NO20011271A - Fremgangsmåte for fremstilling av ren citalopram - Google Patents

Fremgangsmåte for fremstilling av ren citalopram

Info

Publication number
NO20011271A
NO20011271A NO20011271A NO20011271A NO20011271A NO 20011271 A NO20011271 A NO 20011271A NO 20011271 A NO20011271 A NO 20011271A NO 20011271 A NO20011271 A NO 20011271A NO 20011271 A NO20011271 A NO 20011271A
Authority
NO
Norway
Prior art keywords
preparation
pure citalopram
citalopram
pure
Prior art date
Application number
NO20011271A
Other languages
English (en)
Other versions
NO312462B1 (no
NO20011271D0 (no
Inventor
Robert Dancer
Marco Villa
Federico Sbrogiò
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck As filed Critical H Lundbeck As
Publication of NO20011271D0 publication Critical patent/NO20011271D0/no
Publication of NO20011271A publication Critical patent/NO20011271A/no
Publication of NO312462B1 publication Critical patent/NO312462B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87Benzo [c] furans; Hydrogenated benzo [c] furans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
NO20011271A 2000-12-22 2001-03-13 Fremgangsmåte for fremstilling av ren citalopram NO312462B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200001929 2000-12-22

Publications (3)

Publication Number Publication Date
NO20011271D0 NO20011271D0 (no) 2001-03-13
NO20011271A true NO20011271A (no) 2002-05-13
NO312462B1 NO312462B1 (no) 2002-05-13

Family

ID=8159922

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20011271A NO312462B1 (no) 2000-12-22 2001-03-13 Fremgangsmåte for fremstilling av ren citalopram

Country Status (43)

Country Link
US (1) US6455710B1 (no)
EP (2) EP1462447A3 (no)
JP (1) JP3798982B2 (no)
KR (1) KR100439329B1 (no)
CN (1) CN1282648C (no)
AR (1) AR030056A1 (no)
AT (2) ATE277920T1 (no)
AU (2) AU3920101A (no)
BE (2) BE1013212A6 (no)
BG (1) BG65131B1 (no)
BR (1) BR0106272A (no)
CA (1) CA2360303C (no)
CH (1) CH691535A5 (no)
CZ (1) CZ292200B6 (no)
DE (2) DE60105926T2 (no)
DK (1) DK1181713T3 (no)
EA (1) EA003581B1 (no)
ES (2) ES2228824T3 (no)
FI (2) FI108639B (no)
FR (1) FR2812877B1 (no)
GB (1) GB2357763B (no)
GR (1) GR1003874B (no)
HK (1) HK1048812B (no)
HR (1) HRP20020004A2 (no)
HU (2) HU0101029D0 (no)
IE (1) IES20010254A2 (no)
IL (1) IL147226A (no)
IS (1) IS2060B (no)
IT (1) ITMI20010602A1 (no)
MX (1) MXPA01013151A (no)
NL (2) NL1017525C1 (no)
NO (1) NO312462B1 (no)
NZ (1) NZ516298A (no)
PL (1) PL205724B1 (no)
PT (1) PT1181713E (no)
SE (1) SE517623C2 (no)
SG (1) SG167655A1 (no)
SI (1) SI1181713T1 (no)
SK (2) SK284428B6 (no)
TR (1) TR200201166T1 (no)
UA (1) UA71634C2 (no)
WO (1) WO2001045483A2 (no)
ZA (1) ZA200110179B (no)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
DK1173431T4 (da) 1999-04-14 2010-01-04 Lundbeck & Co As H Fremgangsmåde til fremstilling af citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
GB2360281B (en) 1999-10-25 2002-01-16 Lundbeck & Co As H Method for the preparation of citalopram
HUP0203635A3 (en) 1999-12-28 2005-02-28 Lundbeck & Co As H Method for the preparation of citalopram
PT1246813E (pt) 1999-12-30 2004-02-27 Lundbeck & Co As H Metodo para a preparacao de citalopram
CN1195749C (zh) 2000-01-14 2005-04-06 H.隆德贝克有限公司 制备5-氰基2-苯并[c]呋喃酮的方法
NL1017417C1 (nl) 2000-03-03 2001-03-16 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
CN1427835A (zh) 2000-03-13 2003-07-02 H·隆德贝克有限公司 5-取代的1-(4-氟苯基)-1,3-二氢异苯并呋喃的分步烷基化
KR20020080481A (ko) 2000-03-13 2002-10-23 하. 룬트벡 아크티에 셀스카브 시탈로프람의 제조 방법
IES20010206A2 (en) 2000-03-13 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
TR200202155T2 (tr) 2000-03-14 2002-12-23 H. Lundbeck A/S Sitalopramin preparasyon metodu
DE10190485T1 (de) * 2000-03-16 2002-03-21 Lundbeck & Co As H Verfahren zur Herstellung von 5-Cyano-1-(4-fluorphenyl)-1,3-dihydroisobenzofuranen
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
CA2354877C (en) 2000-08-18 2006-05-02 H. Lundbeck A/S Method for the preparation of citalopram
JP2003519121A (ja) 2000-12-28 2003-06-17 ハー・ルンドベック・アクチエゼルスカベット 純粋なシタロプラムの製造方法
GB0105627D0 (en) * 2001-03-07 2001-04-25 Cipla Ltd Preparation of phthalanes
JP2005500256A (ja) * 2001-03-09 2005-01-06 ランバクシー ラボラトリーズ リミテッド シタロプラム製造方法
US6967259B2 (en) * 2001-09-24 2005-11-22 Pharmachem Technologies Limited Process for the preparation of Citalopram intermediate
RU2004117211A (ru) * 2001-11-08 2005-03-27 Сепракор, Инк. (Us) Способы лечения депресии и других рассстройств цнс с использованием энантиомерно обогащшенных десметил-и дидесметилметаболитов циталопрама
US7148364B2 (en) * 2002-01-07 2006-12-12 Sun Pharmaceutical Industries Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran carbonitrile
GB0204607D0 (en) * 2002-02-27 2002-04-10 Matrix Lab Ltd Process
DE60327707D1 (de) * 2002-11-15 2009-07-02 Akzo Nobel Nv Behandlung zur reinigung/entfärbung von fettsäurenitrilen
WO2004085416A1 (en) * 2003-03-24 2004-10-07 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
US7019153B2 (en) * 2003-06-10 2006-03-28 Sun Pharmaceutical Industries Limited Process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran acetamido-3-substituted-3-cephem-4-carboxylic acid
AU2003278409A1 (en) * 2003-10-28 2005-05-19 Krishnaji Upadhye Bhargav Improved process for the manufacture of citalopram hydrobromide
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
TWI347942B (en) * 2005-06-22 2011-09-01 Lundbeck & Co As H Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
CN114763343B (zh) * 2021-01-14 2026-02-10 浙江华海药业股份有限公司 一种西酞普兰或s-西酞普兰的纯化方法

