ATA3589A - Neue isochinolinderivate, ihre herstellung und ihre verwendung - Google Patents

Neue isochinolinderivate, ihre herstellung und ihre verwendung

Info

Publication number: ATA3589A
Authority: AT; Austria
Prior art keywords: isochinol; derivatives; new; production; new isochinol
Prior art date: 1988-01-08

Application number

AT35/89A

Other languages

English (en)

Other versions

AT394365B (de

Inventor

Klaus Hasspacher

Reto Naef

Original Assignee

Sandoz Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-01-08

Filing date

1989-01-09

Publication date

1991-09-15

1989-01-09 Application filed by Sandoz Ag filed Critical Sandoz Ag

1991-09-15 Publication of ATA3589A publication Critical patent/ATA3589A/de

1992-03-25 Application granted granted Critical

1992-03-25 Publication of AT394365B publication Critical patent/AT394365B/de

Links

XNMYNYSCEJBRPZ-UHFFFAOYSA-N 2-[(3-butyl-1-isoquinolinyl)oxy]-N,N-dimethylethanamine Chemical class C1=CC=C2C(OCCN(C)C)=NC(CCCC)=CC2=C1 XNMYNYSCEJBRPZ-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Immunology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT0003589A 1988-01-08 1989-01-09 Neue isochinolinderivate, ihre herstellung und ihre verwendung AT394365B (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB888800397A GB8800397D0 (en)	1988-01-08	1988-01-08	Improvements in/relating to organic compounds

Publications (2)

Publication Number	Publication Date
ATA3589A true ATA3589A (de)	1991-09-15
AT394365B AT394365B (de)	1992-03-25

Family

ID=10629678

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT0003589A AT394365B (de)	1988-01-08	1989-01-09	Neue isochinolinderivate, ihre herstellung und ihre verwendung

Country Status (28)

