ES8604264A1 - Procedimiento para la obtencion de un compuesto peptido para antagonizar la respuesta en vivo de un animal a la accion antidiuretica de una hormona antidiuretica. - Google Patents

Procedimiento para la obtencion de un compuesto peptido para antagonizar la respuesta en vivo de un animal a la accion antidiuretica de una hormona antidiuretica.

Info

Publication number
ES8604264A1
ES8604264A1 ES510579A ES510579A ES8604264A1 ES 8604264 A1 ES8604264 A1 ES 8604264A1 ES 510579 A ES510579 A ES 510579A ES 510579 A ES510579 A ES 510579A ES 8604264 A1 ES8604264 A1 ES 8604264A1
Authority
ES
Spain
Prior art keywords
compound
boc
gly
formula
resin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES510579A
Other languages
English (en)
Other versions
ES510579A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medical College of Ohio
Original Assignee
Medical College of Ohio
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/247,008 external-priority patent/US4367225A/en
Application filed by Medical College of Ohio filed Critical Medical College of Ohio
Publication of ES8604264A1 publication Critical patent/ES8604264A1/es
Publication of ES510579A0 publication Critical patent/ES510579A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/16—Oxytocins; Vasopressins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/15—Oxytocin or vasopressin; related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE UN COMPUESTO PEPTIDO PARA ANTAGONIZAR LA RESPUESTA IN VIVO, DE UN ANIMAL, A LA ACCION ANTIDIURETICA DE UNA HORMONA ANTIDIURETICA. CONSISTE EN: A) TRATAR POR SINTESIS DE FASE SOLIDA BOC-GLY-RESINA Y NEUTRALIZACION Y ACOPLAMIENTO CON UN AMINO-ACIDO, PARA PRODUCIR BOC-PHE-VAL-ASN-CY(BZL)-W-(D O L)-ARG(TOS-GLY-RESINA); B) TRATAR EL COMPUESTO ANTERIOR EN UN CICLO DE DESPROTECCION, NEUTRALIZARLO Y ACOPLARLO CON BOC-X PARA PRODUCIR TERT-BUTOXICARBONIL-OCTAPEPTIDIL RESINA DE FORMULA BOC-X-PHE-VAL-ASN-CY(BZL)-W-)D O L)ARG(TOS-GLY-RESINA); C) AMONOLIZAR EL COMPUESTO OBTENIDO EN B) PARA OBTENER UN COMPUESTO DE FORMULA BOC-XPHE-VAL-ASN-CY(BZL)-W-(D- O L-)-ARG(TOS)-GLY-NH2; D) CONVERTIR EL COMPUESTO OBTENIDO EN C) EN UN COMPUESTO DE FORMULA (II); Y E) CONVERTIR EL COMPUESTO D) EN UN PEPTIDO DE FORMULA (I).
ES510579A 1981-03-24 1982-03-18 Procedimiento para la obtencion de un compuesto peptido para antagonizar la respuesta en vivo de un animal a la accion antidiuretica de una hormona antidiuretica. Expired ES8604264A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/247,008 US4367225A (en) 1981-03-24 1981-03-24 Novel antagonists of the antidiuretic and/or vasopressor action of arginine vasopressin
US06/322,071 US4399125A (en) 1981-03-24 1981-11-16 Novel antagonists of the antidiuretic action of arginine vasopressin

Publications (2)

Publication Number Publication Date
ES8604264A1 true ES8604264A1 (es) 1986-01-16
ES510579A0 ES510579A0 (es) 1986-01-16

Family

ID=26938391

Family Applications (2)

Application Number Title Priority Date Filing Date
ES510579A Expired ES8604264A1 (es) 1981-03-24 1982-03-18 Procedimiento para la obtencion de un compuesto peptido para antagonizar la respuesta en vivo de un animal a la accion antidiuretica de una hormona antidiuretica.
ES546137A Expired ES8703489A1 (es) 1981-03-24 1985-08-14 Procedimiento para la obtencion de un compuesto para antago-nizar la respuesta in vivo,de un animal,a la accion antidiu-retica de una hormona antidiuretica

