ES8603496A1 - Un procedimiento para la preparacion de nuevos derivados de cefalosporina - Google Patents

Un procedimiento para la preparacion de nuevos derivados de cefalosporina

Info

Publication number
ES8603496A1
ES8603496A1 ES535281A ES535281A ES8603496A1 ES 8603496 A1 ES8603496 A1 ES 8603496A1 ES 535281 A ES535281 A ES 535281A ES 535281 A ES535281 A ES 535281A ES 8603496 A1 ES8603496 A1 ES 8603496A1
Authority
ES
Spain
Prior art keywords
procedure
preparation
hydrogen
formula
cephalosporin derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES535281A
Other languages
English (en)
Other versions
ES535281A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Pharma Corp
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Publication of ES535281A0 publication Critical patent/ES535281A0/es
Publication of ES8603496A1 publication Critical patent/ES8603496A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS DERIVADOS DE CEFALOSPORINA. CONSISTE EN OBTENER UN COMPUESTO DE FORMULA (I), EN DONDE R7 ES HIDROGENO O UN GRUPO PROTECTOR, R1 ES HIDROGENO O ALQUILO INFERIOR, R2 ES (1-METIL-1H-TETRAZOL-5-IL)TIO Y R3 ES CARBOXI, HACIENDO REACCIONAR UN COMPUESTO DE FORMULA (II) CON OTRO DE FORMULA (III) EN DONDE Y ES HIDROGENO, HIDROXIMETILO O CARBAMOILO. APLICACION COMO AGENTES ANTIMICROBIANOS.
ES535281A 1982-08-07 1984-08-17 Un procedimiento para la preparacion de nuevos derivados de cefalosporina Expired ES8603496A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8222823 1982-08-07

Publications (2)

Publication Number Publication Date
ES535281A0 ES535281A0 (es) 1985-12-16
ES8603496A1 true ES8603496A1 (es) 1985-12-16

Family

ID=10532181

Family Applications (3)

Application Number Title Priority Date Filing Date
ES524775A Expired ES8502121A1 (es) 1982-08-07 1983-08-05 Derivados del acido 7 b-((z)-2-(2-aminotiazol-4-il)-2-oximinoacetamido)-3-cefem-4-carboxilico
ES531296A Expired ES8506707A1 (es) 1982-08-07 1984-04-04 Un derivado de acido tiazolilacetico
ES535281A Expired ES8603496A1 (es) 1982-08-07 1984-08-17 Un procedimiento para la preparacion de nuevos derivados de cefalosporina

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES524775A Expired ES8502121A1 (es) 1982-08-07 1983-08-05 Derivados del acido 7 b-((z)-2-(2-aminotiazol-4-il)-2-oximinoacetamido)-3-cefem-4-carboxilico
ES531296A Expired ES8506707A1 (es) 1982-08-07 1984-04-04 Un derivado de acido tiazolilacetico

Country Status (23)

Country Link
US (4) US4598075A (es)
EP (2) EP0101265B1 (es)
JP (3) JPS5951292A (es)
KR (1) KR870001440B1 (es)
AT (2) ATE35413T1 (es)
AU (1) AU562248B2 (es)
BG (3) BG42835A3 (es)
CA (1) CA1231940A (es)
CS (2) CS243484B2 (es)
DD (1) DD210053A5 (es)
DE (2) DE3381734D1 (es)
DK (2) DK358983A (es)
ES (3) ES8502121A1 (es)
FI (1) FI74972C (es)
GR (1) GR78864B (es)
IE (1) IE55406B1 (es)
IL (1) IL69246A (es)
NO (1) NO161068C (es)
PH (1) PH18498A (es)
PL (2) PL140023B1 (es)
PT (1) PT77166B (es)
SU (2) SU1227116A3 (es)
ZA (1) ZA835411B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE55406B1 (en) * 1982-08-07 1990-09-12 Tanabe Seiyaku Co Novel cephalosporin compounds and preparation thereof
JPS60132983A (ja) * 1983-12-21 1985-07-16 Tanabe Seiyaku Co Ltd チアゾ−ル酢酸誘導体及びその製法
JPS6178792A (ja) * 1984-09-26 1986-04-22 Yamanouchi Pharmaceut Co Ltd ７−〔α−（２−アミノ−４−チアゾリル）−α−（４−オキソ−２−アゼチジニル置換イミノ）アセトアミド〕−３−置換メチル−Δ↑３−セフエム−４−カルボン酸およびその製造法
JPS6185392A (ja) * 1984-10-03 1986-04-30 Tanabe Seiyaku Co Ltd セフアロスポリン化合物の新規製法
JPS61143379A (ja) * 1984-12-14 1986-07-01 Tanabe Seiyaku Co Ltd チアゾ−ル酢酸誘導体の製法
JPS61143381A (ja) * 1984-12-14 1986-07-01 Tanabe Seiyaku Co Ltd 光学活性チアゾ−ル酢酸誘導体の製法
JPS61143380A (ja) * 1984-12-14 1986-07-01 Tanabe Seiyaku Co Ltd チアゾ−ル酢酸誘導体の製法
CA1263399A (en) * 1984-12-19 1989-11-28 Hoffmann-La Roche Limited Process for the manufacture of aminothiazole acetic acid derivatives
JPS61171464A (ja) * 1985-01-23 1986-08-02 Dai Ichi Seiyaku Co Ltd オキシイミノ酪酸誘導体の製法
JPS63107989A (ja) * 1986-06-04 1988-05-12 Tanabe Seiyaku Co Ltd セファロスポリン化合物
IL82738A0 (en) * 1986-06-16 1987-12-20 Tanabe Seiyaku Co Cephalosporin compounds,their preparation and pharmaceutical compositions containing them
AT389701B (de) * 1987-10-08 1990-01-25 Tanabe Seiyaku Co Neue cephalosporinverbindungen und diese enthaltende pharmazeutische zusammensetzungen
JP4773154B2 (ja) * 2005-07-29 2011-09-14 小澤物産株式会社 レバー式カップリング

