ES8404683A1 - Un procedimiento para la preparacion de antagonistas de los receptores hidrogeno de la histamina. - Google Patents

Un procedimiento para la preparacion de antagonistas de los receptores hidrogeno de la histamina.

Info

Publication number: ES8404683A1
Authority: ES; Spain
Prior art keywords: thiadiazoles; substituted diamino; formula; substituted; diamino
Prior art date: 1982-03-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES520982A

Other languages

English (en)

Spanish (es)

Other versions

ES520982A0 (es

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bristol Myers Co

Original Assignee

Bristol Myers Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-03-29

Filing date

1983-03-25

Publication date

1984-05-16

1983-03-25 Application filed by Bristol Myers Co filed Critical Bristol Myers Co

1984-05-16 Publication of ES520982A0 publication Critical patent/ES520982A0/es

1984-05-16 Publication of ES8404683A1 publication Critical patent/ES8404683A1/es

Status Expired legal-status Critical Current

Links

RSDQVPRBWRLPTR-UHFFFAOYSA-N thiadiazole-4,5-diamine Chemical class NC=1N=NSC=1N RSDQVPRBWRLPTR-UHFFFAOYSA-N 0.000 title 1
229940122957 Histamine H2 receptor antagonist Drugs 0.000 abstract 1
239000003699 antiulcer agent Substances 0.000 abstract 1
RDJGIQPSSNMJPF-UHFFFAOYSA-N ethanediimidamide Chemical class NC(=N)C(N)=N RDJGIQPSSNMJPF-UHFFFAOYSA-N 0.000 abstract 1
239000003485 histamine H2 receptor antagonist Substances 0.000 abstract 1
150000004677 hydrates Chemical class 0.000 abstract 1
231100000252 nontoxic Toxicity 0.000 abstract 1
230000003000 nontoxic effect Effects 0.000 abstract 1
238000006798 ring closing metathesis reaction Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Furan Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Pyridine Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pyrrole Compounds (AREA)
Hydrogenated Pyridines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

ES520982A 1982-03-29 1983-03-25 Un procedimiento para la preparacion de antagonistas de los receptores hidrogeno de la histamina. Expired ES8404683A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US36320782A	1982-03-29	1982-03-29

Publications (2)

Publication Number	Publication Date
ES520982A0 ES520982A0 (es)	1984-05-16
ES8404683A1 true ES8404683A1 (es)	1984-05-16

Family

ID=23429274

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
ES520982A Expired ES8404683A1 (es)	1982-03-29	1983-03-25	Un procedimiento para la preparacion de antagonistas de los receptores hidrogeno de la histamina.
ES527686A Expired ES8505978A1 (es)	1982-03-29	1983-11-30	Un procedimiento para la preparacion de antagonistas de los receptores hidrogeno de la histamina.
ES527685A Granted ES527685A0 (es)	1982-03-29	1983-11-30	Un procedimiento para la preparacion de antagonistas de los receptores hidrogeno de la histamina

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
ES527686A Expired ES8505978A1 (es)	1982-03-29	1983-11-30	Un procedimiento para la preparacion de antagonistas de los receptores hidrogeno de la histamina.
ES527685A Granted ES527685A0 (es)	1982-03-29	1983-11-30	Un procedimiento para la preparacion de antagonistas de los receptores hidrogeno de la histamina

Country Status (30)