Country	Link
US (1)	US4980359A (de)
JP (1)	JPH0649686B2 (de)
KR (1)	KR0142686B1 (de)
AT (1)	AT394365B (de)
AU (1)	AU622429B2 (de)
BE (1)	BE1002730A3 (de)
CA (1)	CA1332944C (de)
CH (1)	CH678727A5 (de)
DE (1)	DE3900233C2 (de)
DK (1)	DK5789A (de)
ES (1)	ES2010071A6 (de)
FI (1)	FI90865C (de)
FR (1)	FR2625743B1 (de)
GB (2)	GB8800397D0 (de)
GR (1)	GR1002750B (de)
HU (1)	HU205083B (de)
IE (1)	IE61914B1 (de)
IL (1)	IL88899A (de)
IT (1)	IT1229523B (de)
LU (1)	LU87423A1 (de)
MY (1)	MY103963A (de)
NL (1)	NL8900029A (de)
NZ (1)	NZ227561A (de)
PH (1)	PH25640A (de)
PL (1)	PL156099B1 (de)
PT (1)	PT89405B (de)
SE (1)	SE501548C2 (de)
ZA (1)	ZA89133B (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2723674A (en) *	1951-11-28	1955-11-15	Charles E Harris	Telephone cableman's tent
US3007541A (en) *	1959-02-24	1961-11-07	Jr John B Mast	Temporary covering and support structure therefor
GB8807922D0 (en) *	1988-04-05	1988-05-05	Fujisawa Pharmaceutical Co	Isoquinoline compound & process for preparation thereof
US4956371A (en) *	1989-09-19	1990-09-11	Euroceltique, S.A.	Substituted isoquinolines and methods of using same
GB8921304D0 (en) *	1989-09-20	1989-11-08	Wyeth John & Brother Ltd	New method of treatment and heterocyclic compounds used therein
GB9027055D0 (en) *	1990-12-13	1991-02-06	Sandoz Ltd	Organic compounds
HUT64676A (en) *	1990-12-17	1994-02-28	Shell Int Research	Fungicidal compositions containing isoquinoline derivatives as actvie agent and process for production of the active agents
CA2093577C (en) *	1992-05-07	2006-01-03	Michael Klaus	Alkyl or alkoxy substituted s-heterocyclic retinoids
US5350423A (en) *	1992-09-23	1994-09-27	Burlington Industries Inc.	Fabric finishing procedure
GB9322828D0 (en) *	1993-11-05	1993-12-22	Sandoz Ltd	Organic compounds
US5683892A (en) *	1994-12-23	1997-11-04	Smithkline Beecham Corporation	DNA encoding recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders
ES2277336T3 (es) *	1994-12-23	2007-07-01	Smithkline Beecham Corporation	Antagonistas de il-5 recombinantes utiles en el tratamiento de enfermadades mediadas por il-5.
US5783184A (en) *	1994-12-23	1998-07-21	Smithkline Beecham Corporation	Method for treatment and diagnosis of IL-5 mediated disorders
US7399837B2 (en)	1995-12-22	2008-07-15	Smithkline Beecham Corporation	Recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders
RU2174123C2 (ru) *	1996-10-28	2001-09-27	Новартис Аг	Производные 8-арил-1,7-нафтиридина и фармацевтическая композиция, обладающая противовоспалительной активностью
GB9622386D0 (en) *	1996-10-28	1997-01-08	Sandoz Ltd	Organic compounds
IT1296985B1 (it)	1997-12-19	1999-08-03	Zambon Spa	Derivati benzazinici inibitori della fosfodiesterasi 4
DE60033918D1 (de)	1999-01-15	2007-04-26	Altana Pharma Ag	Polysubstituted 6-phenylphenanthridines mit pde-iv hemmender wirkung
CZ302882B6 (cs)	1999-08-21	2012-01-04	Nycomed Gmbh	Farmaceutický prostredek
RU2213735C2 (ru) *	2001-09-24	2003-10-10	ГУ Институт технической химии Уральского отделения РАН	Способ получения 1-замещенных 3,3-диметил-3,4-дигидроизохинолинов
MY130622A (en) *	2001-11-05	2007-07-31	Novartis Ag	Naphthyridine derivatives, their preparation and their use as phosphodiesterase isoenzyme 4 (pde4) inhibitors
US7153824B2 (en)	2003-04-01	2006-12-26	Applied Research Systems Ars Holding N.V.	Inhibitors of phosphodiesterases in infertility
EP2152290B1 (de) *	2007-04-30	2014-06-04	GlaxoSmithKline LLC	Verfahren zur verabreichung von anti-il-5-antikörpern
EP2274009B1 (de) *	2008-03-28	2013-11-13	GlaxoSmithKline LLC	Behandlungsverfahren
CA2740873C (en)	2008-10-17	2019-09-10	Wisconsin Alumni Research Foundation	Method of making biologically active alpha-beta peptides
EP3634467A4 (de)	2017-06-06	2021-07-28	GlaxoSmithKline LLC	Biopharmazeutische zusammensetzungen und verfahren für pädiatrische patienten

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB645139A (en) *	1946-10-22	1950-10-25	Servita Gyogyszeryar Es Vegyip	Improved process for the production of isoquinoline derivatives
DE1184344B (de) *	1962-06-16	1964-12-31	Orgamol Sa	Verfahren zur Herstellung von Isochinolinderivaten
US3878215A (en) *	1971-12-01	1975-04-15	Sandoz Ag	2-Alkyl-3-substituted-4-aryl isoquinolines
DE2401453A1 (de) *	1973-01-16	1974-07-18	John James Voorhees	Pharmazeutische zusammensetzung zur behandlung von hautproliferationserkrankungen
US4018927A (en) *	1973-12-17	1977-04-19	The Regents Of The University Of Michigan	Treatment of proliferating skin diseases with papaverine alkaloids
DK136189B (da) *	1974-02-05	1977-08-29	Sandoz Ag	Analogifremgangsmåde til fremstilling af benzo(c)(1,6)naphthyridinderivater eller syreadditionssalte deraf.
DE2811361A1 (de) *	1978-03-16	1979-09-27	Hoechst Ag	Neue isochinolinaldehyde und verfahren zu ihrer herstellung
DE3244594A1 (de) *	1982-12-02	1984-06-07	Hoechst Ag, 6230 Frankfurt	1-phenylisochinolinderivate und verfahren zu ihrer herstellung, diese verbindung enthaltende pharmazeutische praeparate und deren anwendung
HU196758B (en) *	1986-05-21	1989-01-30	Gyogyszerkutato Intezet	Process for production of 3-hidroxi-methil-quinolines and medical compositions containing them
CA1330560C (en) *	1986-05-21	1994-07-05	Maurits E. A. Vandewalle	Di- and tetrahydroisoquinoline derivatives

