GR1003874B - Μεθοδος για την παρασκευη καθαρης σιταλοπραμης - Google Patents

Μεθοδος για την παρασκευη καθαρης σιταλοπραμης

Info

Publication number
GR1003874B
GR1003874B GR20010100132A GR20010100132A GR1003874B GR 1003874 B GR1003874 B GR 1003874B GR 20010100132 A GR20010100132 A GR 20010100132A GR 20010100132 A GR20010100132 A GR 20010100132A GR 1003874 B GR1003874 B GR 1003874B
Authority
GR
Greece
Prior art keywords
citalopram
subjected
preparation
formula
base
Prior art date
Application number
GR20010100132A
Other languages
English (en)
Inventor
Robert Dancer
Federico Sbrogio
Marco Villa
Original Assignee
H.Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H.Lundbeck A/S filed Critical H.Lundbeck A/S
Publication of GR1003874B publication Critical patent/GR1003874B/el

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

παρούσα εφεύρεση αναφέρεται σε μια μέθοδο για την παρασκευή και τον καθαρισμό σιταλοπράμης Χημ. Τύπος (1) στην οποία μια ένωση τύπου (ΙΙ) στον οποίο το Ζ είναι ιώδιο , βρώμιο,χλώριο ή CF3-(CF2)n-SO2-O-, όπου το n είναι 0,1,2,3,4,5,6,7, ή 8, υποβάλλεται σε αντίδραση ανταλλαγής κυανίου με μια πηγή κυανίου το προκύπτον μικτό προιόν σιταλοπράμης υποβάλλεται προαιρετικά σε κάποιον αρχικό καθαρισμό και εν συνεχεία σε επεξεργασία με έναν παράγοντα σχηματισμού ομάδος αμιδίου ή παρόμοιου εν συνεχεία το αντιδρών μίγμα υποβάλλεται σε πλύση με οξύ/βάση και/ή κρυστάλλωση και ανακρυστάλλωση της σιταλοπράμης ώστε να απομακτυνθούν τα σχηματιζόμενα αμίδια απο τη μικτή σιταλοπράμη και η προκύπτουσα σιταλοπράμη προαιρετικά καθαρίζεται περαιτέρω, υποβάλλεται σε επεξεργασία και/ή απομονώνεται ως βάση ή ως φαρμακευτικά αποδεκτό άλας της . ΰ
GR20010100132A 2000-12-22 2001-03-16 Μεθοδος για την παρασκευη καθαρης σιταλοπραμης GR1003874B (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200001929 2000-12-22

Publications (1)

Publication Number Publication Date
GR1003874B true GR1003874B (el) 2002-04-24

Family

ID=8159922

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20010100132A GR1003874B (el) 2000-12-22 2001-03-16 Μεθοδος για την παρασκευη καθαρης σιταλοπραμης

Country Status (43)

Country Link
US (1) US6455710B1 (el)
EP (2) EP1462447A3 (el)
JP (1) JP3798982B2 (el)
KR (1) KR100439329B1 (el)
CN (1) CN1282648C (el)
AR (1) AR030056A1 (el)
AT (2) ATE277920T1 (el)
AU (2) AU2001100405B4 (el)
BE (2) BE1013212A6 (el)
BG (1) BG65131B1 (el)
BR (1) BR0106272A (el)
CA (1) CA2360303C (el)
CH (1) CH691535A5 (el)
CZ (1) CZ292200B6 (el)
DE (2) DE60105926T2 (el)
DK (1) DK1181713T3 (el)
EA (1) EA003581B1 (el)
ES (2) ES2228824T3 (el)
FI (2) FI108639B (el)
FR (1) FR2812877B1 (el)
GB (1) GB2357763B (el)
GR (1) GR1003874B (el)
HK (1) HK1048812B (el)
HR (1) HRP20020004A2 (el)
HU (2) HU0101029D0 (el)
IE (1) IES20010254A2 (el)
IL (1) IL147226A (el)
IS (1) IS2060B (el)
IT (1) ITMI20010602A1 (el)
MX (1) MXPA01013151A (el)
NL (2) NL1017525C1 (el)
NO (1) NO20011271A (el)
NZ (1) NZ516298A (el)
PL (1) PL205724B1 (el)
PT (1) PT1181713E (el)
SE (1) SE517623C2 (el)
SG (1) SG167655A1 (el)
SI (1) SI1181713T1 (el)
SK (2) SK284428B6 (el)
TR (1) TR200201166T1 (el)
UA (1) UA71634C2 (el)
WO (1) WO2001045483A2 (el)
ZA (1) ZA200110179B (el)

