Rezeptorproteins (KDR)
EP0954315A2 (en) 1996-09-13 1999-11-10 Sugen, Inc. Use of quinazoline derivatives for the manufacture of a medicament in the treatment of hyperproliferative skin disorders
GB9619631D0 (en) * 1996-09-20 1996-11-06 British Biotech Pharm Combination therapy
EP0837063A1 (en) 1996-10-17 1998-04-22 Pfizer Inc. 4-Aminoquinazoline derivatives
CO4950519A1 (es) 1997-02-13 2000-09-01 Novartis Ag Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion
US5985325A (en) 1997-06-13 1999-11-16 American Home Products Corporation Rapamycin formulations for oral administration
CO4940418A1 (es) 1997-07-18 2000-07-24 Novartis Ag Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso
US6015815A (en) * 1997-09-26 2000-01-18 Abbott Laboratories Tetrazole-containing rapamycin analogs with shortened half-lives
GB9721069D0 (en) 1997-10-03 1997-12-03 Pharmacia & Upjohn Spa Polymeric derivatives of camptothecin
US6152347A (en) 1998-01-30 2000-11-28 Acco Brands, Inc. Vertical Stapler
ME00189B (me) 1998-03-26 2011-02-10 Astellas Pharma Inc Preparati sa neprekidnim oslobađanjem
US8029561B1 (en) 2000-05-12 2011-10-04 Cordis Corporation Drug combination useful for prevention of restenosis
CA2326222C (en) * 1998-04-27 2008-09-23 Fujisawa Pharmaceutical Co., Ltd. Medicinal compositions
PT1107964E (pt) 1998-08-11 2010-06-11 Novartis Ag Derivados de isoquinolina com actividade inibidora da angiogénese
GB9824579D0 (en) 1998-11-10 1999-01-06 Novartis Ag Organic compounds
UA71587C2 (uk) 1998-11-10 2004-12-15 Шерінг Акцієнгезелльшафт Аміди антранілової кислоти та їхнє застосування як лікарських засобів
DK1140173T4 (da) 1998-12-22 2013-06-10 Genentech Inc Vaskulære endothelcellevækstfaktorantagonister og anvendelser deraf
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
CN1660840A (zh) 1999-03-30 2005-08-31 诺瓦提斯公司 治疗炎性疾病的酞嗪衍生物
US6333348B1 (en) * 1999-04-09 2001-12-25 Aventis Pharma S.A. Use of docetaxel for treating cancers
GB9911582D0 (en) * 1999-05-18 1999-07-21 Pharmacia & Upjohn Spa Combined method of treatment comprising an aromatase inhibitor and a further biologically active compound
EP1074265A1 (en) 1999-08-03 2001-02-07 Erasmus Universiteit Rotterdam Use of AMH and/or AMH agonists and/or AMH antagonists for long-term control of female fertility
JP2003507382A (ja) 1999-08-18 2003-02-25 ワイス 水溶性ｓｄｚ−ｒａｄエステル
WO2001045740A2 (en) 1999-12-22 2001-06-28 The Government Of The United States, Department Of Health And Human Services Compositions and methods for treatment of breast cancer
US6899731B2 (en) 1999-12-30 2005-05-31 Boston Scientific Scimed, Inc. Controlled delivery of therapeutic agents by insertable medical devices
EP1250135B1 (en) * 2000-01-14 2010-07-28 The Trustees of The University of Pennsylvania O-methylated rapamycin derivatives for alleviation and inhibition of lymphoproliferative disorders
US6641811B1 (en) * 2000-02-10 2003-11-04 Cornell Research Foundation, Inc. Use of angiotensin II inhibitors to prevent malignancies associated with immunosuppression
GB0005257D0 (en) 2000-03-03 2000-04-26 Pharmacia & Upjohn Spa Breast cancer hormonal therapy
US6761895B2 (en) 2000-04-17 2004-07-13 Yamanouchi Pharmaceutical Co., Ltd. Drug delivery system for averting pharmacokinetic drug interaction and method thereof
US20020013335A1 (en) * 2000-06-16 2002-01-31 American Home Products Corporation Method of treating cardiovascular disease
GB0017635D0 (en) 2000-07-18 2000-09-06 Pharmacia & Upjohn Spa Antitumor combined therapy
JP2004507465A (ja) 2000-08-11 2004-03-11 ワイス エストロゲン受容体陽性癌腫の治療方法
US20050004007A1 (en) * 2000-09-12 2005-01-06 Steven Grant Promotion of adoptosis in cancer cells by co-administration of cyclin dependent kinase inhibitiors and cellular differentiation agents
AU2001296558A1 (en) 2000-10-03 2002-04-15 Oncopharmaceutical, Inc. Inhibitors of angiogenesis and tumor growth for local and systemic administration
KR20030045847A (ko) 2000-10-31 2003-06-11 쿡 인코포레이티드 코팅된 이식형 의료 장치
TWI286074B (en) 2000-11-15 2007-09-01 Wyeth Corp Pharmaceutical composition containing CCI-779 as an antineoplastic agent
AU2002249826A1 (en) * 2000-12-22 2002-07-30 Avantec Vascular Corporation Delivery of therapeutic capable agents
US20020151508A1 (en) * 2001-02-09 2002-10-17 Schering Corporation Methods for treating proliferative diseases
MX368013B (es) * 2001-02-19 2019-09-13 Novartis Ag Tratamiento de cáncer.
EA010184B1 (ru) 2001-04-06 2008-06-30 Уайт Применение противоопухолевых комбинаций рапамицина с гемцитабином или 5-фторурацилом
PL367267A1 (en) 2001-06-01 2005-02-21 Wyeth Antineoplastic combinations
UA77200C2 (en) 2001-08-07 2006-11-15 Wyeth Corp Antineoplastic combination of cci-779 and bkb-569
US7488313B2 (en) 2001-11-29 2009-02-10 Boston Scientific Scimed, Inc. Mechanical apparatus and method for dilating and delivering a therapeutic agent to a site of treatment
JP2003330447A (ja) 2002-05-15 2003-11-19 Mitsubishi Electric Corp 画像処理装置
NO20220050A1 (no) 2005-11-21 2008-08-12 Novartis Ag Neuroendokrin tumorbehandling
RU2609458C2 (ru) 2011-07-01 2017-02-01 Колопласт А/С Катетер с баллоном
EP2606816A1 (en) 2011-12-22 2013-06-26 Koninklijke Philips Electronics N.V. A method and system for providing an indication as to the amount of milk remaining in a breast during lactation

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