ES8700860A1 - Un procedimiento para la preparacion de acidos 6-metilen sustituido penicilanicos y derivados de los mismos - Google Patents

Un procedimiento para la preparacion de acidos 6-metilen sustituido penicilanicos y derivados de los mismos

Info

Publication number
ES8700860A1
ES8700860A1 ES548426A ES548426A ES8700860A1 ES 8700860 A1 ES8700860 A1 ES 8700860A1 ES 548426 A ES548426 A ES 548426A ES 548426 A ES548426 A ES 548426A ES 8700860 A1 ES8700860 A1 ES 8700860A1
Authority
ES
Spain
Prior art keywords
substituted
acid
cooh
alkyl
thienyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES548426A
Other languages
English (en)
Other versions
ES548426A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of ES8700860A1 publication Critical patent/ES8700860A1/es
Publication of ES548426A0 publication Critical patent/ES548426A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE ACIDOS 6-METILEN(SUSTITUIDO) PENICILANICOS, ESTERES Y SALES Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN, DE FORMULA GENERAL (I). CONSISTE EN PONER EN CONTACTO UN COMPUESTO DE FORMULA GENERAL (II), CON CANTIDADES EQUIMOLECULARES DE UN HALURO DE MAGNESIO O DE UN REACTIVO DE LITIO Y UN ALDEHIDO, EN PRESENCIA DE UN DISOLVENTE INERTE A UNA TEMPERATURA DE C100JC A B25JC OBTENIENDOSE UN COMPUESTO DEL QUE SE ELIMINA EL ATOMO DE BROMO Y SE SOMETE A DESHIDRATACION. SE USAN COMO INHIBIDORES DE BETA-LACTAMASAS.-
ES548426A 1984-01-30 1985-10-31 Un procedimiento para la preparacion de acidos 6-metilen sustituido penicilanicos y derivados de los mismos Expired ES8700860A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57535484A 1984-01-30 1984-01-30

Publications (2)

Publication Number Publication Date
ES8700860A1 true ES8700860A1 (es) 1986-11-16
ES548426A0 ES548426A0 (es) 1986-11-16

Family

ID=24299979

Family Applications (5)

Application Number Title Priority Date Filing Date
ES539890A Expired ES8604972A1 (es) 1984-01-30 1985-01-28 Un procedimiento para la preparacion de acidos 6-metilen-(sustituido) penicilanicos y derivados de los mismos.
ES548429A Expired ES8704952A1 (es) 1984-01-30 1985-10-31 Un procedimiento para la preparacion de acidos 6-metilen sustituido penicilanicos y derivados de los mismos
ES548427A Expired ES8705451A1 (es) 1984-01-30 1985-10-31 Un procedimiento para la preparacion de acidos 6-metilen sustituido penicilanicos y derivados de los mismos
ES548428A Expired ES8702916A1 (es) 1984-01-30 1985-10-31 Un procedimiento para la preparacion de acidos 6-metilen sustituido penicilanicos y derivados de los mismos
ES548426A Expired ES8700860A1 (es) 1984-01-30 1985-10-31 Un procedimiento para la preparacion de acidos 6-metilen sustituido penicilanicos y derivados de los mismos

Family Applications Before (4)

Application Number Title Priority Date Filing Date
ES539890A Expired ES8604972A1 (es) 1984-01-30 1985-01-28 Un procedimiento para la preparacion de acidos 6-metilen-(sustituido) penicilanicos y derivados de los mismos.
ES548429A Expired ES8704952A1 (es) 1984-01-30 1985-10-31 Un procedimiento para la preparacion de acidos 6-metilen sustituido penicilanicos y derivados de los mismos
ES548427A Expired ES8705451A1 (es) 1984-01-30 1985-10-31 Un procedimiento para la preparacion de acidos 6-metilen sustituido penicilanicos y derivados de los mismos
ES548428A Expired ES8702916A1 (es) 1984-01-30 1985-10-31 Un procedimiento para la preparacion de acidos 6-metilen sustituido penicilanicos y derivados de los mismos

Country Status (15)

