HK56696A - Synthetic membrane vesicles containing functionally active fusion peptides as drug delivery systems - Google Patents

Synthetic membrane vesicles containing functionally active fusion peptides as drug delivery systems

Info

Publication number
HK56696A
HK56696A HK56696A HK56696A HK56696A HK 56696 A HK56696 A HK 56696A HK 56696 A HK56696 A HK 56696A HK 56696 A HK56696 A HK 56696A HK 56696 A HK56696 A HK 56696A
Authority
HK
Hong Kong
Prior art keywords
vesicles
cell
detergent
membrane
vesicle
Prior art date
Application number
HK56696A
Other languages
German (de)
English (en)
Inventor
Dr Glueck Reinhard
Dr Herrmann Peter
Klein Peter
Original Assignee
Nika Health Products Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nika Health Products Limited filed Critical Nika Health Products Limited
Publication of HK56696A publication Critical patent/HK56696A/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6839—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting material from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
    • A61K47/6913—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome the liposome being modified on its surface by an antibody
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Feedback Control In General (AREA)
  • Fittings On The Vehicle Exterior For Carrying Loads, And Devices For Holding Or Mounting Articles (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)

Claims (15)

  1. Procédé de préparation de vésicules à double couche de phospholipides contenant des peptides de fusion et, si on le désire, d'autres marqueurs spécifiques des cellules, sur la membrane, et contenant en outre au moins un médicament ou une substance pharmaceutiquement active désirés, comprenant les stades consistant à :
    a) dissoudre les phospholipides, de préférence avec les peptides de fusion, en présence d'un détergent,
    b) ajouter le médicament ou la substance désirée,
    c) éliminer le détergent, provoquant ainsi la formation de vésicules,
    d) traiter les vésicules pour obtenir la taille désirée,
    e) ajouter les peptides de fusion à moins qu'ils n'aient été prévus en a) et
    f) si on le désire, ajouter d'autres marqueurs spécifiques des cellules, de préférence en association avec un agent de réticulation,
    caractérisé en ce qu'on utilise un détergent non ionique, de préférence l'éther monododécylique de l'octaéthylène-glycol, qui ne réagit pas avec l'hémagglutinine, on élimine le détergent par des traitements répétés avec des microsupports de perles de polystyrène et on obtient la taille désirée pour les vésicules par traitement par les ultrasons.
  2. Procédé selon la revendication 1, caractérisé en ce que les microsupports ont une granularité - à l'état mouillé - de 20 à 50 et la taille désirée pour les vésicules est de 50 à 100 nm de diamètre.
  3. Procédé selon les revendications 1 ou 2, caractérisé en ce que la solution de détergent est utilisée à une concentration comprise entre 10 et 250, de préférence entre 80 et 120 »moles/ml et le détergent est éliminé par application de 1 à 2, de préférence d'environ 1,5 g de microsupports de perles de polystyrène pour 100 mg de détergent.
  4. Procédé selon l'une quelconque des revendications précédentes, caractérisé en ce que les peptides de fusion sont choisis parmi le trimère ou le monomère de l'hémagglutinine, une de ses sous-unités coupées ou les deux, les glycopeptides HA1 et HA2, un peptide de fusion isolé de sources naturelles et un peptide de fusion synthétique.
  5. Procédé selon l'une quelconque des revendications précédentes, caractérisé en ce que les vésicules comprennent au moins un anticorps - de préférence monoclonal - en tant que marqueur spécifique des cellules, et de préférence un agent de réticulation auquel l'anticorps est lié de telle manière qu'il ait toujours une activité biologique complète.
  6. Procédé selon l'une quelconque des revendications précédentes, avec l'hémagglutinine comme peptide de fusion, caractérisé en ce que l'hémagglutinine est obtenue à partir d'au moins un membre du groupe constitué du virus de l'influenza, de préférence du sous-type A-H₁N₁, du rhabdovirus, du virus du parainfluenza et du togavirus.
  7. Procédé selon l'une quelconque des revendications 1 à 5, caractérisé en ce que les peptides de fusion comprennent au moins un peptide de fusion sous la forme d'une séquence d'aminoacides, au moins une extrémité de la séquence étant formée par au moins un groupe cystéine, de préférence par trois groupes cystéine.
  8. Procédé selon l'une quelconque des revendications précédentes, dans lequel une partie des phospholipides est obtenue à partir d'au moins un membre du groupe constitué du virus de l'influenza, de préférence du sous-type A-H₁N₁, du rhabdovirus, du virus du parainfluenza et du togavirus, et appliquée en association avec une quantité de 1 à 100 fois, de préférence 5 à 15 fois supérieure de phosphatidylcholine.
  9. Procédé selon l'une quelconque des revendications précédentes, caractérisé en ce que
    - les phospholipides comprennent 70 à 95 % en poids de phosphatidylcholine et 5 à 30, de préférence 10 à 20 % en poids de phosphatidyl éthanolamine ;
    - de 5 à 10, de préférence de 6 à 8 % en poids d'un agent de réticulation, de préférence d'un dérivé sulfosuccinimidylé ;
    - au moins un peptide de fusion, et
    - au moins un anticorps spécifique des cellules lié à l'agent de réticulation.
  10. Procédé selon l'une quelconque des revendications précédentes, dans lequel les vésicules contiennent au moins une des substances suivantes : sulfate de dextrane, ribonucléase dimère, lysozyme dimère, imidazol-carboxamide, hydroxy-urée, adriplastine, endoxane, fluoro-uracile, colchicine.
HK56696A 1991-02-02 1996-03-28 Synthetic membrane vesicles containing functionally active fusion peptides as drug delivery systems HK56696A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP91101414A EP0497997B1 (fr) 1991-02-02 1991-02-02 Vésicules membranaires synthétiques contenant des peptides de fusion fonctionellement actifs comme systèmes de délivrance d'un médicament