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE536169C (de) * 1926-08-21 1931-10-20 British Dyestuffs Corp Ltd Verfahren zur Gewinnung von tertiaeren aromatischen Aminen aus ihren Gemischen mit sekundaeren und primaeren aromatischen Aminen
US1992111A (en) * 1931-06-20 1935-02-19 Du Pont Separation of secondary and tertiary amines
DE1032261B (de) * 1955-03-08 1958-06-19 Leda Chemicals Ltd Verfahren zur Abtrennung sekundaerer Amine aus einer primaeres und sekundaeres Amin enthaltenden Mischung
GB1143703A (no) 1965-03-18
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
US4302399A (en) * 1978-09-28 1981-11-24 Dynapol Acetylation of crude reaction products containing polymeric colorants
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
US4943591A (en) 1984-10-17 1990-07-24 Glaxo Group Limited Dichloroaniline derivatives
DE3926765A1 (de) * 1989-08-12 1991-02-14 Hoechst Ag Verfahren zur verminderung von primaerem und sekundaerem amin in einem tertiaeren amin
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DK213290D0 (da) * 1990-09-06 1990-09-06 Lundbeck & Co As H Treatment of cerebrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
EP0993524B1 (en) * 1997-06-30 2002-11-20 Beloit Technologies, Inc. Method and apparatus for the high speed application of coating to a traveling paper web
ES2148120T3 (es) 1997-07-08 2002-01-16 Lundbeck & Co As H Metodo para la preparacion de citalopram.
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
EA002770B1 (ru) 1997-11-11 2002-08-29 Х.Лундбекк А/С Способ получения циталопрама
PL199423B1 (pl) 1998-10-20 2008-09-30 Lundbeck & Co As H Sposób wytwarzania citalopramu
IL143422A0 (en) 1998-12-23 2002-04-21 Lundbeck & Co As H Method for the preparation of 5-cyanophthalide
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
DK1173431T4 (da) 1999-04-14 2010-01-04 Lundbeck & Co As H Fremgangsmåde til fremstilling af citalopram
ITMI991579A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991486A1 (it) * 1999-07-06 2001-01-06 Vis Farmaceutici S P A Processo per la sintesi di citalopram
GB2360281B (en) 1999-10-25 2002-01-16 Lundbeck & Co As H Method for the preparation of citalopram
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
NL1017415C1 (nl) 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
GB2357762B (en) * 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
CA2354877C (en) 2000-08-18 2006-05-02 H. Lundbeck A/S Method for the preparation of citalopram
JP2003519121A (ja) 2000-12-28 2003-06-17 ハー・ルンドベック・アクチエゼルスカベット 純粋なシタロプラムの製造方法

