ES8800228A1 - Un procedimiento para la preparacion de espiro (imidiazolina-4,1'-(2'h)-naftaleno) y espiro (croman-4,4'-imidazolidinas) - Google Patents

Un procedimiento para la preparacion de espiro (imidiazolina-4,1'-(2'h)-naftaleno) y espiro (croman-4,4'-imidazolidinas)

Info

Publication number
ES8800228A1
ES8800228A1 ES555375A ES555375A ES8800228A1 ES 8800228 A1 ES8800228 A1 ES 8800228A1 ES 555375 A ES555375 A ES 555375A ES 555375 A ES555375 A ES 555375A ES 8800228 A1 ES8800228 A1 ES 8800228A1
Authority
ES
Spain
Prior art keywords
spiral
chroman
procedure
imidiazoline
naphthaleno
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES555375A
Other languages
English (en)
Other versions
ES555375A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of ES8800228A1 publication Critical patent/ES8800228A1/es
Publication of ES555375A0 publication Critical patent/ES555375A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR ESPIRO[IMIDAZOLIDIN-4,1''-(2''H)-NAFTALENOS] Y ESPIRO (CROMAN-4,4''-IMIDAZOLINAS). CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) EN HIDRURO DE DIISOBUTILALUMINIO, EN DISOLUCION DE TETRAHIDROFURANO, Y ENTRE -78 Y 40GC, PARA OBTENER UN COMPUESTO DE FORMULA (I). SIENDO: R ELEVADO A 1, H, HAL Y OTROS; E Y, -O- O -CH2-. SE UTILIZA EN EL TRATAMIENTO DE ALGUNAS COMPLICACIONES CRONICAS DE LAS DIABETES MELITUS. *FORMULA*
ES555375A 1985-05-29 1986-05-27 Un procedimiento para la preparacion de espiro (imidiazolina-4,1'-(2'h)-naftaleno) y espiro (croman-4,4'-imidazolidinas) Expired ES8800228A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/738,924 US4575507A (en) 1985-05-29 1985-05-29 Spiro-imidazolidines as aldose reductase inhibitors and their pharmaceutical use

Publications (2)

Publication Number Publication Date
ES8800228A1 true ES8800228A1 (es) 1987-11-01
ES555375A0 ES555375A0 (es) 1987-11-01

Family

ID=24970055

Family Applications (2)

Application Number Title Priority Date Filing Date
ES555375A Expired ES8800228A1 (es) 1985-05-29 1986-05-27 Un procedimiento para la preparacion de espiro (imidiazolina-4,1'-(2'h)-naftaleno) y espiro (croman-4,4'-imidazolidinas)
ES557391A Expired ES8801830A1 (es) 1985-05-29 1987-02-13 Un procedimiento para la preparacion de espiro(imidazolidin-4,4'-(3'h)quinolinas)

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES557391A Expired ES8801830A1 (es) 1985-05-29 1987-02-13 Un procedimiento para la preparacion de espiro(imidazolidin-4,4'-(3'h)quinolinas)

Country Status (21)

