ES483286A1 - Un procedimiento para la preparacion de nuevas dibenzo (a,d)ciclohepten-5,10-iminas sustituidas - Google Patents

Un procedimiento para la preparacion de nuevas dibenzo (a,d)ciclohepten-5,10-iminas sustituidas

Info

Publication number
ES483286A1
ES483286A1 ES483286A ES483286A ES483286A1 ES 483286 A1 ES483286 A1 ES 483286A1 ES 483286 A ES483286 A ES 483286A ES 483286 A ES483286 A ES 483286A ES 483286 A1 ES483286 A1 ES 483286A1
Authority
ES
Spain
Prior art keywords
methyl
hydrogen
formula
compound
subjecting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES483286A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES483286A1 publication Critical patent/ES483286A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C07D295/116—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings with the doubly bound oxygen or sulfur atoms directly attached to a carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Un procedimiento para la preparación de nuevas dibenzo [a,d] ciclohepten-5,10-iminas sustituidas de fórmula **(Fórmula 01)** en el que R es hidrógeno, metilo, etilo o bencilo; y R2 es hidrógeno, metilo o -CH2OH, cuyo procedimiento se caracteriza porque consiste en a) someter a reacción de reducción un compuesto de fórmula **(Fórmula02)** b) si se desea, someter a reacción de N-alquilación el producto procedente de la etapa anterior donde R es hidrógeno, para producir el compuesto donde R es metilo, etilo o bencilo; y c) a continuación, si se desea, resolver el compuesto obtenido en un enantiómero dextrógiro.
ES483286A 1977-09-19 1979-08-09 Un procedimiento para la preparacion de nuevas dibenzo (a,d)ciclohepten-5,10-iminas sustituidas Expired ES483286A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US83463977A 1977-09-19 1977-09-19

Publications (1)

Publication Number Publication Date
ES483286A1 true ES483286A1 (es) 1980-04-16

Family

ID=25267426

Family Applications (7)

Application Number Title Priority Date Filing Date
ES473492A Expired ES473492A1 (es) 1977-09-19 1978-09-19 Un procedimiento para la preparacion de nuevas dibenzo (a,d)ciclohepten-5,10-iminas.sustituidas.
ES483286A Expired ES483286A1 (es) 1977-09-19 1979-08-09 Un procedimiento para la preparacion de nuevas dibenzo (a,d)ciclohepten-5,10-iminas sustituidas
ES483285A Expired ES483285A1 (es) 1977-09-19 1979-08-09 Un procedimiento para la preparacion de nuevas dibenzo (a,d)ciclohepten-5,10-iminas sustituidas
ES483287A Expired ES483287A1 (es) 1977-09-19 1979-08-09 Un procedimiento para la preparacion de nuevas dibenzo (a,d)ciclohepten-5,10-iminas sustituidas
ES483288A Expired ES483288A1 (es) 1977-09-19 1979-08-09 Un procedimiento para la preparacion de nuevas dibenzo (a,d)ciclohepten-5,10-iminas sustituidas
ES483284A Expired ES483284A1 (es) 1977-09-19 1979-08-09 Un procedimiento para la preparacion de nuevas dibenzo (a,d)ciclohepten-5,10-iminas sustituidas
ES483283A Expired ES483283A1 (es) 1977-09-19 1979-08-09 Un procedimiento para la preparacion de nuevas (a,d) ciclo- hepten-5,10, sustituidas.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES473492A Expired ES473492A1 (es) 1977-09-19 1978-09-19 Un procedimiento para la preparacion de nuevas dibenzo (a,d)ciclohepten-5,10-iminas.sustituidas.

Family Applications After (5)

Application Number Title Priority Date Filing Date
ES483285A Expired ES483285A1 (es) 1977-09-19 1979-08-09 Un procedimiento para la preparacion de nuevas dibenzo (a,d)ciclohepten-5,10-iminas sustituidas
ES483287A Expired ES483287A1 (es) 1977-09-19 1979-08-09 Un procedimiento para la preparacion de nuevas dibenzo (a,d)ciclohepten-5,10-iminas sustituidas
ES483288A Expired ES483288A1 (es) 1977-09-19 1979-08-09 Un procedimiento para la preparacion de nuevas dibenzo (a,d)ciclohepten-5,10-iminas sustituidas
ES483284A Expired ES483284A1 (es) 1977-09-19 1979-08-09 Un procedimiento para la preparacion de nuevas dibenzo (a,d)ciclohepten-5,10-iminas sustituidas
ES483283A Expired ES483283A1 (es) 1977-09-19 1979-08-09 Un procedimiento para la preparacion de nuevas (a,d) ciclo- hepten-5,10, sustituidas.