Also Published As

Publication number Publication date
GR1003874B (el) 2002-04-24
SE0103045D0 (sv) 2001-09-14
KR100439329B1 (ko) 2004-07-07
SK284428B6 (sk) 2005-04-01
CZ2001890A3 (cs) 2002-08-14
AR030056A1 (es) 2003-08-13
HU0102817D0 (en) 2001-09-28
EP1462447A2 (en) 2004-09-29
SK18482001A3 (sk) 2002-05-09
WO2001045483A3 (en) 2001-12-27
CN1282648C (zh) 2006-11-01
EP1462447A3 (en) 2004-11-17
HUP0102817A2 (hu) 2001-12-28
NL1018360C1 (nl) 2001-10-04
DE60105926D1 (de) 2004-11-04
BE1013213A6 (fr) 2001-10-02
ZA200110179B (en) 2002-12-11
IL147226A (en) 2006-04-10
ES2228824T3 (es) 2005-04-16
BR0106272A (pt) 2004-06-15
FI20010500A0 (fi) 2001-03-13
GB0105983D0 (en) 2001-05-02
SE517623C2 (sv) 2002-06-25
UA71634C2 (uk) 2004-12-15
FI109024B (fi) 2002-05-15
AU2001100405A4 (en) 2001-11-01
US6455710B1 (en) 2002-09-24
HK1048812A1 (en) 2003-04-17
CA2360303A1 (en) 2001-06-28
DK1181713T3 (da) 2005-01-31
DE10112829C1 (de) 2002-07-25
FI108639B (fi) 2002-02-28
BE1013212A6 (fr) 2001-10-02
AU2001100405B4 (en) 2002-03-21
CZ292200B6 (cs) 2003-08-13
ITMI20010602A0 (it) 2001-03-22
IL147226A0 (en) 2002-08-14
HU0101029D0 (en) 2001-05-28
ATE277920T1 (de) 2004-10-15
ITMI20010602A1 (it) 2002-09-22
GB2357763B (en) 2002-01-16
JP2003517484A (ja) 2003-05-27
CN1366525A (zh) 2002-08-28
HUP0102817A3 (en) 2003-07-28
SG167655A1 (en) 2011-01-28
EP1181713B1 (en) 2004-09-29
NL1017525C1 (nl) 2001-04-26
IES20010254A2 (en) 2002-03-06
NO312462B1 (no) 2002-05-13
NO20011271D0 (no) 2001-03-13
EA003581B1 (ru) 2003-06-26
WO2001045483A2 (en) 2001-06-28
IS2060B (is) 2005-11-15
KR20020065345A (ko) 2002-08-13
CA2360303C (en) 2003-08-12
ES2170732A1 (es) 2002-08-01
FI20011577A0 (fi) 2001-07-26
DE60105926T2 (de) 2005-11-24
EA200200018A1 (ru) 2002-04-25
HK1048812B (zh) 2007-06-01
BG65131B1 (bg) 2007-03-30
NZ516298A (en) 2002-12-20
TR200201166T1 (tr) 2002-10-21
SI1181713T1 (en) 2005-02-28
AU3920101A (en) 2001-07-03
PL353398A1 (en) 2003-11-17
PL205724B1 (pl) 2010-05-31
FR2812877B1 (fr) 2003-04-04
GB2357763A (en) 2001-07-04
JP3798982B2 (ja) 2006-07-19
FR2812877A1 (fr) 2002-02-15
AT4367U1 (de) 2001-06-25
IS5883A (is) 2001-06-20
CH691535A5 (de) 2001-08-15
PT1181713E (pt) 2005-02-28
SK286283B6 (sk) 2008-06-06
HRP20020004A2 (en) 2003-04-30
EP1181713A2 (en) 2002-02-27
ES2170732B2 (es) 2003-09-16
BG106203A (bg) 2002-08-30
US20020120005A1 (en) 2002-08-29
SE0103045L (sv) 2002-06-23
MXPA01013151A (es) 2002-08-12

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Legal Events

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