BE1002730A3 - Derives d'isoquinoleine, leur preparation et leur utilisation. - Google Patents

Derives d'isoquinoleine, leur preparation et leur utilisation. Download PDF

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Publication number
BE1002730A3
BE1002730A3 BE8900018A BE8900018A BE1002730A3 BE 1002730 A3 BE1002730 A3 BE 1002730A3 BE 8900018 A BE8900018 A BE 8900018A BE 8900018 A BE8900018 A BE 8900018A BE 1002730 A3 BE1002730 A3 BE 1002730A3
Authority
BE
Belgium
Prior art keywords
alkoxy
hydrogen
preparation
alkyl
isoquinolein
Prior art date
Application number
BE8900018A
Other languages
English (en)
Inventor
Klaus Hasspacher
Reto Naef
Original Assignee
Sandoz Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Sa filed Critical Sandoz Sa
Application granted granted Critical
Publication of BE1002730A3 publication Critical patent/BE1002730A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention a pour objet des composés de formule I où R1 est alkyle; R2 est hydrogène et R3 est hydrogène ou alkyle, ou R2 et R3 sont ensemble une liaison supplémentaire indiquée en trait pointillé; R4 est hydrogène, alkyle ou phényle; R5 est méthoxy ou éthoxy; R6 est hydrogène, hydroxy, alcoxy, hydroxy-alcoxy ou alcoxy-alcoxy; R7 et R8 sont chacun alcoxy ou alcoxy-alcoxy et R9 est hydrogène ou halogène.
BE8900018A 1988-01-08 1989-01-06 Derives d'isoquinoleine, leur preparation et leur utilisation. BE1002730A3 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888800397A GB8800397D0 (en) 1988-01-08 1988-01-08 Improvements in/relating to organic compounds

Publications (1)

Publication Number Publication Date
BE1002730A3 true BE1002730A3 (fr) 1991-05-21

Family

ID=10629678

Family Applications (1)

Application Number Title Priority Date Filing Date
BE8900018A BE1002730A3 (fr) 1988-01-08 1989-01-06 Derives d'isoquinoleine, leur preparation et leur utilisation.

Country Status (28)

