ES470407A1 - Procedimiento para la preparacion de un compuesto tetraci- clico - Google Patents

Procedimiento para la preparacion de un compuesto tetraci- clico

Info

Publication number
ES470407A1
ES470407A1 ES470407A ES470407A ES470407A1 ES 470407 A1 ES470407 A1 ES 470407A1 ES 470407 A ES470407 A ES 470407A ES 470407 A ES470407 A ES 470407A ES 470407 A1 ES470407 A1 ES 470407A1
Authority
ES
Spain
Prior art keywords
compound
formula
alkyl
salt
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES470407A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo NV
Original Assignee
Akzo NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo NV filed Critical Akzo NV
Publication of ES470407A1 publication Critical patent/ES470407A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Procedimiento para la preparación de un compuesto tetracíclico de la fórmula: **(Fórmula-01)** o una sal u óxido de nitrógeno del mismo, donde R1, R2, R3 y R4 representan individualmente hidrógeno, hidroxilo, halógeno, alcohilo (1-6 C), alcoxi o alcohiltio con 1-6 átomos de carbono o trifluorometilo, R5 representa hidrógeno, alcohilo con 1-6 átomos de carbono o aralcohilo con 7 a 10 átomos de carbono, X representa oxígeno, azufre, un grupo -CH2- o un grupo -NR6, donde R6 es hidrógeno o alcohilo con 1-4 átomos de carbono, y m representa el número 1 ó 2, caracterizado porque se prepara el compuesto por reducción de una enamina de fórmula III: **(Fórmula-02)** o una sal de la misma, en la que R1, R2, R3, R4, R5 y X tienen los significados indicados anteriormente, tras lo cual el compuesto obtenido puede (ar)alcohilarse, y/o puede dividirse en estereoisómeros o isómeros ópticos separados, y/o puede convertirse en una sal u óxido de nitrógeno del mismo.
ES470407A 1976-05-24 1978-06-01 Procedimiento para la preparacion de un compuesto tetraci- clico Expired ES470407A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL7605526A NL7605526A (nl) 1976-05-24 1976-05-24 Nieuwe tetracyclische derivaten.

Publications (1)

Publication Number Publication Date
ES470407A1 true ES470407A1 (es) 1979-01-01

Family

ID=19826245

Family Applications (3)

Application Number Title Priority Date Filing Date
ES459024A Expired ES459024A1 (es) 1976-05-24 1977-05-21 Procedimiento para la preparacion de un compuesto tetraci- clico.
ES470407A Expired ES470407A1 (es) 1976-05-24 1978-06-01 Procedimiento para la preparacion de un compuesto tetraci- clico
ES470408A Expired ES470408A1 (es) 1976-05-24 1978-06-01 Procedimiento para la preparacion de un compuesto tetraci- clico

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES459024A Expired ES459024A1 (es) 1976-05-24 1977-05-21 Procedimiento para la preparacion de un compuesto tetraci- clico.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES470408A Expired ES470408A1 (es) 1976-05-24 1978-06-01 Procedimiento para la preparacion de un compuesto tetraci- clico

Country Status (18)

Country Link
US (1) US4145434A (es)
JP (2) JPS532465A (es)
AU (1) AU509073B2 (es)
BE (1) BE854915A (es)
CA (1) CA1122976A (es)
CH (2) CH633536A5 (es)
DE (2) DE2760372C2 (es)
DK (1) DK157868C (es)
ES (3) ES459024A1 (es)
FI (1) FI65238C (es)
FR (1) FR2352800A1 (es)
GB (1) GB1567862A (es)
HU (1) HU173795B (es)
IE (1) IE45419B1 (es)
LU (1) LU77387A1 (es)
NL (1) NL7605526A (es)
SE (1) SE436202B (es)
ZA (1) ZA772752B (es)

Families Citing this family (87)

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CH501007A (de) * 1968-11-27 1970-12-31 Ciba Geigy Ag Verfahren zur Herstellung von neuen Thiepin- und Oxepinderivaten
NL178593C (nl) * 1974-01-31 1986-04-16 Akzo Nv Werkwijze ter bereiding van een farmaceutisch preparaat op basis van een tetracyclische verbinding en werkwijze voor de bereiding van de daarbij te gebruiken tetracyclische verbindingen.
AU469026B2 (en) * 1974-11-07 1976-01-29 Ciba-Geigy Ag New azepine derivatives and process forthe production thereof

Also Published As

Publication number Publication date
IE45419L (en) 1977-11-24
AU509073B2 (en) 1980-04-17
FI65238C (fi) 1984-04-10
CA1122976A (en) 1982-05-04
DK157868C (da) 1990-07-30
FI771635A7 (es) 1977-11-25
US4145434A (en) 1979-03-20
SE436202B (sv) 1984-11-19
ES459024A1 (es) 1978-11-01
DK227477A (da) 1977-11-25
GB1567862A (en) 1980-05-21
BE854915A (fr) 1977-11-23
IE45419B1 (en) 1982-08-25
FR2352800B1 (es) 1980-02-01
NL7605526A (nl) 1977-11-28
CH633536A5 (de) 1982-12-15
JPS6238348B2 (es) 1987-08-17
LU77387A1 (es) 1977-08-29
JPS61178965A (ja) 1986-08-11
JPS6134426B2 (es) 1986-08-07
HU173795B (hu) 1979-08-28
FI65238B (fi) 1983-12-30
DE2723209A1 (de) 1977-12-15
JPS532465A (en) 1978-01-11
DE2760372C2 (es) 1991-05-29
ES470408A1 (es) 1979-01-01
CH637382A5 (de) 1983-07-29
SE7705957L (sv) 1977-11-25
FR2352800A1 (fr) 1977-12-23
AU2533177A (en) 1978-11-23
DK157868B (da) 1990-02-26
ZA772752B (en) 1978-04-26

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