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES546137A Expired ES8703489A1 (es) 1981-03-24 1985-08-14 Procedimiento para la obtencion de un compuesto para antago-nizar la respuesta in vivo,de un animal,a la accion antidiu-retica de una hormona antidiuretica

Country Status (21)

Country Link
US (1) US4399125A (es)
EP (1) EP0061356B1 (es)
KR (1) KR880000758B1 (es)
AU (1) AU546865B2 (es)
BG (1) BG38487A3 (es)
CA (1) CA1185235A (es)
DD (2) DD202695A5 (es)
DE (1) DE3264734D1 (es)
DK (1) DK130182A (es)
ES (2) ES8604264A1 (es)
FI (1) FI77047C (es)
HU (1) HU189127B (es)
IE (1) IE52624B1 (es)
IL (1) IL65211A (es)
NO (1) NO162024C (es)
NZ (1) NZ199908A (es)
PH (1) PH19237A (es)
PT (1) PT74615B (es)
RO (1) RO84361B (es)
YU (1) YU63482A (es)
ZW (1) ZW4882A1 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4491577A (en) * 1981-11-16 1985-01-01 The Medical College Of Ohio Antagonists of the antidiuretic action of arginine vasopressin
DK153883A (da) * 1982-04-20 1983-10-21 Ceskoslovenska Akademie Ved Vasopressin-analoge
US4469679A (en) * 1983-02-16 1984-09-04 Smithkline Beckman Corporation Octapeptide vasopressin antagonists
US4587045A (en) * 1983-02-16 1986-05-06 Smithkline Beckman Corporation Intermediates for preparing octapeptide vasopressin antagonists
US4483794A (en) * 1983-05-10 1984-11-20 Ceskoslovenska Akademie Ved Analogs of neurohypophysial hormones
CA1238314A (en) * 1983-09-22 1988-06-21 James F. Callahan Process for preparing basic heptapeptide vasopressin antagonists
US4551445A (en) * 1983-10-14 1985-11-05 The Medical College Of Ohio Derivatives of arginine vasopressin antagonists
US4649130A (en) * 1984-01-26 1987-03-10 Medical College Of Ohio Novel derivatives of arginine vasopressin antagonists
US4714696A (en) * 1984-01-26 1987-12-22 Medical College Of Ohio Novel derivatives of arginine vasopressin antagonists
PH21037A (en) * 1984-03-07 1987-06-30 Smithkline Beckman Corp Des-proline vasopressin antagonists
US4481193A (en) * 1984-03-07 1984-11-06 Smithkline Beckman Corporation Des-proline vasopressin antagonists
US4481194A (en) * 1984-03-07 1984-11-06 Smithkline Beckman Corporation Des-proline-des-glycine vasopressin antagonists
US4719199A (en) * 1984-12-14 1988-01-12 Smithkline Beckman Corporation Diuretic compositions and methods of producing diuresis
US4684716A (en) * 1984-12-14 1987-08-04 Smithkline Beckman Corporation Polypeptide intermediates
US4597901A (en) * 1984-12-14 1986-07-01 Smithkline Beckman Corporation β-indolylalanyl or β-indolylglycinyl vasopressin antagonists
US4624943A (en) * 1985-03-20 1986-11-25 Smithkline Beckman Corporation Aromatic basic-tailed vasopressin antagonists
WO1987002676A1 (en) * 1985-10-25 1987-05-07 Gibson-Stephens Neuropharmaceuticals, Inc. Conformationally constrained oxytocin antagonists with prolonged biological activities
PT84342B (pt) * 1986-02-25 1989-09-14 Smithkline Beecham Corp Processo de preparacao de compostos de vasopressina
US4762820A (en) * 1986-03-03 1988-08-09 Trustees Of Boston University Therapeutic treatment for congestive heart failure
EP0300036A4 (en) * 1987-01-30 1989-06-14 Biomed Res Consultants Ltd PHARMACEUTICAL COMPOSITIONS BASED ON VASOPRESSIN.
US5055448A (en) * 1987-06-25 1991-10-08 Medical College Of Ohio Linear derivatives of arginine vasopressin antagonists
AT398766B (de) * 1988-05-26 1995-01-25 Gebro Broschek Gmbh Verfahren zur intramolekularen oxidation von zwei -sh gruppen in einer peptidverbindung zu einer disulfidbrücke
US5070187A (en) * 1989-11-03 1991-12-03 Trustees Of Boston University Pharmacologically effective antagonists of arginine-vasopressin
US5051400A (en) * 1990-06-28 1991-09-24 Smithkline Beecham Corporation Method of treating nausea and emesis related to motion sickness with vasopressin antagonists
RU2342949C1 (ru) * 2007-03-26 2009-01-10 Юрий Георгиевич Жуковский Применение [дезамино-1, изолейцин-3, аргинин-8]вазопрессина в качестве средства для увеличения выведения почкой солей натрия и усиления обратного избирательного всасывания из почечных канальцев в кровь воды-растворителя
CN111253569B (zh) * 2020-02-26 2021-06-01 山东大学 一种聚合物、其制剂及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1193509B (de) * 1960-06-02 1965-05-26 Hoechst Ag Verfahren zur Herstellung eines neuen Oktapeptids mit vasopressorischer Wirksamkeit
CH426861A (de) * 1963-06-06 1966-12-31 Sandoz Ag Verfahren zur Herstellung eines bisher unbekannten Polypeptids
CH442342A (de) * 1964-07-17 1967-08-31 Sandoz Ag Verfahren zur Herstellung eines neuen Polypeptids
CH460039A (de) * 1965-04-15 1968-07-31 Sandoz Ag Verfahren zur Herstellung eines neuen Polypeptids
CH495957A (de) * 1966-09-15 1970-09-15 Ceskoslovenska Akademie Ved Verfahren zur Herstellung eines antidiuretisch wirksamen Polypeptids
US4148787A (en) * 1976-05-24 1979-04-10 Ferring Ab Antidiuretically effective polypeptide and a process for preparing the same

