ES475140A1 - Un procedimiento para preparar compuestos de 1-oxadestiace- fam - Google Patents
Un procedimiento para preparar compuestos de 1-oxadestiace- famInfo
- Publication number
- ES475140A1 ES475140A1 ES78475140A ES475140A ES475140A1 ES 475140 A1 ES475140 A1 ES 475140A1 ES 78475140 A ES78475140 A ES 78475140A ES 475140 A ES475140 A ES 475140A ES 475140 A1 ES475140 A1 ES 475140A1
- Authority
- ES
- Spain
- Prior art keywords
- image
- following formula
- compounds
- group
- cob
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 238000007796 conventional method Methods 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 230000000269 nucleophilic effect Effects 0.000 abstract 1
- 150000003952 β-lactams Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Un procedimiento para preparar compuestos de 1-oxadestiacefam de la fórmula siguiente**fórmula** [en la que Y es un grupo divalente de la fórmula siguiente **fórmula** en las que COB es carboxi o carboxi protegido, X es hidrógeno o un grupo nucleófilo y Z es un grupo eliminable ) y A es amino o amino sustituido] , caracterizado porque, en una primera etapa, se hace reaccionar una amina o amida de la fórmula siguiente**fórmula** (en la que A e Y son como se han definido anteriormente ), con un agente de halogenación, con lo que se obtiene un producto halogenado en el N del grupo amino o amido representado por A, que a continuación se somete a una eliminación de haluro de hidrógeno con una base para dar el compuesto imino correspondiente, y, en una segunda etapa, dicho compuesto imino se hace reaccionar con metanol para introducir el grupo metoxi- OCH3, danto el compuesto metoxilado pretendido.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1581377A JPS53101391A (en) | 1977-02-15 | 1977-02-15 | 1-oxadithiacephem compounds |
| JP52067025A JPS6040438B2 (ja) | 1977-06-06 | 1977-06-06 | １−オキサデチアセフアロスポリンの製法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES475140A1 true ES475140A1 (es) | 1980-01-01 |
Family
ID=26352032
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES466949A Expired ES466949A1 (es) | 1977-02-15 | 1978-02-14 | Un procedimiento para preparar compuestos de 1-oxadestiace- fam |
| ES78475142A Expired ES475142A1 (es) | 1977-02-15 | 1978-11-16 | Un procedimiento para preparar compuestos de 1-oxadestiace- fem |
| ES475141A Expired ES475141A1 (es) | 1977-02-15 | 1978-11-16 | Un procedimiento para preparar compuestos de 1-oxadestiace- fam |
| ES78475140A Expired ES475140A1 (es) | 1977-02-15 | 1978-11-16 | Un procedimiento para preparar compuestos de 1-oxadestiace- fam |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES466949A Expired ES466949A1 (es) | 1977-02-15 | 1978-02-14 | Un procedimiento para preparar compuestos de 1-oxadestiace- fam |
| ES78475142A Expired ES475142A1 (es) | 1977-02-15 | 1978-11-16 | Un procedimiento para preparar compuestos de 1-oxadestiace- fem |
| ES475141A Expired ES475141A1 (es) | 1977-02-15 | 1978-11-16 | Un procedimiento para preparar compuestos de 1-oxadestiace- fam |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US4366316A (es) |
| AR (1) | AR227867A1 (es) |
| AU (1) | AU514377B2 (es) |
| BG (4) | BG32855A3 (es) |