Publications (1)

Publication Number Publication Date
HK56696A true HK56696A (en) 1996-04-12

Family

ID=8206362

Family Applications (1)

Application Number Title Priority Date Filing Date
HK56696A HK56696A (en) 1991-02-02 1996-03-28 Synthetic membrane vesicles containing functionally active fusion peptides as drug delivery systems

Country Status (22)

Country Link
US (1) US6040167A (fr)
EP (1) EP0497997B1 (fr)
JP (1) JP3404037B2 (fr)
KR (1) KR100205693B1 (fr)
AT (1) ATE125154T1 (fr)
AU (1) AU657730B2 (fr)
BG (1) BG61215B1 (fr)
BR (1) BR9204116A (fr)
CA (1) CA2079685C (fr)
DE (1) DE69111414T2 (fr)
DK (1) DK0497997T3 (fr)
ES (1) ES2077086T3 (fr)
FI (1) FI109969B (fr)
GE (1) GEP20002229B (fr)
GR (1) GR3017490T3 (fr)
HK (1) HK56696A (fr)
HU (1) HU215533B (fr)
NO (1) NO306194B1 (fr)
PL (2) PL296382A1 (fr)
RO (1) RO114736B1 (fr)
RU (1) RU2125868C1 (fr)
WO (1) WO1992013525A1 (fr)

