FR2463614A1 - Composition orale destinee a combattre le tartre dentaire et ameliorer l'hygiene buccale - Google Patents

Composition orale destinee a combattre le tartre dentaire et ameliorer l'hygiene buccale Download PDF

Info

Publication number: FR2463614A1
Authority: FR; France
Prior art keywords: oral; compound; agent; bacterial; pbta
Prior art date: 1979-08-24
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

FR8018031A

Other languages

English (en)

French (fr)

Other versions

FR2463614B1 (da

Inventor

Abdul Gaffar

John J Grecsek

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Colgate Palmolive Co

Original Assignee

Colgate Palmolive Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-08-24

Filing date

1980-08-18

Publication date

1981-02-27

1979-08-24 Priority claimed from US06/069,464 external-priority patent/US4224309A/en

1979-08-24 Priority claimed from US06/069,463 external-priority patent/US4224308A/en

1980-08-18 Application filed by Colgate Palmolive Co filed Critical Colgate Palmolive Co

1981-02-27 Publication of FR2463614A1 publication Critical patent/FR2463614A1/fr

1985-01-11 Application granted granted Critical

1985-01-11 Publication of FR2463614B1 publication Critical patent/FR2463614B1/fr

Status Granted legal-status Critical Current

Links

239000000203 mixture Substances 0.000 title abstract description 45
206010044029 Tooth deposit Diseases 0.000 title description 4
239000003795 chemical substances by application Substances 0.000 abstract description 43
-1 2-PHOSPHONO-BUTANE-1,2,4-TRICARBOXYLIC ACID COMPOUND Chemical class 0.000 abstract description 33
230000000844 anti-bacterial effect Effects 0.000 abstract description 28
230000002882 anti-plaque Effects 0.000 abstract description 23
239000000606 toothpaste Substances 0.000 abstract description 21
230000015572 biosynthetic process Effects 0.000 abstract description 20
229940034610 toothpaste Drugs 0.000 abstract description 19
239000007788 liquid Substances 0.000 abstract description 15
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract description 14
150000003839 salts Chemical class 0.000 abstract description 13
239000002324 mouth wash Substances 0.000 abstract description 11
229940051866 mouthwash Drugs 0.000 abstract description 8
229910052757 nitrogen Inorganic materials 0.000 abstract description 8
150000001875 compounds Chemical class 0.000 description 32
239000000126 substance Substances 0.000 description 30
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 27
238000002360 preparation method Methods 0.000 description 24
GPXCJKUXBIGASD-UHFFFAOYSA-N 1-phosphonobutane-1,2,4-tricarboxylic acid Chemical compound OC(=O)CCC(C(O)=O)C(C(O)=O)P(O)(O)=O GPXCJKUXBIGASD-UHFFFAOYSA-N 0.000 description 19
208000006558 Dental Calculus Diseases 0.000 description 16
125000004432 carbon atom Chemical group C* 0.000 description 15
125000000217 alkyl group Chemical group 0.000 description 14
239000003242 anti bacterial agent Substances 0.000 description 13
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 11
125000002091 cationic group Chemical group 0.000 description 11
239000000686 essence Substances 0.000 description 11
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 10
239000011734 sodium Substances 0.000 description 10
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 9
239000011575 calcium Substances 0.000 description 9
210000003298 dental enamel Anatomy 0.000 description 9
230000000694 effects Effects 0.000 description 9
239000001257 hydrogen Substances 0.000 description 8
229910052739 hydrogen Inorganic materials 0.000 description 8
238000005498 polishing Methods 0.000 description 8
229910052708 sodium Inorganic materials 0.000 description 8
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 7
PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 7
239000001506 calcium phosphate Substances 0.000 description 7
239000013078 crystal Substances 0.000 description 7
235000014113 dietary fatty acids Nutrition 0.000 description 7
239000000194 fatty acid Substances 0.000 description 7
229930195729 fatty acid Natural products 0.000 description 7
229910052588 hydroxylapatite Inorganic materials 0.000 description 7
XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 7
QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 6
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 6
UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 6
229910052791 calcium Inorganic materials 0.000 description 6
150000004665 fatty acids Chemical group 0.000 description 6
238000009472 formulation Methods 0.000 description 6
239000000499 gel Substances 0.000 description 6
239000003906 humectant Substances 0.000 description 6
210000000214 mouth Anatomy 0.000 description 6
239000002245 particle Substances 0.000 description 6
239000000243 solution Substances 0.000 description 6
239000004094 surface-active agent Substances 0.000 description 6
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 6
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 5
208000002064 Dental Plaque Diseases 0.000 description 5
RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 5
239000002253 acid Substances 0.000 description 5
229960001950 benzethonium chloride Drugs 0.000 description 5
229910000389 calcium phosphate Inorganic materials 0.000 description 5
