ES498766A0 - Procedimiento para la preparacion de acidos carboxilicos - Google Patents
Procedimiento para la preparacion de acidos carboxilicosInfo
- Publication number
- ES498766A0 ES498766A0 ES498766A ES498766A ES498766A0 ES 498766 A0 ES498766 A0 ES 498766A0 ES 498766 A ES498766 A ES 498766A ES 498766 A ES498766 A ES 498766A ES 498766 A0 ES498766 A0 ES 498766A0
- Authority
- ES
- Spain
- Prior art keywords
- methyl
- hydrogen
- preparation
- procedure
- carboxyl acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 CARBOXYL ACIDS Chemical class 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 1
- 239000001257 hydrogen Substances 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 4
- CCMLIFHRMDXEBM-UHFFFAOYSA-N 2-phenyl-1,3-thiazol-4-ol Chemical compound OC1=CSC(C=2C=CC=CC=2)=N1 CCMLIFHRMDXEBM-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 230000007691 collagen metabolic process Effects 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19803002989 DE3002989A1 (de) | 1980-01-29 | 1980-01-29 | Hydroxyphenyl-thiazol, -thiazolin und -thiazolidin-carbonsaeuren, verfahren zu ihrer herstellung und ihre verwendung zur beeinflussung des kollagenstoffwechsels |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES498766A0 true ES498766A0 (es) | 1982-05-01 |
| ES8204726A1 ES8204726A1 (es) | 1982-05-01 |
Family
ID=6093111
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES498766A Expired ES8204726A1 (es) | 1980-01-29 | 1981-01-23 | Procedimiento para la preparacion de acidos carboxilicos |
| ES498750A Expired ES8200670A1 (es) | 1980-01-29 | 1981-01-23 | Procedimiento para la preparacion de acidos carboxilicos |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES498750A Expired ES8200670A1 (es) | 1980-01-29 | 1981-01-23 | Procedimiento para la preparacion de acidos carboxilicos |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4457936A (es) |
| EP (1) | EP0033151B1 (es) |
| JP (1) | JPS56120675A (es) |
| AT (1) | ATE7297T1 (es) |
| CA (1) | CA1171420A (es) |
| DE (2) | DE3002989A1 (es) |
| ES (2) | ES8204726A1 (es) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3002989A1 (de) * | 1980-01-29 | 1981-07-30 | Hoechst Ag, 6000 Frankfurt | Hydroxyphenyl-thiazol, -thiazolin und -thiazolidin-carbonsaeuren, verfahren zu ihrer herstellung und ihre verwendung zur beeinflussung des kollagenstoffwechsels |
| US4666897A (en) * | 1983-12-29 | 1987-05-19 | Research Foundation Of State University | Inhibition of mammalian collagenolytic enzymes by tetracyclines |
| US4935412A (en) * | 1983-12-29 | 1990-06-19 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same |
| USRE34656E (en) * | 1983-12-29 | 1994-07-05 | The Research Foundation Of State University Of New York | Use of tetracycline to enhance bone protein synthesis and/or treatment of bone deficiency |
| DE3432094A1 (de) * | 1984-08-31 | 1986-03-06 | Hoechst Ag, 6230 Frankfurt | Ester der pyridin-2,4- und -2,5- dicarbonsaeure als arzneimittel zur inhibierung der prolin- und lysinhydroxylase |
| DE3544338A1 (de) * | 1985-12-14 | 1987-06-19 | Hoechst Ag | Peptid-derivate mit inhibitorischer wirkung auf hydroxylierende enzyme, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung |
| IT1196485B (it) * | 1986-07-14 | 1988-11-16 | Zambon Spa | Derivati dell'acido tiazolidin-4-carbossilico ad attivita' farmaceutica |
| JPS6339868A (ja) * | 1986-08-04 | 1988-02-20 | Otsuka Pharmaceut Factory Inc | ジ低級アルキルフエノ−ル誘導体 |
| DE3643012A1 (de) * | 1986-12-17 | 1988-06-30 | Hoechst Ag | 2,3-disubstituierte isoxazolidine, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung |
| ES2092580T3 (es) * | 1990-11-30 | 1996-12-01 | Teijin Ltd | Derivado de 2-ariltiazol y composicion farmaceutica que contiene el mismo. |
| US5840739A (en) * | 1992-11-16 | 1998-11-24 | University Of Florida Research Foundation, Inc. | Thiazoline acid derivatives |
| US5846988A (en) * | 1996-03-25 | 1998-12-08 | Alcon Laboratories, Inc. | Thiazolidine-4-carboxylic acid derivatives as cytoprotective agents |
| EP0878480A1 (en) * | 1997-05-14 | 1998-11-18 | H.W. Prof. Dr. Müller | A method for the improvement of neuronal regeneration |
| WO1999042466A2 (en) * | 1998-02-19 | 1999-08-26 | Washington University | β-LACTAM-LIKE CHAPERONE INHIBITORS |
| US6083966A (en) | 1998-08-31 | 2000-07-04 | University Of Florida | Thiazoline acid derivatives |