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DK0525132T3 (da) * 1991-02-14 1996-02-05 Baxter Int Binding af genkendende stoffer til liposomer
US7097839B1 (en) * 1993-10-26 2006-08-29 Thomas Jefferson University ST receptor binding compounds and methods of using the same
US5879656A (en) * 1993-10-26 1999-03-09 Thomas Jefferson University Methods of treating metastatic colorectal cancer with ST receptor binding compounds
WO1995032706A1 (fr) * 1994-05-31 1995-12-07 Inex Pharmaceuticals Corp. Virosomes comme vecteur pour introduire des agents therapeutiques a l'interieur de cellules
US6861053B1 (en) * 1999-08-11 2005-03-01 Cedars-Sinai Medical Center Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth
US5908777A (en) * 1995-06-23 1999-06-01 University Of Pittsburgh Lipidic vector for nucleic acid delivery
AU6691496A (en) * 1995-08-01 1997-02-26 Advanced Therapies, Inc. Enhanced artificial viral envelopes for cellular delivery of therapeutic substances
CZ299809B6 (cs) * 1996-05-08 2008-12-03 Nika Health Products Limited Lipidový vácek mající kladne nabitou membránu z lipidové dvojvrstvy pro prenos genetického materiálu a zpusob jeho prípravy
EP1141007B1 (fr) * 1998-12-14 2013-05-15 Dendreon Corporation Compositions et procedes d'amelioration de la presentation d'antigene restreints du complexe majeur d'histocompatibilite de classe i
US7148324B1 (en) 1998-12-14 2006-12-12 Dendreon Corporation Compositions and methods for enhancement of major histocompatibility complex class I restricted antigen presentation
JP2004513059A (ja) 1998-12-24 2004-04-30 ユセベ，ソシエテ　アノニム ペプチド産物、方法及び組成物
MXPA02001417A (es) * 1999-08-09 2002-08-12 Lexigen Pharm Corp Complejos multiples de citosina-anticuerpo.
CZ20021216A3 (cs) * 1999-10-08 2002-10-16 Nika Health Products Limited Lipidové váčky obsahující DOSPER
JP4112860B2 (ja) * 1999-12-17 2008-07-02 ショット アクチエンゲゼルシャフト 乗員の拘束システムの誘導作動式点火カプセルおよび点火カプセル用のテスト回路
US20040028687A1 (en) * 2002-01-15 2004-02-12 Waelti Ernst Rudolf Methods and compositions for the targeted delivery of therapeutic substances to specific cells and tissues
US20040176283A1 (en) * 2002-04-01 2004-09-09 Robinson John A. Methods and compositions for the design of synthetic vaccines
AU2003233981A1 (en) * 2002-04-29 2003-11-17 Biotesys Gmbh Transport system in biological systems
EP1447080A1 (fr) * 2003-02-13 2004-08-18 Bestewil Holding B.V. Procéde de production de particules de type virosome
US8658203B2 (en) 2004-05-03 2014-02-25 Merrimack Pharmaceuticals, Inc. Liposomes useful for drug delivery to the brain
LT3173073T (lt) 2004-05-03 2025-01-10 Ipsen Biopharm Ltd. Liposomos, skirtos vaistų pristatymui
WO2007048019A2 (fr) * 2005-10-20 2007-04-26 The Penn State Research Foundation Systeme d'administration d'agents de diagnostic et therapeutiques
WO2009016433A2 (fr) * 2006-09-15 2009-02-05 Ottawa Health Research Institute Rhabdovirus oncolytique
EP4647126A3 (fr) 2015-10-16 2026-02-11 Ipsen Biopharm Ltd. Stabilisation de compositions pharmaceutiques de camptothecine

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DE3173713D1 (en) * 1980-09-05 1986-03-20 Frappier Armand Inst Formation of an immunosome exclusively made of viral antigens reconstituted on an artificial membrane
US4871488A (en) * 1985-04-22 1989-10-03 Albany Medical College Of Union University Reconstituting viral glycoproteins into large phospholipid vesicles
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Also Published As

Publication number Publication date
GEP20002229B (en) 2000-09-25
JPH05505406A (ja) 1993-08-12
RO114736B1 (ro) 1999-07-30
AU657730B2 (en) 1995-03-23
KR100205693B1 (en) 1999-07-01
JP3404037B2 (ja) 2003-05-06
NO306194B1 (no) 1999-10-04
AU1169392A (en) 1992-09-07
FI109969B (fi) 2002-11-15
BG96928A (bg) 1994-03-24
EP0497997B1 (fr) 1995-07-19
GR3017490T3 (en) 1995-12-31
HU215533B (hu) 1999-01-28
CA2079685C (fr) 2001-11-27
FI924418A7 (fi) 1993-04-03
RU2125868C1 (ru) 1999-02-10
FI924418A0 (fi) 1992-10-01
DE69111414D1 (de) 1995-08-24
PL170169B1 (en) 1996-10-31
NO923703L (no) 1992-11-26
ATE125154T1 (de) 1995-08-15
NO923703D0 (no) 1992-09-24
PL296382A1 (en) 1993-11-02
US6040167A (en) 2000-03-21
HU9203141D0 (en) 1992-12-28
HUT66194A (en) 1994-10-28
BG61215B1 (en) 1997-03-31
BR9204116A (pt) 1993-06-08
ES2077086T3 (es) 1995-11-16
DE69111414T2 (de) 1996-02-01
CA2079685A1 (fr) 1992-08-03
WO1992013525A1 (fr) 1992-08-20
EP0497997A1 (fr) 1992-08-12
DK0497997T3 (da) 1995-11-27

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