Country Link
US (1) US4575507A (es)
EP (1) EP0203791B1 (es)
JP (1) JPS61277671A (es)
KR (1) KR890001548B1 (es)
AT (1) ATE46332T1 (es)
AU (1) AU560429B2 (es)
DD (5) DD251972A5 (es)
DE (1) DE3665584D1 (es)
DK (1) DK248886A (es)
EG (1) EG17859A (es)
ES (2) ES8800228A1 (es)
FI (1) FI862251A7 (es)
GR (1) GR861388B (es)
HU (4) HUT49879A (es)
IL (1) IL78954A (es)
NO (1) NO862123L (es)
NZ (1) NZ216334A (es)
PH (1) PH22213A (es)
PL (5) PL146020B1 (es)
PT (1) PT82650B (es)
ZA (1) ZA863934B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986000807A1 (en) * 1984-07-20 1986-02-13 Pfizer Inc. Spiro-imidazolones for treatment of diabetes complications
US4762839A (en) * 1985-06-06 1988-08-09 Tanabe Seiyaku Co., Ltd. Quinazolinone copmpounds useful for the prophyloxis and treatment of diabetic complications
JPS63132889A (ja) * 1986-11-21 1988-06-04 Tanabe Seiyaku Co Ltd キナゾリノン誘導体
WO1988006887A1 (en) * 1987-03-20 1988-09-22 Alcon Laboratories, Inc. Use of aldose reductase inhibitors to enhance insulin sensitivity in diabetes mellitus
US5202339A (en) * 1987-08-28 1993-04-13 Mochida Pharmaceutical Co., Ltd. Hydantoin derivatives
US5004751A (en) * 1987-08-28 1991-04-02 Mochida Pharmaceutical Co., Ltd. Hydantoin derivatives
FI902028A7 (fi) * 1988-08-24 1990-04-23 Mochida Pharm Co Ltd Hydantoiinijohdannaisia
US5068332A (en) * 1990-10-12 1991-11-26 American Home Products Corporation Alkylidene analogs of 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones useful as aldose reductase inhibitors
US8326636B2 (en) * 2008-01-16 2012-12-04 Canyon Ip Holdings Llc Using a physical phenomenon detector to control operation of a speech recognition engine
WO2013117568A1 (de) * 2012-02-09 2013-08-15 Boehringer Ingelheim International Gmbh Verfahren zur stereoselektiven synthese von 1,4-geschützten 9-hydroxy-5-oxo-1,4-diaza-spiro [5.5] undecane

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4117230A (en) 1976-10-18 1978-09-26 Pfizer Inc. Hydantoin derivatives as therapeutic agents
CA1088945A (en) * 1976-10-18 1980-11-04 Pfizer Limited Hydantoin derivatives as therapeutic agents
US4235911A (en) * 1979-06-13 1980-11-25 Pfizer Inc. Hydantoin derivatives
US4248882A (en) * 1980-02-12 1981-02-03 Pfizer Inc. Treating diabetes-associated complications with hydantoin amines
JPS5745185A (en) * 1980-07-21 1982-03-13 Eisai Co Ltd Hydantoin derivative and its preparation
DE3367103D1 (en) * 1982-11-10 1986-11-27 Pfizer Sorbinil by optical resolution with aminopinane derivatives
US4556670A (en) 1982-12-06 1985-12-03 Pfizer Inc. Spiro-3-hetero-azolones for treatment of diabetic complications
SU1380610A3 (ru) * 1982-12-06 1988-03-07 Пфайзер Инк. (Фирма) Способ получени спирогетероазолидиндионов или их фармацевтически приемлемых солей
DE3561198D1 (en) * 1984-03-23 1988-01-28 Pfizer Spiro-indenes and spiro-1,2-dihydro-naphthalenes for treatment of diabetic complications
US4762838A (en) 1985-08-30 1988-08-09 Pfizer Inc. Quinazolin-4(3H)-one derivatives as anticoccidial agents

Also Published As

Publication number Publication date
PL147400B1 (en) 1989-05-31
AU560429B2 (en) 1987-04-09
DK248886D0 (da) 1986-05-28
HUT49879A (en) 1989-11-28
NZ216334A (en) 1988-08-30
EP0203791A1 (en) 1986-12-03
DD273258A5 (de) 1989-11-08
PH22213A (en) 1988-06-28
ATE46332T1 (de) 1989-09-15
JPS61277671A (ja) 1986-12-08
ES555375A0 (es) 1987-11-01
ES557391A0 (es) 1988-02-16
KR860008984A (ko) 1986-12-19
PT82650A (en) 1986-06-01
ES8801830A1 (es) 1988-02-16
HUT44767A (en) 1988-04-28
HU199845B (en) 1990-03-28
FI862251L (fi) 1986-11-30
AU5801286A (en) 1987-01-08
DD264213A5 (de) 1989-01-25
PL266365A1 (en) 1988-03-03
EP0203791B1 (en) 1989-09-13
PT82650B (pt) 1988-11-30
ZA863934B (en) 1988-01-27
DD264214A5 (de) 1989-01-25
HU196060B (en) 1988-09-28
PL147399B1 (en) 1989-05-31
FI862251A7 (fi) 1986-11-30
FI862251A0 (fi) 1986-05-28
PL147397B1 (en) 1989-05-31
EG17859A (en) 1991-11-30
KR890001548B1 (en) 1989-05-08
DE3665584D1 (de) 1989-10-19
IL78954A (en) 1989-09-28
IL78954A0 (en) 1986-09-30
US4575507A (en) 1986-03-11
GR861388B (en) 1986-09-17
DD251972A5 (de) 1987-12-02
DK248886A (da) 1986-11-30
PL266364A1 (en) 1988-03-03
NO862123L (no) 1986-12-01
PL146020B1 (en) 1988-12-31
PL147398B1 (en) 1989-05-31
PL266363A1 (en) 1988-03-03
DD264215A5 (de) 1989-01-25
HUT49882A (en) 1989-11-28
PL266366A1 (en) 1988-03-03
HU893127D0 (en) 1990-01-28

