ES8306325A1 - "proceso para la produccion microbiana de interferon fibroblasto humano". - Google Patents

"proceso para la produccion microbiana de interferon fibroblasto humano".

Info

Publication number
ES8306325A1
ES8306325A1 ES515033A ES515033A ES8306325A1 ES 8306325 A1 ES8306325 A1 ES 8306325A1 ES 515033 A ES515033 A ES 515033A ES 515033 A ES515033 A ES 515033A ES 8306325 A1 ES8306325 A1 ES 8306325A1
Authority
ES
Spain
Prior art keywords
human fibroblast
interfered
microbial production
polypeptide
microorganism
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES515033A
Other languages
English (en)
Other versions
ES515033A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26886463&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8306325(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of ES515033A0 publication Critical patent/ES515033A0/es
Publication of ES8306325A1 publication Critical patent/ES8306325A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE MICROORGANISMOS CAPACES DE PRODUCIR UN POLIPEPTIDO DEL TIPO QUE COMPRENDE LA SECUENCIA AMINOACIDA DE UN INTERFERON FIBROBLASTO HUMANO. CONSISTE EN TRANSFORMAR UN MICROORGANISMO CON UN VEHICULO DE EXPRESION MICROBIANA REPETIBLE CAPAZ DE EXPRESAR DICHO POLIPEPTIDO; SEGUIDO DEL CULTIVO DEL MICROORGANISMO TRANSFORMADO. EL MICROORGANISMO TRANSFORMADO PUEDE SER UNA CEPA E. COLI, BACILLUS SUBTILIS O SACHAROMYCES CEREVISIAE. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTIVIRAL.
ES515033A 1980-09-25 1982-08-16 "proceso para la produccion microbiana de interferon fibroblasto humano". Expired ES8306325A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19079980A 1980-09-25 1980-09-25
US29189281A 1981-08-11 1981-08-11

Publications (2)

Publication Number Publication Date
ES515033A0 ES515033A0 (es) 1983-06-01
ES8306325A1 true ES8306325A1 (es) 1983-06-01

Family

ID=26886463

Family Applications (3)

Application Number Title Priority Date Filing Date
ES505742A Expired ES8307297A1 (es) 1980-09-25 1981-09-24 Proceso para la produccion microbiana de interferon fibro- blasto humano
ES515033A Expired ES8306325A1 (es) 1980-09-25 1982-08-16 "proceso para la produccion microbiana de interferon fibroblasto humano".
ES515032A Granted ES515032A0 (es) 1980-09-25 1982-08-16 "proceso para la produccion microbiana de interferon fibroblasto humano".

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES505742A Expired ES8307297A1 (es) 1980-09-25 1981-09-24 Proceso para la produccion microbiana de interferon fibro- blasto humano

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES515032A Granted ES515032A0 (es) 1980-09-25 1982-08-16 "proceso para la produccion microbiana de interferon fibroblasto humano".

Country Status (33)

