FR2625743B1 - Derives d'isoquinoleine, leur preparation et leur utilisation - Google Patents

Derives d'isoquinoleine, leur preparation et leur utilisation

Info

Publication number
FR2625743B1
FR2625743B1 FR898900128A FR8900128A FR2625743B1 FR 2625743 B1 FR2625743 B1 FR 2625743B1 FR 898900128 A FR898900128 A FR 898900128A FR 8900128 A FR8900128 A FR 8900128A FR 2625743 B1 FR2625743 B1 FR 2625743B1
Authority
FR
France
Prior art keywords
preparation
isoquinolein
derivatives
isoquinolein derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR898900128A
Other languages
English (en)
Other versions
FR2625743A1 (fr
Inventor
Klaus Hasspacher
Reto Naef
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of FR2625743A1 publication Critical patent/FR2625743A1/fr
Application granted granted Critical
Publication of FR2625743B1 publication Critical patent/FR2625743B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR898900128A 1988-01-08 1989-01-06 Derives d'isoquinoleine, leur preparation et leur utilisation Expired - Lifetime FR2625743B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888800397A GB8800397D0 (en) 1988-01-08 1988-01-08 Improvements in/relating to organic compounds

Publications (2)

Publication Number Publication Date
FR2625743A1 FR2625743A1 (fr) 1989-07-13
FR2625743B1 true FR2625743B1 (fr) 1990-11-09

Family

ID=10629678

Family Applications (1)

Application Number Title Priority Date Filing Date
FR898900128A Expired - Lifetime FR2625743B1 (fr) 1988-01-08 1989-01-06 Derives d'isoquinoleine, leur preparation et leur utilisation

Country Status (28)

Country Link
US (1) US4980359A (fr)
JP (1) JPH0649686B2 (fr)
KR (1) KR0142686B1 (fr)
AT (1) AT394365B (fr)
AU (1) AU622429B2 (fr)
BE (1) BE1002730A3 (fr)
CA (1) CA1332944C (fr)
CH (1) CH678727A5 (fr)
DE (1) DE3900233C2 (fr)
DK (1) DK5789A (fr)
ES (1) ES2010071A6 (fr)
FI (1) FI90865C (fr)
FR (1) FR2625743B1 (fr)
GB (2) GB8800397D0 (fr)
GR (1) GR1002750B (fr)
HU (1) HU205083B (fr)
IE (1) IE61914B1 (fr)
IL (1) IL88899A (fr)
IT (1) IT1229523B (fr)
LU (1) LU87423A1 (fr)
MY (1) MY103963A (fr)
NL (1) NL8900029A (fr)
NZ (1) NZ227561A (fr)
PH (1) PH25640A (fr)
PL (1) PL156099B1 (fr)
PT (1) PT89405B (fr)
SE (1) SE501548C2 (fr)
ZA (1) ZA89133B (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2723674A (en) * 1951-11-28 1955-11-15 Charles E Harris Telephone cableman's tent
US3007541A (en) * 1959-02-24 1961-11-07 Jr John B Mast Temporary covering and support structure therefor
GB8807922D0 (en) * 1988-04-05 1988-05-05 Fujisawa Pharmaceutical Co Isoquinoline compound & process for preparation thereof
US4956371A (en) * 1989-09-19 1990-09-11 Euroceltique, S.A. Substituted isoquinolines and methods of using same
GB8921304D0 (en) * 1989-09-20 1989-11-08 Wyeth John & Brother Ltd New method of treatment and heterocyclic compounds used therein
GB9027055D0 (en) * 1990-12-13 1991-02-06 Sandoz Ltd Organic compounds
HUT64676A (en) * 1990-12-17 1994-02-28 Shell Int Research Fungicidal compositions containing isoquinoline derivatives as actvie agent and process for production of the active agents
CA2093577C (fr) * 1992-05-07 2006-01-03 Michael Klaus Retinoides s-heterocyclique alkyl ou alkoxy substitues
US5350423A (en) * 1992-09-23 1994-09-27 Burlington Industries Inc. Fabric finishing procedure
GB9322828D0 (en) * 1993-11-05 1993-12-22 Sandoz Ltd Organic compounds
US5683892A (en) * 1994-12-23 1997-11-04 Smithkline Beecham Corporation DNA encoding recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders
ES2277336T3 (es) * 1994-12-23 2007-07-01 Smithkline Beecham Corporation Antagonistas de il-5 recombinantes utiles en el tratamiento de enfermadades mediadas por il-5.
US5783184A (en) * 1994-12-23 1998-07-21 Smithkline Beecham Corporation Method for treatment and diagnosis of IL-5 mediated disorders
US7399837B2 (en) 1995-12-22 2008-07-15 Smithkline Beecham Corporation Recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders
RU2174123C2 (ru) * 1996-10-28 2001-09-27 Новартис Аг Производные 8-арил-1,7-нафтиридина и фармацевтическая композиция, обладающая противовоспалительной активностью
GB9622386D0 (en) * 1996-10-28 1997-01-08 Sandoz Ltd Organic compounds
IT1296985B1 (it) 1997-12-19 1999-08-03 Zambon Spa Derivati benzazinici inibitori della fosfodiesterasi 4
DE60033918D1 (de) 1999-01-15 2007-04-26 Altana Pharma Ag Polysubstituted 6-phenylphenanthridines mit pde-iv hemmender wirkung
CZ302882B6 (cs) 1999-08-21 2012-01-04 Nycomed Gmbh Farmaceutický prostredek
RU2213735C2 (ru) * 2001-09-24 2003-10-10 ГУ Институт технической химии Уральского отделения РАН Способ получения 1-замещенных 3,3-диметил-3,4-дигидроизохинолинов
MY130622A (en) * 2001-11-05 2007-07-31 Novartis Ag Naphthyridine derivatives, their preparation and their use as phosphodiesterase isoenzyme 4 (pde4) inhibitors
US7153824B2 (en) 2003-04-01 2006-12-26 Applied Research Systems Ars Holding N.V. Inhibitors of phosphodiesterases in infertility
EP2152290B1 (fr) * 2007-04-30 2014-06-04 GlaxoSmithKline LLC Méthodes pour administrer des anticorps anti-il-5
EP2274009B1 (fr) * 2008-03-28 2013-11-13 GlaxoSmithKline LLC Procédés de traitement
CA2740873C (fr) 2008-10-17 2019-09-10 Wisconsin Alumni Research Foundation Procede de realisation de peptides alpha-beta biologiquement actifs
EP3634467A4 (fr) 2017-06-06 2021-07-28 GlaxoSmithKline LLC Compositions biopharmaceutiques et procédés pour patients pédiatriques

