FR63M - Nouveau 1-(tertio-amino-alcoyl)-5-nitro-7-azabenzimidazole utilisable en thérapeutique. - Google Patents

Nouveau 1-(tertio-amino-alcoyl)-5-nitro-7-azabenzimidazole utilisable en thérapeutique. Download PDF

Info

Publication number: FR63M
Authority: FR; France
Prior art keywords: nitro; aza; amino; novel; benzimidazole
Prior art date: 1959-03-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

FR833705A

Other languages

English (en)

French (fr)

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Novartis AG

Original Assignee

Ciba Geigy AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1959-03-18

Filing date

1960-07-22

Publication date

1961-01-13

1960-07-22 Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG

1961-01-13 Application granted granted Critical

1961-01-13 Publication of FR63M publication Critical patent/FR63M/fr

Status Expired legal-status Critical Current

Links

238000002560 therapeutic procedure Methods 0.000 title description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 17
239000000047 product Substances 0.000 description 11
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 10
239000000243 solution Substances 0.000 description 10
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 9
239000000155 melt Substances 0.000 description 9
239000003814 drug Substances 0.000 description 7
NYSTWXCATZYTAU-UHFFFAOYSA-N 6-nitro-1h-imidazo[4,5-b]pyridine Chemical compound [O-][N+](=O)C1=CN=C2NC=NC2=C1 NYSTWXCATZYTAU-UHFFFAOYSA-N 0.000 description 6
BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 6
229910021529 ammonia Inorganic materials 0.000 description 5
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UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
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239000012876 carrier material Substances 0.000 description 3
230000000994 depressogenic effect Effects 0.000 description 3
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235000019253 formic acid Nutrition 0.000 description 3
239000008101 lactose Substances 0.000 description 3
239000000203 mixture Substances 0.000 description 3
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 3
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FTOAOBMCPZCFFF-UHFFFAOYSA-N 5,5-diethylbarbituric acid Chemical compound CCC1(CC)C(=O)NC(=O)NC1=O FTOAOBMCPZCFFF-UHFFFAOYSA-N 0.000 description 2
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RGHFKWPGWBFQLN-UHFFFAOYSA-M sodium;5,5-diethylpyrimidin-3-ide-2,4,6-trione Chemical compound [Na+].CCC1(CC)C([O-])=NC(=O)NC1=O RGHFKWPGWBFQLN-UHFFFAOYSA-M 0.000 description 2
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XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
QLHVJBXAQWPEDI-UHFFFAOYSA-N 2-chloro-3,5-dinitropyridine Chemical compound [O-][N+](=O)C1=CN=C(Cl)C([N+]([O-])=O)=C1 QLHVJBXAQWPEDI-UHFFFAOYSA-N 0.000 description 1
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RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
241000282326 Felis catus Species 0.000 description 1
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230000004872 arterial blood pressure Effects 0.000 description 1
229960002319 barbital Drugs 0.000 description 1
230000006399 behavior Effects 0.000 description 1
235000019445 benzyl alcohol Nutrition 0.000 description 1
150000003938 benzyl alcohols Chemical class 0.000 description 1
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239000000872 buffer Substances 0.000 description 1
210000000795 conjunctiva Anatomy 0.000 description 1
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235000011090 malic acid Nutrition 0.000 description 1
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UDGSVBYJWHOHNN-UHFFFAOYSA-N n',n'-diethylethane-1,2-diamine Chemical compound CCN(CC)CCN UDGSVBYJWHOHNN-UHFFFAOYSA-N 0.000 description 1
230000003204 osmotic effect Effects 0.000 description 1
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239000000546 pharmaceutical excipient Substances 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Natural Medicines & Medicinal Plants (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Alternative & Traditional Medicine (AREA)
Biotechnology (AREA)
Botany (AREA)
Medical Informatics (AREA)
Microbiology (AREA)
Mycology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

FR833705A 1959-03-18 1960-07-22 Nouveau 1-(tertio-amino-alcoyl)-5-nitro-7-azabenzimidazole utilisable en thérapeutique. Expired FR63M (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH7094459A CH386438A (de)	1959-03-18	1959-03-18	Verfahren zur Herstellung neuer 7-Aza-benzimidazole

Publications (1)

Publication Number	Publication Date
FR63M true FR63M (fr)	1961-01-13

Family

ID=4530649

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FR833705A Expired FR63M (fr)	1959-03-18	1960-07-22	Nouveau 1-(tertio-amino-alcoyl)-5-nitro-7-azabenzimidazole utilisable en thérapeutique.