235000011010 calcium phosphates Nutrition 0.000 description 5
235000003599 food sweetener Nutrition 0.000 description 5
235000011187 glycerol Nutrition 0.000 description 5
239000006072 paste Substances 0.000 description 5
239000000843 powder Substances 0.000 description 5
239000007787 solid Substances 0.000 description 5
239000000600 sorbitol Substances 0.000 description 5
239000003765 sweetening agent Substances 0.000 description 5
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 4
229910019142 PO4 Inorganic materials 0.000 description 4
ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 4
239000000654 additive Substances 0.000 description 4
229910052783 alkali metal Inorganic materials 0.000 description 4
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 4
239000007859 condensation product Substances 0.000 description 4
239000000796 flavoring agent Substances 0.000 description 4
235000013355 food flavoring agent Nutrition 0.000 description 4
150000002431 hydrogen Chemical class 0.000 description 4
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 4
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 4
239000010452 phosphate Substances 0.000 description 4
PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 4
238000005406 washing Methods 0.000 description 4
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
125000001931 aliphatic group Chemical group 0.000 description 3
150000001340 alkali metals Chemical class 0.000 description 3
229910052782 aluminium Inorganic materials 0.000 description 3
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 3
125000000129 anionic group Chemical group 0.000 description 3
230000002821 anti-nucleating effect Effects 0.000 description 3
229960001927 cetylpyridinium chloride Drugs 0.000 description 3
YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 3
229960003260 chlorhexidine Drugs 0.000 description 3
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
230000007423 decrease Effects 0.000 description 3
239000012458 free base Substances 0.000 description 3
239000003349 gelling agent Substances 0.000 description 3
150000002357 guanidines Chemical class 0.000 description 3
239000004615 ingredient Substances 0.000 description 3
230000005764 inhibitory process Effects 0.000 description 3
229910052751 metal Inorganic materials 0.000 description 3
239000002184 metal Substances 0.000 description 3
125000005341 metaphosphate group Chemical group 0.000 description 3
238000000034 method Methods 0.000 description 3
OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 3
239000002667 nucleating agent Substances 0.000 description 3
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 3
229940081974 saccharin Drugs 0.000 description 3
235000019204 saccharin Nutrition 0.000 description 3
239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 3
239000000377 silicon dioxide Substances 0.000 description 3
238000010186 staining Methods 0.000 description 3
IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 description 2
108010011485 Aspartame Proteins 0.000 description 2
241000894006 Bacteria Species 0.000 description 2
CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 2
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 2
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
229920000663 Hydroxyethyl cellulose Polymers 0.000 description 2
239000004354 Hydroxyethyl cellulose Substances 0.000 description 2
BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 2
229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
LFVVNPBBFUSSHL-UHFFFAOYSA-N alexidine Chemical compound CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC LFVVNPBBFUSSHL-UHFFFAOYSA-N 0.000 description 2
229950010221 alexidine Drugs 0.000 description 2
229910021529 ammonia Inorganic materials 0.000 description 2
229940027983 antiseptic and disinfectant quaternary ammonium compound Drugs 0.000 description 2
IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 2
239000002585 base Substances 0.000 description 2
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
230000001680 brushing effect Effects 0.000 description 2
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230000008859 change Effects 0.000 description 2
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150000002222 fluorine compounds Chemical class 0.000 description 2
208000007565 gingivitis Diseases 0.000 description 2
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238000000338 in vitro Methods 0.000 description 2
229910052500 inorganic mineral Inorganic materials 0.000 description 2
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239000011707 mineral Substances 0.000 description 2
235000010755 mineral Nutrition 0.000 description 2
229920000233 poly(alkylene oxides) Polymers 0.000 description 2
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229910052700 potassium Inorganic materials 0.000 description 2
NROKBHXJSPEDAR-UHFFFAOYSA-M potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 description 2
239000002244 precipitate Substances 0.000 description 2
239000002243 precursor Substances 0.000 description 2
230000008569 process Effects 0.000 description 2
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235000013024 sodium fluoride Nutrition 0.000 description 2
