RO87021B - Procedeu de preparare a acidului 2(6-metoxi-2-naftil)-propionic - Google Patents

Procedeu de preparare a acidului 2(6-metoxi-2-naftil)-propionic

Info

Publication number
RO87021B
RO87021B RO109274A RO10927482A RO87021B RO 87021 B RO87021 B RO 87021B RO 109274 A RO109274 A RO 109274A RO 10927482 A RO10927482 A RO 10927482A RO 87021 B RO87021 B RO 87021B
Authority
RO
Romania
Prior art keywords
methoxy
formula
preparation
general formula
compound
Prior art date
Application number
RO109274A
Other languages
English (en)
Other versions
RO87021A (ro
Inventor
George Schloemer
Original Assignee
Syntex Pharmaceuticals International Limited Bermuda
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23286496&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RO87021(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Syntex Pharmaceuticals International Limited Bermuda filed Critical Syntex Pharmaceuticals International Limited Bermuda
Publication of RO87021A publication Critical patent/RO87021A/ro
Publication of RO87021B publication Critical patent/RO87021B/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/313—Compounds having groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/315—Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/54—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition of compounds containing doubly bound oxygen atoms, e.g. esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/277—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/02—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/02—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 2
    • C07D317/06—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 2 condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/02—Magnesium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/06—Zinc compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Luminescent Compositions (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Seasonings (AREA)
  • Peptides Or Proteins (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Transmission And Conversion Of Sensor Element Output (AREA)

Abstract

Inventia se refera la un procedeu de preparare a acidului 2-(6-metoxi-2-naftil)-propionoc cu formula generala I (vezi formula) sau o sare acceptabila farmaceutic a acestuia prin prepararea unui compus cu formula generala Ii (vezi formula) în care Z este un rest amino al unui acid, grupele hidroxi sau grupa hidroxi protejata la care în scopul obtinerii unu singur stereoizomer al compusului cu formula II, se trateaza un compus organometalic ales dintre bromura sau clorura de '-(6-metoxi-2-naftil)-mangan si di-(6-metoxi-2-naftil)-zinc cu o substanta optic activa cu formula generala III în care Z este definit ca mai sus si Y este (vezi formula) halogen, preferabil clor sau brom sau un grup cu formula -N)R') (R'' în care R' si R'' sînt alchil sau aril luate împreuna cu N formeaza o parte heterociclica care poate contine si alti atomi hetero sau aciloxi, în tetrahidrofuran la temperaturi cuprinse între -70 degree C si temperatura camerei.
RO109274A 1981-12-11 1982-12-09 Procedeu de preparare a acidului 2(6-metoxi-2-naftil)-propionic RO87021B (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US32967281A 1981-12-11 1981-12-11

Publications (2)

Publication Number Publication Date
RO87021A RO87021A (ro) 1985-05-20
RO87021B true RO87021B (ro) 1985-05-31

Family

ID=23286496

Family Applications (1)

Application Number Title Priority Date Filing Date
RO109274A RO87021B (ro) 1981-12-11 1982-12-09 Procedeu de preparare a acidului 2(6-metoxi-2-naftil)-propionic

Country Status (29)