| CA (1) | CA1099715A (es) |
| CH (1) | CH636618A5 (es) |
| DE (1) | DE2806457A1 (es) |
| DK (1) | DK168217B1 (es) |
| ES (4) | ES466949A1 (es) |
| FI (1) | FI68401C (es) |
| FR (1) | FR2380284A1 (es) |
| GB (1) | GB1557552A (es) |
| GR (1) | GR69965B (es) |
| HU (1) | HU177897B (es) |
| IE (1) | IE47711B1 (es) |
| IL (1) | IL54044A (es) |
| MX (1) | MX5479E (es) |
| NL (1) | NL191891C (es) |
| NO (1) | NO162343C (es) |
| NZ (1) | NZ186437A (es) |
| PH (4) | PH15515A (es) |
| PL (1) | PL114451B1 (es) |
| PT (1) | PT67648B (es) |
| RO (3) | RO79886A (es) |
| SE (1) | SE443144B (es) |
| YU (2) | YU41307B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4259485A (en) * | 1979-04-24 | 1981-03-31 | Eli Lilly And Company | Crystallization process |
| US4304774A (en) | 1980-09-17 | 1981-12-08 | Eli Lilly And Company | Bis-tetrazolmethyl substituted β-lactam antibiotics |
| JPS58185588A (ja) * | 1982-04-23 | 1983-10-29 | Shionogi & Co Ltd | 空気酸化によるハロメチル化合物の酸化方法および酸化生成物 |
| DE3231060A1 (de) * | 1982-08-20 | 1984-02-23 | Bayer Ag, 5090 Leverkusen | In 6-stellung unsubstituierte 7-oxo-4-oxa-diazabicyclo-(3.2.0)-hept-2-en derivate, verfahren zu ihrer herstellung und ihre verwendung als zwischenprodukte zur synthese von ss-lactamantibiotika |
| US4458071A (en) * | 1982-11-16 | 1984-07-03 | Eli Lilly And Company | Process for 1-oxa-β-lactams |
| US4652651A (en) * | 1983-05-31 | 1987-03-24 | Hoffmann-La Roche Inc. | Process for the manufacture of 1-sulpho-2-oxoazetidine carboxylic acid intermediates via catalytic ester cleavage |
| DE3404906A1 (de) * | 1984-02-11 | 1985-08-14 | Bayer Ag, 5090 Leverkusen | 1-oxadethiacephalosporinderivate sowie verfahren zu ihrer herstellung |
| US4645769A (en) * | 1985-03-01 | 1987-02-24 | Merck & Co., Inc. | 1-oxa-1-dethia-cephalosporin compounds and antibacterial agent comprising the same |
| CN102286004A (zh) * | 2011-09-21 | 2011-12-21 | 河北九派制药有限公司 | 拉氧头孢钠中间体的制备方法 |
| CN103254215B (zh) * | 2013-05-24 | 2015-06-03 | 浙江东邦药业有限公司 | 一种烯丙基氯代氧头孢化合物的制备方法 |
| CN106749335B (zh) * | 2016-11-29 | 2019-02-12 | 浙江新和成股份有限公司 | 一种卤代氧头孢类中间体的制备方法和应用 |
| CN107118224B (zh) * | 2017-06-15 | 2019-09-17 | 浙江新和成股份有限公司 | 一种氧头孢母核中间体的制备方法、其溶剂化合物及其制备方法 |
| CN114315858B (zh) * | 2022-01-11 | 2023-05-09 | 深圳市立国药物研究有限公司 | 一种氟氧头孢中间体的合成方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL178005C (nl) * | 1972-11-06 | 1986-01-02 | Merck & Co Inc | Werkwijze voor het bereiden van een farmaceutisch preparaat met antibacteriele werking, alsmede werkwijze ter bereiding van een cefalosporine-antibioticum. |
| GB1510794A (en) * | 1974-08-06 | 1978-05-17 | Univ Kingston | 1-oxacephems and intermediates therefor |
| FR2361114A1 (fr) * | 1975-11-12 | 1978-03-10 | Shionogi & Co | Procede de preparation d'analogues de cephalosporine a propriete antibacterienne et nouveaux produits ainsi obtenus |
| US4150156A (en) * | 1975-11-21 | 1979-04-17 | Merck & Co., Inc. | 7-(Substituted methyl)-3-(substituted thio)-cephalosporins, derivatives and pharmaceutical compositions containing them |
| CY1158A (en) * | 1976-03-25 | 1983-01-28 | Shionogi & Co | Arylmalonamido-1-oxadethiacephalosporins |
| CA1085392A (en) * | 1976-03-25 | 1980-09-09 | Masayuki Narisada | Arylmalonamido-1-oxadethiacephalosporins |
