FR2332009A1 - Nouveaux derives polyprenyliques, leur procede de preparation et leurs applications - Google Patents

Nouveaux derives polyprenyliques, leur procede de preparation et leurs applications

Info

Publication number
FR2332009A1
FR2332009A1 FR7634791A FR7634791A FR2332009A1 FR 2332009 A1 FR2332009 A1 FR 2332009A1 FR 7634791 A FR7634791 A FR 7634791A FR 7634791 A FR7634791 A FR 7634791A FR 2332009 A1 FR2332009 A1 FR 2332009A1
Authority
FR
France
Prior art keywords
applications
new
preparation process
polyprenyl derivatives
polyprenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7634791A
Other languages
English (en)
Other versions
FR2332009B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Publication of FR2332009A1 publication Critical patent/FR2332009A1/fr
Application granted granted Critical
Publication of FR2332009B1 publication Critical patent/FR2332009B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/64—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of functional groups containing oxygen only in singly bound form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/02—Acyclic alcohols with carbon-to-carbon double bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/16—Preparation of ethers by reaction of esters of mineral or organic acids with hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/15—Unsaturated ethers containing only non-aromatic carbon-to-carbon double bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/007—Esters of unsaturated alcohols having the esterified hydroxy group bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/12—Acetic acid esters
    • C07C69/16—Acetic acid esters of dihydroxylic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/12—Acetic acid esters
    • C07C69/18—Acetic acid esters of trihydroxylic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/22—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety
    • C07C69/28—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with dihydroxylic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/533—Monocarboxylic acid esters having only one carbon-to-carbon double bond
    • C07C69/56—Crotonic acid esters; Vinyl acetic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/612—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety
    • C07C69/614—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety of phenylacetic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/612—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety
    • C07C69/618—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety having unsaturation outside the six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/78—Benzoic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
    • C07C69/92—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with etherified hydroxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FR7634791A 1975-11-18 1976-11-18 Nouveaux derives polyprenyliques, leur procede de preparation et leurs applications Granted FR2332009A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/633,097 US4059641A (en) 1975-11-18 1975-11-18 Polyprenyl derivatives

Publications (2)

Publication Number Publication Date
FR2332009A1 true FR2332009A1 (fr) 1977-06-17
FR2332009B1 FR2332009B1 (fr) 1981-08-14

Family

ID=24538267

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7634791A Granted FR2332009A1 (fr) 1975-11-18 1976-11-18 Nouveaux derives polyprenyliques, leur procede de preparation et leurs applications

Country Status (9)

Country Link
US (1) US4059641A (fr)
JP (1) JPS5820933B2 (fr)
CH (2) CH631145A5 (fr)
DE (2) DE2660851C2 (fr)
DK (1) DK145492C (fr)
ES (2) ES453455A1 (fr)
FR (1) FR2332009A1 (fr)
GB (1) GB1533377A (fr)
PH (1) PH13382A (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2399993A1 (fr) * 1977-08-10 1979-03-09 Eisai Co Ltd Composition pour le traitement de l'hypertension a base d'un alcool polyprenylique ou d'un de ses esters
FR2420523A1 (fr) * 1978-03-23 1979-10-19 Nisshin Flour Milling Co Nouveaux derives acides et esters et leur application comme agents antiulcere
FR2422617A1 (fr) * 1976-04-24 1979-11-09 Sankyo Co Derives polyprenyliques, leur procede de preparation et leur application en therapeutique
FR2443245A1 (fr) * 1978-12-07 1980-07-04 Nisshin Flour Milling Co Nouveaux agents anti-ulcere et compositions pharmaceutiques les contenant
FR2473519A1 (fr) * 1980-01-12 1981-07-17 Eisai Co Ltd Terpenoides contenant deux groupes fonctionnels, leur preparation et leur application therapeutique
FR2502006A1 (fr) * 1981-03-17 1982-09-24 Sankyo Co Composes polyprenyliques favorisant la guerison des plaies et compositions les contenant
DE3318989A1 (de) * 1982-05-28 1983-12-01 Eisai Co., Ltd., Tokyo Ss,(gamma)-dihydropolyprenylalkoholderivate und arzneimittel, welche diese enthalten