Similar Documents

Publication Publication Date Title
GR900300016T1 (en) A composition of matter for increasing intracellular atp levels and physical performance levels and for increasing the rate of wound repair
DE3772521D1 (de) Insulinzubereitung fuer nicht-parenterale verabreichung.
EP0377729A4 (en) Improved methods of using chemiluminescent 1,2-dioxetanes
ES548667A0 (es) Un procedimiento para la preparacion de polipeptidos.
YU47800B (sr) Estri tienil-karboksilne kiseline sa aminoalkoholima, njihova kvaterna jedinjenja kao i pripremanje tih jedinjenja
DE3780316D1 (de) Verwendung von interleukin-1 zur induzierung der bildung von multipotenten haemopoietischen zellpopulationen.
MX159833A (es) Mejoras en procedimiento para obtener metanol
ES8700661A1 (es) Un procedimiento para preparar derivados de pirimidina
NO902488D0 (no) Karboplatinapreparat.
DE3477488D1 (en) Polymethoxybenzyl piperazine derivatives, processes for their preparation and pharmaceutical compositions containing said derivatives
IT1231509B (it) Composizione farmceutica ad uso topico per la terapia della fragilita' capillare.
AU611113B2 (en) Basically substituted phenylacetonitriles, their preparation and drugs containing these compounds
CA2011992A1 (en) Use of human interferon-beta for stimulation of erythropoiesis
ES555375A0 (es) Un procedimiento para la preparacion de espiro (imidiazolina-4,1'-(2'h)-naftaleno) y espiro (croman-4,4'-imidazolidinas)
ES2016305B3 (es) Compuestos de piperazina, procedimiento para prepararlos y composicion farmaceutica y su uso.
ZA872736B (en) Use of 3-carbamoyl-4-hydroxy-coumarins for combating parasitic helminths,new 3-carbamoyl-4-hydroxy-coumarins and their preparation
ES550742A0 (es) Un procedimiento para la preparacion de una octahidroindo- lizina
AU6826887A (en) 5-substituted octahydroindolizine analgesics compounds and 7-keto intermediates
FI884838A0 (fi) Nytt s-timololderivat och foerfarande foer dess framstaellning.
ES2064652T3 (es) Derivados de naftaleno- y tetrahidronaftaleno-gem-difosfonato.
ES550824A0 (es) Procedimiento para preparar 12-amino-piridazino(4',5':3,4)- pirrolo(2,1-a)isoquinoleinas
JPS5436255A (en) Novel sesquiterpene analogue, its preparation, and pharmatheutical containing the same
EP0189306A3 (en) [alpha, omega-bis(diphenylphosphino)hydrocarbon]bis[(thiosugar)-gold]and bis[selenosugar)gold]derivatives
JPS6434942A (en) Cycloheptenone derivative and remedy for hepatopathy containing said derivative
KR900012884A (ko) (+)1-[(3,4,5-트리메톡시)-벤질옥시메틸]-1-페닐-N,N-디메틸-n-프로필아민, 그의 제조방법 및 치료학적 용도