ES8501732A1 - Procedimiento para preparar acidos x-arilalcanoicos opticamente activos. - Google Patents

Procedimiento para preparar acidos x-arilalcanoicos opticamente activos.

Info

Publication number
ES8501732A1
ES8501732A1 ES518086A ES518086A ES8501732A1 ES 8501732 A1 ES8501732 A1 ES 8501732A1 ES 518086 A ES518086 A ES 518086A ES 518086 A ES518086 A ES 518086A ES 8501732 A1 ES8501732 A1 ES 8501732A1
Authority
ES
Spain
Prior art keywords
alpha
optically active
preparation
substituted aryl
arylalkanoic acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES518086A
Other languages
English (en)
Other versions
ES518086A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex Pharmaceuticals International Ltd
Original Assignee
Syntex Pharmaceuticals International Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23286496&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8501732(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Syntex Pharmaceuticals International Ltd filed Critical Syntex Pharmaceuticals International Ltd
Publication of ES8501732A1 publication Critical patent/ES8501732A1/es
Publication of ES518086A0 publication Critical patent/ES518086A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/313—Compounds having groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/315—Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/54—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition of compounds containing doubly bound oxygen atoms, e.g. esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/277—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/02—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/02—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 2
    • C07D317/06—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 2 condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/02—Magnesium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/06—Zinc compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Luminescent Compositions (AREA)
  • Transmission And Conversion Of Sensor Element Output (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Seasonings (AREA)
  • Peptides Or Proteins (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR ACIDOS BAB-ARILALCANOICOS OPTICAMENTE ACTIVOS, DE FORMULA GENERAL (I), Y SUS SALES FARMACEUTICAMENTE ACEPTABLES, SUS ESTERES, SUS ORTOESTERES Y SUS AMIDAS.CONSISTE EN HACER REACCIONAR UN COMPUESTO ORGANOMETALICO DE FORMULA: ARMX, (AR)2M O ARM, CON UN HALURO DE ACILO, UNA ACIL-AMINA O UN ANHIDRIDO DE ACIDO, OPTICAMENTE ACTIVOS, DE FORMULA GENERAL (II), PARA OBTENER UN COMPUESTO DE FORMULA GENERAL (III). DICHO COMPUESTO DE FORMULA (III) SE CETALIZA MEDIANTE UN AGENTE CETALIZANTE, PARA OBTENER EL ACIDO BAB-ARILALCANOICO.DE APLICACION EN FARMACIA POR SU ACTIVIDAD ANTI-INFLAMATORIA, ANALGESICA Y ANTI-PIRETICA.
ES518086A 1981-12-11 1982-12-10 Procedimiento para preparar acidos x-arilalcanoicos opticamente activos. Granted ES518086A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US32967281A 1981-12-11 1981-12-11

Publications (2)

Publication Number Publication Date
ES8501732A1 true ES8501732A1 (es) 1984-12-16
ES518086A0 ES518086A0 (es) 1984-12-16

Family

ID=23286496

Family Applications (1)

Application Number Title Priority Date Filing Date
ES518086A Granted ES518086A0 (es) 1981-12-11 1982-12-10 Procedimiento para preparar acidos x-arilalcanoicos opticamente activos.

Country Status (29)