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB645139A (en) * 1946-10-22 1950-10-25 Servita Gyogyszeryar Es Vegyip Improved process for the production of isoquinoline derivatives
DE1184344B (de) * 1962-06-16 1964-12-31 Orgamol Sa Verfahren zur Herstellung von Isochinolinderivaten
US3878215A (en) * 1971-12-01 1975-04-15 Sandoz Ag 2-Alkyl-3-substituted-4-aryl isoquinolines
DE2401453A1 (de) * 1973-01-16 1974-07-18 John James Voorhees Pharmazeutische zusammensetzung zur behandlung von hautproliferationserkrankungen
US4018927A (en) * 1973-12-17 1977-04-19 The Regents Of The University Of Michigan Treatment of proliferating skin diseases with papaverine alkaloids
DK136189B (da) * 1974-02-05 1977-08-29 Sandoz Ag Analogifremgangsmåde til fremstilling af benzo(c)(1,6)naphthyridinderivater eller syreadditionssalte deraf.
DE2811361A1 (de) * 1978-03-16 1979-09-27 Hoechst Ag Neue isochinolinaldehyde und verfahren zu ihrer herstellung
DE3244594A1 (de) * 1982-12-02 1984-06-07 Hoechst Ag, 6230 Frankfurt 1-phenylisochinolinderivate und verfahren zu ihrer herstellung, diese verbindung enthaltende pharmazeutische praeparate und deren anwendung
HU196758B (en) * 1986-05-21 1989-01-30 Gyogyszerkutato Intezet Process for production of 3-hidroxi-methil-quinolines and medical compositions containing them
CA1330560C (fr) * 1986-05-21 1994-07-05 Maurits E. A. Vandewalle Derives di- et tetrahydroisoquinoline

Also Published As

Publication number Publication date
DK5789A (da) 1989-07-09
GR1002750B (el) 1997-08-26
HUT52061A (en) 1990-06-28
AT394365B (de) 1992-03-25
PH25640A (en) 1991-08-21
US4980359A (en) 1990-12-25
FR2625743A1 (fr) 1989-07-13
SE8900039D0 (sv) 1989-01-05
BE1002730A3 (fr) 1991-05-21
NL8900029A (nl) 1989-08-01
NZ227561A (en) 1991-11-26
DE3900233A1 (de) 1989-07-20
PT89405A (pt) 1990-02-08
FI890072A0 (fi) 1989-01-06
IL88899A0 (en) 1989-08-15
PL277092A1 (en) 1989-09-04
PT89405B (pt) 1993-09-30
GB8900102D0 (en) 1989-03-01
GB2213482A (en) 1989-08-16
CA1332944C (fr) 1994-11-08
GB8800397D0 (en) 1988-02-10
SE8900039L (sv) 1989-07-09
FI90865C (fi) 1994-04-11
ATA3589A (de) 1991-09-15
AU622429B2 (en) 1992-04-09
IE61914B1 (en) 1994-11-30
IL88899A (en) 1994-07-31
HU205083B (en) 1992-03-30
ZA89133B (en) 1990-09-26
FI90865B (fi) 1993-12-31
AU2779589A (en) 1989-07-20
IE890037L (en) 1989-07-08
MY103963A (en) 1993-10-30
DE3900233C2 (de) 2000-04-27
LU87423A1 (fr) 1989-08-30
PL156099B1 (pl) 1992-02-28
FI890072A7 (fi) 1989-07-09
DK5789D0 (da) 1989-01-06
ES2010071A6 (es) 1989-10-16
IT1229523B (it) 1991-09-04
JPH01213267A (ja) 1989-08-28
JPH0649686B2 (ja) 1994-06-29
CH678727A5 (fr) 1991-10-31
KR0142686B1 (ko) 1998-07-15
GR890100008A (el) 1994-03-31
SE501548C2 (sv) 1995-03-13
KR890011851A (ko) 1989-08-22
IT8947504A0 (it) 1989-01-04
GB2213482B (en) 1991-09-11

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Legal Events

Date Code Title Description
TP Transmission of property
ST Notification of lapse