Country Link
JP (1) JPS61109791A (es)
KR (1) KR880001029B1 (es)
CS (5) CS248748B2 (es)
DD (3) DD234015A5 (es)
EG (1) EG16904A (es)
ES (5) ES8604972A1 (es)
FI (1) FI85376C (es)
HU (2) HU194891B (es)
IL (1) IL74190A (es)
NO (1) NO165594C (es)
PL (5) PL149797B1 (es)
PT (1) PT79893B (es)
SU (4) SU1395144A3 (es)
YU (5) YU44770B (es)
ZA (1) ZA85682B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE74359T1 (de) * 1987-01-27 1992-04-15 Pfizer 6-beta(substituierte)-(s)hydroxymethylpenicillans|ure und deren derivate.
ATE219085T1 (de) 1997-12-29 2002-06-15 Res Corp Technologies Inc 2-beta-substituierte-6-alkylidenpenizillansäure derivate als beta-laktamase inhibitoren
US6407091B1 (en) 1999-04-15 2002-06-18 Research Corporation Technologies, Inc. β-lactamase inhibiting compounds
US6916801B2 (en) 2001-07-24 2005-07-12 Alamx, Llc 7-Alkylidene-3-substituted-3-cephem-4-carboxylates as β-lactamase inhibitors
WO2003087105A1 (en) 2002-04-04 2003-10-23 Alamx, L.L.C. INHIBITORS OF SERINE AND METALLO-ß-LACTAMASES
GB0711776D0 (en) * 2007-06-18 2007-07-25 Syngenta Participations Ag Substituted aromatic heterocyclic compounds as fungicides
JP6183053B2 (ja) * 2012-08-22 2017-08-23 宇部興産株式会社 テトラヒドロピラニルピリミジン化合物の製造方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4272439A (en) * 1978-06-02 1981-06-09 Schering Corporation 6-(Substituted-hydroxymethylene penams)
DE2927004A1 (de) * 1979-07-04 1981-05-27 Bayer Ag, 5090 Leverkusen Penicillansaeure-1,1-dioxide, ihre herstellung und ihre verwendung als arzneimittel als arzneimittel
US4287181A (en) * 1979-10-22 1981-09-01 Pfizer Inc. Derivatives of 6β-hydroxyalkylpenicillanic acids as β-lactamase inhibitors

Also Published As

Publication number Publication date
FI85376C (fi) 1992-04-10
SU1396969A3 (ru) 1988-05-15
ES8705451A1 (es) 1987-05-01
YU44770B (en) 1991-02-28
ZA85682B (en) 1986-09-24
ES548428A0 (es) 1987-01-16
FI850375L (fi) 1985-07-31
CS248747B2 (en) 1987-02-12
CS248746B2 (en) 1987-02-12
PL256013A1 (en) 1986-10-21
CS248748B2 (en) 1987-02-12
YU44634B (en) 1990-10-31
PT79893B (en) 1987-02-03
YU44635B (en) 1990-10-31
SU1395144A3 (ru) 1988-05-07
PL145130B1 (en) 1988-08-31
KR850005445A (ko) 1985-08-26
IL74190A0 (en) 1985-04-30
ES8702916A1 (es) 1987-01-16
ES8704952A1 (es) 1987-04-16
YU119487A (en) 1988-02-29
JPS61109791A (ja) 1986-05-28
PL149242B1 (en) 1990-01-31
HU194567B (en) 1988-02-29
KR880001029B1 (ko) 1988-06-15
ES8604972A1 (es) 1986-02-16
SU1503683A3 (ru) 1989-08-23
PL145990B1 (en) 1988-12-31
HU194891B (en) 1988-03-28
EG16904A (en) 1992-06-30
PL256015A1 (en) 1986-11-18
PL256016A1 (en) 1986-12-02
YU14085A (en) 1987-12-31
HUT37799A (en) 1986-02-28
NO165594C (no) 1991-03-06
YU119687A (en) 1988-04-30
ES548427A0 (es) 1987-05-01
YU119587A (en) 1988-02-29
YU44636B (en) 1990-10-31
HUT40443A (en) 1986-12-28
PL251750A1 (en) 1985-12-17
PL147514B1 (en) 1989-06-30
DD247677A5 (de) 1987-07-15
CS248733B2 (en) 1987-02-12
ES539890A0 (es) 1986-02-16
IL74190A (en) 1989-09-28
ES548426A0 (es) 1986-11-16
NO850350L (no) 1985-07-31
NO165594B (no) 1990-11-26
ES548429A0 (es) 1987-04-16
DD234015A5 (de) 1986-03-19
YU119787A (en) 1988-04-30
FI85376B (fi) 1991-12-31
PT79893A (en) 1985-02-01
CS248749B2 (en) 1987-02-12
DD247678A5 (de) 1987-07-15
PL149797B1 (en) 1990-03-31
SU1508961A3 (ru) 1989-09-15
FI850375A0 (fi) 1985-01-29
PL256014A1 (en) 1986-12-02
YU44805B (en) 1991-02-28

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970519