Country	Link
JP (2)	JPS58180477A (de)
KR (1)	KR880002209B1 (de)
AT (1)	AT386599B (de)
AU (2)	AU557577B2 (de)
BE (1)	BE896291A (de)
CH (2)	CH655111A5 (de)
CS (2)	CS250240B2 (de)
DD (2)	DD210909A5 (de)
DE (1)	DE3311281A1 (de)
DK (2)	DK166677B1 (de)
ES (3)	ES8404683A1 (de)
FR (2)	FR2542741B1 (de)
GB (2)	GB2117769B (de)
GR (1)	GR78524B (de)
HU (2)	HU188742B (de)
IE (1)	IE55596B1 (de)
IL (1)	IL68259A0 (de)
IT (1)	IT1164633B (de)
LU (1)	LU84716A1 (de)
MY (1)	MY8700942A (de)
NL (1)	NL8301063A (de)
NO (1)	NO163055C (de)
NZ (1)	NZ203726A (de)
OA (1)	OA07356A (de)
PT (1)	PT76459B (de)
SE (2)	SE461040B (de)
SU (2)	SU1419518A3 (de)
YU (1)	YU44849B (de)
ZA (1)	ZA832154B (de)
ZW (1)	ZW7683A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2222083A (en) *	1982-12-14	1984-06-21	Smith Kline & French Laboratories Limited	Pyridine derivatives
US4593039A (en) *	1984-04-02	1986-06-03	Merck & Co., Inc.	1-aryloxy-3-(substituted aminoalkylamino)-2-propanols
US4644006A (en) *	1984-06-22	1987-02-17	Bristol-Myers Company	Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity
JPH0622828B2 (ja) *	1986-06-30	1994-03-30	フアナツク株式会社	直圧式型締機構
WO2022034121A1 (en)	2020-08-11	2022-02-17	Université De Strasbourg	H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3018289A (en) *	1960-02-10	1962-01-23	Wyandotte Chemicals Corp	Process for preparing oxamidines
GB1595291A (en) *	1976-09-21	1981-08-12	Smith Kline French Lab	Pyrimidone and thiopyrimidone derivatives
DK160611C (da) *	1979-09-04	1991-09-16	Bristol Myers Squibb Co	Analogifremgangsmaade til fremstilling af 3,4-disubstituerede 1,2,5-thiadiazol-1-oxider og -1,1-dioxider
EP0040696B1 (de) *	1980-04-30	1986-08-27	Merck & Co. Inc.	Aminothiadiazole als gastrische Inhibitoren
AU2222083A (en) *	1982-12-14	1984-06-21	Smith Kline & French Laboratories Limited	Pyridine derivatives

1983
- 1983-03-25 ES ES520982A patent/ES8404683A1/es not_active Expired
- 1983-03-25 NL NL8301063A patent/NL8301063A/nl not_active Application Discontinuation
- 1983-03-25 ZW ZW76/83A patent/ZW7683A1/xx unknown
- 1983-03-25 ZA ZA832154A patent/ZA832154B/xx unknown
- 1983-03-25 FR FR838304934A patent/FR2542741B1/fr not_active Expired
- 1983-03-28 GB GB08308518A patent/GB2117769B/en not_active Expired
- 1983-03-28 PT PT76459A patent/PT76459B/pt not_active IP Right Cessation
- 1983-03-28 SE SE8301725A patent/SE461040B/sv not_active IP Right Cessation
- 1983-03-28 IL IL68259A patent/IL68259A0/xx not_active IP Right Cessation
- 1983-03-28 IT IT48005/83A patent/IT1164633B/it active
- 1983-03-28 GR GR70903A patent/GR78524B/el unknown
- 1983-03-28 DE DE19833311281 patent/DE3311281A1/de not_active Withdrawn
- 1983-03-28 IE IE686/83A patent/IE55596B1/en not_active IP Right Cessation
- 1983-03-28 SU SU833568849A patent/SU1419518A3/ru active
- 1983-03-28 HU HU831040A patent/HU188742B/hu not_active IP Right Cessation
- 1983-03-28 BE BE0/210417A patent/BE896291A/fr not_active IP Right Cessation
- 1983-03-28 AU AU12907/83A patent/AU557577B2/en not_active Ceased
- 1983-03-28 HU HU854071A patent/HU196386B/hu not_active IP Right Cessation
- 1983-03-28 DK DK141383A patent/DK166677B1/da not_active IP Right Cessation
- 1983-03-28 LU LU84716A patent/LU84716A1/fr unknown
- 1983-03-28 NO NO831100A patent/NO163055C/no unknown
- 1983-03-28 NZ NZ203726A patent/NZ203726A/en unknown
- 1983-03-29 KR KR1019830001283A patent/KR880002209B1/ko not_active Expired
- 1983-03-29 JP JP58051740A patent/JPS58180477A/ja active Granted
- 1983-03-29 OA OA57955A patent/OA07356A/xx unknown
- 1983-03-29 DD DD83249300A patent/DD210909A5/de not_active IP Right Cessation
- 1983-03-29 AT AT0111083A patent/AT386599B/de not_active IP Right Cessation
- 1983-03-29 YU YU744/83A patent/YU44849B/xx unknown
- 1983-03-29 CH CH1749/83A patent/CH655111A5/de not_active IP Right Cessation
- 1983-03-29 CH CH575/86A patent/CH660880A5/de not_active IP Right Cessation
- 1983-03-29 DD DD83260707A patent/DD219768A5/de not_active IP Right Cessation
- 1983-03-29 CS CS841958A patent/CS250240B2/cs unknown
- 1983-03-29 CS CS832191A patent/CS250229B2/cs unknown
- 1983-11-30 ES ES527686A patent/ES8505978A1/es not_active Expired
- 1983-11-30 ES ES527685A patent/ES527685A0/es active Granted
1984
- 1984-06-08 SU SU843750493A patent/SU1355123A3/ru active
- 1984-12-31 GB GB08432809A patent/GB2149406B/en not_active Expired
1986
- 1986-09-30 AU AU63272/86A patent/AU586037B2/en not_active Ceased
1987
- 1987-05-22 FR FR878707197A patent/FR2597867B1/fr not_active Expired
- 1987-11-25 SE SE8704689A patent/SE464302B/sv not_active IP Right Cessation
- 1987-12-30 MY MY942/87A patent/MY8700942A/xx unknown
1992
- 1992-06-18 DK DK92811A patent/DK81192D0/da not_active Application Discontinuation
1993
- 1993-04-16 JP JP5124585A patent/JPH06135925A/ja active Pending