| US4079179A (en) * | 1976-03-30 | 1978-03-14 | Merck & Co., Inc. | 6-Loweralkoxy or loweralkylthio-3-cephem-4-carboxylic acids |
| JPS607635B2 (ja) * | 1976-04-27 | 1985-02-26 | 塩野義製薬株式会社 | オキサゾリジン化合物 |
| US4044002A (en) * | 1976-06-09 | 1977-08-23 | Eli Lilly And Company | Reduction process for cephalosporin sulfoxides |
| JPS609514B2 (ja) * | 1976-08-05 | 1985-03-11 | 塩野義製薬株式会社 | ７−アミノ−３′−ノルセファロスポラン酸類 |
| CA1090806A (en) * | 1977-01-10 | 1980-12-02 | Mitsuru Yoshioka | Oxazolines |
| JPS5398951A (en) * | 1977-02-08 | 1978-08-29 | Shionogi & Co Ltd | Azetidinone derivatives and process for their preparation |
| US4207782A (en) * | 1978-07-31 | 1980-06-17 | Brunswick Corporation | Multi-conductor insulation stripping apparatus |
-
1978
- 1978-02-09 AU AU33164/78A patent/AU514377B2/en not_active Expired
- 1978-02-09 GB GB5339/78A patent/GB1557552A/en not_active Expired
- 1978-02-10 NZ NZ186437A patent/NZ186437A/xx unknown
- 1978-02-10 IE IE298/78A patent/IE47711B1/en not_active IP Right Cessation
- 1978-02-10 CA CA296,776A patent/CA1099715A/en not_active Expired
- 1978-02-10 DK DK060678A patent/DK168217B1/da not_active IP Right Cessation
- 1978-02-13 PT PT67648A patent/PT67648B/pt unknown
- 1978-02-13 IL IL54044A patent/IL54044A/xx unknown
- 1978-02-14 YU YU335/78A patent/YU41307B/xx unknown
- 1978-02-14 BG BG040119A patent/BG32855A3/bg unknown
- 1978-02-14 NO NO780508A patent/NO162343C/no unknown
- 1978-02-14 GR GR55452A patent/GR69965B/el unknown
- 1978-02-14 SE SE7801697A patent/SE443144B/sv not_active IP Right Cessation
- 1978-02-14 RO RO78100614A patent/RO79886A/ro unknown
- 1978-02-14 RO RO78100613A patent/RO79398A/ro unknown
- 1978-02-14 ES ES466949A patent/ES466949A1/es not_active Expired
- 1978-02-14 FR FR7804162A patent/FR2380284A1/fr active Granted
- 1978-02-14 RO RO78100612A patent/RO78545A/ro unknown
- 1978-02-14 BG BG038671A patent/BG32853A3/xx unknown
- 1978-02-14 MX MX786846U patent/MX5479E/es unknown
- 1978-02-14 BG BG040118A patent/BG32854A3/xx unknown
- 1978-02-14 PL PL1978204616A patent/PL114451B1/pl unknown
- 1978-02-14 HU HU78SI1619A patent/HU177897B/hu unknown
- 1978-02-14 FI FI780474A patent/FI68401C/fi not_active IP Right Cessation
- 1978-02-15 CH CH167278A patent/CH636618A5/de not_active IP Right Cessation
- 1978-02-15 DE DE19782806457 patent/DE2806457A1/de active Granted
- 1978-02-15 PH PH20789A patent/PH15515A/en unknown
- 1978-02-15 NL NL7801708A patent/NL191891C/xx not_active IP Right Cessation
- 1978-06-16 BG BG040120A patent/BG32856A3/bg unknown
- 1978-11-16 ES ES78475142A patent/ES475142A1/es not_active Expired
- 1978-11-16 ES ES475141A patent/ES475141A1/es not_active Expired
- 1978-11-16 ES ES78475140A patent/ES475140A1/es not_active Expired
-
1979
- 1979-12-20 PH PH23440A patent/PH15291A/en unknown
- 1979-12-20 PH PH23438A patent/PH15294A/en unknown
- 1979-12-20 PH PH23439A patent/PH15513A/en unknown
-
1981
- 1981-11-18 US US06/322,662 patent/US4366316A/en not_active Expired - Lifetime
-
1982
- 1982-01-01 AR AR22786782D patent/AR227867A1/es active
-
1983
- 1983-03-07 YU YU548/83A patent/YU42073B/xx unknown
Also Published As
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