Country Link
US (1) US5460811A (es)
EP (1) EP0048970A3 (es)
AT (1) AT380694B (es)
AU (1) AU582110B2 (es)
BR (1) BR8106137A (es)
CA (1) CA1341569C (es)
CH (2) CH651309A5 (es)
DD (3) DD209652A5 (es)
DE (1) DE3138096A1 (es)
DK (1) DK423381A (es)
ES (3) ES8307297A1 (es)
FI (1) FI812993A7 (es)
FR (1) FR2490675B1 (es)
GB (1) GB2098996B (es)
GR (1) GR81946B (es)
HK (1) HK43686A (es)
IE (1) IE51679B1 (es)
IL (1) IL63916A0 (es)
IT (1) IT1139487B (es)
KE (1) KE3630A (es)
LU (1) LU83648A1 (es)
MC (1) MC1423A1 (es)
MT (1) MTP900B (es)
MY (1) MY8600634A (es)
NL (1) NL8104400A (es)
NO (1) NO813248L (es)
NZ (1) NZ198445A (es)
OA (1) OA06908A (es)
PL (1) PL233194A1 (es)
PT (1) PT73728B (es)
SE (1) SE8105657L (es)
YU (1) YU44835B (es)
ZW (1) ZW23981A1 (es)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK33181A (da) * 1980-02-06 1981-08-07 Searle & Co Fremgangsmaade til fremstilling af et interferonlignende protein
ZA811368B (en) 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
DE3177213D1 (de) 1980-04-03 1990-10-18 Biogen Inc Dns-sequenzen, rekombinante dns-molekuele und verfahren zur herstellung von dem menschlichen fibroblast-interferon.
EP0042246B1 (en) * 1980-06-12 1987-03-18 The Cancer Institute Of Japanese Foundation For Cancer Research Plasmid
DK489481A (da) * 1980-11-10 1982-05-11 Searle & Co Plasmidvektor og frmgangsmaade til fremstilling deraf
NZ199722A (en) * 1981-02-25 1985-12-13 Genentech Inc Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
JPS58110600A (ja) * 1981-12-25 1983-07-01 Kyowa Hakko Kogyo Co Ltd ヒトβ型インタ−フエロン遺伝子を含む組みかえ体プラスミド
US6432677B1 (en) 1982-03-08 2002-08-13 Genentech, Inc. Non-human animal interferons
US4775622A (en) * 1982-03-08 1988-10-04 Genentech, Inc. Expression, processing and secretion of heterologous protein by yeast
IE54592B1 (en) * 1982-03-08 1989-12-06 Genentech Inc Anumal interferons, processes involved in their production, compositions containing them, dna sequences coding therefor and espression vehicles containing such sequences and cells transformed thereby
US5827694A (en) * 1982-03-08 1998-10-27 Genentech, Inc. DNA encoding non-human animal interferons, vectors and hosts therefor, and recombinant production of IFN polypeptides
EP0121569B1 (en) * 1982-10-08 1990-08-22 Kyowa Hakko Kogyo Co., Ltd. Novel vector
US5831023A (en) * 1982-11-01 1998-11-03 Genentech, Inc. Recombinant animal interferon polypeptides
US4599197A (en) * 1982-12-22 1986-07-08 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4511502A (en) * 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4512922A (en) * 1982-12-22 1985-04-23 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4518526A (en) * 1982-12-22 1985-05-21 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4620948A (en) * 1982-12-22 1986-11-04 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
GR79124B (es) * 1982-12-22 1984-10-02 Genentech Inc
US5683688A (en) * 1984-05-31 1997-11-04 Genentech, Inc. Unglycosylated recombinant human lymphotoxin polypeptides and compositions
GB8414354D0 (en) * 1984-06-05 1984-07-11 Biogen Nv Purifying protein
US5231176A (en) * 1984-08-27 1993-07-27 Genentech, Inc. Distinct family DNA encoding of human leukocyte interferons
EP0174143B1 (en) * 1984-08-27 1989-11-08 Genentech, Inc. Novel, distinct family of human leukocyte interferons, compositions containing them, methods for their production, and dna and transfected hosts therefor
US4680262A (en) * 1984-10-05 1987-07-14 Genentech, Inc. Periplasmic protein recovery
US5618920A (en) 1985-11-01 1997-04-08 Xoma Corporation Modular assembly of antibody genes, antibodies prepared thereby and use
EP0237019A3 (en) * 1986-03-14 1988-03-09 Toray Industries, Inc. Interferon conjugate and production thereof using recombinant gene
GB9022543D0 (en) * 1990-10-17 1990-11-28 Wellcome Found Antibody production
FR2686899B1 (fr) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
US20030026779A1 (en) * 1999-10-15 2003-02-06 Liming Yu Treatment of tumors and viral infections with a hybrid conjugate of interferon and an immunoglobulin Fc
US20050002902A1 (en) * 1995-12-28 2005-01-06 Liming Yu Hybrid with interferon-alpha and an immunoglobulin Fc for treatment of tumors and viral infections
US5723125A (en) * 1995-12-28 1998-03-03 Tanox Biosystems, Inc. Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide
US6713609B1 (en) * 1996-07-16 2004-03-30 Genentech, Inc. Monoclonal antibodies to type I interferon receptor
JP3576819B2 (ja) 1997-07-30 2004-10-13 キヤノン株式会社 情報処理装置及び印刷制御方法並びに記憶媒体
US20030018174A1 (en) * 1997-10-06 2003-01-23 Genentech, Inc. Monoclonal antibodies to IFNAR2
CA2368672A1 (en) 1999-03-24 2000-09-28 Genset S.A. Genomic sequence of the purh gene and purh-related biallelic markers
EP1274720A4 (en) 2000-04-12 2004-08-18 Human Genome Sciences Inc FUSION PROTEINS CONTAINING ALBUMIN
AU2002246955B2 (en) * 2001-01-09 2007-03-22 Baylor Research Institute Methods for treating autoimmune diseases in a subject and in vitro diagnostic assays
KR101271635B1 (ko) * 2001-12-21 2013-06-12 휴먼 게놈 사이언시즈, 인코포레이티드 알부민 융합 단백질
PT1463751E (pt) 2001-12-21 2013-08-26 Human Genome Sciences Inc Proteínas de fusão de albumina
CN102319437B (zh) 2002-12-26 2017-10-13 山景医药公司 具有增强的生物学效用的干扰素‑β的聚合物缀合物
AU2003303636B2 (en) * 2002-12-26 2010-08-05 Mountain View Pharmaceuticals, Inc. Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity
CA2513213C (en) 2003-01-22 2013-07-30 Human Genome Sciences, Inc. Albumin fusion proteins
CN103755800B (zh) 2004-02-02 2016-02-24 Ambrx公司 经修饰的人类生长激素多肽与其用途
US20070081995A1 (en) * 2005-06-22 2007-04-12 Genentech, Inc. Methods and compositions for targeting IFNAR2
NZ602170A (en) 2008-02-08 2014-03-28 Ambrx Inc Modified leptin polypeptides and their uses