1988
- 1988-01-08 GB GB888800397A patent/GB8800397D0/en active Pending
1989
- 1989-01-03 HU HU8911A patent/HU205083B/hu not_active IP Right Cessation
- 1989-01-04 GB GB8900102A patent/GB2213482B/en not_active Expired - Lifetime
- 1989-01-04 IT IT8947504A patent/IT1229523B/it active
- 1989-01-05 CA CA000587599A patent/CA1332944C/en not_active Expired - Fee Related
- 1989-01-05 SE SE8900039A patent/SE501548C2/sv unknown
- 1989-01-05 DE DE3900233A patent/DE3900233C2/de not_active Expired - Fee Related
- 1989-01-05 ES ES8900053A patent/ES2010071A6/es not_active Expired
- 1989-01-06 JP JP1001898A patent/JPH0649686B2/ja not_active Expired - Lifetime
- 1989-01-06 AU AU27795/89A patent/AU622429B2/en not_active Ceased
- 1989-01-06 PT PT89405A patent/PT89405B/pt not_active IP Right Cessation
- 1989-01-06 ZA ZA89133A patent/ZA89133B/xx unknown
- 1989-01-06 FI FI890072A patent/FI90865C/fi not_active IP Right Cessation
- 1989-01-06 NL NL8900029A patent/NL8900029A/nl not_active Application Discontinuation
- 1989-01-06 PL PL1989277092A patent/PL156099B1/pl unknown
- 1989-01-06 LU LU87423A patent/LU87423A1/fr unknown
- 1989-01-06 IL IL8889989A patent/IL88899A/en not_active IP Right Cessation
- 1989-01-06 BE BE8900018A patent/BE1002730A3/fr not_active IP Right Cessation
- 1989-01-06 MY MYPI89000013A patent/MY103963A/en unknown
- 1989-01-06 PH PH38011A patent/PH25640A/en unknown
- 1989-01-06 FR FR898900128A patent/FR2625743B1/fr not_active Expired - Lifetime
- 1989-01-06 NZ NZ227561A patent/NZ227561A/xx unknown
- 1989-01-06 DK DK005789A patent/DK5789A/da not_active Application Discontinuation
- 1989-01-06 IE IE3789A patent/IE61914B1/en not_active IP Right Cessation
- 1989-01-07 KR KR1019890000151A patent/KR0142686B1/ko not_active Expired - Fee Related
- 1989-01-09 CH CH59/89A patent/CH678727A5/de not_active IP Right Cessation
- 1989-01-09 AT AT0003589A patent/AT394365B/de not_active IP Right Cessation
- 1989-01-09 GR GR890100008A patent/GR1002750B/el unknown
1990
- 1990-04-10 US US07/507,702 patent/US4980359A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DK5789A (da)	1989-07-09
FR2625743B1 (fr)	1990-11-09
GR1002750B (el)	1997-08-26
HUT52061A (en)	1990-06-28
AT394365B (de)	1992-03-25
PH25640A (en)	1991-08-21
US4980359A (en)	1990-12-25
FR2625743A1 (fr)	1989-07-13
SE8900039D0 (sv)	1989-01-05
BE1002730A3 (fr)	1991-05-21
NL8900029A (nl)	1989-08-01
NZ227561A (en)	1991-11-26
DE3900233A1 (de)	1989-07-20
PT89405A (pt)	1990-02-08
FI890072A0 (fi)	1989-01-06
IL88899A0 (en)	1989-08-15
PL277092A1 (en)	1989-09-04
PT89405B (pt)	1993-09-30
GB8900102D0 (en)	1989-03-01
GB2213482A (en)	1989-08-16
CA1332944C (en)	1994-11-08
GB8800397D0 (en)	1988-02-10
SE8900039L (sv)	1989-07-09
FI90865C (fi)	1994-04-11
AU622429B2 (en)	1992-04-09
IE61914B1 (en)	1994-11-30
IL88899A (en)	1994-07-31
HU205083B (en)	1992-03-30
ZA89133B (en)	1990-09-26
FI90865B (fi)	1993-12-31
AU2779589A (en)	1989-07-20
IE890037L (en)	1989-07-08
MY103963A (en)	1993-10-30
DE3900233C2 (de)	2000-04-27
LU87423A1 (fr)	1989-08-30
PL156099B1 (pl)	1992-02-28
FI890072A7 (fi)	1989-07-09
DK5789D0 (da)	1989-01-06
ES2010071A6 (es)	1989-10-16
IT1229523B (it)	1991-09-04
JPH01213267A (ja)	1989-08-28
JPH0649686B2 (ja)	1994-06-29
CH678727A5 (de)	1991-10-31
KR0142686B1 (ko)	1998-07-15
GR890100008A (el)	1994-03-31
SE501548C2 (sv)	1995-03-13
KR890011851A (ko)	1989-08-22
IT8947504A0 (it)	1989-01-04
GB2213482B (en)	1991-09-11