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NZ514671A (en) 1999-04-14 2003-10-31 H Method for the preparation of citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
CH692298A5 (de) 1999-10-25 2002-04-30 Lundbeck & Co As H Verfahren zur Herstellung von Zwischenstufen für die Citalopramsynthese sowie zur Herstellung von Escitalopram.
EA004742B1 (ru) 1999-12-28 2004-08-26 Х.Лундбекк А/С Способ получения циталопрама
WO2001049672A1 (en) 1999-12-30 2001-07-12 H. Lundbeck A/S Method for the preparation of citalopram
TR200201783T2 (tr) 2000-01-14 2002-12-23 H. Lundbeck A/S 5-Siyanofatalid hazırlamak için yöntem
NL1017417C1 (nl) 2000-03-03 2001-03-16 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
KR20020080481A (ko) 2000-03-13 2002-10-23 하. 룬트벡 아크티에 셀스카브 시탈로프람의 제조 방법
CZ20023100A3 (cs) * 2000-03-13 2003-02-12 H. Lundbeck A/S Způsob výroby citalopramu
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
SK14512002A3 (sk) 2000-03-14 2003-03-04 H. Lundbeck A/S Spôsob výroby citalopramu, medziprodukt a citalopram výrobený týmto spôsobom
EP1274699A1 (en) * 2000-03-16 2003-01-15 H. Lundbeck A/S Method for the preparation of 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
IL144817A0 (en) 2000-08-18 2002-06-30 Lundbeck & Co As H Method for the preparation of citalopram
CA2359810C (en) 2000-12-28 2002-11-05 H. Lundbeck A/S Process for the preparation of pure citalopram
GB0105627D0 (en) * 2001-03-07 2001-04-25 Cipla Ltd Preparation of phthalanes
CN1221541C (zh) * 2001-03-09 2005-10-05 兰贝克塞实验室有限公司 制备西酞普兰的方法
US6967259B2 (en) * 2001-09-24 2005-11-22 Pharmachem Technologies Limited Process for the preparation of Citalopram intermediate
EP1446396A1 (en) * 2001-11-08 2004-08-18 Sepracor, Inc. Methods for treating depression and other cns disorders using enantiomerically enriched desmethyl- and didesmethyl-metabolites of citalopram
WO2003057132A2 (en) * 2002-01-07 2003-07-17 Sun Pharmaceutical Industries Limited Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile
GB0204607D0 (en) * 2002-02-27 2002-04-10 Matrix Lab Ltd Process
KR20050086560A (ko) * 2002-11-15 2005-08-30 아크조 노벨 엔.브이. 지방 니트릴용 정제/탈색 처리 방법
TR200504022T1 (tr) * 2003-03-24 2006-08-21 Hetero Drugs Limited (S)-sitalopram oksalatın yeni sıvı kristal formları.
US7019153B2 (en) * 2003-06-10 2006-03-28 Sun Pharmaceutical Industries Limited Process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran acetamido-3-substituted-3-cephem-4-carboxylic acid
AU2003278409A1 (en) * 2003-10-28 2005-05-19 Krishnaji Upadhye Bhargav Improved process for the manufacture of citalopram hydrobromide
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
TWI347942B (en) * 2005-06-22 2011-09-01 Lundbeck & Co As H Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
CN114763343B (zh) * 2021-01-14 2026-02-10 浙江华海药业股份有限公司 一种西酞普兰或s-西酞普兰的纯化方法