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MW3378A1 (en) * 1977-11-08 1980-03-12 Genentech Inc Method and means for microbial polypeptide expression;synthetic dna and process therefor
US4411994A (en) * 1978-06-08 1983-10-25 The President And Fellows Of Harvard College Protein synthesis
IN150740B (es) * 1978-11-24 1982-12-04 Hoffmann La Roche
US4332892A (en) * 1979-01-15 1982-06-01 President And Fellows Of Harvard College Protein synthesis
US4262090A (en) * 1979-06-04 1981-04-14 Cetus Corporation Interferon production
US4342832A (en) * 1979-07-05 1982-08-03 Genentech, Inc. Method of constructing a replicable cloning vehicle having quasi-synthetic genes
ZA803943B (en) * 1979-07-31 1981-06-24 Hoffmann La Roche Homogeneous fibroblast interferon and method for manufacture thereof
US4289689A (en) * 1980-03-14 1981-09-15 Hoffmann-La Roche Inc. Preparation of homogeneous human fibroblast interferon
AU538665B2 (en) * 1979-10-30 1984-08-23 Juridical Foundation, Japanese Foundation For Cancer Research Human interferon dna
IL58765A (en) * 1979-11-21 1986-09-30 Yeda Res & Dev Process for the production of essentially pure messenger rna of human fibroblast interferon and process for the production of interferon beta
US4418149A (en) * 1980-01-10 1983-11-29 President And Fellows Of Harvard College Fused hybrid gene
GB2068970B (en) * 1980-02-06 1983-06-22 Searle & Co Recombinant dna technique for the preparation of a protein resembling human interferon
DK33181A (da) * 1980-02-06 1981-08-07 Searle & Co Fremgangsmaade til fremstilling af et interferonlignende protein
DE3005843A1 (de) * 1980-02-16 1981-09-10 Hoechst Ag, 6000 Frankfurt Genprodukt eines hoeheren organismus aus einem dieses gen enthaltenden mikroorganismus
DE3177213D1 (de) * 1980-04-03 1990-10-18 Biogen Inc Dns-sequenzen, rekombinante dns-molekuele und verfahren zur herstellung von dem menschlichen fibroblast-interferon.
EP0042246B1 (en) * 1980-06-12 1987-03-18 The Cancer Institute Of Japanese Foundation For Cancer Research Plasmid
US4874702A (en) * 1980-09-08 1989-10-17 Biogen, Inc. Vectors and methods for making such vectors and for expressive cloned genes