AYGJDUHQRFKLBG-UHFFFAOYSA-M sodium;1,1-dioxo-1,2-benzothiazol-3-olate;dihydrate Chemical compound O.O.[Na+].C1=CC=C2C(=O)[N-]S(=O)(=O)C2=C1 AYGJDUHQRFKLBG-UHFFFAOYSA-M 0.000 description 2
ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 2
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DLYUQMMRRRQYAE-UHFFFAOYSA-N tetraphosphorus decaoxide Chemical compound O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 description 2
YUOWTJMRMWQJDA-UHFFFAOYSA-J tin(iv) fluoride Chemical compound [F-].[F-].[F-].[F-].[Sn+4] YUOWTJMRMWQJDA-UHFFFAOYSA-J 0.000 description 2
230000000007 visual effect Effects 0.000 description 2
239000000341 volatile oil Substances 0.000 description 2
BHHYHSUAOQUXJK-UHFFFAOYSA-L zinc fluoride Chemical compound F[Zn]F BHHYHSUAOQUXJK-UHFFFAOYSA-L 0.000 description 2
OERWVEWSIJIHNO-UHFFFAOYSA-N (1-bromo-2-methylpentadecan-2-yl)oxybenzene Chemical compound C(CCCCCCCCCCC)CC(CBr)(OC1=CC=CC=C1)C OERWVEWSIJIHNO-UHFFFAOYSA-N 0.000 description 1
LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
PBYSGNVIJLMHLI-UHFFFAOYSA-N 1-[n'-[(4-chlorophenyl)methyl]carbamimidoyl]-2-(3-dodecoxypropyl)guanidine Chemical compound CCCCCCCCCCCCOCCCNC(=N)NC(=N)NCC1=CC=C(Cl)C=C1 PBYSGNVIJLMHLI-UHFFFAOYSA-N 0.000 description 1
OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
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NGOZDSMNMIRDFP-UHFFFAOYSA-N 2-[methyl(tetradecanoyl)amino]acetic acid Chemical group CCCCCCCCCCCCCC(=O)N(C)CC(O)=O NGOZDSMNMIRDFP-UHFFFAOYSA-N 0.000 description 1
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UDIPTWFVPPPURJ-UHFFFAOYSA-M Cyclamate Chemical compound [Na+].[O-]S(=O)(=O)NC1CCCCC1 UDIPTWFVPPPURJ-UHFFFAOYSA-M 0.000 description 1
RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 description 1
239000005696 Diammonium phosphate Substances 0.000 description 1
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125000001624 naphthyl group Chemical group 0.000 description 1
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201000001245 periodontitis Diseases 0.000 description 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
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239000011698 potassium fluoride Substances 0.000 description 1
235000003270 potassium fluoride Nutrition 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
238000003825 pressing Methods 0.000 description 1
150000003141 primary amines Chemical class 0.000 description 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
239000000047 product Substances 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
230000009257 reactivity Effects 0.000 description 1
230000002829 reductive effect Effects 0.000 description 1
235000009566 rice Nutrition 0.000 description 1
235000002020 sage Nutrition 0.000 description 1
108700004121 sarkosyl Proteins 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
239000000741 silica gel Substances 0.000 description 1
229910002027 silica gel Inorganic materials 0.000 description 1
230000035943 smell Effects 0.000 description 1
239000000344 soap Substances 0.000 description 1
229940077386 sodium benzenesulfonate Drugs 0.000 description 1
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FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical class [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
AQMNWCRSESPIJM-UHFFFAOYSA-M sodium metaphosphate Chemical compound [Na+].[O-]P(=O)=O AQMNWCRSESPIJM-UHFFFAOYSA-M 0.000 description 1
KKCBUQHMOMHUOY-UHFFFAOYSA-N sodium oxide Chemical compound [O-2].[Na+].[Na+] KKCBUQHMOMHUOY-UHFFFAOYSA-N 0.000 description 1
229910001948 sodium oxide Inorganic materials 0.000 description 1
239000001488 sodium phosphate Substances 0.000 description 1
229910000162 sodium phosphate Inorganic materials 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 description 1
229910052911 sodium silicate Inorganic materials 0.000 description 1
MZSDGDXXBZSFTG-UHFFFAOYSA-M sodium;benzenesulfonate Chemical compound [Na+].[O-]S(=O)(=O)C1=CC=CC=C1 MZSDGDXXBZSFTG-UHFFFAOYSA-M 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
150000005846 sugar alcohols Polymers 0.000 description 1
150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
229910021653 sulphate ion Inorganic materials 0.000 description 1
239000000725 suspension Substances 0.000 description 1
239000003826 tablet Substances 0.000 description 1
150000003512 tertiary amines Chemical class 0.000 description 1
150000003568 thioethers Chemical class 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
235000019731 tricalcium phosphate Nutrition 0.000 description 1
229940078499 tricalcium phosphate Drugs 0.000 description 1
GSEJCLTVZPLZKY-UHFFFAOYSA-O triethanolammonium Chemical compound OCC[NH+](CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-O 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
239000008170 walnut oil Substances 0.000 description 1
239000000811 xylitol Substances 0.000 description 1
235000010447 xylitol Nutrition 0.000 description 1
HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
229960002675 xylitol Drugs 0.000 description 1
UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
229910052726 zirconium Inorganic materials 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Oral & Maxillofacial Surgery (AREA)
Birds (AREA)
Epidemiology (AREA)
Cosmetics (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