Country Link
US (1) US4980359A (fr)
JP (1) JPH0649686B2 (fr)
KR (1) KR0142686B1 (fr)
AT (1) AT394365B (fr)
AU (1) AU622429B2 (fr)
BE (1) BE1002730A3 (fr)
CA (1) CA1332944C (fr)
CH (1) CH678727A5 (fr)
DE (1) DE3900233C2 (fr)
DK (1) DK5789A (fr)
ES (1) ES2010071A6 (fr)
FI (1) FI90865C (fr)
FR (1) FR2625743B1 (fr)
GB (2) GB8800397D0 (fr)
GR (1) GR1002750B (fr)
HU (1) HU205083B (fr)
IE (1) IE61914B1 (fr)
IL (1) IL88899A (fr)
IT (1) IT1229523B (fr)
LU (1) LU87423A1 (fr)
MY (1) MY103963A (fr)
NL (1) NL8900029A (fr)
NZ (1) NZ227561A (fr)
PH (1) PH25640A (fr)
PL (1) PL156099B1 (fr)
PT (1) PT89405B (fr)
SE (1) SE501548C2 (fr)
ZA (1) ZA89133B (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2723674A (en) * 1951-11-28 1955-11-15 Charles E Harris Telephone cableman's tent
US3007541A (en) * 1959-02-24 1961-11-07 Jr John B Mast Temporary covering and support structure therefor
GB8807922D0 (en) * 1988-04-05 1988-05-05 Fujisawa Pharmaceutical Co Isoquinoline compound & process for preparation thereof
US4956371A (en) * 1989-09-19 1990-09-11 Euroceltique, S.A. Substituted isoquinolines and methods of using same
GB8921304D0 (en) * 1989-09-20 1989-11-08 Wyeth John & Brother Ltd New method of treatment and heterocyclic compounds used therein
GB9027055D0 (en) * 1990-12-13 1991-02-06 Sandoz Ltd Organic compounds
WO1992011242A1 (fr) * 1990-12-17 1992-07-09 Shell Internationale Research Maatschappij B.V. Derives d'isoquinoline fongicides
CA2093577C (fr) * 1992-05-07 2006-01-03 Michael Klaus Retinoides s-heterocyclique alkyl ou alkoxy substitues
US5350423A (en) * 1992-09-23 1994-09-27 Burlington Industries Inc. Fabric finishing procedure
GB9322828D0 (en) * 1993-11-05 1993-12-22 Sandoz Ltd Organic compounds
US7399837B2 (en) 1995-12-22 2008-07-15 Smithkline Beecham Corporation Recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders
US5783184A (en) * 1994-12-23 1998-07-21 Smithkline Beecham Corporation Method for treatment and diagnosis of IL-5 mediated disorders
US5683892A (en) * 1994-12-23 1997-11-04 Smithkline Beecham Corporation DNA encoding recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders
ATE346867T1 (de) * 1994-12-23 2006-12-15 Smithkline Beecham Corp Rekombinante il-5 antagonisten für die behandlung von il-5 bedingten krankheiten
GB9622386D0 (en) * 1996-10-28 1997-01-08 Sandoz Ltd Organic compounds
RU2174123C2 (ru) * 1996-10-28 2001-09-27 Новартис Аг Производные 8-арил-1,7-нафтиридина и фармацевтическая композиция, обладающая противовоспалительной активностью
IT1296985B1 (it) * 1997-12-19 1999-08-03 Zambon Spa Derivati benzazinici inibitori della fosfodiesterasi 4
DE60033918D1 (de) 1999-01-15 2007-04-26 Altana Pharma Ag Polysubstituted 6-phenylphenanthridines mit pde-iv hemmender wirkung
CA2715683A1 (fr) 1999-08-21 2001-03-01 Nycomed Gmbh Combinaison synergiste
RU2213735C2 (ru) * 2001-09-24 2003-10-10 ГУ Институт технической химии Уральского отделения РАН Способ получения 1-замещенных 3,3-диметил-3,4-дигидроизохинолинов
AR037517A1 (es) * 2001-11-05 2004-11-17 Novartis Ag Derivados de naftiridinas, un proceso para su preparacion, composicion farmaceutica y el uso de los mismos para la preparacion de un medicamento para el tratamiento de una enfermedad inflamatoria
EA200501548A1 (ru) 2003-04-01 2006-02-24 Апплайд Резеч Системз Арс Холдинг Н.В. Ингибиторы фосфодиэстераз при бесплодии
JP2010526087A (ja) * 2007-04-30 2010-07-29 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー 抗ｉｌ−５抗体を投与するための方法
JP5917143B2 (ja) * 2008-03-28 2016-05-11 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ 処置方法
JP6265583B2 (ja) 2008-10-17 2018-01-24 ウィスコンシン アルムニ リサーチ ファンデイション 生理活性アルファベータペプチドを作製する方法
WO2018226339A1 (fr) 2017-06-06 2018-12-13 Glaxosmithkline Llc Compositions biopharmaceutiques et procédés pour patients pédiatriques