Country Status (4)

Country	Link
CH (1)	CH386438A (de)
ES (1)	ES256409A1 (de)
FR (1)	FR63M (de)
GB (1)	GB945147A (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES473201A1 (es) *	1977-09-26	1979-03-16	Degussa	Procedimiento para la preparacion de 7-azabencimidazoles

1959
- 1959-03-18 CH CH7094459A patent/CH386438A/de unknown
1960
- 1960-03-10 ES ES0256409A patent/ES256409A1/es not_active Expired
- 1960-03-18 GB GB9778/60A patent/GB945147A/en not_active Expired
- 1960-07-22 FR FR833705A patent/FR63M/fr not_active Expired

Also Published As

Publication number	Publication date
ES256409A1 (es)	1960-11-01
GB945147A (en)	1963-12-23
CH386438A (de)	1965-01-15

Publication	Publication Date	Title
CH637927A5 (fr)	1983-08-31	Derives de 4-amino-5-alkylsulfonyl ortho-anisamides et leurs procedes de preparation.
CH644348A5 (fr)	1984-07-31	Amino-ethers oxydes, leur procede de preparation et medicament les contenant.
CH639369A5 (fr)	1983-11-15	Benzamides heterocycliques substitues et leurs procedes de preparation.
CH635832A5 (fr)	1983-04-29	Derives du tetrazole et composition pharmaceutique les contenant.
CA1131230A (fr)	1982-09-07	Procede de preparation de nouveaux derives de 1,3-dihydro3-/1-/2-(2,3-dihydro 1,4-benzodioxin-2-yl) 2-hydroxy-ethyl/piperidin-4-yl/2h-indol-2-one
EP0048705B1 (de)	1984-07-11	2-(4-(Diphenylmethylen)-1-piperidinyl)essigsäuren und ihre Amide, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
US2868802A (en)	1959-01-13	Nxchj
FR63M (fr)	1961-01-13	Nouveau 1-(tertio-amino-alcoyl)-5-nitro-7-azabenzimidazole utilisable en thérapeutique.
EP0429360A2 (de)	1991-05-29	Verhinderung von Entzugserscheinungen
EP0089894A1 (de)	1983-09-28	N-(2-(4-Hydroxy-3-methoxy-phenyl)-2-Hydroxy-Ethyl)3-Amino-1-(1-Benzimidazolyl)-Butan und Salze und Hydrate mit Beta-adrenergischer Aktivität, therapeutische Anwendungen und Verfahren zu deren Herstellung
EP0008259A1 (de)	1980-02-20	Piperidylbenzimidazolinon-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
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EP0074873A1 (de)	1983-03-23	Derivate von 3-Phenoxy-2-propanolen, ihre Herstellung und ihre therapeutische Verwendung
EP0047207B1 (de)	1985-02-20	N-(1-allyl-2-pyrrolidinyl-methyl)-2-methoxy-4-amino-5-methylsulfamoyl-benzamide, Verfahren zur Herstellung und Verwendung als Heilmittel
EP0065907B1 (de)	1984-12-05	((Tetra- und Hexahydro-pyridyl-4)-2-äthyl)-3-indole und ihre Verwendung als Arzneimittel
EP0035945B1 (de)	1983-12-21	Acylguanidine, Harnstoffe und substituierte Harnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
EP0859775A1 (de)	1998-08-26	3-(benzofuran-5-yl)oxazolidin-2-one-derivate, ihre herstellung und therapeutische verwendung
FR199F (fr)	1968-06-24	Chlorhydrate de 7-{3-[2-(3,4-dihydroxyphényl)-2-hydroxy-éthylaminol]-propyl}-théophylline
BE897217A (fr)	1983-11-03	NOUVEAU MEDICAMENT ANTI-INFLAMMATOIRE, ANALGESIQUE ET ANTIPYRETIQUE A BASE DE (P-CHLOROBENZOYL-1, METHYL- 2- Methoxy-5) Indole-3 Acetate de P-Acetamidophenol
MC475A1 (fr)	1965-03-02	Nouveaux dérivés alcoxyles d'anilines et leur préparation
FR225M (de)	1961-02-10
FR2718M (de)	1964-09-11
EP0356323A1 (de)	1990-02-28	Benzopyrrolidinon-Derivate, Verfahren zu ihrer Herstellung und Arzneimittel, die sie enthalten
WO1988007995A2 (fr)	1988-10-20	Composes possedant des proprietes de beta-antagonistes et alpha-antagonistes, utilisables pour abaisser la pression intra-oculaire, composition pharmaceutique contenant ces composes, leur utilisation
CA2010713A1 (fr)	1990-08-23	Derives de la 1-arylsulfonyl pyrrolidin-2-thione ou de la 1-arylsulfonyl piperidin-2-thione, leur procede de preparation, leur application comme medicaments et les compositions les renfermant