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1399086A (en) * 1971-05-14 1975-06-25 Glaxo Lab Ltd Cephalosporin compounds
GB1536281A (en) * 1975-06-09 1978-12-20 Takeda Chemical Industries Ltd Cephem compounds
DE2760123C2 (de) * 1976-01-23 1986-04-30 Roussel-Uclaf, Paris 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
IE44888B1 (en) * 1976-03-09 1982-05-05 Fujisawa Pharmaceutical Co 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for the preparation theroef
DE2760484C2 (es) * 1976-04-14 1992-12-03 Takeda Chemical Industries, Ltd., Osaka, Jp
FR2384782A1 (fr) * 1977-03-25 1978-10-20 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-acetoxymethyl 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
SE448379B (sv) * 1978-03-31 1987-02-16 Roussel Uclaf O-substituerade oximderivat av 7-amino-tiazolyl-acetamidocefalosporansyra
AR228726A1 (es) * 1978-05-26 1983-04-15 Glaxo Group Ltd Procedimiento para la preparacion del antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)acetamido)-3-(1-piridiniometil)cef-3-em-4-carboxilato
EP0059486B1 (en) * 1978-07-17 1985-10-02 Fujisawa Pharmaceutical Co., Ltd. New starting compounds for preparing cephem compounds and processes for their preparation
US4284631A (en) * 1978-07-31 1981-08-18 Fujisawa Pharmaceutical Co., Ltd. 7-Substituted cephem compounds and pharmaceutical antibacterial compositions containing them
GB2028305A (en) * 1978-08-03 1980-03-05 Hoechst Ag Cephem derivatives and processes for their manufacture
US4271157A (en) * 1980-02-28 1981-06-02 E. R. Squibb & Sons, Inc. Imidazole derivatives of 7-[(2-amino-4-thiazolyl)-oximino] cephalosporins
GB2061276B (en) * 1979-10-25 1983-05-25 Squibb & Sons Inc Imidazole and tetrazole derivatives of 7-((2-amino-4-thiazolyl)-oximino)cephalosporins
US4416879A (en) * 1980-09-08 1983-11-22 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
IE55406B1 (en) * 1982-08-07 1990-09-12 Tanabe Seiyaku Co Novel cephalosporin compounds and preparation thereof
JPS59155391A (ja) * 1983-02-22 1984-09-04 Tanabe Seiyaku Co Ltd 新規セファロスポリン誘導体

Also Published As

Publication number Publication date
PL140023B1 (en) 1987-03-31
FI74972B (fi) 1987-12-31
IE831648L (en) 1984-02-07
CA1231940A (en) 1988-01-26
US4598154A (en) 1986-07-01
CS196483A2 (en) 1985-08-22
IE55406B1 (en) 1990-09-12
AU562248B2 (en) 1987-06-04
DD210053A5 (de) 1984-05-30
ES535281A0 (es) 1985-12-16
DE3377213D1 (en) 1988-08-04
AU1710483A (en) 1984-02-09
BG42835A3 (bg) 1988-02-15
EP0101265A2 (en) 1984-02-22
KR870001440B1 (ko) 1987-08-06
EP0245619A1 (en) 1987-11-19
ZA835411B (en) 1984-03-28
SU1227116A3 (ru) 1986-04-23
DK361587D0 (da) 1987-07-10
IL69246A (en) 1986-07-31
FI832770A0 (fi) 1983-08-02
DK361587A (da) 1987-07-10
FI74972C (fi) 1988-04-11
BG37838A3 (bg) 1985-08-15
ES524775A0 (es) 1984-12-16
CS236798B2 (en) 1985-05-15
NO161068C (no) 1989-06-28
JPH0246588B2 (es) 1990-10-16
IL69246A0 (en) 1983-11-30
ATE35413T1 (de) 1988-07-15
PT77166A (en) 1983-09-01
PT77166B (pt) 1986-01-28
US4742174A (en) 1988-05-03
PL249964A1 (en) 1985-05-07
ES8502121A1 (es) 1984-12-16
BG40967A3 (bg) 1987-03-14
GR78864B (es) 1984-10-02
PL139932B1 (en) 1987-03-31
NO832828L (no) 1984-02-08
US4727071A (en) 1988-02-23
NO161068B (no) 1989-03-20
PH18498A (en) 1985-08-02
KR840005816A (ko) 1984-11-19
DK358983D0 (da) 1983-08-05
JPH0145473B2 (es) 1989-10-03
SU1324586A3 (ru) 1987-07-15
JPS62294615A (ja) 1987-12-22
EP0245619B1 (en) 1990-07-11
CS243484B2 (en) 1986-06-12
JPS5951292A (ja) 1984-03-24
US4598075A (en) 1986-07-01
EP0101265A3 (en) 1985-04-10
ES531296A0 (es) 1985-08-01
EP0101265B1 (en) 1988-06-29
JPH0360803B2 (es) 1991-09-17
PL243329A1 (en) 1985-02-13
FI832770L (fi) 1984-02-08
JPS62294681A (ja) 1987-12-22
ATE54450T1 (de) 1990-07-15
DK358983A (da) 1984-02-08
DE3381734D1 (de) 1990-08-16
ES8506707A1 (es) 1985-08-01

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