Also Published As

Publication number Publication date
HU189127B (en) 1986-06-30
AU8161782A (en) 1982-09-30
ZW4882A1 (en) 1983-02-23
PT74615B (en) 1983-10-20
FI821019A0 (fi) 1982-03-23
CA1185235A (en) 1985-04-09
FI821019L (fi) 1982-09-25
DK130182A (da) 1982-09-25
IL65211A (en) 1986-02-28
KR880000758B1 (ko) 1988-05-06
NO162024C (no) 1989-10-25
IE52624B1 (en) 1988-01-06
RO84361B (ro) 1984-07-30
US4399125A (en) 1983-08-16
NO820967L (no) 1982-09-27
NO162024B (no) 1989-07-17
DD212735A5 (de) 1984-08-22
AU546865B2 (en) 1985-09-26
RO84361A (ro) 1984-05-23
PH19237A (en) 1986-02-14
IL65211A0 (en) 1982-05-31
FI77047C (fi) 1989-01-10
YU63482A (en) 1985-10-31
NZ199908A (en) 1985-09-13
ES510579A0 (es) 1986-01-16
BG38487A3 (en) 1985-12-16
EP0061356B1 (en) 1985-07-17
DE3264734D1 (en) 1985-08-22
DD202695A5 (de) 1983-09-28
PT74615A (en) 1982-04-01
KR830008683A (ko) 1983-12-14
FI77047B (fi) 1988-09-30
EP0061356A2 (en) 1982-09-29
EP0061356A3 (en) 1982-12-29
ES8703489A1 (es) 1987-03-01
ES546137A0 (es) 1987-03-01
IE820465L (en) 1982-09-24

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