GR3036623T3 - Thiazolidinedione derivatives, production and use thereof. - Google Patents

Thiazolidinedione derivatives, production and use thereof.

Info

Publication number
GR3036623T3
GR3036623T3 GR20010401481T GR20010401481T GR3036623T3 GR 3036623 T3 GR3036623 T3 GR 3036623T3 GR 20010401481 T GR20010401481 T GR 20010401481T GR 20010401481 T GR20010401481 T GR 20010401481T GR 3036623 T3 GR3036623 T3 GR 3036623T3
Authority
GR
Greece
Prior art keywords
production
thiazolidinedione derivatives
general formula
thiazolidinedione derivative
thiazolidinedione
Prior art date
Application number
GR20010401481T
Other languages
English (en)
Inventor
Takashi Sohda
Hitoshi Ikeda
John C Greenfield
Jerry R Colca
Edgar N Petzold
Original Assignee
Upjohn Co
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=13672917&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GR3036623(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Upjohn Co, Takeda Chemical Industries Ltd filed Critical Upjohn Co
Publication of GR3036623T3 publication Critical patent/GR3036623T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Lubricants (AREA)
  • Graft Or Block Polymers (AREA)
GR20010401481T 1991-04-11 2001-09-17 Thiazolidinedione derivatives, production and use thereof. GR3036623T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP7883691 1991-04-11
PCT/US1992/002566 WO1992018501A1 (en) 1991-04-11 1992-04-06 Thiazolidinedione derivatives, production and use thereof

Publications (1)

Publication Number Publication Date
GR3036623T3 true GR3036623T3 (en) 2001-12-31

Family

ID=13672917

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20010401481T GR3036623T3 (en) 1991-04-11 2001-09-17 Thiazolidinedione derivatives, production and use thereof.

Country Status (19)