| EP1488791A3 (en) * | 1998-09-21 | 2005-04-06 | University Of Florida Research Foundation, Inc. | Antimalarial agents |
| WO2000016763A2 (en) | 1998-09-21 | 2000-03-30 | University Of Florida Research Foundation, Inc. | Antimalarial agents |
| WO2000033836A1 (en) * | 1998-12-04 | 2000-06-15 | Ontogen Corporation | 5-membered heterocycles for the treatment of human diseases involving modulators of selectins |
| US7002036B2 (en) | 2002-05-15 | 2006-02-21 | Genzyme Corporation | Synthesis of 2-alkyl amino acids |
| WO2005034949A1 (en) | 2003-09-09 | 2005-04-21 | University Of Florida | Desferrithiocin derivatives and their use as iron chelators |
| WO2005055931A2 (en) * | 2003-12-03 | 2005-06-23 | University Of Medicine And Dentistry Of New Jersey | Method of preventing survival of retrovirally cells and of inhibiting formation of infectious retroviruses |
| BRPI0515862A2 (pt) | 2004-12-23 | 2011-10-11 | Arena Pharm Inc | uso de fentermina e agonista seletivo do receptor de 5ht-2c na preparação de composições, composições moduladoras do receptor de 5ht-2c e forma de dosagem unitária compreendendo as mesmas |
| BRPI0610644B8 (pt) | 2005-04-04 | 2021-05-25 | Univ Florida | composto e composição farmacêutica que compreende tal composto e um veículo ou diluente farmaceuticamente aceitável. |
| JP5439193B2 (ja) | 2007-03-15 | 2014-03-12 | ユニバーシティー オブ フロリダ リサーチ ファンデーション， インク． | デスフェリチオシンポリエーテル類似体 |
| US9045440B2 (en) | 2010-05-04 | 2015-06-02 | Ferrokin Biosciences, Inc. | Desazadesferrothiocin and desazadesferrothiocin polyether analogues as metal chelation agents |
| JP6539046B2 (ja) | 2011-12-16 | 2019-07-03 | ユニバーシティー オブ フロリダ リサーチ ファンデーション， インク． | ４’−デスフェリチオシン類似体の使用 |
| CA2930966A1 (en) | 2013-11-22 | 2015-05-28 | University Of Florida Research Foundation, Inc. | Desferrithiocin analogs and uses thereof |
| EP3288557A4 (en) | 2015-04-27 | 2018-11-07 | University of Florida Research Foundation, Inc. | Metabolically programmed metal chelators and uses thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB584981A (en) * | 1945-03-12 | 1947-01-28 | Herbert Clare Carrington | Manufacture of thiazoline derivatives |
| US3809754A (en) * | 1968-12-31 | 1974-05-07 | Medial De Toledo & Cie | Method of treating diseases of the mucous membrane using compounds of a thiazolidine carboxylic acid and pharmaceutical preparations thereof |
| US3882110A (en) * | 1969-06-11 | 1975-05-06 | Roussel Uclaf | Novel 2-alkyl-5-thiazole-carboxylic acid derivatives |
| FR2062210A5 (es) * | 1969-09-17 | 1971-06-25 | Godo Shusei Kk | |
| FR2062120A5 (es) * | 1969-10-10 | 1971-06-25 | Messier Fa | |
| FR2141526B1 (es) * | 1971-06-14 | 1975-05-30 | Roussel Uclaf | |
| DE2245560A1 (de) * | 1972-09-16 | 1974-03-21 | Basf Ag | Verfahren zur herstellung von 4alkoxycarbonyl-2-thiazolinen |
| GB1584981A (en) * | 1977-01-13 | 1981-02-18 | Davy Instr Ltd | Conveyor weigher |
| DE3002989A1 (de) * | 1980-01-29 | 1981-07-30 | Hoechst Ag, 6000 Frankfurt | Hydroxyphenyl-thiazol, -thiazolin und -thiazolidin-carbonsaeuren, verfahren zu ihrer herstellung und ihre verwendung zur beeinflussung des kollagenstoffwechsels |
| US4367233A (en) * | 1981-10-02 | 1983-01-04 | American Home Products Corporation | Inhibitors of mammalian collagenase |
-
1980
- 1980-01-29 DE DE19803002989 patent/DE3002989A1/de not_active Withdrawn
-
1981
- 1981-01-23 ES ES498766A patent/ES8204726A1/es not_active Expired
- 1981-01-23 ES ES498750A patent/ES8200670A1/es not_active Expired
- 1981-01-24 AT AT81100532T patent/ATE7297T1/de not_active IP Right Cessation
- 1981-01-24 DE DE8181100532T patent/DE3163339D1/de not_active Expired
- 1981-01-24 EP EP81100532A patent/EP0033151B1/de not_active Expired
- 1981-01-28 CA CA000369496A patent/CA1171420A/en not_active Expired
- 1981-01-29 JP JP1221281A patent/JPS56120675A/ja active Pending
-
1982
- 1982-04-07 US US06/366,318 patent/US4457936A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US4457936A (en) | 1984-07-03 |
| ES498750A0 (es) | 1981-11-01 |
| EP0033151B1 (de) | 1984-05-02 |
| ES8200670A1 (es) | 1981-11-01 |
| DE3002989A1 (de) | 1981-07-30 |
| DE3163339D1 (en) | 1984-06-07 |
| ATE7297T1 (de) | 1984-05-15 |
| ES8204726A1 (es) | 1982-05-01 |
| EP0033151A1 (de) | 1981-08-05 |
| JPS56120675A (en) | 1981-09-22 |
| CA1171420A (en) | 1984-07-24 |
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