Country Link
EP (1) EP0081993B1 (es)
JP (4) JPS58135833A (es)
KR (1) KR890000375B1 (es)
AT (1) ATE36517T1 (es)
AU (1) AU560800B2 (es)
CA (2) CA1259627A (es)
CS (1) CS259510B2 (es)
DD (1) DD206372A5 (es)
DE (1) DE3278907D1 (es)
DK (6) DK551782A (es)
ES (1) ES518086A0 (es)
FI (2) FI82680C (es)
GR (1) GR77059B (es)
HK (1) HK51489A (es)
HU (1) HU191621B (es)
IE (1) IE53922B1 (es)
IL (1) IL67455A (es)
IN (1) IN156354B (es)
IT (1) IT1155421B (es)
MX (1) MX159862A (es)
NO (1) NO156650C (es)
NZ (1) NZ202773A (es)
PH (5) PH20529A (es)
PL (1) PL142997B1 (es)
PT (1) PT75973B (es)
RO (1) RO87021B (es)
SG (1) SG3089G (es)
SU (1) SU1577694A3 (es)
ZA (1) ZA829101B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE53333B1 (en) * 1980-09-11 1988-10-26 Syntex Pharma Int Process for preparing alpha-aromatic group substituted alkanoic acids or esters thereof
IT1208109B (it) * 1983-11-23 1989-06-06 Alfa Chem Ital Procedimento per la risoluzione ottica di acidi arilpropionici
ATE23987T1 (de) * 1984-02-02 1986-12-15 Zambon Spa Verfahren zur herstellung von alpharylalkans|uren.
IT1173216B (it) * 1984-02-03 1987-06-18 Zambon Spa Processo per la preparazione di acidi alfa-idrossiaril-alcanoici
IT1174084B (it) * 1984-05-10 1987-07-01 Blaschim Spa Procentimento per preparare il naproxen
US4670586A (en) * 1984-09-12 1987-06-02 Nippon Chemicals Co., Ltd. Method for the production of α-aryl-alkanoic acid
IT1190362B (it) * 1985-05-30 1988-02-16 Zambon Spa Preparazione del (6-metossi-2-naftil)-(1-bormoetil)-chetone e dei suoi derivati
IT1188181B (it) * 1985-07-31 1988-01-07 Zambon Spa Processo per la preparazione di acidi carbossilici otticamente attivi e relativi intermedi
IT1198237B (it) * 1986-12-23 1988-12-21 Zambon Spa Intermedi per la sintesi di composti organici
WO1989010350A1 (en) * 1988-04-21 1989-11-02 Ici Australia Operations Proprietary Limited Preparation of an epoxide
EP0380316A3 (en) * 1989-01-25 1990-11-28 Syntex Pharmaceuticals International Limited Preparation of alpha-methylareneacetic acids
IT1251958B (it) * 1991-10-18 1995-05-27 Zambon Spa Processo per la dealogenazione di derivati del naftalene
JP3563406B2 (ja) * 1994-06-08 2004-09-08 塩野義製薬株式会社 ４−オキソ−２−アルケン酸エステルの製造方法
JP3744060B2 (ja) * 1996-06-20 2006-02-08 ダイソー株式会社 アシルオキシスルホン酸エステル誘導体の製造法
EP1422215A4 (en) * 2001-08-08 2005-07-06 Kaneka Corp PROCESS FOR PRODUCING OPTICALLY ACTIVE 2-SUBSTITUTED CARBOXYLIC ACID
MXPA04001253A (es) 2001-08-09 2004-06-03 Ono Pharmaceutical Co Derivados de acidos carboxilicos y agente farmaceutico que comprende los mismos como ingrediente activo.
SK16482002A3 (sk) * 2002-11-20 2004-06-08 Slovakofarma, A. S. Spôsob prípravy substituovaných derivátov 2-aryl alkánových kyselín
CN106496092B (zh) * 2016-08-30 2019-03-29 江苏宇田医药有限公司 一种用于合成西洛多辛的中间体的制备方法
CN112110801B (zh) * 2020-10-09 2022-07-19 浙江工业大学 一种γ-芳基取代酮类化合物的合成方法
CN114644554A (zh) * 2020-12-21 2022-06-21 上海医药工业研究院 (s)-氟比洛芬的制备方法及其中间体

