ES8506748A1 - Procedimiento para la obtencion del factor 2 de la teicomicina a2 - Google Patents

Procedimiento para la obtencion del factor 2 de la teicomicina a2

Info

Publication number
ES8506748A1
ES8506748A1 ES536770A ES536770A ES8506748A1 ES 8506748 A1 ES8506748 A1 ES 8506748A1 ES 536770 A ES536770 A ES 536770A ES 536770 A ES536770 A ES 536770A ES 8506748 A1 ES8506748 A1 ES 8506748A1
Authority
ES
Spain
Prior art keywords
teichomycin
factor
production
pure single
single factors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES536770A
Other languages
English (en)
Other versions
ES536770A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruppo Lepetit SpA
Original Assignee
Gruppo Lepetit SpA
Lepetit SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruppo Lepetit SpA, Lepetit SpA filed Critical Gruppo Lepetit SpA
Publication of ES536770A0 publication Critical patent/ES536770A0/es
Publication of ES8506748A1 publication Critical patent/ES8506748A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/045—Actinoplanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Fodder In General (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DEL FACRTOR 2 DE LA TEICOMICINA A2.COMPRENDE: A) DISOLVER EL COMPLEJO DE TEICOMICINA A2 EN UNA MEZCLA DE FORMATO DE AMONIO Y ACETONITRILO (9/1); B) AJUSTAR EL PIE DE LA DISOLUCION A 7,5 POR ADICION DE NAOH; C) HACER PASAR LA DISOLUCION AJUSTADA A TRAVES DE UNA COLUMNA DE SILICAGEL SILAMIZADO; D) REVELAR LA COLUMNA DE SILICAGEL SILICAMIZADO CON LA DISOLUCION DE LA ETAPA (C) EN UNA SOLUCIONCON 10 A 20 DE ACETONITRILO Y 0,2 DE FORMATO DE AMONIO; E) RECOGER LAS FRACCIONES DE REVELADO QUE TENGAN LA MISMA CARACTERISTICA DE PERFIL DE HPLC DEL FACTOR DE LA TEICOMICINA A2; F) EVAPORAR EL SOLVENTE ORGANICO BAJO PRESION REDUCIDA DE LAS FRACCIONES DE REVELADO, PARA OBTENER UNA SOLUCION ACUOSA; G) DESALIFICAR LA SOLUCION ACUOSA EN UNA COLUMNA DE SILICAGEL SILIMIZADO; H) LAVAR LA COLUMNA DESALIFICADA CON AGUA; I) ELUIR LA COLUMNA LAVADA CON ACEOTINITRILO ACUOSO AL 50 PARA OBTENER UN ELUATO; J) CONCENTRAR AL ELUATO Y K) PRECIPITAR EL FACTOR 2 PURO DE LA FEICOMICINA A2 EN ELELUATO.
ES536770A 1982-06-08 1984-10-15 Procedimiento para la obtencion del factor 2 de la teicomicina a2 Expired ES8506748A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8216590 1982-06-08

Publications (2)

Publication Number Publication Date
ES536770A0 ES536770A0 (es) 1985-08-16
ES8506748A1 true ES8506748A1 (es) 1985-08-16

Family

ID=10530888

Family Applications (2)

Application Number Title Priority Date Filing Date
ES522941A Granted ES522941A0 (es) 1982-06-08 1983-06-01 "procedimiento para la obtencion de compuestos farmacologicamente activos por aislamiento de los factores individuales del complejo antibiotico teicomicina a2".
ES536770A Expired ES8506748A1 (es) 1982-06-08 1984-10-15 Procedimiento para la obtencion del factor 2 de la teicomicina a2

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES522941A Granted ES522941A0 (es) 1982-06-08 1983-06-01 "procedimiento para la obtencion de compuestos farmacologicamente activos por aislamiento de los factores individuales del complejo antibiotico teicomicina a2".