FR8018031A 1979-08-24 1980-08-18 Composition orale destinee a combattre le tartre dentaire et ameliorer l'hygiene buccale Granted FR2463614A1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/069,464 US4224309A (en)	1979-08-24	1979-08-24	Antibacterial oral composition
US06/069,463 US4224308A (en)	1979-08-24	1979-08-24	Anticalculus oral composition

Publications (2)

Publication Number	Publication Date
FR2463614A1 true FR2463614A1 (fr)	1981-02-27
FR2463614B1 FR2463614B1 (da)	1985-01-11

Family

ID=26750094

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FR8018031A Granted FR2463614A1 (fr)	1979-08-24	1980-08-18	Composition orale destinee a combattre le tartre dentaire et ameliorer l'hygiene buccale

Country Status (14)

Country	Link
AT (1)	AT390188B (da)
AU (1)	AU534902B2 (da)
CA (1)	CA1150151A (da)
CH (1)	CH646051A5 (da)
DE (1)	DE3029921A1 (da)
DK (1)	DK159372C (da)
FR (1)	FR2463614A1 (da)
GB (1)	GB2056857B (da)
IT (1)	IT1188989B (da)
NL (1)	NL8004619A (da)
NZ (1)	NZ194476A (da)
PH (1)	PH16103A (da)
PT (1)	PT71722B (da)
SE (1)	SE8005622L (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0110568A1 (en) *	1982-10-29	1984-06-13	The Procter & Gamble Company	Oral compositions
US5468777A (en) *	1984-03-19	1995-11-21	The Rockefeller University	Method and agents for preventing and reversing the staining of teeth
US4575456A (en) *	1984-11-30	1986-03-11	Colgate-Palmolive Company	Gel dentifrice of desirable consistency

Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2185385A1 (da) *	1972-05-19	1974-01-04	Henkel & Cie Gmbh
US3886204A (en) *	1970-12-16	1975-05-27	Bayer Ag	2-Phosphono-butane-1,2,3,4-tetracarboxylic acids
US3886205A (en) *	1970-12-16	1975-05-27	Bayer Ag	2-Phosphono-butane-1,2,4-tricarboxylic acids
FR2361865A1 (fr) *	1976-08-16	1978-03-17	Colgate Palmolive Co	Composition pour l'hygiene buccale et son procede de preparation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4118476A (en) *	1976-08-16	1978-10-03	Colgate-Palmolive Company	Antibacterial oral composition

1980
- 1980-07-28 NZ NZ194476A patent/NZ194476A/xx unknown
- 1980-08-04 AU AU61037/80A patent/AU534902B2/en not_active Ceased
- 1980-08-04 DK DK335380A patent/DK159372C/da not_active IP Right Cessation
- 1980-08-07 DE DE19803029921 patent/DE3029921A1/de not_active Withdrawn
- 1980-08-08 SE SE8005622A patent/SE8005622L/xx not_active Application Discontinuation
- 1980-08-12 AT AT0412680A patent/AT390188B/de not_active IP Right Cessation
- 1980-08-14 NL NL8004619A patent/NL8004619A/nl not_active Application Discontinuation
- 1980-08-18 CH CH622580A patent/CH646051A5/de not_active IP Right Cessation
- 1980-08-18 FR FR8018031A patent/FR2463614A1/fr active Granted
- 1980-08-18 CA CA000358476A patent/CA1150151A/en not_active Expired
- 1980-08-20 IT IT49530/80A patent/IT1188989B/it active
- 1980-08-21 PT PT71722A patent/PT71722B/pt unknown
- 1980-08-22 PH PH24479A patent/PH16103A/en unknown
- 1980-08-22 GB GB8027340A patent/GB2056857B/en not_active Expired