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3637767A (en) * 1968-07-30 1972-01-25 Syntex Corp 2-(6'-methoxynaphth-2'-yl)propylene oxide and 5'-halo derivatives
ES455064A1 (es) * 1977-01-17 1978-02-01 Valles Quimica Nuevo procedimiento para la obtencion del acido (d)-2(6-me- toxi-2-naftil)-propionico.
JPS5519214A (en) * 1978-07-27 1980-02-09 Ono Pharmaceut Co Ltd 2-acyl-6-aminomethylphenol derivative and its preparation
JPS55130934A (en) * 1979-03-31 1980-10-11 Masao Sato Ketone synthesis from grignard reagent and acid halide
IT1212408B (it) * 1980-02-26 1989-11-22 Blaschim Spa Processo per la produzione di acidi alcanoici alfa sostituiti.
IE50897B1 (en) * 1980-02-26 1986-08-06 Blaschim Spa Process for preparing esters of alkanoic acids via rearrangement of alpha-haloketals
IE53333B1 (en) * 1980-09-11 1988-10-26 Syntex Pharma Int Process for preparing alpha-aromatic group substituted alkanoic acids or esters thereof
JPS5798232A (en) * 1980-11-10 1982-06-18 Sagami Chem Res Center 1-(6-methoxy-2-naphthyl)-2-oxy-1-alkanone acetal
IL65629A (en) * 1981-04-30 1987-08-31 Syntex Pharma Int Preparation of alpha-arylalkanoic acids and esters and salts thereof
JPS5810525A (ja) * 1981-06-15 1983-01-21 Sagami Chem Res Center 光学活性な１−芳香族基置換−１−アルカノン類の製造方法

Also Published As

Publication number Publication date
PH21336A (en) 1987-10-13
IT1155421B (it) 1987-01-28
CA1259627A (en) 1989-09-19
DK461388A (da) 1988-08-17
JPH02270840A (ja) 1990-11-05
KR840002764A (ko) 1984-07-16
IN156354B (es) 1985-06-29
EP0081993A2 (en) 1983-06-22
AU560800B2 (en) 1987-04-16
PH22187A (en) 1988-06-28
DD206372A5 (de) 1984-01-25
DE3278907D1 (en) 1988-09-22
RO87021A (ro) 1985-05-20
FI824203L (fi) 1983-06-12
EP0081993A3 (en) 1984-01-11
PL239456A1 (en) 1984-03-12
PT75973B (en) 1985-10-04
NO156650C (no) 1987-10-28
DK461188A (da) 1988-08-17
HK51489A (en) 1989-07-07
ES518086A0 (es) 1984-12-16
HU191621B (en) 1987-03-30
DK461588D0 (da) 1988-08-17
SG3089G (en) 1989-06-02
JPH0420901B2 (es) 1992-04-07
RO87021B (ro) 1985-05-31
FI824203A0 (fi) 1982-12-07
SU1577694A3 (ru) 1990-07-07
DK461588A (da) 1988-08-17
KR890000375B1 (en) 1989-03-15
AU9146482A (en) 1983-06-16
DK461488D0 (da) 1988-08-17
DK461488A (da) 1988-08-17
GR77059B (es) 1984-09-05
DK461288D0 (da) 1988-08-17
FI82680C (fi) 1991-04-10
PL142997B1 (en) 1987-12-31
JPH02262533A (ja) 1990-10-25
DK461288A (da) 1988-08-17
NO824175L (no) 1983-06-13
PH20529A (en) 1987-02-09
PH20059A (en) 1986-09-18
CA1338433C (en) 1996-07-02
JPH02262532A (ja) 1990-10-25
CS903882A2 (en) 1988-03-15
FI901487A0 (fi) 1990-03-26
CS259510B2 (en) 1988-10-14
FI82680B (fi) 1990-12-31
EP0081993B1 (en) 1988-08-17
JPH0354652B2 (es) 1991-08-20
NZ202773A (en) 1985-12-13
ATE36517T1 (de) 1988-09-15
MX159862A (es) 1989-09-21
IT8224665A1 (it) 1984-06-10
IT8224665A0 (it) 1982-12-10
FI901487A7 (fi) 1990-03-26
IE53922B1 (en) 1989-04-12
IL67455A (en) 1992-09-06
NO156650B (no) 1987-07-20
DK551782A (da) 1983-09-26
ZA829101B (en) 1984-07-25
JPS58135833A (ja) 1983-08-12
DK461188D0 (da) 1988-08-17
DK461388D0 (da) 1988-08-17
PH20169A (en) 1986-10-09
IE822945L (en) 1983-06-11

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970519