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4199587A (en) * 1977-08-10 1980-04-22 Eisai Co., Ltd. Method of treating hypertension with polyprenyl alcohol ester
US4175139A (en) * 1977-08-10 1979-11-20 Eisai Co. Ltd. Hypertension treating agent containing polyprenyl alcohol
US4158096A (en) * 1978-03-13 1979-06-12 Zoecon Corporation Intermediates for insect pheromone
US4483871A (en) * 1978-03-23 1984-11-20 Nisshin Flour Milling Co., Ltd. Antiulcer compounds
US4642314A (en) * 1978-03-23 1987-02-10 Nisshin Flour Milling Co., Ltd. Antiulcer compounds
US4738801A (en) * 1978-03-23 1988-04-19 Nisshin Flour Milling Co., Ltd. Antiulcer compounds
US4267363A (en) * 1978-06-26 1981-05-12 Zoecon Corporation Intermediates for a sex pheramone for yellow scale
JPS5742643A (en) * 1980-08-29 1982-03-10 Eisai Co Ltd 6,10,14,18-tetramethyl-5,9,13,17-nonadecatetraene-2-ol
JPS5815940A (ja) * 1981-07-23 1983-01-29 Eisai Co Ltd ポリプレニル系化合物およびその製造方法ならびにそれを含有する医薬
US5280048A (en) * 1982-05-28 1994-01-18 Eisai Co., Ltd. β,γ-dihydropolyprenyl alcohol derivatives and pharmaceutical composition containing a polyprenyl compound
US5658958A (en) * 1982-05-28 1997-08-19 Eisai Co., Ltd. β, γ-dihydropolyprenyl alcohol derivatives effective at mitigating stress in animals
JPS60158126A (ja) * 1984-01-30 1985-08-19 Eisai Co Ltd シス型イソプレノイド
GB2216003B (en) * 1988-02-18 1992-06-10 Toyama Chemical Co Ltd Hair restorer
JPH0639449B2 (ja) * 1989-04-10 1994-05-25 エーザイ株式会社 ポリプレニル系化合物およびその製造方法ならびにそれを含有する医薬
US5399724A (en) * 1989-11-29 1995-03-21 Mitsubishi Kasei Corporation Acyclic terpene compound
US5298655A (en) * 1991-09-27 1994-03-29 Merck & Co., Inc. Farnesyl pyrophosphate analogs
AU4357993A (en) * 1992-07-01 1994-01-31 Sankyo Company Limited Composition for buccal application containing polyprenyl derivative as active ingredient
CZ282294B6 (cs) * 1993-12-01 1997-06-11 Sankyo Company Limited Inhibitor tvorby zánětlivého cytokinu obsahující polyprenylové deriváty, činidlo pro profylaxi a terapii zánětlivých střevních onemocnění a použití polyprenylových derivátů
JP2002205939A (ja) * 2001-01-05 2002-07-23 Sankyo Co Ltd 抗潰瘍剤組成物
US9872867B2 (en) * 2008-06-06 2018-01-23 Tanya Kuritz Methods and compositions for modulation of innate immunity
EP2423177A1 (fr) * 2010-08-25 2012-02-29 Nyken Holding B.V. Analogues du géranylgéranylacétone (GGA)
US9045403B2 (en) 2012-02-29 2015-06-02 Coyote Pharmaceuticals, Inc. Geranyl geranyl acetone (GGA) derivatives and compositions thereof
TW201427938A (zh) * 2012-10-01 2014-07-16 Coyote Pharmaceuticals Inc 香葉基香葉基丙酮（ｇｇａ）和其衍生物之製備方法及彼等與脲或硫脲之共結晶作用
US9119808B1 (en) 2012-10-08 2015-09-01 Coyote Pharmaceuticals, Inc. Treating neurodegenerative diseases with GGA or a derivative thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2850539A (en) * 1953-12-16 1958-09-02 Nat Distillers Chem Corp Synthesis of glycols from conjugated aliphatic diolefins
CH376898A (de) * 1958-08-07 1964-04-30 Hoffmann La Roche Verfahren zur Herstellung von in 6-Stellung substituierten 2,3-Dimethoxy-5-methyl-benzohydrochinonen-(1,4) bzw.-benzochinonen-(1,4)
US3080384A (en) * 1958-12-31 1963-03-05 Hoffmann La Roche Substituted benzoquinones and preparation thereof
US3449407A (en) * 1966-01-11 1969-06-10 Int Flavors & Fragrances Inc Lactic acid esters of polyisoprenoid alcohols
DE2019835C3 (de) * 1969-04-24 1974-08-15 Nisshin Flour Milling Co. Ltd., Tokio Verfahren zur Gewinnung von Solanesol
US3939202A (en) * 1973-01-31 1976-02-17 Teikoku Chemical Industry Co., Ltd. Process for preparing polyene compounds

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2422617A1 (fr) * 1976-04-24 1979-11-09 Sankyo Co Derives polyprenyliques, leur procede de preparation et leur application en therapeutique
FR2399993A1 (fr) * 1977-08-10 1979-03-09 Eisai Co Ltd Composition pour le traitement de l'hypertension a base d'un alcool polyprenylique ou d'un de ses esters
FR2420523A1 (fr) * 1978-03-23 1979-10-19 Nisshin Flour Milling Co Nouveaux derives acides et esters et leur application comme agents antiulcere
FR2443245A1 (fr) * 1978-12-07 1980-07-04 Nisshin Flour Milling Co Nouveaux agents anti-ulcere et compositions pharmaceutiques les contenant
FR2473519A1 (fr) * 1980-01-12 1981-07-17 Eisai Co Ltd Terpenoides contenant deux groupes fonctionnels, leur preparation et leur application therapeutique
FR2502006A1 (fr) * 1981-03-17 1982-09-24 Sankyo Co Composes polyprenyliques favorisant la guerison des plaies et compositions les contenant
DE3318989A1 (de) * 1982-05-28 1983-12-01 Eisai Co., Ltd., Tokyo Ss,(gamma)-dihydropolyprenylalkoholderivate und arzneimittel, welche diese enthalten
FR2569108A1 (fr) * 1982-05-28 1986-02-21 Eisai Co Ltd Composition pharmaceutique contenant un compose polyprenylique

Also Published As

Publication number Publication date
ES465099A1 (es) 1978-10-01
DK145492B (da) 1982-11-29
DE2652256C2 (de) 1985-10-31
CH631145A5 (de) 1982-07-30
ES453455A1 (es) 1978-02-16
FR2332009B1 (fr) 1981-08-14
DK145492C (da) 1983-05-02
GB1533377A (en) 1978-11-22
JPS5262213A (en) 1977-05-23
PH13382A (en) 1980-03-25
DE2652256A1 (de) 1977-06-02
DK518176A (da) 1977-05-19
DE2660851C2 (de) 1986-02-13
CH629471A5 (de) 1982-04-30
JPS5820933B2 (ja) 1983-04-26
US4059641A (en) 1977-11-22

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