Legal Events

Date	Code	Title	Description
2002-05-15	ELJ	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATA3589A (de)	1991-09-15	Neue isochinolinderivate, ihre herstellung und ihre verwendung
ATE89560T1 (de)	1993-06-15	Makrolid-derivate, ihre herstellung und ihre verwendung.
ATE123030T1 (de)	1995-06-15	Piperidin-derivate, ihre herstellung und ihre verwendung.
DE3578418D1 (de)	1990-08-02	Chinonderivate, ihre herstellung und verwendung.
DE3777366D1 (de)	1992-04-16	2,3-dihydro-cumaron-derivate, ihre herstellung und verwendung.
DE3885534D1 (de)	1993-12-16	Arylphosphorderivate, ihre Herstellung und Verwendung.
DE69008454D1 (de)	1994-06-01	Nitrolsothiolderivate, ihre Herstellung und Verwendung.
DE3788709D1 (de)	1994-02-17	Piperidin-Derivate, ihre Herstellung und Anwendung.
DE3879024D1 (de)	1993-04-15	Pyridinium-derivate, ihre herstellung und verwendung.
DE69027170D1 (de)	1996-07-04	Uracilderivate, ihre Herstellung und ihre Verwendung
DE59409541D1 (de)	2000-11-02	Bicyclen-derivate, ihre herstellung und verwendung
DE59710272D1 (de)	2003-07-17	Neue alpha-hydroxysäurederivate, ihre herstellung und verwendung
DE3777604D1 (de)	1992-04-23	Makrolid-verbindungen, ihre herstellung und ihre verwendung.
ATE73762T1 (de)	1992-04-15	N-aminobutyl-n-phenylarylamid-derivate, ihre herstellung und ihre verwendung in der heilkunde.
DE3784602D1 (de)	1993-04-15	Inonos-derivate, ihre herstellung und verwendung.
DE3774718D1 (de)	1992-01-09	Benzothiazolylazolidine und ihre herstellung und verwendung.
DE3773722D1 (de)	1991-11-21	Inosose-derivate und ihre herstellung.
DE3863191D1 (de)	1991-07-18	Substituierte aminderivate, ihre herstellung und verwendung.
ATE268760T1 (de)	2004-06-15	Neue carbonsäurederivate, ihre herstellung und verwendung
PT85396A (de)	1987-08-01	Neue 1,4-benzodiazepine ihre herstellung und verwendung
DE69327813D1 (de)	2000-03-16	Alpha-Glucosyl-Catecholaminderivate, ihre Salze, Herstellung und Verwendung
ATA280489A (de)	1993-12-15	Neue adenosin-derivate, deren herstellung und verwendung
ATA125788A (de)	1990-04-15	Neue derivate von 5-aminomethyl-2-furanmethanol, ihre herstellung und verwendung
DE68908389D1 (de)	1993-09-16	Amidofluoroverbindungen, ihre herstellung und ihre verwendung.
DE68919259D1 (de)	1994-12-15	N-Phenylimide, ihre Herstellung und Verwendung.