Country Status (32)

Country Link
US (1) US4542018A (es)
JP (5) JPS591423A (es)
KR (1) KR900008246B1 (es)
AU (1) AU560966B2 (es)
BE (1) BE896993A (es)
BG (1) BG60529B2 (es)
CA (1) CA1208204A (es)
CH (1) CH657139A5 (es)
DE (1) DE3320342A1 (es)
DK (1) DK159117C (es)
ES (2) ES522941A0 (es)
FI (1) FI73697C (es)
FR (1) FR2528050B1 (es)
GB (1) GB2121401B (es)
GR (1) GR78267B (es)
HK (1) HK55887A (es)
HU (1) HU193538B (es)
IE (1) IE55025B1 (es)
IL (1) IL68819A0 (es)
IT (1) IT1212085B (es)
LU (1) LU84853A1 (es)
MY (1) MY8700002A (es)
NL (1) NL8301980A (es)
NO (1) NO159104C (es)
NZ (1) NZ204480A (es)
PH (1) PH19533A (es)
PT (1) PT76831B (es)
SE (1) SE459094B (es)
SG (1) SG70686G (es)
SU (1) SU1318170A3 (es)
UA (1) UA6025A1 (es)
ZA (1) ZA833607B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8307847D0 (en) * 1983-03-22 1983-04-27 Lepetit Spa Antibiotics l 17054 and l 17046
US4696817A (en) * 1983-10-11 1987-09-29 The Dow Chemical Company Extraction of teichomycin A2 from whole culture fermentation broth
GB8333624D0 (en) * 1983-12-16 1984-01-25 Lepetit Spa Antibiotics l 17054 and l 17392
GB8415093D0 (en) * 1984-06-13 1984-07-18 Lepetit Spa Antibiotic l 17392
GB8415092D0 (en) * 1984-06-13 1984-07-18 Lepetit Spa Ester derivatives
GB8428619D0 (en) * 1984-11-13 1984-12-19 Lepetit Spa Derivatives of antibiotic l 17046
GB8512795D0 (en) * 1985-05-21 1985-06-26 Lepetit Spa Increasing ratio of components of teicoplanin a2 complex
US4694069A (en) * 1985-09-30 1987-09-15 Smithkline Beckman Corporation Kibdelosporangium aridum SK&F-AAD-609
JPS61241319A (ja) * 1986-04-25 1986-10-27 Kanegafuchi Chem Ind Co Ltd 新規エーテル‐エステルブロツク共重合体を含有する室温硬化性組成物
US4845194A (en) * 1987-02-27 1989-07-04 Eli Lilly And Company Glycopeptide recovery process
GB8715735D0 (en) * 1987-07-03 1987-08-12 Lepetit Spa De-mannosyl teicoplanin derivatives
US5213797A (en) * 1987-07-13 1993-05-25 Eli Lilly And Company A80407 antibiotics
US4996148A (en) * 1987-07-13 1991-02-26 Eli Lilly And Company A80407 antibiotics
GB8720980D0 (en) * 1987-09-07 1987-10-14 Lepetit Spa Derivatives
US5194424A (en) * 1988-12-27 1993-03-16 Gruppo Lepetit Spa C63 -amide derivatives of 34-de(acetylglucosaminyl)-34-deoxy-teicoplanin and their use as medicaments against bacteria resistant to glycopeptide antibiotics
WO1992010516A1 (en) * 1990-12-05 1992-06-25 Gruppo Lepetit S.P.A. 38-decarboxy-38-hydroxymethyl derivatives of teicoplanin antibiotics, and a process for preparing them
US5606036A (en) * 1991-03-27 1997-02-25 Gruppo Lepetit Spa Antibiotic A 40926 ester derivatives
KR20000010589A (ko) 1996-04-23 2000-02-15 클라우디오 쿼르타 항생제a40926의아미드유도체의개선된화학적제조방법
KR100476818B1 (ko) * 2002-07-19 2005-03-17 종근당바이오 주식회사 테이코플라닌 에이 투 정제 방법
US7119061B2 (en) * 2002-11-18 2006-10-10 Vicuron Pharmaceuticals, Inc. Dalbavancin compositions for treatment of bacterial infections
AU2003294262B2 (en) * 2002-11-18 2007-08-23 Vicuron Pharmaceuticals Inc. Methods of administering dalbavancin for treatment of bacterial infections
US20060074014A1 (en) 2002-11-18 2006-04-06 Vicuron Pharmaceuticals Inc. Dalbavancin compositions for treatment of bacterial infections
EP1806150A1 (en) * 2006-01-05 2007-07-11 NEED PHARMA S.r.l. Teicoplanin composition
CN102718843B (zh) * 2012-06-30 2014-05-14 华北制药集团新药研究开发有限责任公司 一种替考拉宁单组份的制备方法
CN114112612A (zh) * 2021-10-28 2022-03-01 丽珠集团福州福兴医药有限公司 一种替考拉宁i5杂质的分离纯化方法及其应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1496386A (en) * 1975-03-05 1977-12-30 Lepetit Spa Antibiotics