Country Status (33)

Country Link
JP (1) JPS5463100A (es)
AR (1) AR231544A1 (es)
AT (1) AT370103B (es)
AU (1) AU520178B2 (es)
BE (1) BE870562A (es)
CA (1) CA1129850A (es)
CH (1) CH637954A5 (es)
CY (1) CY1283A (es)
DE (1) DE2840786A1 (es)
DK (1) DK153843C (es)
ES (7) ES473492A1 (es)
FI (1) FI65618C (es)
FR (1) FR2403334A1 (es)
GB (2) GB2061947B (es)
GR (1) GR65703B (es)
HK (1) HK30885A (es)
HU (1) HU180868B (es)
IE (1) IE47355B1 (es)
IL (1) IL55521A0 (es)
IT (1) IT1113279B (es)
KE (1) KE3501A (es)
LU (1) LU80262A1 (es)
NL (1) NL191488C (es)
NO (1) NO151861C (es)
NZ (1) NZ188361A (es)
PH (1) PH15920A (es)
PL (3) PL112834B1 (es)
PT (1) PT68544A (es)
SE (1) SE437520B (es)
SG (1) SG9585G (es)
SU (2) SU895288A3 (es)
YU (1) YU41432B (es)
ZA (1) ZA785291B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4232158A (en) * 1979-06-04 1980-11-04 Merck & Co., Inc. 10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imines
US4477668A (en) * 1982-04-07 1984-10-16 Merck & Co., Inc. Process for 5-methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5,10-imine
GB8719199D0 (en) * 1987-08-13 1987-09-23 Merck Sharp & Dohme Chemical compounds
US5686614A (en) * 1995-04-11 1997-11-11 Neurogen Corporation Preparation of chiral 5-aminocarbonyl-5H-dibenzo a,d!cyclohepten-5,10-imines by optical resolution
US5739337A (en) * 1996-03-08 1998-04-14 Neurogen Corporation Process for preparing dibenzo-1-carboxamido-1,4-azabicyclo 3.2.1!octanes
EP3383429B1 (en) 2015-11-30 2020-10-14 INSERM - Institut National de la Santé et de la Recherche Médicale Nmdar antagonists for the treatment of tumor angiogenesis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE794904A (fr) * 1972-02-04 1973-08-02 Roussel Uclaf Nouveaux derives du dibenzocycloheptene et leur preparation
BE829075A (fr) * 1974-05-15 1975-11-14 9,10-dihydroanthracen-9,10-imines substituees et leurs analogues heterocycliques (aza)

Also Published As

Publication number Publication date
ATA669778A (de) 1982-07-15
GB2061947B (en) 1982-08-04
AT370103B (de) 1983-03-10
YU219678A (en) 1983-02-28
NO151861C (no) 1985-06-19
FI65618C (fi) 1984-06-11
NL191488C (nl) 1995-08-04
AR231544A1 (es) 1984-12-28
ES483283A1 (es) 1980-04-16
IL55521A0 (en) 1978-12-17
HK30885A (en) 1985-04-26
SG9585G (en) 1985-08-08
JPS5463100A (en) 1979-05-21
AU3966878A (en) 1980-03-13
AU520178B2 (en) 1982-01-21
PT68544A (en) 1978-10-01
NO151861B (no) 1985-03-11
SE7809187L (sv) 1979-03-20
DE2840786A1 (de) 1979-03-22
CY1283A (en) 1985-07-05
DK153843C (da) 1989-01-23
KE3501A (en) 1985-02-22
DK389978A (da) 1979-03-20
LU80262A1 (fr) 1979-06-01
DE2840786C2 (es) 1987-05-21
NL7808847A (nl) 1979-03-21
GB2004872A (en) 1979-04-11
ES483284A1 (es) 1980-09-01
ES483288A1 (es) 1980-04-16
BE870562A (fr) 1979-03-19
NZ188361A (en) 1982-06-29
ZA785291B (en) 1980-04-30
FR2403334B1 (es) 1982-11-19
SU915800A3 (en) 1982-03-23
YU41432B (en) 1987-06-30
DK153843B (da) 1988-09-12
NO783017L (no) 1979-03-20
PL118478B1 (en) 1981-10-31
PL121605B1 (en) 1982-05-31
PL112834B1 (en) 1980-11-29
GR65703B (en) 1980-10-22
PL209632A1 (pl) 1979-06-04
CA1129850A (en) 1982-08-17
SU895288A3 (ru) 1981-12-30
IE47355B1 (en) 1984-02-22
GB2004872B (en) 1982-04-15
ES473492A1 (es) 1980-07-16
HU180868B (en) 1983-04-29
ES483285A1 (es) 1980-09-01
CH637954A5 (de) 1983-08-31
FR2403334A1 (fr) 1979-04-13
NL191488B (nl) 1995-04-03
PH15920A (en) 1983-04-22
IT7851126A0 (it) 1978-09-18
SE437520B (sv) 1985-03-04
FI782680A7 (fi) 1979-03-20
IE781866L (en) 1979-03-19
ES483287A1 (es) 1980-04-16
FI65618B (fi) 1984-02-29
JPS5639315B2 (es) 1981-09-11
GB2061947A (en) 1981-05-20
IT1113279B (it) 1986-01-20