Also Published As

Publication number	Publication date
DD219768A5 (de)	1985-03-13
NO831100L (no)	1983-09-30
SE8301725L (sv)	1983-11-25
KR880002209B1 (ko)	1988-10-18
PT76459A (en)	1983-04-01
ZA832154B (en)	1983-12-28
DK166677B1 (da)	1993-06-28
ES527686A0 (es)	1985-06-16
HU188742B (en)	1986-05-28
SE8301725D0 (sv)	1983-03-28
GR78524B (de)	1984-09-27
ES8505978A1 (es)	1985-06-16
SU1419518A3 (ru)	1988-08-23
CS250229B2 (en)	1987-04-16
SE464302B (sv)	1991-04-08
NO163055B (no)	1989-12-18
CH655111A5 (de)	1986-03-27
ES520982A0 (es)	1984-05-16
SE461040B (sv)	1989-12-18
PT76459B (en)	1986-03-11
DK81192A (da)	1992-06-18
GB8308518D0 (en)	1983-05-05
AU6327286A (en)	1987-01-08
YU44849B (en)	1991-04-30
JPH06135925A (ja)	1994-05-17
BE896291A (fr)	1983-09-28
GB8432809D0 (en)	1985-02-06
IL68259A0 (en)	1983-06-15
YU74483A (en)	1986-02-28
LU84716A1 (fr)	1983-12-05
ES8505977A1 (es)	1985-06-16
AU586037B2 (en)	1989-06-29
ATA111083A (de)	1988-02-15
FR2597867A1 (fr)	1987-10-30
GB2117769A (en)	1983-10-19
ZW7683A1 (en)	1984-01-04
CS250240B2 (en)	1987-04-16
FR2542741B1 (fr)	1989-12-08
GB2117769B (en)	1985-08-29
SU1355123A3 (ru)	1987-11-23
SE8704689D0 (sv)	1987-11-25
SE8704689L (sv)	1987-11-25
HU196386B (en)	1988-11-28
NZ203726A (en)	1986-05-09
AT386599B (de)	1988-09-12
DE3311281A1 (de)	1983-11-24
JPH0568472B2 (de)	1993-09-29
GB2149406B (en)	1986-01-02
NL8301063A (nl)	1983-10-17
GB2149406A (en)	1985-06-12
DK141383D0 (da)	1983-03-28
ES527685A0 (es)	1985-06-16
IT1164633B (it)	1987-04-15
OA07356A (fr)	1984-08-31
IE55596B1 (en)	1990-11-21
FR2597867B1 (fr)	1989-12-08
IT8348005A0 (it)	1983-03-28
CH660880A5 (de)	1987-05-29
IE830686L (en)	1983-09-29
JPS58180477A (ja)	1983-10-21
DK81192D0 (da)	1992-06-18
NO163055C (no)	1990-03-28
AU1290783A (en)	1983-10-06
AU557577B2 (en)	1986-12-24
KR840004095A (ko)	1984-10-06
DD210909A5 (de)	1984-06-27
DK141383A (da)	1983-09-30
MY8700942A (en)	1987-12-31
FR2542741A1 (fr)	1984-09-21