Country Link
EP (1) EP0081993B1 (ro)
JP (4) JPS58135833A (ro)
KR (1) KR890000375B1 (ro)
AT (1) ATE36517T1 (ro)
AU (1) AU560800B2 (ro)
CA (2) CA1259627A (ro)
CS (1) CS259510B2 (ro)
DD (1) DD206372A5 (ro)
DE (1) DE3278907D1 (ro)
DK (6) DK551782A (ro)
ES (1) ES8501732A1 (ro)
FI (2) FI901487A7 (ro)
GR (1) GR77059B (ro)
HK (1) HK51489A (ro)
HU (1) HU191621B (ro)
IE (1) IE53922B1 (ro)
IL (1) IL67455A (ro)
IN (1) IN156354B (ro)
IT (1) IT1155421B (ro)
MX (1) MX159862A (ro)
NO (1) NO156650C (ro)
NZ (1) NZ202773A (ro)
PH (5) PH20529A (ro)
PL (1) PL142997B1 (ro)
PT (1) PT75973B (ro)
RO (1) RO87021B (ro)
SG (1) SG3089G (ro)
SU (1) SU1577694A3 (ro)
ZA (1) ZA829101B (ro)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE53333B1 (en) * 1980-09-11 1988-10-26 Syntex Pharma Int Process for preparing alpha-aromatic group substituted alkanoic acids or esters thereof
IT1208109B (it) * 1983-11-23 1989-06-06 Alfa Chem Ital Procedimento per la risoluzione ottica di acidi arilpropionici
EP0151817B1 (en) * 1984-02-02 1986-12-03 ZAMBON S.p.A. Process for preparing alpha-arylalkanoic acids
IT1173216B (it) * 1984-02-03 1987-06-18 Zambon Spa Processo per la preparazione di acidi alfa-idrossiaril-alcanoici
IT1174084B (it) * 1984-05-10 1987-07-01 Blaschim Spa Procentimento per preparare il naproxen
US4670586A (en) * 1984-09-12 1987-06-02 Nippon Chemicals Co., Ltd. Method for the production of α-aryl-alkanoic acid
IT1190362B (it) * 1985-05-30 1988-02-16 Zambon Spa Preparazione del (6-metossi-2-naftil)-(1-bormoetil)-chetone e dei suoi derivati
IT1188181B (it) * 1985-07-31 1988-01-07 Zambon Spa Processo per la preparazione di acidi carbossilici otticamente attivi e relativi intermedi
IT1198237B (it) * 1986-12-23 1988-12-21 Zambon Spa Intermedi per la sintesi di composti organici
WO1989010350A1 (en) * 1988-04-21 1989-11-02 Ici Australia Operations Proprietary Limited Preparation of an epoxide
IT1240228B (it) * 1989-01-25 1993-11-27 Syntex Inc Preparazione di acidi alfa-metilarenacetici.
IT1251958B (it) * 1991-10-18 1995-05-27 Zambon Spa Processo per la dealogenazione di derivati del naftalene
JP3563406B2 (ja) * 1994-06-08 2004-09-08 塩野義製薬株式会社 ４−オキソ−２−アルケン酸エステルの製造方法
JP3744060B2 (ja) * 1996-06-20 2006-02-08 ダイソー株式会社 アシルオキシスルホン酸エステル誘導体の製造法
US20050245764A1 (en) * 2001-08-08 2005-11-03 Koki Yamashita Process for producing optically active 2-substituted carboxylic acid
NZ531153A (en) 2001-08-09 2005-10-28 Ono Pharmaceutical Co Carboxylic acid derivative compounds and drugs comprising these compounds as the active ingredient
SK16482002A3 (sk) * 2002-11-20 2004-06-08 Slovakofarma, A. S. Spôsob prípravy substituovaných derivátov 2-aryl alkánových kyselín
CN106496092B (zh) * 2016-08-30 2019-03-29 江苏宇田医药有限公司 一种用于合成西洛多辛的中间体的制备方法
CN112110801B (zh) * 2020-10-09 2022-07-19 浙江工业大学 一种γ-芳基取代酮类化合物的合成方法
CN114644554A (zh) * 2020-12-21 2022-06-21 上海医药工业研究院 (s)-氟比洛芬的制备方法及其中间体

