HK58589A - Ether prodrugs of anti-inflammatory oxicams - Google Patents

Ether prodrugs of anti-inflammatory oxicams Download PDF

Info

Publication number
HK58589A
HK58589A HK585/89A HK58589A HK58589A HK 58589 A HK58589 A HK 58589A HK 585/89 A HK585/89 A HK 585/89A HK 58589 A HK58589 A HK 58589A HK 58589 A HK58589 A HK 58589A
Authority
HK
Hong Kong
Prior art keywords
mmol
methyl
nmr
delta
pyridyl
Prior art date
Application number
HK585/89A
Other languages
German (de)
English (en)
French (fr)
Inventor
Anthony Marfat
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of HK58589A publication Critical patent/HK58589A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C68/00—Preparation of esters of carbonic or haloformic acids
    • C07C68/02—Preparation of esters of carbonic or haloformic acids from phosgene or haloformates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HK585/89A 1983-12-21 1989-07-20 Ether prodrugs of anti-inflammatory oxicams HK58589A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56390283A 1983-12-21 1983-12-21
US06/606,113 US4551452A (en) 1983-12-21 1984-05-02 Anti-inflammatory 2-methyl-2H-1,2-benzo-(or -thieno-)thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor

Publications (1)

Publication Number Publication Date
HK58589A true HK58589A (en) 1989-07-28

Family

ID=27073413

Family Applications (1)

Application Number Title Priority Date Filing Date
HK585/89A HK58589A (en) 1983-12-21 1989-07-20 Ether prodrugs of anti-inflammatory oxicams

Country Status (26)

Country Link
US (1) US4551452A (da)
EP (1) EP0147177B1 (da)
KR (1) KR860002035B1 (da)
AU (1) AU552940B2 (da)
BG (1) BG47946A3 (da)
CA (1) CA1255302A (da)
DD (1) DD229125A5 (da)
DE (1) DE3466776D1 (da)
DK (1) DK166678B1 (da)
EG (1) EG17049A (da)
ES (1) ES8604215A1 (da)
FI (1) FI79850C (da)
GR (1) GR82512B (da)
HK (1) HK58589A (da)
HU (1) HU201063B (da)
IE (1) IE57680B1 (da)
IL (1) IL73873A (da)
MX (2) MX174596B (da)
NO (1) NO161317C (da)
NZ (1) NZ210632A (da)
PH (1) PH21447A (da)
PL (1) PL145989B1 (da)
PT (1) PT79700B (da)
RO (1) RO90048A (da)
SG (1) SG27001G (da)
YU (1) YU43677B (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4906635A (en) * 1983-11-25 1990-03-06 Schering Corporation Carboxyalkyl dipeptides as antiglaucoma agents
US5017567A (en) * 1983-11-25 1991-05-21 Schering Corporation Carboxyalkyl dipeptides as antiglaucoma agents
US4778795A (en) * 1983-11-25 1988-10-18 Schering Corporation Carboxyalkyl dipeptides as antiglaucoma agents
US4616012A (en) * 1983-11-25 1986-10-07 Schering Corporation Carboxyalkyl dipeptides as antiglaucoma agents
US4623486A (en) * 1985-05-29 1986-11-18 Pfizer Inc. [4-substituted benzoyloxy]-N-substituted-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides having anti-arthritic activity
KR890001236B1 (ko) * 1985-10-02 1989-04-28 화이자 인코포레이티드 소염제 조성물의 제조방법
US4771071A (en) * 1986-05-05 1988-09-13 Merck & Co., Inc. Antihypercholesterolemic compounds
WO1987006933A1 (en) * 1986-05-16 1987-11-19 Pfizer Inc. Benzothiazine dioxide derivatives
WO1989003682A1 (en) * 1987-10-26 1989-05-05 Pfizer Inc. Benzothiazine dioxide derivatives
IL87951A (en) * 1987-10-29 1992-03-29 Chem Pharm Forsch Gmbh Carbonic acid esters of 6-chloro-4-(1-hydroxyethoxy)-2-methyl-n-(2-pyridyl)-2h-thieno(2,3-e)-1,2-thiazine-3-carboxamide 1,1-dioxide,their preparation and pharmaceutical compositions containing them
ZA945190B (en) * 1993-07-30 1995-02-24 Kotobuki Seiyaku Co Ltd Carboxymethylidenecycloheptimidazole derivatives method or manufacturing the same and therapeutic agents containing these compounds
IT1308633B1 (it) 1999-03-02 2002-01-09 Nicox Sa Nitrossiderivati.
CN100389114C (zh) * 2006-01-17 2008-05-21 南京新港医药有限公司 一种安吡昔康的精制方法
US20090238763A1 (en) 2006-07-09 2009-09-24 Chongxi Yu High penetration compositions and uses thereof
US20090221703A1 (en) 2006-07-09 2009-09-03 Chongxi Yu High penetration composition and uses thereof
CN101522692A (zh) * 2006-10-11 2009-09-02 于崇曦 具有快速皮肤穿透速度的带正电荷的水溶性的昔康及其相关化合物的前药
WO2008149181A1 (en) * 2007-06-04 2008-12-11 Techfields Inc Pro-drugs of nsaias with very high skin and membranes penetration rates and their new medicinal uses
WO2010065936A1 (en) 2008-12-04 2010-06-10 Chongxi Yu High penetration compositions and their applications
WO2013093931A2 (en) 2011-09-19 2013-06-27 Sun Pharma Advanced Research Company Ltd. Novel prodrugs of phenolic drugs

