ES2689746T3 - Anticuerpos monoclonales contra la claudina-18 para el tratamiento de cáncer - Google Patents

Anticuerpos monoclonales contra la claudina-18 para el tratamiento de cáncer Download PDF

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Publication number
ES2689746T3
ES2689746T3 ES10011772.0T ES10011772T ES2689746T3 ES 2689746 T3 ES2689746 T3 ES 2689746T3 ES 10011772 T ES10011772 T ES 10011772T ES 2689746 T3 ES2689746 T3 ES 2689746T3
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amino acid
acid sequence
chain comprises
sequence represented
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Inventor
Ugur Sahin
Özlem TÜRECI
Dirk Usener
Stefan Fritz
Christoph Uherek
Gunda Brandenburg
Harald-Gerhard Geppert
Anja Kristina SCHRÖDER
Philippe Thiel
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TRON Translationale Onkologie an der Universitaetsmedizin der Johannes Gutenberg Universitaet Mainz gGmbH
Astellas Pharma Inc
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TRON Translationale Onkologie an der Universitaetsmedizin der Johannes Gutenberg Universitaet Mainz gGmbH
Astellas Pharma Inc
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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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Abstract

Un anticuerpo monoclonal que comprende una modificación alotípica en la cadena pesada del anticuerpo, en donde el anticuerpo comprende una combinación de cadenas pesadas y cadenas ligeras seleccionadas de las siguientes posibilidades (i) a (ix): (i) la cadena pesada comprende una secuencia de aminoácidos representada por la SEQ ID NO: 115 y la cadena ligera comprende una secuencia de aminoácidos representada por la SEQ ID NO: 122, (ii) la cadena pesada comprende una secuencia de aminoácidos representada por la SEQ ID NO: 116 y la cadena ligera comprende una secuencia de aminoácidos representada por la SEQ ID NO: 121, (iii) la cadena pesada comprende una secuencia de aminoácidos representada por la SEQ ID NO: 117 y la cadena ligera comprende una secuencia de aminoácidos representada por la SEQ ID NO: 123, (iv) la cadena pesada comprende una secuencia de aminoácidos representada por la SEQ ID NO: 119 y la cadena ligera comprende una secuencia de aminoácidos representada por la SEQ ID NO: 126, (v) la cadena pesada comprende una secuencia de aminoácidos representada por la SEQ ID NO: 118 y la cadena ligera comprende una secuencia de aminoácidos representada por la SEQ ID NO: 125, (vi) la cadena pesada comprende una secuencia de aminoácidos representada por la SEQ ID NO: 120 y la cadena ligera comprende una secuencia de aminoácidos representada por la SEQ ID NO: 124, (vii) la cadena pesada comprende una secuencia de aminoácidos representada por la SEQ ID NO: 120 y la cadena ligera comprende una secuencia de aminoácidos representada por la SEQ ID NO: 127, (viii) la cadena pesada comprende una secuencia de aminoácidos representada por la SEQ ID NO: 120 y la cadena ligera comprende una secuencia de aminoácidos representada por la SEQ ID NO: 128, y (ix) la cadena pesada comprende una secuencia de aminoácidos representada por la SEQ ID NO: 120 y la cadena ligera comprende una secuencia de aminoácidos representada por la SEQ ID NO: 129; en donde dicha cadena pesada comprende las secuencias de aminoácidos de la SEQ ID NO: 46 y la modificación alotípica es un reemplazo de K93R, D235E y L237M dentro de la secuencia de aminoácidos de la SEQ ID NO: 46.
ES10011772.0T 2005-11-24 2006-11-24 Anticuerpos monoclonales contra la claudina-18 para el tratamiento de cáncer Active ES2689746T3 (es)

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ES22154316T Active ES3036370T3 (en) 2005-11-24 2006-11-24 Monoclonal antibodies against claudin-18 for treatment of cancer
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