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3637767A (en) * 1968-07-30 1972-01-25 Syntex Corp 2-(6'-methoxynaphth-2'-yl)propylene oxide and 5'-halo derivatives
ES455064A1 (es) * 1977-01-17 1978-02-01 Valles Quimica Nuevo procedimiento para la obtencion del acido (d)-2(6-me- toxi-2-naftil)-propionico.
JPS5519214A (en) * 1978-07-27 1980-02-09 Ono Pharmaceut Co Ltd 2-acyl-6-aminomethylphenol derivative and its preparation
JPS55130934A (en) * 1979-03-31 1980-10-11 Masao Sato Ketone synthesis from grignard reagent and acid halide
IE50898B1 (en) * 1980-02-26 1986-08-06 Blaschim Spa Process for preparing esters of 2-(6'-methoxy-2'-naphthyl)-propionic acid via rearrangement of new ketals of 2-halo-1-(6'-methoxy-2'-naphthyl)-propan-1-one
IT1212408B (it) * 1980-02-26 1989-11-22 Blaschim Spa Processo per la produzione di acidi alcanoici alfa sostituiti.
JPS5798232A (en) * 1980-11-10 1982-06-18 Sagami Chem Res Center 1-(6-methoxy-2-naphthyl)-2-oxy-1-alkanone acetal
IE53333B1 (en) * 1980-09-11 1988-10-26 Syntex Pharma Int Process for preparing alpha-aromatic group substituted alkanoic acids or esters thereof
IL65629A (en) * 1981-04-30 1987-08-31 Syntex Pharma Int Preparation of alpha-arylalkanoic acids and esters and salts thereof
JPS5810525A (ja) * 1981-06-15 1983-01-21 Sagami Chem Res Center 光学活性な１−芳香族基置換−１−アルカノン類の製造方法

Also Published As

Publication number Publication date
IE53922B1 (en) 1989-04-12
IL67455A (en) 1992-09-06
DK461388D0 (da) 1988-08-17
FI901487A0 (fi) 1990-03-26
PL239456A1 (en) 1984-03-12
FI824203A0 (fi) 1982-12-07
DK551782A (da) 1983-09-26
JPH0354652B2 (ro) 1991-08-20
PH22187A (en) 1988-06-28
ATE36517T1 (de) 1988-09-15
EP0081993A2 (en) 1983-06-22
PT75973B (en) 1985-10-04
DK461288A (da) 1988-08-17
JPH02270840A (ja) 1990-11-05
IT8224665A1 (it) 1984-06-10
KR840002764A (ko) 1984-07-16
EP0081993A3 (en) 1984-01-11
NZ202773A (en) 1985-12-13
DK461288D0 (da) 1988-08-17
DD206372A5 (de) 1984-01-25
GR77059B (ro) 1984-09-05
JPH02262533A (ja) 1990-10-25
DE3278907D1 (en) 1988-09-22
PH21336A (en) 1987-10-13
NO824175L (no) 1983-06-13
AU560800B2 (en) 1987-04-16
PH20169A (en) 1986-10-09
JPH02262532A (ja) 1990-10-25
IT8224665A0 (it) 1982-12-10
ES518086A0 (es) 1984-12-16
JPS58135833A (ja) 1983-08-12
FI901487A7 (fi) 1990-03-26
AU9146482A (en) 1983-06-16
IN156354B (ro) 1985-06-29
FI82680B (fi) 1990-12-31
PH20059A (en) 1986-09-18
DK461388A (da) 1988-08-17
IT1155421B (it) 1987-01-28
DK461488A (da) 1988-08-17
FI824203L (fi) 1983-06-12
RO87021A (ro) 1985-05-20
EP0081993B1 (en) 1988-08-17
HK51489A (en) 1989-07-07
SG3089G (en) 1989-06-02
IE822945L (en) 1983-06-11
ES8501732A1 (es) 1984-12-16
DK461588A (da) 1988-08-17
CA1259627A (en) 1989-09-19
ZA829101B (en) 1984-07-25
NO156650B (no) 1987-07-20
PL142997B1 (en) 1987-12-31
KR890000375B1 (en) 1989-03-15
SU1577694A3 (ru) 1990-07-07
CS903882A2 (en) 1988-03-15
FI82680C (fi) 1991-04-10
DK461188A (da) 1988-08-17
DK461488D0 (da) 1988-08-17
JPH0420901B2 (ro) 1992-04-07
PH20529A (en) 1987-02-09
CA1338433C (en) 1996-07-02
HU191621B (en) 1987-03-30
DK461188D0 (da) 1988-08-17
CS259510B2 (en) 1988-10-14
MX159862A (es) 1989-09-21
NO156650C (no) 1987-10-28
DK461588D0 (da) 1988-08-17

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