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3591584A (en) * 1968-08-27 1971-07-06 Pfizer Benzothiazine dioxides
US3787324A (en) * 1971-03-01 1974-01-22 Warner Lambert Co 4-hydroxy-3-(3-isoxazolocarbamyl)-2h-1,2-benzothiazine 1,dioxides and process for their production
US3892740A (en) * 1974-10-15 1975-07-01 Pfizer Process for the production of carboxamides of oxo-1,2-benzothiazine-1,1-dioxides
AU518216B2 (en) * 1977-09-06 1981-09-17 Hafslund Nycomed Pharma Aktiengesellschaft Thienothiazine derivatives
US4309427A (en) * 1981-01-15 1982-01-05 Pfizer Inc. Benzothiazine dioxide derivatives
IT1168064B (it) * 1981-11-12 1987-05-20 Prodotti Antibiotici Spa Composto ad azione antinfiammatoria
IT8219486A0 (it) * 1982-02-05 1982-02-05 Chiesi Farma Spa Nuovi composti ad attivita'antiinfiammatoria, procedimento per la loro preparazione e relative composizioni farmaceutiche.

Also Published As

Publication number Publication date
IL73873A (en) 1988-02-29
HUT37426A (en) 1985-12-28
DK614984A (da) 1985-07-17
FI845074A0 (fi) 1984-12-20
EP0147177A3 (en) 1985-08-14
US4551452A (en) 1985-11-05
EP0147177A2 (en) 1985-07-03
NO161317C (no) 1989-08-02
NO161317B (no) 1989-04-24
IE57680B1 (en) 1993-02-24
HU201063B (en) 1990-09-28
PT79700B (en) 1986-12-30
DD229125A5 (de) 1985-10-30
MX9203740A (es) 1992-09-01
AU552940B2 (en) 1986-06-26
NO845145L (no) 1985-06-24
FI79850C (fi) 1990-03-12
FI845074L (fi) 1985-06-22
IL73873A0 (en) 1985-03-31
FI79850B (fi) 1989-11-30
PH21447A (en) 1987-10-28
PL251040A1 (en) 1985-10-22
KR850004492A (ko) 1985-07-15
ES8604215A1 (es) 1986-01-16
BG47946A3 (en) 1990-10-15
AU3699784A (en) 1985-07-04
NZ210632A (en) 1987-02-20
KR860002035B1 (ko) 1986-11-17
DE3466776D1 (en) 1987-11-19
ES538907A0 (es) 1986-01-16
DK614984D0 (da) 1984-12-20
SG27001G (en) 1989-08-11
YU43677B (en) 1989-10-31
GR82512B (en) 1985-04-22
DK166678B1 (da) 1993-06-28
PL145989B1 (en) 1988-12-31
EP0147177B1 (en) 1987-10-14
CA1255302A (en) 1989-06-06
YU216084A (en) 1986-10-31
RO90048A (ro) 1986-09-30
EG17049A (en) 1991-03-30
IE843260L (en) 1985-06-21
MX174596B (es) 1994-05-30
PT79700A (en) 1985-01-01

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)