Also Published As

Publication number Publication date
JPH02288888A (ja) 1990-11-28
IE831329L (en) 1983-12-08
JPH02288887A (ja) 1990-11-28
SG70686G (en) 1987-07-03
FI831660L (fi) 1983-12-09
FI831660A0 (fi) 1983-05-12
JPH0224278B2 (es) 1990-05-29
SE459094B (sv) 1989-06-05
MY8700002A (en) 1987-12-31
PT76831A (en) 1983-07-01
GR78267B (es) 1984-09-26
FR2528050B1 (fr) 1987-03-20
KR840005170A (ko) 1984-11-05
SE8303211D0 (sv) 1983-06-07
HU193538B (en) 1987-10-28
ES8503689A1 (es) 1985-04-01
ES522941A0 (es) 1985-04-01
PH19533A (en) 1986-05-20
DK159117C (da) 1991-02-11
JPS591423A (ja) 1984-01-06
NO159104B (no) 1988-08-22
NO159104C (no) 1988-11-30
NZ204480A (en) 1986-04-11
JPH0415238B2 (es) 1992-03-17
BG60529B2 (bg) 1995-07-28
CH657139A5 (fr) 1986-08-15
UA6025A1 (uk) 1994-12-29
LU84853A1 (fr) 1984-03-07
GB8315003D0 (en) 1983-07-06
DK245883D0 (da) 1983-05-31
ES536770A0 (es) 1985-08-16
DK245883A (da) 1983-12-09
IE55025B1 (en) 1990-04-25
IT1212085B (it) 1989-11-08
HK55887A (en) 1987-08-07
JPH0517236B2 (es) 1993-03-08
SE8303211L (sv) 1983-12-09
IT8321432A0 (it) 1983-06-02
FR2528050A1 (fr) 1983-12-09
DK159117B (da) 1990-09-03
ZA833607B (en) 1984-03-28
GB2121401A (en) 1983-12-21
BE896993A (fr) 1983-12-07
PT76831B (en) 1986-04-09
US4542018A (en) 1985-09-17
SU1318170A3 (ru) 1987-06-15
DE3320342A1 (de) 1983-12-08
NO831754L (no) 1983-12-09
NL8301980A (nl) 1984-01-02
FI73697C (fi) 1987-11-09
AU560966B2 (en) 1987-04-30
DE3320342C2 (es) 1991-07-11
JPH02291278A (ja) 1990-12-03
JPH02291279A (ja) 1990-12-03
IL68819A0 (en) 1983-09-30
GB2121401B (en) 1985-09-18
JPH0517237B2 (es) 1993-03-08
FI73697B (fi) 1987-07-31
KR900008246B1 (ko) 1990-11-06
AU1496883A (en) 1983-12-15
JPH0415237B2 (es) 1992-03-17
CA1208204A (en) 1986-07-22

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Legal Events

Date Code Title Description
PC1A Transfer granted
FD1A Patent lapsed

Effective date: 20050426