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3886204A (en) *	1970-12-16	1975-05-27	Bayer Ag	2-Phosphono-butane-1,2,3,4-tetracarboxylic acids
US3886205A (en) *	1970-12-16	1975-05-27	Bayer Ag	2-Phosphono-butane-1,2,4-tricarboxylic acids
FR2185385A1 (da) *	1972-05-19	1974-01-04	Henkel & Cie Gmbh
FR2361865A1 (fr) *	1976-08-16	1978-03-17	Colgate Palmolive Co	Composition pour l'hygiene buccale et son procede de preparation

Also Published As

Publication number	Publication date
GB2056857A (en)	1981-03-25
DK159372B (da)	1990-10-08
IT1188989B (it)	1988-01-28
GB2056857B (en)	1984-07-25
DK159372C (da)	1991-03-18
IT8049530A1 (it)	1982-02-20
PH16103A (en)	1983-06-24
CA1150151A (en)	1983-07-19
NL8004619A (nl)	1981-02-26
IT8049530A0 (it)	1980-08-20
AU6103780A (en)	1981-02-26
AT390188B (de)	1990-03-26
NZ194476A (en)	1982-05-25
AU534902B2 (en)	1984-02-23
CH646051A5 (de)	1984-11-15
DK335380A (da)	1981-02-25
PT71722B (en)	1981-09-03
SE8005622L (sv)	1981-02-25
FR2463614B1 (da)	1985-01-11
ATA412680A (de)	1984-09-15
PT71722A (en)	1980-09-01
DE3029921A1 (de)	1981-03-12

Legal Events

Date	Code	Title	Description
1993-07-02	ST	Notification of lapse

Publication	Publication Date	Title
US4370314A (en)	1983-01-25	Oral composition containing antibacterial agent
US4273759A (en)	1981-06-16	Antibacterial oral composition
FR2587209A1 (fr)	1987-03-20	Compositions destinees a combattre la mauvaise haleine contenant un sel de zinc et un derive cetonique et leur procede d'utilisation
MC1416A1 (fr)	1982-10-18	Compositions orales contenant de l'hexetidine et des sels de zinc pour l'inhibition synergique de la plaque dentaire
LU86581A1 (fr)	1988-04-05	Composition anti-tartre a usage buccal a base de polyphosphate,son procede de fabrication et procede l'utilisant
US4224308A (en)	1980-09-23	Anticalculus oral composition
FR2610195A1 (fr)	1988-08-05	Composition a usage buccal comprenant un polyphosphate et un agent antibacterien et son procede d'utilisation pour inhiber la plaque et le tartre dentaire
FR2474864A1 (fr)	1981-08-07	Composition buccale utilisable pour le traitement de la gingivite, a base d'acide trans-4-(aminomethyl)-cyclohexane-1-carboxylique
JPS6216924B2 (da)	1987-04-15
BE1000312A4 (fr)	1988-10-18	Composition anti-plaque a usage buccal, a base d'hexetidine et de tridecanol.
BE1001658A5 (fr)	1990-01-23	Composition dentifrice antiplaque stable.
FR2474862A1 (fr)	1981-08-07	Composition buccale prophylactique a base d'acide trans-4-(aminomethyl)cyclohexane-1-carboxylique
US4339431A (en)	1982-07-13	Anticalculus oral composition
FR2475899A1 (fr)	1981-08-21	Composition antigingivite non colorante a base d'acide trans-4-(aminomethyl) cyclohexane-1-carboxylique
FR2573981A1 (fr)	1986-06-06	Gel dentifrice et son procede de preparation
JPH02286613A (ja)	1990-11-26	新規組成物
FR2578420A1 (fr)	1986-09-12	Composition buccale antitartre a base d'acide phosphonoformique, procede pour sa preparation et son utilisation
US4118476A (en)	1978-10-03	Antibacterial oral composition
US4215105A (en)	1980-07-29	Anticalculus oral composition
JPH0239482B2 (da)	1990-09-05
WO1992020319A1 (fr)	1992-11-26	Composition pour l'hygiene bucco-dentaire et son procede d'utilisation
DK148898B (da)	1985-11-11	Antibakterielt mundplejemiddel
KR880001750B1 (ko)	1988-09-12	항치석제를 함유한 구강용 조성물
NZ231330A (en)	1991-07-26	Antibacterial antiplaque oral composition containing an additive that prevents the staining of dental surfaces
FR2463614A1 (fr)	1981-02-27	Composition orale destinee a combattre le tartre dentaire et ameliorer l'hygiene buccale