Similar Documents

Publication Publication Date Title
ES483286A1 (es) Un procedimiento para la preparacion de nuevas dibenzo (a,d)ciclohepten-5,10-iminas sustituidas
FI891625A0 (fi) Foerfarande foer framstaellning av aminocyanacetamid.
NL183357C (nl) (2.3-dihydro-2.2-dimethyl-benzofuran-7-yloxy-n-methylcarbamoyl)-(n&#39;-alkylcarbamoyl)-sulfiden, werkwijze voor de bereiding daarvan, werkwijze voor de bereiding van een insecticide preparaat alsmede werkwijze voor de bestrijding van insecten.
HU9203838D0 (en) Method for producing isohirudin of improved stability
IE781438L (en) Tetraline derivatives
EG13590A (en) Process for the production of trans-5-aryl-2,3,4,4a,5,9b-hexahydro-th-pyrido(4,3-b)indoles of use as tranquilizing agents
DE3855002D1 (de) Verfahren zur Herstellung von Dodecahydro-3a,6,6,9a-tetramethylnaphto(2,1-b)furan
FR2389625A1 (es)
JPS5423184A (en) Fermentor of organic waste
ATE5077T1 (de) 22-arylsulfonyl-24,25-dihydroxy-cholestane und verfahren zu ihrer herstellung.
ATE8638T1 (de) Verfahren zur herstellung von 17-alpha-hydroxy17beta-hydroxyacetyl-steroiden und die erhaltenen entsprechenden zwischenprodukte.
ES2070334T3 (es) Procedimiento para la preparacion de derivados de progesterona.
NL188037C (nl) Werkwijze voor de bereiding van dl-fenylglycine-amide via racemisatie.
GB2001310A (en) Process for the preparation of 5,6 Diaminouracil
EG14087A (en) Process for preparing of 7,8,9,10-tetrahydrothieno(3,2-e)pyrido(4,3-b)indole compounds and their medicinal use
ES8207501A1 (es) Metodo para preparar el acidoz-(2,6 dicloroamilino)-fenilacetido.
DZ1366A1 (fr) Nouveaux dérivés de la méthoxycarbonyl-2 n,n&#39;-di-(triméthoxybenzoyle) pipérazine, ainsi que leur procédé de préparation.
IL82936A0 (en) Pyrrolinone derivatives,process for the preparation thereof and the use thereof for the preparation of tetramic acid
JPS51139688A (en) Process for preparing new alkaloid tm-64 substance by fermentation
ES2034252T3 (es) Procedimiento para la preparacion de compuestos macrolidos.
GR64457B (en) Process for preparation of 9-(2,6-dihalobenzyl)adenines
PT71895A (en) Process for the preparation of nb-quaternary 10-bromosanduicine and 10-bromoisosanduicine derivatives
ES471088A1 (es) Un procedimiento para la preparacion de derivados de 2-oxa- zolidinona
JPS53128452A (en) Method of production heating equipment for beauty apparatus
JPS5419726A (en) Tone generating circuit