Also Published As

Publication number Publication date
MY8600634A (en) 1986-12-31
IE812224L (en) 1982-03-25
NZ198445A (en) 1984-05-31
DD202085A5 (de) 1983-08-24
SE8105657L (sv) 1982-03-26
ES505742A0 (es) 1983-07-01
ES515033A0 (es) 1983-06-01
PT73728B (en) 1984-05-08
ES8307297A1 (es) 1983-07-01
EP0048970A2 (en) 1982-04-07
IT8124109A0 (it) 1981-09-23
FR2490675A1 (fr) 1982-03-26
DK423381A (da) 1982-03-26
FI812993L (fi) 1982-03-26
DD209477A5 (de) 1984-05-09
CH656388A5 (de) 1986-06-30
ATA410381A (de) 1985-11-15
ZW23981A1 (en) 1982-04-28
DE3138096A1 (de) 1982-06-09
CH651309A5 (de) 1985-09-13
PT73728A (en) 1981-10-01
AU582110B2 (en) 1989-03-16
HK43686A (en) 1986-06-20
IL63916A0 (en) 1981-12-31
IT1139487B (it) 1986-09-24
GB2098996A (en) 1982-12-01
DD209652A5 (de) 1984-05-16
FI812993A7 (fi) 1982-03-26
GR81946B (es) 1984-12-12
ES8306324A1 (es) 1983-06-01
LU83648A1 (de) 1983-06-08
NO813248L (no) 1982-03-26
FR2490675B1 (fr) 1985-11-15
CA1341569C (en) 2008-03-25
EP0048970A3 (en) 1982-08-18
AT380694B (de) 1986-06-25
OA06908A (fr) 1983-05-31
BR8106137A (pt) 1982-06-15
YU229781A (en) 1984-02-29
ES515032A0 (es) 1983-06-01
PL233194A1 (en) 1983-07-18
MC1423A1 (fr) 1982-10-18
IE51679B1 (en) 1987-02-04
US5460811A (en) 1995-10-24
GB2098996B (en) 1985-02-06
KE3630A (en) 1986-05-16
NL8104400A (nl) 1982-04-16
MTP900B (en) 1985-02-28
AU7564981A (en) 1982-04-01
YU44835B (en) 1991-04-30

Similar Documents

Publication Publication Date Title
AR241314A1 (es) Aislado de adn, vector en base en dicho aislado cultivo de celulas tratadas con dicho vector y preparacion de factor viii humano funcional.
FI100056B (fi) Ihmisproapolipoproteiinin A-I ilmaiseminen
ES8505724A1 (es) Procedimiento para la produccion de polipetidos mediante levadura.
MX9700818A (es) Produccion bacteriana de polipeptidos hidrofobicos.
AR241654A1 (es) Procedimiento para producir activador de plasminogeno de tejido humano.
GEP19960519B (en) Method of producing human luecocytary interferons
ES2063515T3 (es) Ifn-alfa o-glucosilados.
ES8703490A1 (es) Un procedimiento para producir un polipeptido que tiene o contiene un polipeptido de factor de necrosis de tumor humano
ES8705467A1 (es) Un procedimiento para producir la proteina apoacuorina
ES8306324A1 (es) "proceso para la produccion microbiana de interferon fibroblasto humano".
ES8304203A1 (es) Un procedimiento para la preparacion del complejo antibiotico a-4696.
MD1652G2 (ro) Proteină cu activitate de tip citochină, ADN recombinant, codificator pentru această proteină, celule şi microorganisme transformate, vector de expresie, procedeu de obţinere a proteinei şi remediu care conţine această proteină
ES420458A1 (es) Procedimiento para la preparacion de heptapeptidos.
MY102918A (en) Purified antineoplaston fractions and methods of treating neoplastic disease.
ES2006476A6 (es) Un procedimiento para obtener interleukin-2 humana
ES2109412T3 (es) (-)-cimaterol en esencia opticamente puro y sus sales por adicion de acidos, asi como su empleo como medicamento o favorecedor del rendimiento.
ES2068201T3 (es) Produccion de kalicreina.
AU1299588A (en) Polypeptides with activity against gram-positive and gram-negative bacteria
ES8700232A1 (es) Un procedimiento para producir 1a,25-dihidroxi-26,27-dime- tilcolecalciferol
ES8300857A1 (es) Un procedimiento para la sintesis de insulina humana
ES8205416A1 (es) Un procedimiento para obtener el factor a2 del antibiotico a-16686.
ES2133819T3 (es) Procedimiento para preparar n-fosfonometilglicina.
ES8707554A1 (es) Procedimiento para preparar interferon-a recombinante
ES8800722A1 (es) Metodo de produccion de un factor liberador de la hormona del crecimiento por la expresion en e. coli de polipeptidos hibridos
CA2151381A1 (fr) Lipase gastrique du chien recombinante et compositions pharmaceutiques

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970505