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Also Published As

Publication number Publication date
EA003581B1 (ru) 2003-06-26
EP1181713B1 (en) 2004-09-29
HK1048812A1 (en) 2003-04-17
DE10112829C1 (de) 2002-07-25
HUP0102817A2 (hu) 2001-12-28
NO312462B1 (no) 2002-05-13
ITMI20010602A0 (it) 2001-03-22
FI20011577A0 (fi) 2001-07-26
JP3798982B2 (ja) 2006-07-19
FI109024B (fi) 2002-05-15
ZA200110179B (en) 2002-12-11
IES20010254A2 (en) 2002-03-06
CA2360303C (en) 2003-08-12
US20020120005A1 (en) 2002-08-29
ATE277920T1 (de) 2004-10-15
HRP20020004A2 (en) 2003-04-30
SK286283B6 (sk) 2008-06-06
NL1017525C1 (nl) 2001-04-26
ES2228824T3 (es) 2005-04-16
EP1181713A2 (en) 2002-02-27
TR200201166T1 (tr) 2002-10-21
SI1181713T1 (en) 2005-02-28
AT4367U1 (de) 2001-06-25
AR030056A1 (es) 2003-08-13
PL205724B1 (pl) 2010-05-31
AU3920101A (en) 2001-07-03
UA71634C2 (uk) 2004-12-15
BR0106272A (pt) 2004-06-15
FR2812877A1 (fr) 2002-02-15
CA2360303A1 (en) 2001-06-28
FR2812877B1 (fr) 2003-04-04
DE60105926T2 (de) 2005-11-24
CN1366525A (zh) 2002-08-28
WO2001045483A3 (en) 2001-12-27
FI108639B (fi) 2002-02-28
IS2060B (is) 2005-11-15
CH691535A5 (de) 2001-08-15
GB2357763A (en) 2001-07-04
KR100439329B1 (ko) 2004-07-07
PL353398A1 (en) 2003-11-17
ITMI20010602A1 (it) 2002-09-22
SE0103045L (sv) 2002-06-23
EP1462447A3 (en) 2004-11-17
DK1181713T3 (da) 2005-01-31
FI20010500A0 (fi) 2001-03-13
AU2001100405A4 (en) 2001-11-01
SE0103045D0 (sv) 2001-09-14
SK284428B6 (sk) 2005-04-01
BE1013213A6 (fr) 2001-10-02
US6455710B1 (en) 2002-09-24
GB0105983D0 (en) 2001-05-02
BE1013212A6 (fr) 2001-10-02
HUP0102817A3 (en) 2003-07-28
KR20020065345A (ko) 2002-08-13
CN1282648C (zh) 2006-11-01
IL147226A0 (en) 2002-08-14
HU0102817D0 (en) 2001-09-28
EP1462447A2 (en) 2004-09-29
GB2357763B (en) 2002-01-16
ES2170732A1 (es) 2002-08-01
BG106203A (bg) 2002-08-30
NO20011271D0 (no) 2001-03-13
CZ2001890A3 (cs) 2002-08-14
SK18482001A3 (sk) 2002-05-09
WO2001045483A2 (en) 2001-06-28
HU0101029D0 (en) 2001-05-28
CZ292200B6 (cs) 2003-08-13
NL1018360C1 (nl) 2001-10-04
SE517623C2 (sv) 2002-06-25
PT1181713E (pt) 2005-02-28
BG65131B1 (bg) 2007-03-30
HK1048812B (zh) 2007-06-01
JP2003517484A (ja) 2003-05-27
DE60105926D1 (de) 2004-11-04
MXPA01013151A (es) 2002-08-12
AU2001100405B4 (en) 2002-03-21
NZ516298A (en) 2002-12-20
EA200200018A1 (ru) 2002-04-25
IS5883A (is) 2001-06-20
NO20011271A (no) 2002-05-13
IL147226A (en) 2006-04-10
ES2170732B2 (es) 2003-09-16
SG167655A1 (en) 2011-01-28

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