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB645139A (en) * 1946-10-22 1950-10-25 Servita Gyogyszeryar Es Vegyip Improved process for the production of isoquinoline derivatives
FR1362765A (fr) * 1962-06-16 1964-06-05 Orgamol Sa Procédé de préparation de dérivés de l'isoquinoléine
FR2221133A1 (fr) * 1973-01-16 1974-10-11 Voorhees John
FR2599033A1 (fr) * 1986-05-21 1987-11-27 Egyt Gyogyszervegyeszeti Gyar Derives des 3-(hydroxymethyl)-isoquinoleine, procede pour les preparer et compositions pharmaceutiques les contenant
EP0251361A1 (fr) * 1986-05-21 1988-01-07 Duphar International Research B.V Dérivés de la di- et tétrahydroisoquinoléine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3878215A (en) * 1971-12-01 1975-04-15 Sandoz Ag 2-Alkyl-3-substituted-4-aryl isoquinolines
US4018927A (en) * 1973-12-17 1977-04-19 The Regents Of The University Of Michigan Treatment of proliferating skin diseases with papaverine alkaloids
FI750205A7 (fr) * 1974-02-05 1975-08-06 Sandoz Ag
DE2811361A1 (de) * 1978-03-16 1979-09-27 Hoechst Ag Neue isochinolinaldehyde und verfahren zu ihrer herstellung
DE3244594A1 (de) * 1982-12-02 1984-06-07 Hoechst Ag, 6230 Frankfurt 1-phenylisochinolinderivate und verfahren zu ihrer herstellung, diese verbindung enthaltende pharmazeutische praeparate und deren anwendung

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB645139A (en) * 1946-10-22 1950-10-25 Servita Gyogyszeryar Es Vegyip Improved process for the production of isoquinoline derivatives
FR1362765A (fr) * 1962-06-16 1964-06-05 Orgamol Sa Procédé de préparation de dérivés de l'isoquinoléine
FR2221133A1 (fr) * 1973-01-16 1974-10-11 Voorhees John
FR2599033A1 (fr) * 1986-05-21 1987-11-27 Egyt Gyogyszervegyeszeti Gyar Derives des 3-(hydroxymethyl)-isoquinoleine, procede pour les preparer et compositions pharmaceutiques les contenant
EP0251361A1 (fr) * 1986-05-21 1988-01-07 Duphar International Research B.V Dérivés de la di- et tétrahydroisoquinoléine

Also Published As

Publication number Publication date
AU622429B2 (en) 1992-04-09
DE3900233C2 (de) 2000-04-27
LU87423A1 (fr) 1989-08-30
PL156099B1 (pl) 1992-02-28
AT394365B (de) 1992-03-25
KR0142686B1 (ko) 1998-07-15
DK5789D0 (da) 1989-01-06
ATA3589A (de) 1991-09-15
US4980359A (en) 1990-12-25
PT89405B (pt) 1993-09-30
SE8900039D0 (sv) 1989-01-05
GB8800397D0 (en) 1988-02-10
GB2213482A (en) 1989-08-16
ES2010071A6 (es) 1989-10-16
DE3900233A1 (de) 1989-07-20
GR890100008A (el) 1994-03-31
IT8947504A0 (it) 1989-01-04
IL88899A0 (en) 1989-08-15
NL8900029A (nl) 1989-08-01
FI90865B (fi) 1993-12-31
IL88899A (en) 1994-07-31
FR2625743A1 (fr) 1989-07-13
GB2213482B (en) 1991-09-11
SE8900039L (sv) 1989-07-09
IT1229523B (it) 1991-09-04
NZ227561A (en) 1991-11-26
FI90865C (fi) 1994-04-11
MY103963A (en) 1993-10-30
PL277092A1 (en) 1989-09-04
FI890072A0 (fi) 1989-01-06
HUT52061A (en) 1990-06-28
IE890037L (en) 1989-07-08
FI890072A7 (fi) 1989-07-09
PH25640A (en) 1991-08-21
IE61914B1 (en) 1994-11-30
DK5789A (da) 1989-07-09
HU205083B (en) 1992-03-30
PT89405A (pt) 1990-02-08
AU2779589A (en) 1989-07-20
SE501548C2 (sv) 1995-03-13
JPH01213267A (ja) 1989-08-28
JPH0649686B2 (ja) 1994-06-29
GB8900102D0 (en) 1989-03-01
CA1332944C (fr) 1994-11-08
CH678727A5 (fr) 1991-10-31
GR1002750B (el) 1997-08-26
ZA89133B (en) 1990-09-26
KR890011851A (ko) 1989-08-22
FR2625743B1 (fr) 1990-11-09

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: NOVARTIS A.G.

Effective date: 20010131