Country Link
EP (1) EP0579733B1 (el)
JP (1) JP3176694B2 (el)
KR (1) KR100249988B1 (el)
AT (1) ATE202352T1 (el)
AU (1) AU1743292A (el)
CA (1) CA2106967C (el)
CZ (1) CZ196693A3 (el)
DE (1) DE69231886T2 (el)
DK (1) DK0579733T3 (el)
ES (1) ES2161692T3 (el)
FI (1) FI934426A7 (el)
GR (1) GR3036623T3 (el)
HU (1) HUT68370A (el)
MX (1) MX9201637A (el)
NO (1) NO933615L (el)
PT (1) PT100366A (el)
SK (1) SK109993A3 (el)
TW (1) TW209864B (el)
WO (1) WO1992018501A1 (el)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4104593A (en) * 1992-05-05 1993-11-29 Upjohn Company, The A process for producing pioglitazone metabolite
TW268952B (el) * 1993-02-26 1996-01-21 Takeda Pharm Industry Co Ltd
NO305987B1 (no) * 1994-04-11 1999-08-30 Sankyo Co Heterosykliske forbindelser med antidiabetisk aktivitet, deres anvendelse og farmasoeytisk preparat inneholdende disse
TWI238064B (en) * 1995-06-20 2005-08-21 Takeda Chemical Industries Ltd A pharmaceutical composition for prophylaxis and treatment of diabetes
US5952509A (en) * 1996-06-27 1999-09-14 Takeda Chemical Industries, Ltd. Production of benzaldehyde compounds
KR20070011651A (ko) 1997-06-18 2007-01-24 스미스클라인비이참피이엘시이 티아졸리딘디온 및 술포닐우레아를 사용한 당뇨병의 치료
HK1040910B (en) 1998-11-12 2009-06-26 Smithkline Beecham Plc Pharmaceutical composition for modified release of an insulin sensitiser and metformin
AR023700A1 (es) 1998-11-12 2002-09-04 Smithkline Beecham Plc Un procedimiento para preparar una composicion farmaceutica que comprende un sensibilizador de insulina
GB0014969D0 (en) 2000-06-19 2000-08-09 Smithkline Beecham Plc Novel method of treatment
DE20119200U1 (de) 2001-11-27 2003-04-10 Joh. Winklhofer & Söhne GmbH und Co KG, 81369 München Kettenspanner mit mechanischer Verriegelung
US8268352B2 (en) 2002-08-05 2012-09-18 Torrent Pharmaceuticals Limited Modified release composition for highly soluble drugs
US8216609B2 (en) 2002-08-05 2012-07-10 Torrent Pharmaceuticals Limited Modified release composition of highly soluble drugs
KR100646128B1 (ko) 2005-04-21 2006-11-14 전라옥 ＰＰＡＲγ에 선택적으로 작용하는 테트라하이드로퀴놀린계열 티아졸리딘디온 유도체 및 그 합성방법
CN101448500A (zh) * 2006-03-16 2009-06-03 新陈代谢解决方案开发公司 噻唑烷二酮类似物和糖皮质激素激动剂的组合疗法
AU2013200104B2 (en) * 2006-03-16 2014-05-15 Metabolic Solutions Development Company, Llc Thiazolidinedione analogues for the treatment of metabolic inflammation mediated disease
UA96441C2 (ru) * 2006-03-16 2011-11-10 Метаболик Солюшнз Девелопмент Компани Фармацевтическая композиция, которая содержит аналог тиазолидиндиона митоглитазон, для лечения заболеваний, опосредованных метаболическим воспалением
WO2007109037A2 (en) * 2006-03-16 2007-09-27 Metabolic Solutions Development Company Thiazolidinedione analogues for the treatment of hypertension and for lowering lipids
US7435741B2 (en) 2006-05-09 2008-10-14 Teva Pharmaceutical Industries, Ltd. 2-N{5-[[4-[2-(methyl-2-pyridinylamino) ethoxy] phenyl]methyl]-2,4-thiazolidinedione} butanedioic acid, methods of preparation and compositions with rosiglitazone maleate
WO2008038359A1 (en) 2006-09-28 2008-04-03 Daido Kogyo Co., Ltd. Chain tensioner
KR101537830B1 (ko) 2007-09-14 2015-07-17 메타볼릭 솔루션스 디벨롭먼트 컴퍼니, 엘엘씨 고혈압 치료용 티아졸리딘디온 유사체
US8304441B2 (en) 2007-09-14 2012-11-06 Metabolic Solutions Development Company, Llc Thiazolidinedione analogues for the treatment of metabolic diseases
US8722710B2 (en) 2007-09-26 2014-05-13 Deuterx, Llc Deuterium-enriched pioglitazone
RU2564661C2 (ru) 2009-12-15 2015-10-10 МЕТАБОЛИК СОЛЮШНЗ ДЕВЕЛОПМЕНТ КОМПАНИ, ЭлЭлСи Соли тиазолидиндиона со сниженным сродством к ppar для лечения нарушений обмена веществ
MX2012012092A (es) * 2010-04-19 2012-12-17 Metabolic Solutions Dev Co Llc Sintesis novedosa para compuestos de tiazolidinadiona.
AU2011242955A1 (en) * 2010-04-19 2012-11-01 Metabolic Solutions Development Company, Llc Novel synthesis for thiazolidinedione compounds
KR101988203B1 (ko) 2010-08-10 2019-06-11 씨리우스 테라퓨틱스, 엘엘씨 티아졸리딘디온 화합물의 신규한 합성법
CA2807815C (en) * 2010-08-10 2018-10-02 Metabolic Solutions Development Company, Llc Novel synthesis for thiazolidinedione compounds
US20120094959A1 (en) 2010-10-19 2012-04-19 Bonnie Blazer-Yost Treatment of cystic diseases
CA2941562C (en) * 2013-03-14 2021-09-21 Deuterx, Llc Deuterium-enriched 2,4-thiazolidinediones and methods of treatment
US10188639B2 (en) 2014-01-15 2019-01-29 Deuterx, Llc Methods of treating neurological, metabolic, and other disorders using enantiopure deuterium-enriched pioglitazone
EP3125888B1 (en) * 2014-04-02 2018-05-23 Minoryx Therapeutics S.L. 2,4-thiazolidinedione derivatives in the treatment of central nervous system disorders
WO2016071727A1 (en) 2014-11-04 2016-05-12 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the prevention and the treatment of rapidly progressive glomerulonephritis
EP3548026B1 (en) 2016-12-01 2021-01-20 Minoryx Therapeutics S.L. 5-[[4-[2-[5-(1-hydroxyethyl)pyridin-2-yl]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione for treating nonalcoholic fatty liver disease
EP3559010B1 (en) * 2016-12-23 2022-06-08 Minoryx Therapeutics S.L. Process for preparing 5-[[4-[2-[5-(1-hydroxyethyl)-2-pyridinyl]ethoxy]phenyl]methyl]-2,4-thiazolidinedione and salts thereof
US11767317B1 (en) 2020-06-30 2023-09-26 Poxel Sa Methods of synthesizing enantiopure deuterium-enriched pioglitazone
US11319313B2 (en) 2020-06-30 2022-05-03 Poxel Sa Crystalline forms of deuterium-enriched pioglitazone
MX2025013233A (es) * 2023-05-09 2026-02-03 Minoryx Therapeutics S L Formas polimorficas y formulaciones de leriglitazona