Legal Events

Date	Code	Title	Description
2000-01-01	FD1A	Patent lapsed	Effective date: 19991108

Publication	Publication Date	Title
ES8404993A1 (es)	1984-05-16	Procedimiento para preparar derivados de piridina
PL295911A1 (en)	1993-03-22	Method of obtaining imidazo-condensed iso- ane heterocyclic compounds
ES8602721A1 (es)	1985-12-01	Un procedimiento para la preparacion de antagonistas de los receptores h-2 de la histamina.
EP0251299A3 (en)	1989-10-11	Cephalosporin compounds, processes for their preparation and antibacterial agents
IE840182L (en)	1984-08-01	Des-proline vasopressin antagonists
CA2038848A1 (en)	1991-09-25	Hydantoin derivatives
ES8507103A1 (es)	1985-08-16	Un procedimiento para la preparacion de nuevas sulfonamidas.
ES8705892A1 (es)	1987-05-16	Un metodo para preparar derivados de cefem
ES8100273A1 (es)	1980-11-01	Procedimiento para la preparacion de nuevos derivados de alfa-(3,4-diclorofenil)-2-imidazolina-2-metanol y alfa-(3,4-diclorofenil)-1,4,5,6-tetrahidro-2-pirimidinametanol
AU546158B2 (en)	1985-08-15	Cycloaliphatic pharmaceutical compounds
ES8505978A1 (es)	1985-06-16	Un procedimiento para la preparacion de antagonistas de los receptores hidrogeno de la histamina.
CA1228067A (en)	1987-10-13	3,4-DIAMINO-1,2,5-THIADIAZOLE SUBSTITUTION DERIVATIVES, ANTAGONISTS FOR H.SUB.2 HISTAMINE RECEPTORS
GR3030506T3 (en)	1999-10-29	1-azaadamantane derivatives as 5-ht agonists or antagonists.
ES8702881A1 (es)	1987-01-16	Un procedimiento para la preparacion de etanodiimidamidas
ES8403911A1 (es)	1984-04-16	Procedimiento de preparacion de mononitratos de 1.4,3.6- dianhidro-hexito sustituidos en 2-0 y 5-0
SE321467B (de)	1970-03-09
ES8200880A1 (es)	1981-11-16	Procedimiento para la obtencion de nuevos tioles
IL62226A (en)	1984-03-30	((substituted pyrimidinyl-ureido)-(2,3-dihydro-2-imino-4-thiazolyl))acetamido-cephalosporins,their preparation and pharmaceutical compositions containing them
DE3461375D1 (en)	1987-01-08	1-acetonyl-2-(phenylimino)-imidazolidines, their addition salts, their pharmaceutical compositions and their preparation
PL246418A1 (en)	1985-07-02	Process for preparing n-/3-trifluoromethylphenyl/-n'-propargylpiperazine
ES479033A1 (es)	1980-06-16	Un procedimiento para la preparacion de derivados de n-iminometil piperidina.
ES468675A1 (es)	1978-12-01	Procedimiento de fabricacion de tiobencilpirimidinas y sus compuestos medicamentosos.
ES459963A1 (es)	1978-05-01	Procedimiento para la obtencion de 1-(aralcoxifenilo azaci- clico)-2- o -3-(bis-arilalquilamino)-alcanos.
DE3469738D1 (en)	1988-04-14	Spirobenzofuranones, their production and use
EP0177897A3 (de)	1988-03-09	Antibakterielles 7-beta-heterocyclisch-Cephem