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5522636A (en) * 1978-08-04 1980-02-18 Takeda Chem Ind Ltd Thiazoliding derivative
AR240698A1 (es) * 1985-01-19 1990-09-28 Takeda Chemical Industries Ltd Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales

Also Published As

Publication number Publication date
PT100366A (pt) 1993-06-30
JPH0586057A (ja) 1993-04-06
CA2106967C (en) 2003-12-09
NO933615D0 (no) 1993-10-08
SK109993A3 (en) 1994-12-07
AU1743292A (en) 1992-11-17
DK0579733T3 (da) 2001-10-15
WO1992018501A1 (en) 1992-10-29
FI934426A0 (fi) 1993-10-08
KR100249988B1 (ko) 2000-04-01
CA2106967A1 (en) 1992-10-12
EP0579733A1 (en) 1994-01-26
FI934426L (fi) 1993-10-08
ES2161692T3 (es) 2001-12-16
JP3176694B2 (ja) 2001-06-18
NO933615L (no) 1993-10-08
DE69231886T2 (de) 2002-03-28
DE69231886D1 (de) 2001-07-26
HUT68370A (en) 1995-06-28
TW209864B (el) 1993-07-21
EP0579733B1 (en) 2001-06-20
ATE202352T1 (de) 2001-07-15
FI934426A7 (fi) 1993-10-08
MX9201637A (es) 1993-08-01
CZ196693A3 (en) 1994-05-18

Similar Documents

Publication Publication Date Title
GR3036623T3 (en) Thiazolidinedione derivatives, production and use thereof.
KR0156747B1 (en) Use of 1,3-oxathiolan nucleoside analogues in the treatment of hepatitis-b
MY104626A (en) A 1-phenylimidazole derivative and its production and use.
SG40895A1 (en) Propiophenone derivative and processes for preparing the same
CA2065799A1 (en) Thiazolidinedione derivatives, their production and their use
AU8347991A (en) 1-methylcarbapenem derivatives and process for preparation thereof
AU8156394A (en) Methods for inhibiting LDL oxidation and atheroclerosis
MY117092A (en) Chemotherapeutic pyrrolocarbazole derivatives
CA2007771A1 (en) Ocular lens material
MY102135A (en) A benzoylurea derivative and its production and use.
AU3445793A (en) Use of fluorine interhalogen compounds as a sterilizing agent
EP1156057A4 (en) MALTO-OLIGOSACCHARID DERIVATIVES AND THEIR APPLICATIONS
MY108303A (en) Neuroleptic 2-substituted perhydro-1-h-pyrido [1,2-a]pyrazines.
NZ334119A (en) Use of pentynoic acid derivatives as neurotrophic and antiproliferative agents
TW282470B (el)
JPS5419969A (en) Proline derivative and its preparation
HU9904686D0 (en) New hydroxy-bicyclolactam derivatives, their use and medicaments containing them
HUT52044A (en) Process for producing pyrrolidine derivatives
EP0564648A4 (en) Novel aconitine compound and analgesic/antiinflammatory agent.
IL113451A (en) Process for the preparation of 5,6-dihydroxy-2-amino-1,2,3,4-tetrahydronaphthalene derivatives
TW239124B (en) Process for the preparation of 2,4,5-tribromopyrrole-3-carbonitrile
AU3703093A (en) Monoquaternary 2,16-bispiperidinylandrostane derivatives
HU912216D0 (en) Process for the production of purinyl-and pirimidinyl - tetrahydrofurane derivatives and medical preparations containing them
AU2532692A (en) Method for treating hypertension
IL114866A0 (en) Process for the preparation of the (-)-n-methyl-n-Ú4-(4-phenyl-4-acetylaminopiperidin-1-yl-2-(3,4-dichlorophenyl) butyl¾ benzamide